Identifying microbiotal triggers of inflammatory bowel disease through the lens of the immune system

Informazioni relative al progetto

IMMUNOBIOME

ID dell’accordo di sovvenzione: 648889

DOI 10.3030/648889

Progetto chiuso

Data della firma CE 3 Luglio 2015

Data di avvio 1 Gennaio 2016

Data di completamento 31 Dicembre 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 304 375,00

Contributo UE € 2 304 375,00

Coordinato da

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Pubblicazioni

Peer reviewed articles (15)

Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress

Autori: Stephanie T. Stengel, Antonella Fazio, Simone Lipinski, Martin T. Jahn, Konrad Aden, Go Ito, Felix Wottawa, Jan W.P. Kuiper, Olivia I. Coleman, Florian Tran, Dora Bordoni, Joana P. Bernardes, Marlene Jentzsch, Anne Luzius, Sandra Bierwirth, Berith Messner, Anna Henning, Lina Welz, Nassim Kakavand, Maren Falk-Paulsen, Simon Imm, Finn Hinrichsen, Matthias Zilbauer, Stefan Schreiber, Arthur Kaser, Ri
Pubblicato in: Gastroenterology, 2020, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.06.088

Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment

Autori: Ester Pagano, Joshua E Elias, Georg Schneditz, Svetlana Saveljeva, Lorraine M Holland, Francesca Borrelli, Tom H Karlsen, Arthur Kaser, Nicole C Kaneider
Pubblicato in: Gut, 2021, Pagina/e gutjnl-2020-323363, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323363

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle

Autori: M. Zaeem Cader, Rodrigo Pereira de Almeida Rodrigues, James A. West, Gavin W. Sewell, Muhammad N. Md-Ibrahim, Stephanie Reikine, Giuseppe Sirago, Lukas W. Unger, Ana Belén Iglesias-Romero, Katharina Ramshorn, Lea-Maxie Haag, Svetlana Saveljeva, Jana-Fabienne Ebel, Philip Rosenstiel, Nicole C. Kaneider, James C. Lee, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Yorgo Modis, Julian L. Griffin, A
Pubblicato in: Cell, Numero 180/2, 2020, Pagina/e 278-295.e23, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2019.12.017

Impaired Autophagy in CD11b + Dendritic Cells Expands CD4 + Regulatory T Cells and Limits Atherosclerosis in Mice

Autori: Marc Clement, Juliette Raffort, Fabien Lareyre, Dimitrios Tsiantoulas, Stephen Newland, Yuning Lu, Leanne Masters, James Harrison, Svetlana Saveljeva, Marcella K.L. Ma, Maria Ozsvar-Kozma, Brian Y.H. Lam, Giles S.H. Yeo, Christoph J. Binder, Arthur Kaser, Ziad Mallat
Pubblicato in: Circulation Research, Numero 125/11, 2019, Pagina/e 1019-1034, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315248

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

Autori: Konrad Aden, Florian Tran, Go Ito, Raheleh Sheibani-Tezerji, Simone Lipinski, Jan W. Kuiper, Markus Tschurtschenthaler, Svetlana Saveljeva, Joya Bhattacharyya, Robert Häsler, Kareen Bartsch, Anne Luzius, Marlene Jentzsch, Maren Falk-Paulsen, Stephanie T. Stengel, Lina Welz, Robin Schwarzer, Björn Rabe, Winfried Barchet, Stefan Krautwald, Gunther Hartmann, Manolis Pasparakis, Richard S. Blumberg,
Pubblicato in: The Journal of Experimental Medicine, 2018, Pagina/e jem.20171029, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20171029

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation

Autori: Konrad Aden, Ateequr Rehman, Maren Falk-Paulsen, Thomas Secher, Jan Kuiper, Florian Tran, Steffen Pfeuffer, Raheleh Sheibani-Tezerji, Alexandra Breuer, Anne Luzius, Marlene Jentzsch, Robert Häsler, Susanne Billmann-Born, Olga Will, Simone Lipinski, Richa Bharti, Timon Adolph, Juan L. Iovanna, Sarah L. Kempster, Richard S. Blumberg, Stefan Schreiber, Burkhard Becher, Mathias Chamaillard, Arthur
Pubblicato in: Cell Reports, Numero 16/8, 2016, Pagina/e 2208-2218, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.07.054

Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation

Autori: Shuhei Hosomi, Joep Grootjans, Markus Tschurtschenthaler, Niklas Krupka, Juan D. Matute, Magdalena B. Flak, Eduardo Martinez-Naves, Manuel Gomez del Moral, Jonathan N. Glickman, Mizuki Ohira, Lewis L. Lanier, Arthur Kaser, Richard Blumberg
Pubblicato in: The Journal of Experimental Medicine, Numero 214/10, 2017, Pagina/e 2985-2997, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20162041

Personalized Treatment in Inflammatory Bowel Disease: For Another Time

Autori: Nicole C. Kaneider, Arthur Kaser
Pubblicato in: Gastroenterology, 2018, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.09.004

New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1

Autori: Shuhei Hosomi, Joep Grootjans, Yu-Hwa Huang, Arthur Kaser, Richard S. Blumberg
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2018.01324

The unfolded protein response in immunity and inflammation

Autori: Joep Grootjans, Arthur Kaser, Randal J. Kaufman, Richard S. Blumberg
Pubblicato in: Nature Reviews Immunology, Numero 16/8, 2016, Pagina/e 469-484, ISSN 1474-1733
Editore: Nature Publishing Group
DOI: 10.1038/nri.2016.62

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

Autori: Georg Schneditz, Joshua E. Elias, Ester Pagano, M. Zaeem Cader, Svetlana Saveljeva, Kathleen Long, Subhankar Mukhopadhyay, Maryam Arasteh, Trevor D. Lawley, Gordon Dougan, Andrew Bassett, Tom H. Karlsen, Arthur Kaser, Nicole C. Kaneider
Pubblicato in: Science Signaling, Numero 12/562, 2019, Pagina/e eaau9048, ISSN 1937-9145
Editore: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aau9048

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

Autori: Joep Grootjans, Niklas Krupka, Shuhei Hosomi, Juan D. Matute, Thomas Hanley, Svetlana Saveljeva, Thomas Gensollen, Jarom Heijmans, Hai Li, Julien P. Limenitakis, Stephanie C. Ganal-Vonarburg, Shengbao Suo, Adrienne M. Luoma, Yosuke Shimodaira, Jinzhi Duan, David Q. Shih, Margaret E. Conner, Jonathan N. Glickman, Gwenny M. Fuhler, Noah W. Palm, Marcel R. de Zoete, C. Janneke van der Woude, Guo-Chen
Pubblicato in: Science, Numero 363/6430, 2019, Pagina/e 993-998, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aat7186

Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis

Autori: Markus Tschurtschenthaler, Timon E. Adolph, Jonathan W. Ashcroft, Lukas Niederreiter, Richa Bharti, Svetlana Saveljeva, Joya Bhattacharyya, Magdalena B. Flak, David Q. Shih, Gwenny M. Fuhler, Miles Parkes, Kenji Kohno, Takao Iwawaki, C. Janneke van der Woude, Heather P. Harding, Andrew M. Smith, Maikel P. Peppelenbosch, Stephan R. Targan, David Ron, Philip Rosenstiel, Richard S. Blumberg, Arthur K
Pubblicato in: The Journal of Experimental Medicine, Numero 214/2, 2017, Pagina/e 401-422, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20160791

The road to Crohn's disease

Autori: Arthur Kaser, Richard S. Blumberg
Pubblicato in: Science, Numero 357/6355, 2017, Pagina/e 976-977, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aao4158

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

Autori: Nick Powell, Eirini Pantazi, Polychronis Pavlidis, Anastasia Tsakmaki, Katherine Li, Feifei Yang, Aimee Parker, Carmen Pin, Domenico Cozzetto, Danielle Minns, Emilie Stolarczyk, Svetlana Saveljeva, Rami Mohamed, Paul Lavender, Behdad Afzali, Jonathan Digby-Bell, Tsui Tjir-Li, Arthur Kaser, Joshua Friedman, Thomas T MacDonald, Gavin A Bewick, Graham M Lord
Pubblicato in: Gut, Numero 69/3, 2020, Pagina/e 578-590, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-318483

Diritti di proprietà intellettuale

Patent (2)

METHODS OF CANCER TREATMENT

Numero candidatura/pubblicazione: 20 19084265
Data: 2019-12-09

FAMIN ASSAY METHODS

Numero candidatura/pubblicazione: 20 19084256
Data: 2019-12-09