Maintaining synaptic function for a healthy brain: Membrane trafficking and autophagy in neurodegeneration

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Author(s): Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis E. Adamopoulos, Khosrow Adeli, Timon E. Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B. Aggarwal, Maria Agnello, Patrizia Agostinis, Javed N. Agrewala, Alexander A
Published in: Autophagy, Issue 17(12), 2021, Page(s) 1-382, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2020.1797280

Presynaptic Autophagy and the Connection With Neurotransmission

Author(s): Marianna Decet, Patrik Verstreken
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2022, Page(s) 790721, ISSN 2296-634X
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2021.790721

Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms

Author(s): Julie Jacquemyn, Joyce Foroozandeh, Katlijn Vints, Jef Swerts, Patrik Verstreken, Natalia V Gounko, Sandra F Gallego, Rose Goodchild
Published in: The EMBO Journal, Issue 40(17), 2021, Page(s) e106914, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020106914

MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome

Author(s): Cedric Thues, Jorge S. Valadas, Liesbeth Deaulmerie, Ann Geens, Amit K. Chouhan, Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Michaela Bartusel, Rizwan Rehimi, Alvaro Rada-Iglesias, Patrik Verstreken & Hilde Van Esch
Published in: Scientific Reports, Issue 11(1), 2021, Page(s) 4976, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-83771-3

A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

Author(s): Jone Paesmans, Ella Martin, Babette Deckers, Marjolijn Berghmans, Ritika Sethi, Yannick Loeys, Els Pardon, Jan Steyaert, Patrik Verstreken, Christian Galicia, Wim Versées
Published in: eLife, Issue 9, 2020, Page(s) e64922, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.64922

Molecule-to-Circuit Disease Mechanisms of a Synaptic SNAREopathy

Author(s): Roman Praschberger, Julie Jacquemyn, Patrik Verstreken
Published in: Neuron, Issue 109(1), 2021, Page(s) 1-3, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.12.009

Endophilin-B regulates autophagy during synapse development and neurodegeneration

Author(s): Sergio Hernandez-Diaz, Saurav Ghimire, Irene Sanchez-Mirasierra, Carla Montecinos-Oliva, Jef Swerts, Sabine Kuenen, Patrik Verstreken, Sandra-Fausia Soukup
Published in: Neurobiology of Disease, Issue 163, 2022, Page(s) 105595, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2021.105595

Synaptic proteostasis in Parkinson’s disease

Author(s): Eliana Nachman, Patrik Verstreken
Published in: Current Opinion in Neurobiology, Issue 72, 2021, Page(s) 72-79, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2021.09.001

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.

Author(s): Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, Julien Chapuis, Nicolas Barois, Fabien Delahaye, Bart Dermaut, Jean-Charles Lambert, Marcos R. Costa & Pierre Dourlen
Published in: Acta Neuropathologica Communications, Issue 10(1), 2022, Page(s) 4, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-021-01285-5

Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation

Author(s): Luis Aragão Gomes, Valerie Uytterhoeven, Diego Lopez-Sanmartin, Sandra O. Tomé, Thomas Tousseyn, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A. F. von Arnim, Patrik Verstreken, Dietmar Rudolf Thal
Published in: Acta Neuropathologica, Issue 141, 2021, Page(s) 173-192, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-020-02251-6

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Author(s): Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L. Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreken
Published in: Neuron, Issue 97/4, 2018, Page(s) 823-835.e8, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2018.01.022

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

Author(s): Kristofer Davie, Jasper Janssens, Duygu Koldere, Maxime De Waegeneer, Uli Pech, Łukasz Kreft, Sara Aibar, Samira Makhzami, Valerie Christiaens, Carmen Bravo González-Blas, Suresh Poovathingal, Gert Hulselmans, Katina I. Spanier, Thomas Moerman, Bram Vanspauwen, Sarah Geurs, Thierry Voet, Jeroen Lammertyn, Bernard Thienpont, Sha Liu, Nikos Konstantinides, Mark Fiers, Patrik Verstreken, Stein Aert
Published in: Cell, 2018, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.05.057

