Livrables
Presentation of a document describing methods for preprocessing and processing of spectral data.
Proof of concept to determine GAGs composition in cancer stromal tissueReport on the experimental results on the proof of concept to determine GAGs composition in cancer stromal tissue.
Changes in invasive behaviourReport on experimental results on changes in invasive behaviour of cancer cells subjected to PG/GAG manipulation.
Functional in vitro studiesReport on the experimental results of functional in vitro experiments after treatments of cancer cell lines stimulating or inhibiting HBP, O-GlcNAcylation and epigenetic modifications.
Analysis of angiogenic factors in immunomodulatory cellsReport on the experimental results of the analysis of angiogenic factors in immunomodulatory cells in the context of inflammatory breast cancer.
microRNA regulation of Glypican-1, Syndecan-2 and HAS1-3 in breast and colon cancerReport on experimental results of microRNA regulation of Glypican-1, Syndecan-2 and HAS1-3 in breast and colon cancer.
Characterization of HS disaccharide structure from 8 breast cancer cell lines with altered Syndecan-1, 3-O-HS sulfation and 2-O-HS sulfationReport on experimental results regarding the characterization of HS disaccharide structure from 8 breast cancer cell lines with altered Syndecan-1, 3-O-HS sulfation and 2-O-HS sulfation.
Correlation of GAG structure with clinicopathological parametersReport on the correlation of GAG structure with clinicopathological parameters, including statistical analysis.
microRNA-regulation of Syndecan-1 in clinical IBC specimensReport on experimental results of microRNA-regulation of Syndecan-1 in clinical IBC specimens.
Flow cytometric analysis of SP and ALDH phenotypeReport on the experimental results of flow cytometric analysis of SP and ALDH phenotype of cancer stem cells.
Chemotherapeutic resistanceReport on experimental results regarding chemotherapeutic resistance of PG/GAG-manipulated cancer stem cells.
In vivo study on the premetastatic nicheReport on the experimental results of the in vivo study on the premetastatic niche.
Diagnostic value of Syndecan-1 in IBCReport on the diagnostic value of Syndecan-1 in IBC including statistical analysis.
ChIP experimentsReport on the experimental results of chromatin immunoprecipitation experiments.
Nanostic analysisReport on the experimental results of the nanostic analysis of cancer cells.
Standardized protocol for FTIR and RAMAN spectroscopic analysis of GAGs in cells and conditioned media.Presentation of a standardized experimental protocol for FTIR and RAMAN spectroscopic analysis of GAGs in cells and conditioned media.
qPCR analysis of angiogenic factors in tumorsExperimental data report on qPCR analysis of angiogenic factors in tumors related to syndecan-1.
Spectroscopic delineation of the expression of GAGs in mice lung metastatic nodulesReport on the experimental results of spectroscopic analysis of the expression of GAGs in mice lung metastatic nodules.
3D cultureReport on the experimental results of 3D cultures of cancer stem cell-enriched cultures.
Functional impact of miRNA-dependent PG and HAS regulationReport on the experimental results of the functional impact of miRNA-dependent PG and HAS regulation.
Spectroscopic delineation of the expression of GAGs in murine melanoma, and PG-manuipulated cancer cell linesReport on the experimental results of the spectroscopic analysis of the expression of GAGs in murine melanoma, and PG-manuipulated cancer cell lines.
Mechanistic in vitro investigation of Syndecan-dependenttranscriptional activationReport on the experimental results of the mechanistic in vitro investigation of Syndecan-dependent transcriptional activation.
Characterization of HA molecular weight from tumor and control tissue of at least three in vivo mouse tumor modelsReport on the experimental results of the characterization of HA molecular weight from tumor and control tissue of at least three in vivo mouse tumor models.
In vitro analysis of microRNA-dependent Syndecan-1 regulation in IBCReport on experimental results of the in vitro analysis of microRNA-dependent Syndecan-1 regulation in IBC.
Standardized Protocol for Tissue Microarray Analysis by FTIR and RAMAN spectroscopyPresentation of a standardized Protocol (Document) for Tissue Microarray Analysis by FTIR and RAMAN spectroscopy.
Analysis of signaling pathwaysReport on experimental results of signal transduction analysis in cancer stem cells.
Immune cells in the microenvironmentExperimental data report on the analysis of immune cells in the tumor microenvironment.
Role of Syndecan-1 oligomerization in FAK activationReport on the experimental results on the role of Syndecan-1 oligomerization in FAK activation.
Therapeutic potential of Ascidian GAGsReport on experimental data regarding the therapeutic potential of Ascidian GAGs in malignant disease.
Impact of PG/HA on DNA damage responseReport on the experimental results of the impact of PG/HA on the DNA damage response.
