Mechanobiology of nuclear import of transcription factors modeled within a bioengineered stem cell niche.

Project Information

NICHOID

Grant agreement ID: 646990

DOI 10.3030/646990

Project closed

EC signature date 1 April 2015

Start date 1 May 2015

End date 31 July 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 903 330,00

EU contribution € 1 903 330,00

Coordinated by

POLITECNICO DI MILANO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (27)

Dissecting the Effect of a 3D Microscaffold on the Transcriptome of Neural Stem Cells with Computational Approaches: A Focus on Mechanotransduction

Author(s): Federica Rey, Cecilia Pandini, Bianca Barzaghini, Letizia Messa, Toniella Giallongo, Orietta Pansarasa, Stella Gagliardi, Matteo Brilli, Gian Vincenzo Zuccotti, Cristina Cereda, Manuela Teresa Raimondi, Stephana Carelli
Published in: International Journal of Molecular Sciences, Issue 21/18, 2020, Page(s) 6775, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21186775

Tissue engineering and regenerative medicine strategies for the female breast

Author(s): Claudio Conci, Lorenzo Bennati, Chiara Bregoli, Federica Buccino, Francesca Danielli, Michela Gallan, Ereza Gjini, Manuela T. Raimondi
Published in: Journal of Tissue Engineering and Regenerative Medicine, Issue 14/2, 2020, Page(s) 369-387, ISSN 1932-6254
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/term.2999

Effect of the 3D Artificial Nichoid on the Morphology and Mechanobiological Response of Mesenchymal Stem Cells Cultured In Vitro

Author(s): Andrea Remuzzi, Barbara Bonandrini, Matteo Tironi, Lorena Longaretti, Marina Figliuzzi, Sara Conti, Tommaso Zandrini, Roberto Osellame, Giulio Cerullo, Manuela Teresa Raimondi
Published in: Cells, Issue 9/8, 2020, Page(s) 1873, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9081873

Neural precursors cells expanded in a 3D micro-engineered niche present enhanced therapeutic efficacy in vivo

Author(s): Stephana Carelli, Toniella Giallongo, Federica Rey, Bianca Barzaghini, Tommaso Zandrini, Andrea Pulcinelli, Riccardo Nardomarino, Giulio Cerullo, Roberto Osellame, Cristina Cereda, Gian Vincenzo Zuccotti, Manuela Teresa Raimondi
Published in: Nanotheranostics, Issue 5/1, 2021, Page(s) 8-26, ISSN 2206-7418
Publisher: Ivyspring International Publisher Pty Ltd
DOI: 10.7150/ntno.50633

iPS, organoids and 3D models as advanced tools for in vitro toxicology

Author(s): Nathalie Steimberg
Published in: ALTEX, 2020, Page(s) 136-140, ISSN 1868-596X
Publisher: Springer Nature
DOI: 10.14573/altex.1911071

Nonlinear Optical Microscopy: From Fundamentals to Applications in Live Bioimaging

Author(s): Valentina Parodi, Emanuela Jacchetti, Roberto Osellame, Giulio Cerullo, Dario Polli, Manuela Teresa Raimondi
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2020.585363

Advantages and limitations of a supernegative GFP in facilitating MyoD intracellular tracking

Author(s): Lucia Boeri, Emanuela Jacchetti, Monica Soncini, Alessandro Negro, Diego Albani, Manuela Teresa Raimondi
Published in: Methods and Applications in Fluorescence, Issue 8/2, 2020, Page(s) 025007, ISSN 2050-6120
Publisher: IOP publications
DOI: 10.1088/2050-6120/ab797c

Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19

Author(s): Manuela Teresa Raimondi, Francesca Donnaloja, Bianca Barzaghini, Alberto Bocconi, Claudio Conci, Valentina Parodi, Emanuela Jacchetti, Stephana Carelli
Published in: Theranostics, Issue 10/16, 2020, Page(s) 7034-7052, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.47406

Natural and Synthetic Polymers for Bone Scaffolds Optimization

Author(s): Francesca Donnaloja, Emanuela Jacchetti, Monica Soncini, Manuela T. Raimondi
Published in: Polymers, Issue 12/4, 2020, Page(s) 905, ISSN 2073-4360
Publisher: Molecular Diversity Preservation International
DOI: 10.3390/polym12040905

