Exploiting MELanoma disease comPLEXity to address European research training needs in translational cancer systems biology and cancer systems medicine

Risultati finali

Dissemination report 2

Annual dissemination and outreach report (events, talks, publications, posters, public engagement, etc.)

Dissemination report 1

Dissemination and outreach report (events, talks, publications, posters, public engagement etc.)

Dissemination report 3

Report on events, talks, publications, posters, public engagement, demonstrations etc.

Final dissemination report

Final dissemination and outreach report (events, talks, publications, posters, public engagement etc.)

MEL-PLEX conference

Open MEL-PLEX conference, dissemination

Website

Project website and brochure

Pubblicazioni

BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells

Autori: Erminia Romano, Nicole Rufo, Hannelie Korf, Chantal Mathieu, Abhishek D. Garg, Patrizia Agostinis
Pubblicato in: Oncotarget, Numero 9/25, 2018, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.24815

Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment

Autori: Kotryna Seip, Kjetil Jørgensen, Marco Vincent Haselager, Marco Albrecht, Mads Haugland Haugen, Eivind Valen Egeland, Philippe Lucarelli, Olav Engebraaten, Thomas Sauter, Gunhild Mari Mælandsmo, Lina Prasmickaite
Pubblicato in: Cancer Letters, Numero 439, 2018, Pagina/e 1-13, ISSN 0304-3835
Editore: Elsevier BV
DOI: 10.1016/j.canlet.2018.09.023

Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma

Autori: Jan Rožanc, Theodore Sakellaropoulos, Asier Antoranz, Cristiano Guttà, Biswajit Podder, Vesna Vetma, Nicole Rufo, Patrizia Agostinis, Vaia Pliaka, Thomas Sauter, Dagmar Kulms, Markus Rehm, Leonidas G. Alexopoulos
Pubblicato in: Cell Death & Differentiation, 2018, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-018-0210-8

Epigenetics of malignant melanoma

Autori: Bruce Moran, Romina Silva, Antoinette S. Perry, William M. Gallagher
Pubblicato in: Seminars in Cancer Biology, Numero 51, 2018, Pagina/e 80-88, ISSN 1044-579X
Editore: Academic Press
DOI: 10.1016/j.semcancer.2017.10.006

Using Regularization to Infer Cell Line Specificity in Logical Network Models of Signaling Pathways

Autori: Sébastien De Landtsheer, Philippe Lucarelli, Thomas Sauter
Pubblicato in: Frontiers in Physiology, Numero 9, 2018, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00550

Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma

Autori: Greta Del Mistro, Philippe Lucarelli, Ines Müller, Sébastien De Landtsheer, Anna Zinoveva, Meike Hutt, Martin Siegemund, Roland E. Kontermann, Stefan Beissert, Thomas Sauter, Dagmar Kulms
Pubblicato in: npj Systems Biology and Applications, Numero 4/1, 2018, ISSN 2056-7189
Editore: Systems Biology Institute
DOI: 10.1038/s41540-018-0075-y

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling

Autori: Oleksii S. Rukhlenko, Fahimeh Khorsand, Aleksandar Krstic, Jan Rozanc, Leonidas G. Alexopoulos, Nora Rauch, Keesha E. Erickson, William S. Hlavacek, Richard G. Posner, Silvia Gómez-Coca, Edina Rosta, Cheree Fitzgibbon, David Matallanas, Jens Rauch, Walter Kolch, Boris N. Kholodenko
Pubblicato in: Cell Systems, Numero 7/2, 2018, Pagina/e 161-179.e14, ISSN 2405-4712
Editore: Elsevier B.V.
DOI: 10.1016/j.cels.2018.06.002

Multiplex Staining by Sequential Immunostaining and Antibody Removal on Routine Tissue Sections

Autori: Maddalena Maria Bolognesi, Marco Manzoni, Carla Rossana Scalia, Stefano Zannella, Francesca Maria Bosisio, Mario Faretta, Giorgio Cattoretti
Pubblicato in: Journal of Histochemistry & Cytochemistry, Numero 65/8, 2017, Pagina/e 431-444, ISSN 0022-1554
Editore: Histochemical Society
DOI: 10.1369/0022155417719419

