Molecular dissection of titin-based mechanisms in charge of cardiomyocyte dysfunction in terminal feart failure

Resultado final

The summary of data generated in first 12 months of project

The summary of raw data and metadata generated in first 12 months of project

Publicaciones

HSPB7 is indispensable for heart development by modulating actin filament assembly

Autores: Tongbin Wu, Yongxin Mu, Julius Bogomolovas, Xi Fang, Jennifer Veevers, Roberta B. Nowak, Christopher T. Pappas, Carol C. Gregorio, Sylvia M. Evans, Velia M. Fowler, Ju Chen
Publicado en: Proceedings of the National Academy of Sciences, Edición 114/45, 2017, Página(s) 11956-11961, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1713763114

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy

Autores: Xi Fang, Julius Bogomolovas, Tongbin Wu, Wei Zhang, Canzhao Liu, Jennifer Veevers, Matthew J. Stroud, Zhiyuan Zhang, Xiaolong Ma, Yongxin Mu, Dieu-Hung Lao, Nancy D. Dalton, Yusu Gu, Celine Wang, Michael Wang, Yan Liang, Stephan Lange, Kunfu Ouyang, Kirk L. Peterson, Sylvia M. Evans, Ju Chen
Publicado en: Journal of Clinical Investigation, Edición 127/8, 2017, Página(s) 3189-3200, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI94310

Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages

Autores: Thomas Moore-Morris, Paola Cattaneo, Nuno Guimarães-Camboa, Julius Bogomolovas, Marta Cedenilla, Indroneal Banerjee, Mercedes Ricote, Tatiana Kisseleva, Lunfeng Zhang, Yusu Gu, Nancy D Dalton, Kirk L Peterson, Ju Chen, Michel Puceat, Sylvia M Evans
Publicado en: Circulation Research, 2017, Página(s) CIRCRESAHA.117.311490, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.311490

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development

Autores: Cornelis J Boogerd, Xiaoming Zhu, Ivy Aneas, Noboru J Sakabe, Lunfeng Zhang, Debora R Sobreira, Lindsey E Montefiori, Julius Bogomolovas, Amelia C Joslin, Bin Zhou, Ju Chen, Marcelo Nobrega, Sylvia M Evans
Publicado en: Circulation Research, 2018, Página(s) CIRCRESAHA.118.311339, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.118.311339

The BAG3-dependent and -independent roles of cardiac small heat shock proteins

Autores: Xi Fang, Julius Bogomolovas, Christa Trexler, Ju Chen
Publicado en: JCI Insight, Edición 4/4, 2019, ISSN 2379-3708
Editor: JCI Insight
DOI: 10.1172/jci.insight.126464

PKC and PKN in heart disease

Autores: Valeria Marrocco, Julius Bogomolovas, Elisabeth Ehler, Cristobal G. dos Remedios, Jiayu Yu, Chen Gao, Stephan Lange
Publicado en: Journal of Molecular and Cellular Cardiology, Edición 128, 2019, Página(s) 212-226, ISSN 0022-2828
Editor: Academic Press
DOI: 10.1016/j.yjmcc.2019.01.029

Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury

Autores: Julius Bogomolovas, Alexander Gasch, Vilhelmas Bajoras, Dovilė Karčiauskaitė, Pranas Šerpytis, Virginija Grabauskienė, Dittmar Labeit, Siegfried Labeit
Publicado en: International Journal of Cardiology, Edición 212, 2016, Página(s) 232-234, ISSN 0167-5273
Editor: Elsevier BV
DOI: 10.1016/j.ijcard.2016.03.045

A Novel Murine Model of Parvovirus Associated Dilated Cardiomyopathy Induced by Immunization with VP1-Unique Region of Parvovirus B19

Autores: Julijus Bogomolovas, Egidijus Šimoliūnas, Ieva Rinkūnaitė, Luka Smalinskaitė, Andrej Podkopajev, Daiva Bironaitė, Cleo-Aron Weis, Alexander Marx, Virginija Bukelskienė, Norbert Gretz, Virginija Grabauskienė, Dittmar Labeit, Siegfried Labeit
Publicado en: BioMed Research International, Edición 2016, 2016, Página(s) 1-9, ISSN 2314-6133
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2016/1627184

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

Autores: Tiankun Zhou, Jennifer R. Fleming, Barbara Franke, Julius Bogomolovas, Igor Barsukov, Daniel J. Rigden, Siegfried Labeit, Olga Mayans
Publicado en: FEBS Letters, Edición 590/18, 2016, Página(s) 3098-3110, ISSN 0014-5793
Editor: Elsevier BV
DOI: 10.1002/1873-3468.12362

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