A poroelastic mixture model of mechanobiological processes in biomass growth: theory and application to tissue engineering

Author(s): Riccardo Sacco, Paola Causin, Chiara Lelli, Manuela T. Raimondi
Published in: Meccanica, Issue 52/14, 2017, Page(s) 3273-3297, ISSN 0025-6455
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11012-017-0638-9

Scaling-Up Techniques for the Nanofabrication of Cell Culture Substrates via Two-Photon Polymerization for Industrial-Scale Expansion of Stem Cells

Author(s): Davide Ricci, Michele Nava, Tommaso Zandrini, Giulio Cerullo, Manuela Raimondi, Roberto Osellame
Published in: Materials, Issue 10/1, 2017, Page(s) 66, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma10010066

An experimental-numerical investigation on the effects of macroporous scaffold geometry on cell culture parameters

Author(s): Hadis Eghbali, Michele M. Nava, Gabriella Leonardi, Davod Mohebbi-Kalhori, Roberto Sebastiano, Abdolreza Samimi, Manuela T. Raimondi
Published in: The International Journal of Artificial Organs, Issue 40/4, 2017, Page(s) 185-195, ISSN 0391-3988
Publisher: Wichtig Editore
DOI: 10.5301/ijao.5000554

Human bone perivascular niche-on-a-chip for studying metastatic colonization

Author(s): Alessandro Marturano-Kruik, Michele Maria Nava, Keith Yeager, Alan Chramiec, Luke Hao, Samuel Robinson, Edward Guo, Manuela Teresa Raimondi, Gordana Vunjak-Novakovic
Published in: Proceedings of the National Academy of Sciences, Issue 115/6, 2018, Page(s) 1256-1261, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1714282115

Oxygen measurement in interstitially perfused cellularized constructs cultured in a miniaturized bioreactor

Author(s): Manuela T. Raimondi, Carmen Giordano, Riccardo Pietrabissa
Published in: Journal of Applied Biomaterials & Functional Materials, Issue 13/4, 2015, Page(s) 0-0, ISSN 2280-8000
Publisher: Wichtig Editore s.r.l.
DOI: 10.5301/jabfm.5000246

Synthetic niche substrates engineered via two-photon laser polymerization for the expansion of human mesenchymal stromal cells

Author(s): Michele M. Nava, Nunzia Di Maggio, Tommaso Zandrini, Giulio Cerullo, Roberto Osellame, Ivan Martin, Manuela T. Raimondi
Published in: Journal of Tissue Engineering and Regenerative Medicine, 2016, ISSN 1932-6254
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/term.2187

Computational prediction of strain-dependent diffusion of transcription factors through the cell nucleus

Author(s): Michele M. Nava, Roberto Fedele, Manuela T. Raimondi
Published in: Biomechanics and Modeling in Mechanobiology, Issue 15/4, 2016, Page(s) 983-993, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-015-0737-2

Hollow fiber bioreactor technology for tissue engineering applications

Author(s): Hadis Eghbali, Michele M. Nava, Davod Mohebbi-Kalhori, Manuela T. Raimondi
Published in: The International Journal of Artificial Organs, Issue 39/1, 2016, Page(s) 1-15, ISSN 0391-3988
Publisher: Wichtig Editore
DOI: 10.5301/ijao.5000466

Distributed and Lumped Parameter Models for the Characterization of High Throughput Bioreactors

Author(s): Laura Iannetti, Giovanna D’Urso, Gioacchino Conoscenti, Elena Cutrì, Rocky S. Tuan, Manuela T. Raimondi, Riccardo Gottardi, Paolo Zunino
Published in: PLOS ONE, Issue 11/9, 2016, Page(s) e0162774, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0162774

Two-photon polymerized “nichoid” substrates maintain function of pluripotent stem cells when expanded under feeder-free conditions