Proof of concept for in vivo Raman probes for diagnosis of melanoma in patients and application to tumor-associated macrophagesReport on the experimental results delivering proof of concept for in vivo Raman probes for diagnosis of melanoma in patients and application to tumor-associated macrophages.
Angiogenesis regulatorsExperimental data report on the analysis of hyaluronic acid-dependent angiogenesis regulators.
Impact of conventional therapeutics on the premetastatic nicheReport on experimental data of the impact of conventional therapeutics on the premetastatic niche.
In vivo model of hepatocarcinogenesisExytablishment of, and report on the experimental results of the in vivo model of hepatocarcinogenesis.
Inhibitory effect of 4- MU in vivoExperimental data report on the inhibitory effect of 4- MU in vivo.
Evaluation of HA related enzyme expressionExperimental data report on the evaluation of Evaluation of HA related enzyme expression in mouse cancerous tissues.
Microvascular densityExperimental data report on the analysis of microvascular densitty in in vivo models.
Impact of PGs and GAGs on premature senescence of cancer cellsReport on experimental results of the studies on the impact of PGs and GAGs on premature senescence of cancer cells.
Epigenetic HAS2 promoter regulationReport on the experimental results of epigenetic HAS2 promoter regulation.
Flow cytometric and qPCR analysis of stem cell markersReport on experimental results of flow cytometric and qPCR analysis of stem cell markers.
In vitro functional assays in a novel 3D culture systemEstablishment and report on experimental data of functional in vitro assays in a novel 3D culture system.
In vitro study of the premetastatic nicheReport on experimental results on the in vitro study of the premetastatic niche.
Changes in EMT marker expressionReport on the experimental results of changes in EMT marker expression in cancer cells subjected to PG/GAG manipulation.
Analysis of glioblastoma cell line GAG structureReport on the experimental results of the analysis of glioblastoma cell line GAG structure.
Role of PGs in TGFbeta induced EMTReport of experimental results on the role of PGs in TGFbeta induced EMT.
Website reporting and dissemination on the Workshop on PGs and GAGs in metastasis organized by WWU.
Workshop on epigenetic regulationWebsite report and dissemination on the workshop epigenetic regulation of PG and GAG expression and function organized by partner UNINSUBRIA.
Establichment of GLYCANC WebsiteEstablishment of GLYCANC website and social media presence (Facebook, Research Gate).
Publications
Auteurs:
Alexandra Fullár, Katalin Karászi, Péter Hollósi, Gábor Lendvai, Lászlóné Oláh, Andrea Reszegi, Zoltán Papp, Gábor Sobel, József Dudás, Ilona Kovalszky
Publié dans:
PLOS ONE, Numéro 15/6, 2020, Page(s) e0234873, ISSN 1932-6203
Éditeur:
Public Library of Science
DOI:
10.1371/journal.pone.0234873
Auteurs:
Stéphane Brézillon, Valérie Untereiner, Hossam Taha Mohamed, Estelle Ahallal, Isabelle Proult, Pierre Nizet, Camille Boulagnon-Rombi, Ganesh. D. Sockalingum
Publié dans:
Frontiers in Cell and Developmental Biology, Numéro 8, 2020, ISSN 2296-634X
Éditeur:
Frontiers Media SA
DOI:
10.3389/fcell.2020.00377
Auteurs:
Mennatullah El-Nadi, Hebatallah Hassan, Moshira Ezzat Saleh, Eyyad Nassar, Yahia Mahmoud Ismail, Mahmoud Amer, Burkhard Greve, Martin Götte, Mohamed El-Shinawi, Sherif Abdelaziz Ibrahim
Publié dans:
Matrix Biology Plus, Numéro 6-7, 2020, Page(s) 100030, ISSN 2590-0285
Éditeur:
Elsevier
DOI:
10.1016/j.mbplus.2020.100030
Auteurs:
Sampath Kumar Katakam, Valeria Tria, Wey‐Cheng Sim, George W. Yip, Stefano Molgora, Theodoros Karnavas, Eslam A. Elghonaimy, Paride Pelucchi, Eleonora Piscitelli, Sherif Abdelaziz Ibrahim, Ileana Zucchi, Rolland Reinbold, Burkhard Greve, Martin Götte
Publié dans:
The FEBS Journal, Numéro 288/2, 2021, Page(s) 486-506, ISSN 1742-464X
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/febs.15356
Auteurs:
Hossam Taha Mohamed, Valérie Untereiner, Gianfelice Cinque, Sherif Abdelaziz Ibrahim, Martin Götte, Nguyet Que Nguyen, Romain Rivet, Ganesh D. Sockalingum, Stéphane Brézillon
Publié dans:
Molecules, Numéro 25/18, 2020, Page(s) 4300, ISSN 1420-3049
Éditeur:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/molecules25184300
Auteurs:
Zoi Piperigkou, Martin Götte, Achilleas D. Theocharis, Nikos K. Karamanos
Publié dans:
Advanced Drug Delivery Reviews, 2017, ISSN 0169-409X
Éditeur:
Elsevier BV
DOI:
10.1016/j.addr.2017.10.008
Auteurs:
Eleni Mavrogonatou, Harris Pratsinis, Adamantia Papadopoulou, Nikos K. Karamanos, Dimitris Kletsas
Publié dans:
Matrix Biology, 2017, ISSN 0945-053X
Éditeur:
Elsevier BV
DOI:
10.1016/j.matbio.2017.10.004
Auteurs:
Viviana Filpa, Michela Bistoletti, Ilaria Caon, Elisabetta Moro, Annalisa Grimaldi, Paola Moretto, Andreina Baj, Maria Cecilia Giron, Evgenia Karousou, Manuela Viola, Francesca Crema, Gianmario Frigo, Alberto Passi, Cristina Giaroni, Davide Vigetti
Publié dans:
Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41598-017-18020-7
Auteurs:
Eszter Regős, Hadeer Hesham Abdelfattah, Andrea Reszegi, László Szilák, Klára Werling, Gábor Szabó, András Kiss, Zsuzsa Schaff, Ilona Kovalszky, Kornélia Baghy
Publié dans:
Matrix Biology, 2018, ISSN 0945-053X
Éditeur:
Elsevier BV
DOI:
10.1016/j.matbio.2018.02.008
Auteurs:
Zoi Piperigkou, Benedikt Mohr, Nikos Karamanos, Martin Götte
Publié dans:
Cell and Tissue Research, 2016, ISSN 0302-766X
Éditeur:
Springer Verlag
DOI:
10.1007/s00441-016-2452-4
Auteurs:
Martin Götte, Ilona Kovalszky
Publié dans:
Matrix Biology, 2018, ISSN 0945-053X
Éditeur:
Elsevier BV
DOI:
10.1016/j.matbio.2018.02.018
Auteurs:
Theodoros T. Karalis, Paraskevi Heldin, Demitrios H. Vynios, Thomas Neill, Simone Buraschi, Renato V. Iozzo, Nikos K. Karamanos, Spyros S. Skandalis
Publié dans:
Matrix Biology, 2018, ISSN 0945-053X
Éditeur:
Elsevier BV
DOI:
10.1016/j.matbio.2018.04.007
Auteurs:
Daiana L. Vitale, Fiorella M. Spinelli, Daiana Del Dago, Antonella Icardi, Gianina Demarchi, Ilaria Caon, Mariana García, Marcela F. Bolontrade, Alberto Passi, Carolina Cristina, Laura Alaniz
Publié dans:
Oncotarget, Numéro 9/93, 2018, ISSN 1949-2553
Éditeur:
Impact Journals
DOI:
10.18632/oncotarget.26379
Auteurs:
Alexander Schwickert, Esther Weghake, Kathrin Brüggemann, Annika Engbers, Benjamin F. Brinkmann, Björn Kemper, Jochen Seggewiß, Christian Stock, Klaus Ebnet, Ludwig Kiesel, Christoph Riethmüller, Martin Götte
Publié dans:
PLOS ONE, Numéro 10/12, 2015, Page(s) e0143993, ISSN 1932-6203
Éditeur:
Public Library of Science
DOI:
10.1371/journal.pone.0143993
Auteurs:
Eszter Regős, Katalin Karászi, Andrea Reszegi, András Kiss, Zsuzsa Schaff, Kornélia Baghy, Ilona Kovalszky
Publié dans:
Pathology & Oncology Research, 2019, ISSN 1219-4956
Éditeur:
Springer Verlag
DOI:
10.1007/s12253-019-00617-0
Auteurs:
Nikolaos A. Afratis, Panagiotis Bouris, Spyros S. Skandalis, Hinke A. Multhaupt, John R. Couchman, Achilleas D. Theocharis, Nikos K. Karamanos
Publié dans:
Scientific Reports, Numéro 7, 2017, Page(s) 40138, ISSN 2045-2322
Éditeur:
Nature Publishing Group
DOI:
10.1038/srep40138
Auteurs:
Hossam Taha Mohamed, Valérie Untereiner, Ganesh D. Sockalingum, Stéphane Brézillon
Publié dans:
Glycoconjugate Journal, 2016, ISSN 0282-0080