Immunoplasticity in cutaneous melanoma: beyond pure morphology

Autori: Joost J van den Oord; Bosisio, Francesca Maria
Pubblicato in: Virchows Archiv, Numero 1, 2016, ISSN 0945-6317
Editore: Springer Verlag
DOI: 10.1007/s00428-016-2058-y

Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation

Autori: A D Garg, E Romano, N Rufo, P Agostinis
Pubblicato in: Cell Death and Differentiation, Numero 23/6, 2016, Pagina/e 938-951, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/cdd.2016.5

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Autori: Abhishek D. Garg, Lorenzo Galluzzi, Lionel Apetoh, Thais Baert, Raymond B. Birge, José Manuel Bravo-San Pedro, Karine Breckpot, David Brough, Ricardo Chaurio, Mara Cirone, An Coosemans, Pierre G. Coulie, Dirk De Ruysscher, Luciana Dini, Peter de Witte, Aleksandra M. Dudek-Peric, Alberto Faggioni, Jitka Fucikova, Udo S. Gaipl, Jakub Golab, Marie-Lise Gougeon, Michael R. Hamblin, Akseli Hemminki, M
Pubblicato in: Frontiers in Immunology, Numero 6, 2015, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2015.00588

TTCA: an R package for the identification of differentially expressed genes in time course microarray data

Autori: Marco Albrecht, Damian Stichel, Benedikt Müller, Ruth Merkle, Carsten Sticht, Norbert Gretz, Ursula Klingmüller, Kai Breuhahn and Franziska Matthäus
Pubblicato in: BMC Bioinformatics, 2017, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-016-1440-8

Examining the In-Vitro Efficacy of the IAP Antagonist Birinapant as a Single-Agent or in Combination with Dacarbazine to Induce Melanoma Cell Death

Autori: Vesna Vetma, Jan Rožanc, Emilie M Charles, Christian T Hellwig, Leonidas G Alexopoulos, Markus Rehm
Pubblicato in: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2017, ISSN 0965-0407
Editore: Cognizant Communication Corp.
DOI: 10.3727/096504017X14897145996933

Plasma cells in primary melanoma. Prognostic significance and possible role of IgA

Autori: Francesca M Bosisio, James S Wilmott, Nathalie Volders, Marjorie Mercier, Jasper Wouters, Marguerite Stas, Willeke AM Blokx, Daniela Massi, John F Thompson, Richard A Scolyer, Nicolas van Baren, Joost J van den Oord
Pubblicato in: Modern Pathology, Numero 29/4, 2016, Pagina/e 347-358, ISSN 0893-3952
Editore: Nature Publishing Group
DOI: 10.1038/modpathol.2016.28

Master Transcriptional Regulators in Cancer: Discovery via Reverse Engineering Approaches and Subsequent Validation

Autori: Bruce Moran, Arman Rahman, Katja Palonen, Fiona T. Lanigan, William M. Gallagher
Pubblicato in: Cancer Research, Numero 77/9, 2017, Pagina/e 2186-2190, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-16-1813

FALCON: a toolbox for the fast contextualization of logical networks

Autori: Sébastien De Landtsheer, Panuwat Trairatphisan, Philippe Lucarelli, Thomas Sauter
Pubblicato in: Bioinformatics, 2017, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btx380

The Unfolded Protein Response in Immunogenic Cell Death and Cancer Immunotherapy

Autori: Nicole Rufo, Abhishek D. Garg, Patrizia Agostinis
Pubblicato in: Trends in Cancer, 2017, ISSN 2405-8033
Editore: Elsevier B.V.
DOI: 10.1016/j.trecan.2017.07.002

Thermodynamically constrained averaging theory for cancer growth modelling

Autori: Marco Albrecht, Giuseppe Sciume, Philippe Lucarelli, Thomas Sauter
Pubblicato in: IFAC Papers Online, Numero 49/26, 2016
Editore: Elsevier
DOI: 10.1016/j.ifacol.2016.12.141

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