Author(s): Michele M. Nava, Alessio Piuma, Marina Figliuzzi, Irene Cattaneo, Barbara Bonandrini, Tommaso Zandrini, Giulio Cerullo, Roberto Osellame, Andrea Remuzzi, Manuela T. Raimondi
Published in: Stem Cell Research & Therapy, Issue 7/1, 2016, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-016-0387-z

Optimization of a 3D Dynamic Culturing System for In Vitro Modeling of Frontotemporal Neurodegeneration-Relevant Pathologic Features

Author(s): Marta Tunesi, Federica Fusco, Fabio Fiordaliso, Alessandro Corbelli, Gloria Biella, Manuela T. Raimondi
Published in: Frontiers in Aging Neuroscience, Issue 8, 2016, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2016.00146

Modeling of the mechano-chemical behaviour of the nuclear pore complex: current research and perspectives

Author(s): Alberto Garcia, Jose F. Rodriguez Matas, Manuela T. Raimondi
Published in: Integrative Biology, Issue 8/10, 2016, Page(s) 1011-1021, ISSN 1757-9694
Publisher: Royal Society of Chemistry
DOI: 10.1039/c6ib00153j

Secretome released from hydrogel-embedded adipose mesenchymal stem cells protects against the Parkinson’s disease related toxin 6-hydroxydopamine

Author(s): Armando Chierchia, Nino Chirico, Lucia Boeri, Ilaria Raimondi, Giovanni A. Riva, Manuela Teresa Raimondi, Marta Tunesi, Carmen Giordano, Gianluigi Forloni, Diego Albani
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 121, 2017, Page(s) 113-120, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2017.09.014

Mechanical regulation of nucleocytoplasmic translocation in mesenchymal stem cells: characterization and methods for investigation

Author(s): Lucia Boeri, Diego Albani, Manuela Teresa Raimondi, Emanuela Jacchetti
Published in: Biophysical Reviews, Issue 11/5, 2019, Page(s) 817-831, ISSN 1867-2450
Publisher: Springer Verlag
DOI: 10.1007/s12551-019-00594-3

The Effect of Cell Morphology on the Permeability of the Nuclear Envelope to Diffusive Factors

Author(s): Alberto García-González, Emanuela Jacchetti, Roberto Marotta, Marta Tunesi, José F. Rodríguez Matas, Manuela T. Raimondi
Published in: Frontiers in Physiology, Issue 9, 2018, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00925

Mechanosensing at the Nuclear Envelope by Nuclear Pore Complex Stretch Activation and Its Effect in Physiology and Pathology

Author(s): F. Donnaloja, E. Jacchetti, M. Soncini, M. T. Raimondi
Published in: Frontiers in Physiology, Issue 10, 2019, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00896

Lamin A/C Mechanotransduction in Laminopathies

Author(s): Francesca Donnaloja, Federica Carnevali, Emanuela Jacchetti, Manuela Teresa Raimondi
Published in: Cells, Issue 9/5, 2020, Page(s) 1306, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9051306

Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases

Author(s): Federica Rey, Bianca Barzaghini, Alessandra Nardini, Matteo Bordoni, Gian Vincenzo Zuccotti, Cristina Cereda, Manuela Teresa Raimondi, Stephana Carelli
Published in: Cells, Issue 9/7, 2020, Page(s) 1636, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9071636

Intellectual Property Rights

Patent (6)

IMPLANTABLE MEDICAL DEVICE

Application/Publication number: 20 18060222
Date: 2018-12-18

SYNTHETIC NICHE MATRICES FOR STEM CELL CULTURE

Application/Publication number: 16 763469
Date: 2016-08-31

SYNTHETIC NICHE MATRICES FOR STEM CELL CULTURE

Application/Publication number: 16 763469
Date: 2016-08-31
Applicant(s): POLITECNICO DI MILANO

A DEVICE FOR CELL CULTURE

Application/Publication number: 17 732566
Date: 2017-05-05
Applicant(s): POLITECNICO DI MILANO

IMPLANTABLE MEDICAL DEVICE

Application/Publication number: 20 18060222
Date: 2018-12-18
Applicant(s): POLITECNICO DI MILANO

A DEVICE FOR CELL CULTURE

Application/Publication number: 17 732566
Date: 2017-05-05