GENEtic DiSsection of Innate Immune Sensing and Signalling

Project Information

GENESIS

Grant agreement ID: 647858

DOI 10.3030/647858

Project closed

EC signature date 11 September 2015

Start date 1 October 2015

End date 30 September 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 970 000,00

EU contribution € 1 970 000,00

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

Publications

Peer reviewed articles (10)

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

Author(s): Sarah Kim-Hellmuth, Matthias Bechheim, Benno Pütz, Pejman Mohammadi, Yohann Nédélec, Nicholas Giangreco, Jessica Becker, Vera Kaiser, Nadine Fricker, Esther Beier, Peter Boor, Stephane E. Castel, Markus M. Nöthen, Luis B. Barreiro, Joseph K. Pickrell, Bertram Müller-Myhsok, Tuuli Lappalainen, Johannes Schumacher, Veit Hornung
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-00366-1

Alternative inflammasome activation enables IL-1β release from living cells

Author(s): Moritz M Gaidt, Veit Hornung
Published in: Current Opinion in Immunology, Issue 44, 2017, Page(s) 7-13, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2016.10.007

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Author(s): Moritz M. Gaidt, Thomas S. Ebert, Dhruv Chauhan, Katharina Ramshorn, Francesca Pinci, Sarah Zuber, Fionan O’Duill, Jonathan L. Schmid-Burgk, Florian Hoss, Raymund Buhmann, Georg Wittmann, Eicke Latz, Marion Subklewe, Veit Hornung
Published in: Cell, Issue 171/5, 2017, Page(s) 1110-1124.e18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.09.039

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism

Author(s): Jonathan L. Schmid-Burgk, Klara Höning, Thomas S. Ebert, Veit Hornung
Published in: Nature Communications, Issue 7, 2016, Page(s) 12338, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms12338

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

Author(s): Jonathan L. Schmid-Burgk, Dhruv Chauhan, Tobias Schmidt, Thomas S. Ebert, Julia Reinhardt, Elmar Endl, Veit Hornung
Published in: Journal of Biological Chemistry, Issue 291/1, 2016, Page(s) 103-109, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.C115.700492

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

Author(s): Søren R. Paludan, Line S. Reinert, Veit Hornung
Published in: Nature Reviews Immunology, Issue 19/3, 2019, Page(s) 141-153, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-018-0117-0

Molecular mechanisms and cellular functions of cGAS–STING signalling

Author(s): Karl-Peter Hopfner, Veit Hornung
Published in: Nature Reviews Molecular Cell Biology, 2020, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-020-0244-x

TLR8 Is a Sensor of RNase T2 Degradation Products

Author(s): Wilhelm Greulich, Mirko Wagner, Moritz M. Gaidt, Che Stafford, Yiming Cheng, Andreas Linder, Thomas Carell, Veit Hornung
Published in: Cell, Issue 179/6, 2019, Page(s) 1264-1275.e13, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.11.001

C-tag TNF: a reporter system to study TNF shedding

Author(s): Francesca Pinci, Moritz M Gaidt, Christophe Jung, Gunnar Kuut, Margaret A Jackson, Stefan Bauernfried, Veit Hornung
Published in: Journal of Biological Chemistry, 2020, Page(s) jbc.RA120.015248, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.015248

Human NLRP1 is a sensor for double-stranded RNA

Author(s): Stefan Bauernfried, Matthias J. Scherr, Andreas Pichlmair, Karl E. Duderstadt, Veit Hornung
Published in: Science, 2020, Page(s) eabd0811, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abd0811