Reprogramming neurodegeneration in the big data era

Author(s): Lujia Zhou, Patrik Verstreken
Published in: Current Opinion in Neurobiology, Issue 48, 2018, Page(s) 167-173, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2017.12.015

p13 protects against Parkinson's disease

Author(s): Jorge S Valadas, Patrik Verstreken
Published in: EMBO reports, Issue 19/3, 2018, Page(s) e45900, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201845900

ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease

Author(s): Jorge S. Valadas, Giovanni Esposito, Dirk Vandekerkhove, Katarzyna Miskiewicz, Liesbeth Deaulmerie, Susanna Raitano, Philip Seibler, Christine Klein, Patrik Verstreken
Published in: Neuron, Issue 98/6, 2018, Page(s) 1155-1169.e6, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2018.05.022

Tau association with synaptic vesicles causes presynaptic dysfunction

Author(s): Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G. Herrmann, Rosemary J. Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L. Spires-Jones, Joris De Wit, Patrik Verstreken
Published in: Nature Communications, Issue 8, 2017, Page(s) 15295, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15295

Shawn, the Drosophila Homolog of SLC25A39/40, Is a Mitochondrial Carrier That Promotes Neuronal Survival

Author(s): J. R. Slabbaert, S. Kuenen, J. Swerts, I. Maes, V. Uytterhoeven, J. Kasprowicz, A. C. Fernandes, R. Blust, P. Verstreken
Published in: Journal of Neuroscience, Issue 36/6, 2016, Page(s) 1914-1929, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.3432-15.2016

Torsins Are Essential Regulators of Cellular Lipid Metabolism

Author(s): Micheline Grillet, Beatriz Dominguez Gonzalez, Adria Sicart, Maria Pöttler, Ana Cascalho, Karolien Billion, Sergio Hernandez Diaz, Jef Swerts, Teresa V. Naismith, Natalia V. Gounko, Patrik Verstreken, Phyllis I. Hanson, Rose E. Goodchild
Published in: Developmental Cell, Issue 38/3, 2016, Page(s) 235-247, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2016.06.017

Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification

Author(s): Wim Dejonghe, Sabine Kuenen, Evelien Mylle, Mina Vasileva, Olivier Keech, Corrado Viotti, Jef Swerts, Matyáš Fendrych, Fausto Andres Ortiz-Morea, Kiril Mishev, Simon Delang, Stefan Scholl, Xavier Zarza, Mareike Heilmann, Jiorgos Kourelis, Jaroslaw Kasprowicz, Le Son Long Nguyen, Andrzej Drozdzecki, Isabelle Van Houtte, Anna-Mária Szatmári, Mateusz Majda, Gary Baisa, Sebastian York Bednarek, St
Published in: Nature Communications, Issue 7, 2016, Page(s) 11710, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms11710

Loss of Bin1 Promotes the Propagation of Tau Pathology

Author(s): Sara Calafate, William Flavin, Patrik Verstreken, Diederik Moechars
Published in: Cell Reports, Issue 17/4, 2016, Page(s) 931-940, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.09.063

Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function

Author(s): Baptiste Fischer, Kevin Lüthy, Jone Paesmans, Charlotte De Koninck, Ine Maes, Jef Swerts, Sabine Kuenen, Valerie Uytterhoeven, Patrik Verstreken, Wim Versées
Published in: Nature Structural & Molecular Biology, Issue 23/11, 2016, Page(s) 965-973, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/nsmb.3297

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

Author(s): John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic
Published in: Cell Reports, Issue 17/4, 2016, Page(s) 1071-1086, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.09.058

