Muscle Stress Relief: An integrated research program linking together basic research on secondary myopathies in stress states to innovative translation in applied myology.

Project Information

Muscle stress relief

Grant agreement ID: 645648

DOI 10.3030/645648

Project closed

EC signature date 3 December 2014

Start date 1 March 2016

End date 29 February 2020

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 1 606 500,00

EU contribution € 1 458 000,00

Coordinated by

PANEPISTIMIO THESSALIAS
Greece

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Management

D7.1 Establish the Muscle Stress Relief network office and the project's website

Other (1)

Workshop

D 7.3: Workshop in Athens (as above, as a Satellite event) and biannual ESR retreat

Publications

Peer reviewed articles (24)

Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence

Author(s): Caterina Tezze, Vanina Romanello, Maria Andrea Desbats, Gian Paolo Fadini, Mattia Albiero, Giulia Favaro, Stefano Ciciliot, Maria Eugenia Soriano, Valeria Morbidoni, Cristina Cerqua, Stefan Loefler, Helmut Kern, Claudio Franceschi, Stefano Salvioli, Maria Conte, Bert Blaauw, Sandra Zampieri, Leonardo Salviati, Luca Scorrano, Marco Sandri
Published in: Cell Metabolism, Issue 25/6, 2017, Page(s) 1374-1389.e6, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2017.04.021

Modulators of actin-myosin dissociation: basis for muscle type functional differences during fatigue

Author(s): Christina Karatzaferi, Nancy Adamek, Michael A Geeves
Published in: American Journal of Physiology - Cell Physiology, 2017, Page(s) ajpcell.00023.2017, ISSN 0363-6143
Publisher: American Physiological Society
DOI: 10.1152/ajpcell.00023.2017

Immunostick ELISA for rapid and easy diagnosis of myasthenia gravis

Author(s): Nikolaos Trakas, Socrates J. Tzartos
Published in: Journal of Immunological Methods, Issue 460, 2018, Page(s) 107-112, ISSN 0022-1759
Publisher: Elsevier BV
DOI: 10.1016/j.jim.2018.06.016

Positive End-Expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers

Author(s): Johan Lindqvist, Marloes van den Berg, Robbert van der Pijl, Pleuni E. Hooijman, Albertus Beishuizen, Judith Elshof, Monique de Waard, Armand Girbes, Angelique Spoelstra-de Man, Zhong-Hua Shi, Charissa van den Brom, Sylvia Bogaards, Shengyi Shen, Joshua Strom, Henk Granzier, Jeroen Kole, René J. P. Musters, Marinus A. Paul, Leo M. A. Heunks, Coen A. C. Ottenheijm
Published in: American Journal of Respiratory and Critical Care Medicine, Issue 198/4, 2018, Page(s) 472-485, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.201709-1917OC

Functional responses of uremic single skeletal muscle fibers to redox imbalances

Author(s): Mitrou GI, Poulianiti KP, Koutedakis Y, Jamurtas AZ, Maridaki MD, Stefanidis I, Sakkas GK, Karatzaferi C
Published in: Hippokratia, Issue 21(1), 2017, Page(s) 3-7, ISSN 1108-4189
Publisher: Lithografia Antoniadis I - Psarras Th G.P

Evidence of Blood and Muscle Redox Status Imbalance in Experimentally Induced Renal Insufficiency in a Rabbit Model

Author(s): Konstantina P. Poulianiti, Aggeliki Karioti, Antonia Kaltsatou, Georgia I. Mitrou, Yiannis Koutedakis, Konstantinos Tepetes, Grigoris Christodoulidis, Giannis Giakas, Maria D. Maridaki, Ioannis Stefanidis, Athanasios Z. Jamurtas, Giorgos K. Sakkas, Christina Karatzaferi
Published in: Oxidative Medicine and Cellular Longevity, Issue 2019, 2019, Page(s) 1-14, ISSN 1942-0900
Publisher: Landes Bioscience
DOI: 10.1155/2019/8219283

Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency

Author(s): Georgia I. Mitrou, Giorgos K. Sakkas, Konstantina P. Poulianiti, Aggeliki Karioti, Konstantinos Tepetes, Grigorios Christodoulidis, Giannis Giakas, Ioannis Stefanidis, Michael A. Geeves, Yiannis Koutedakis, Christina Karatzaferi
Published in: Journal of Biomechanics, Issue 82, 2019, Page(s) 259-265, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.1016/j.jbiomech.2018.10.035