Éditeur:
Kluwer Academic Publishers
DOI:
10.1007/s10719-016-9743-6
Auteurs:
Fiorella M. Spinelli, Daiana L. Vitale, Antonella Icardi, Ilaria Caon, Alejandra Brandone, Paula Giannoni, Virginia Saturno, Alberto Passi, Mariana García, Ina Sevic, Laura Alaniz
Publié dans:
The FEBS Journal, 2019, ISSN 1742-464X
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/febs.14871
Auteurs:
Daiana Vitale, Sampath Kumar Katakam, Burkhard Greve, Bohee Jang, Eok-Soo Oh, Laura Alaniz, Martin Götte
Publié dans:
The FEBS Journal, 2019, ISSN 1742-464X
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/febs.14967
Auteurs:
Zsolt Horváth, Andrea Reszegi, László Szilák, Titanilla Dankó, Ilona Kovalszky, Kornélia Baghy
Publié dans:
Cellular Signalling, 2019, Page(s) 109354, ISSN 0898-6568
Éditeur:
Elsevier BV
DOI:
10.1016/j.cellsig.2019.109354
Auteurs:
Moshira Ezzat Saleh, Ramy Gadalla, Hebatallah Hassan, Ahmed Afifi, Martin Götte, Mohamed El-Shinawi, Mona Mostafa Mohamed, Sherif Abdelaziz Ibrahim
Publié dans:
PLOS ONE, Numéro 14/5, 2019, Page(s) e0217550, ISSN 1932-6203
Éditeur:
Public Library of Science
DOI:
10.1371/journal.pone.0217550
Auteurs:
Anastasia-Gerasimoula Tavianatou, Zoi Piperigkou, Carlo Barbera, Riccardo Beninatto, Valentina Masola, Ilaria Caon, Maurizio Onisto, Marco Franchi, Devis Galesso, Nikos K. Karamanos
Publié dans:
Matrix Biology Plus, 2019, Page(s) 100008, ISSN 2590-0285
Éditeur:
Elsevier
DOI:
10.1016/j.mbplus.2019.100008
Auteurs:
Hossam Taha Mohamed, Valérie Untereiner, Isabelle Proult, Sherif Abdelaziz Ibrahim, Martin Götte, Mohamed El-Shinawi, Mona Mostafa Mohamed, Ganesh D. Sockalingum, Stéphane Brézillon
Publié dans:
The Analyst, Numéro 143/24, 2018, Page(s) 6103-6112, ISSN 0003-2654
Éditeur:
Royal Society of Chemistry
DOI:
10.1039/c8an01292j
Auteurs:
Alberto Passi, Davide Vigetti, Simone Buraschi, Renato V. Iozzo
Publié dans:
The FEBS Journal, Numéro 286/15, 2019, Page(s) 2937-2949, ISSN 1742-464X
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/febs.14847
Auteurs:
Achilleas D. Theocharis, Dimitra Manou, Nikos K. Karamanos
Publié dans:
The FEBS Journal, Numéro 286/15, 2019, Page(s) 2830-2869, ISSN 1742-464X
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/febs.14818
Auteurs:
S. Brézillon, V. Untereiner, H. T. Mohamed, J. Hodin, A. Chatron-Colliet, F.-X. Maquart, G. D. Sockalingum
Publié dans:
The Analyst, Numéro 142/8, 2017, Page(s) 1333-1341, ISSN 0003-2654
Éditeur:
Royal Society of Chemistry
DOI:
10.1039/C6AN01951J
Auteurs:
Evgenia Karousou, Suniti Misra, Shibnath Ghatak, Katalin Dobra, Martin Götte, Davide Vigetti, Alberto Passi, Nikos K. Karamanos, Spyros S. Skandalis
Publié dans:
Matrix Biology, Numéro 59, 2017, Page(s) 3-22, ISSN 0945-053X
Éditeur:
Elsevier BV
DOI:
10.1016/j.matbio.2016.10.001
Auteurs:
Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A. El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed, Martin Götte
Publié dans:
Molecular Cancer, Numéro 16/1, 2017, Page(s) 57, ISSN 1476-4598
Éditeur:
BioMed Central
DOI:
10.1186/s12943-017-0621-z
Auteurs:
Zoi Piperigkou, Marco Franchi, Martin Götte, Nikos K. Karamanos
Publié dans:
Matrix Biology, 2017, ISSN 0945-053X
Éditeur:
Elsevier BV
DOI:
10.1016/j.matbio.2017.08.002
Auteurs:
Argyris Spyrou, Soumi Kundu, Lulu Haseeb, Di Yu, Tommie Olofsson, Keith Dredge, Edward Hammond, Uri Barash, Israel Vlodavsky, Karin Forsberg-Nilsson
Publié dans:
Molecular Cancer Therapeutics, Numéro 16/8, 2017, Page(s) 1705-1716, ISSN 1535-7163
Éditeur:
American Association for Cancer Research
DOI:
10.1158/1535-7163.MCT-16-0900
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