A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals

Author(s): Sandra-Fausia Soukup, Sabine Kuenen, Roeland Vanhauwaert, Julia Manetsberger, Sergio Hernández-Díaz, Jef Swerts, Nils Schoovaerts, Sven Vilain, Natalia V. Gounko, Katlijn Vints, Ann Geens, Bart De Strooper, Patrik Verstreken
Published in: Neuron, Issue 92/4, 2016, Page(s) 829-844, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2016.09.037

EndoA/Endophilin-A creates docking stations for autophagic proteins at synapses

Author(s): Sandra-Fausia Soukup, Patrik Verstreken
Published in: Autophagy, Issue 13/5, 2017, Page(s) 971-972, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2017.1286440

In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Author(s): Adekunle T. Bademosi, Elsa Lauwers, Pranesh Padmanabhan, Lorenzo Odierna, Ye Jin Chai, Andreas Papadopulos, Geoffrey J. Goodhill, Patrik Verstreken, Bruno van Swinderen, Frédéric A. Meunier
Published in: Nature Communications, Issue 8, 2017, Page(s) 13660, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13660

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency

Author(s): Melissa Vos, Ann Geens, Claudia Böhm, Liesbeth Deaulmerie, Jef Swerts, Matteo Rossi, Katleen Craessaerts, Elvira P. Leites, Philip Seibler, Aleksandar Rakovic, Thora Lohnau, Bart De Strooper, Sarah-Maria Fendt, Vanessa A. Morais, Christine Klein, Patrik Verstreken
Published in: The Journal of Cell Biology, Issue 216/3, 2017, Page(s) 695-708, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201511044

Neurons eat glutamate to stay alive

Author(s): Sarah-Maria Fendt, Patrik Verstreken
Published in: The Journal of Cell Biology, Issue 216/4, 2017, Page(s) 863-865, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201702003

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

Author(s): Roeland Vanhauwaert, Sabine Kuenen, Roy Masius, Adekunle Bademosi, Julia Manetsberger, Nils Schoovaerts, Laura Bounti, Serguei Gontcharenko, Jef Swerts, Sven Vilain, Marina Picillo, Paolo Barone, Shashini T Munshi, Femke MS de Vrij, Steven A Kushner, Natalia V Gounko, Wim Mandemakers, Vincenzo Bonifati, Frederic A Meunier, Sandra‐Fausia Soukup, Patrik Verstreken
Published in: The EMBO Journal, Issue 36/10, 2017, Page(s) 1392-1411, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201695773

Presynaptic protein homeostasis and neuronal function

Author(s): Yu-Chun Wang, Elsa Lauwers, Patrik Verstreken
Published in: Current Opinion in Genetics & Development, Issue 44, 2017, Page(s) 38-46, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2017.01.015

Autophagy in the presynaptic compartment in health and disease

Author(s): Vinoy Vijayan, Patrik Verstreken
Published in: The Journal of Cell Biology, Issue 216/7, 2017, Page(s) 1895-1906, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201611113

Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic

Author(s): Adekunle T. Bademosi, James Steeves, Shanker Karunanithi, Oressia H. Zalucki, Rachel S. Gormal, Shu Liu, Elsa Lauwers, Patrik Verstreken, Victor Anggono, Frederic A. Meunier, Bruno van Swinderen
Published in: Cell Reports, Issue 22/2, 2018, Page(s) 427-440, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.12.054

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

Author(s): Tom Cornelissen, Sven Vilain, Katlijn Vints, Natalia Gounko, Patrik Verstreken, Wim Vandenberghe
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.35878

Hsp90 Mediates Membrane Deformation and Exosome Release

Author(s): Elsa Lauwers, Yu-Chun Wang, Rodrigo Gallardo, Rob Van der Kant, Emiel Michiels, Jef Swerts, Pieter Baatsen, Samantha S. Zaiter, Shelli R. McAlpine, Natalia V. Gounko, Frederic Rousseau, Joost Schymkowitz, Patrik Verstreken
Published in: Molecular Cell, Issue 71/5, 2018, Page(s) 689-702.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.07.016