MuRF1 and MuRF2 are key players in skeletal muscle regeneration involving myogenic deficit and deregulation of the chromatin-remodeling complex

Author(s): Anselmo Sigari Moriscot, Igor Luchini Baptista, William José Silva, João Guilherme Silvestre, Volker Adams, Alexander Gasch, Julius Bogomolovas, Siegfried Labeit
Published in: JCSM Rapid Communications, Issue 2/1, 2019, Page(s) 1-25, ISSN 2617-1619
Publisher: Wiley Online Library
DOI: 10.1002/j.2617-1619.2019.tb00010.x

miR‐29c improves skeletal muscle mass and function throughout myocyte proliferation and differentiation and by repressing atrophy‐related genes

Author(s): William José Silva, Flavia Aparecida Graça, André Cruz, João Guilherme Silvestre, Siegfried Labeit, Elen Haruka Miyabara, Chao Yun Irene Yan, Da Zhi Wang, Anselmo Sigari Moriscot
Published in: Acta Physiologica, 2019, Page(s) e13278, ISSN 1748-1708
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/apha.13278

Diaphragm contractile weakness due to reduced mechanical loading: role of titin

Author(s): Robbert J. van der Pijl, Henk L. Granzier, Coen A. C. Ottenheijm
Published in: American Journal of Physiology-Cell Physiology, Issue 317/2, 2019, Page(s) C167-C176, ISSN 0363-6143
Publisher: American Physiological Society
DOI: 10.1152/ajpcell.00509.2018

Titin-based mechanosensing modulates muscle hypertrophy

Author(s): Robbert van der Pijl, Joshua Strom, Stefan Conijn, Johan Lindqvist, Siegfried Labeit, Henk Granzier, Coen Ottenheijm
Published in: Journal of Cachexia, Sarcopenia and Muscle, Issue 9/5, 2018, Page(s) 947-961, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.12319

The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts

Author(s): J.G. Silvestre, I.L. Baptista, W.J. Silva, A. Cruz, M.T. Silva, E.H. Miyabara, S. Labeit, A.S. Moriscot
Published in: Brazilian Journal of Medical and Biological Research, Issue 52/9, 2019, ISSN 0100-879X
Publisher: Associacao Brasileira de Divulgacao Cientifica
DOI: 10.1590/1414-431x20198551

Deciphering anti-MOG IgG antibodies: Clinical and radiological spectrum, and comparison of antibody detection assays

Author(s): John S. Tzartos, Katerina Karagiorgou, Dimitrios Tzanetakos, Marianthi Breza, Maria Eleftheria Evangelopoulos, Sygkliti-Henrietta Pelidou, Christos Bakirtzis, Ioannis Nikolaidis, Georgios Koutsis, Konstantinos Notas, Elisabeth Chroni, Ioannis Markakis, Nikolaos C. Grigoriadis, Maria Anagnostouli, Anastasios Orologas, Dimitrios Parisis, Theodoros Karapanayiotides, Dimitra Papadimitriou, Vasiliki Ko
Published in: Journal of the Neurological Sciences, Issue 410, 2020, Page(s) 116673, ISSN 0022-510X
Publisher: Elsevier BV
DOI: 10.1016/j.jns.2020.116673

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

Author(s): Giulia Favaro, Vanina Romanello, Tatiana Varanita, Maria Andrea Desbats, Valeria Morbidoni, Caterina Tezze, Mattia Albiero, Marta Canato, Gaia Gherardi, Diego De Stefani, Cristina Mammucari, Bert Blaauw, Simona Boncompagni, Feliciano Protasi, Carlo Reggiani, Luca Scorrano, Leonardo Salviati, Marco Sandri
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-10226-9

Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles

Author(s): Vanina Romanello, Marco Scalabrin, Mattia Albiero, Bert Blaauw, Luca Scorrano, Marco Sandri
Published in: Cells, Issue 8/6, 2019, Page(s) 597, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells8060597

Small‐molecule‐mediated chemical knock‐down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure

Author(s): Volker Adams, T. Scott Bowen, Sarah Werner, Peggy Barthel, Christina Amberger, Anne Konzer, Johannes Graumann, Peter Sehr, Joe Lewis, Jan Provaznik, Vladimir Benes, Petra Büttner, Alexander Gasch, Norman Mangner, Christian C. Witt, Dittmar Labeit, Axel Linke, Siegfried Labeit
Published in: Journal of Cachexia, Sarcopenia and Muscle, Issue 10/5, 2019, Page(s) 1102-1115, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.12448

Effects of Redox Disturbances on Motility, Contractility and Muscle Tissue Pathogenesis

Author(s): C. Karatzaferi, M. Sandri, G. K. Sakkas, C. Smith
Published in: Oxidative Medicine and Cellular Longevity, Issue 2019, 2019, Page(s) 1-2, ISSN 1942-0900
Publisher: Landes Bioscience
DOI: 10.1155/2019/3272035

Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model

Author(s): Thanh Nguyen, T. Scott Bowen, Antje Augstein, Antje Schauer, Alexander Gasch, Axel Linke, Siegfried Labeit, Volker Adams
Published in: Skeletal Muscle, Issue 10/1, 2020, ISSN 2044-5040
Publisher: BioMed Central
DOI: 10.1186/s13395-020-00229-2

Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury

Author(s): Julius Bogomolovas, Alexander Gasch, Vilhelmas Bajoras, Dovilė Karčiauskaitė, Pranas Šerpytis, Virginija Grabauskienė, Dittmar Labeit, Siegfried Labeit
Published in: International Journal of Cardiology, Issue 212, 2016, Page(s) 232-234, ISSN 0167-5273
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2016.03.045

Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy

Author(s): C. J. Malavaki, G. K. Sakkas, G. I. Mitrou, A. Kalyva, I. Stefanidis, K. H. Myburgh, C. Karatzaferi
Published in: Journal of Muscle Research and Cell Motility, Issue 36/6, 2015, Page(s) 405-421, ISSN 0142-4319
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10974-015-9439-8

Titin antibodies in “seronegative” myasthenia gravis — A new role for an old antigen

Author(s): C. Stergiou, K. Lazaridis, V. Zouvelou, J. Tzartos, R. Mantegazza, C. Antozzi, F. Andreetta, A. Evoli, F. Deymeer, G. Saruhan-Direskeneli, H. Durmus, T. Brenner, A. Vaknin, S. Berrih-Aknin, A. Behin, T. Sharshar, M. De Baets, M. Losen, P. Martinez-Martinez, K.A. Kleopa, E. Zamba-Papanicolaou, T. Kyriakides, A. Kostera-Pruszczyk, P. Szczudlik, B. Szyluk, D. Lavrnic, I. Basta, S. Peric, C. Tallaksen
Published in: Journal of Neuroimmunology, Issue 292, 2016, Page(s) 108-115, ISSN 0165-5728
Publisher: Elsevier BV
DOI: 10.1016/j.jneuroim.2016.01.018

The Binding Sites of miR-619-5p in the mRNAs of Human and Orthologous Genes

Author(s): Shara Atambayeva, Raigul Niyazova, Anatoliy Ivashchenko, Anna Pyrkova, Ilya Pinsky, Aigul Akimniyazova, Siegfried Labeit
Published in: BMC Genomics, Issue 18/1, 2017, ISSN 1471-2164
Publisher: BioMed Central
DOI: 10.1186/s12864-017-3811-6

Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia

Author(s): Thomas Scott Bowen, Volker Adams, Sarah Werner, Tina Fischer, Paulien Vinke, Maria Noel Brogger, Norman Mangner, Axel Linke, Peter Sehr, Joe Lewis, Dittmar Labeit, Alexander Gasch, Siegfried Labeit
Published in: Journal of Cachexia, Sarcopenia and Muscle, 2017, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.12233

Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Improves Energetic Status and Cardiomyogenic Differentiation of Human Dilated Myocardium-Derived Primary Mesenchymal Cells

Author(s): Rokas Miksiunas, Kestutis Rucinskas, Vilius Janusauskas, Siegfried Labeit, Daiva Bironaite
Published in: International Journal of Molecular Sciences, Issue 21/14, 2020, Page(s) 4845, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21144845