Parkinson's disease: convergence on synaptic homeostasis

Author(s): Sandra‐Fausia Soukup, Roeland Vanhauwaert, Patrik Verstreken
Published in: The EMBO Journal, Issue 37/18, 2018, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201898960

Excess Lipin enzyme activity contributes to TOR1A recessive disease and DYT-TOR1A dystonia

Author(s): Ana Cascalho, Joyce Foroozandeh, Lise Hennebel, Jef Swerts, Christine Klein, Stef Rous, Beatriz Dominguez Gonzalez, Antonio Pisani, Maria Meringolo, Sandra F Gallego, Patrik Verstreken, Philip Seibler, Rose E Goodchild
Published in: Brain, Issue 143/6, 2020, Page(s) 1746-1765, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awaa139

LifeTime and improving European healthcare through cell-based interceptive medicine

Author(s): Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A Gorski, Stein Aerts, Ido Amit, Michela G Bertero, Christoph Bock, Annelien L Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M Fernández, Marek Figlerowicz, Susan M Gasser, Norbert Hubner, Jørgen Kjems, Jürgen A Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean-Ch
Published in: Nature, Issue 587 (7834), 2020, Page(s) 377-386, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2715-9

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Author(s): Pablo Largo-Barrientos, Nuno Apóstolo, Eline Creemers, Zsuzsanna Callaerts-Vegh, Jef Swerts, Caitlin Davies, Joseph McInnes, Keimpe Wierda, Bart De Strooper, Tara Spires-Jones, Joris de Wit, Valerie Uytterhoeven, Patrik Verstreken
Published in: Neuron, Issue 109(5), 2021, Page(s) 767-777, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.12.016

α-Synuclein and Tau: Mitochondrial Kill Switches

Author(s): Ulrike Pech, Patrik Verstreken
Published in: Neuron, Issue 97/1, 2018, Page(s) 3-4, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2017.12.024

Membrane Lipids in Presynaptic Function and Disease

Author(s): Elsa Lauwers, Rose Goodchild, Patrik Verstreken
Published in: Neuron, Issue 90/1, 2016, Page(s) 11-25, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2016.02.033

Imaging mitophagy in the fruit fly

Author(s): Tom Cornelissen, Patrik Verstreken, Wim Vandenberghe
Published in: Autophagy, Issue 14/9, 2018, Page(s) 1656-1657, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2018.1496720

Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites

Author(s): Pranesh Padmanabhan, Adekunle T. Bademosi, Ravikiran Kasula, Elsa Lauwers, Patrik Verstreken, Frédéric A. Meunier
Published in: Neuropharmacology, Issue 169, 2020, Page(s) 107554, ISSN 0028-3908
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2019.02.036

Author(s): Kevin Lüthy, Davide Mei, Baptiste Fischer, Maurizio De Fusco, Jef Swerts, Jone Paesmans, Elena Parrini, Naomi Lubarr, Inge A Meijer, Katherine M Mackenzie, Wang-Tso Lee, Davide Cittaro, Paolo Aridon, Nils Schoovaerts, Wim Versées, Patrik Verstreken, Giorgio Casari, Renzo Guerrini
Published in: Brain, Issue 142/8, 2019, Page(s) 2319-2335, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awz175

Mitochondria Re-set Epilepsy

Author(s): Valerie Uytterhoeven, Natalie Kaempf, Patrik Verstreken
Published in: Neuron, Issue 102/5, 2019, Page(s) 907-910, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2019.05.023

Assaying Mutants of Clathrin-Mediated Endocytosis in the Fly Eye

Author(s): Elsa Lauwers, Patrik Verstreken
Published in: Clathrin-Mediated Endocytosis - Methods and Protocols, Issue 1847, 2018, Page(s) 109-119, ISBN 978-1-4939-8717-7
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8719-1_9

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