combining SYnthetic Biology and chemistry to create novel CO2-fixing enzymes, ORGanelles and ORGanisms

Project Information

SYBORG

Grant agreement ID: 637675

DOI 10.3030/637675

Project closed

EC signature date 9 March 2015

Start date 1 May 2015

End date 31 December 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 746 038,00

EU contribution € 1 746 038,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

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Publications

Peer reviewed articles (16)

A critical comparison of cellular and cell-free bioproduction systems

Author(s): Nico J Claassens, Simon Burgener, Bastian Vögeli, Tobias J Erb, Arren Bar-Even
Published in: Current Opinion in Biotechnology, Issue 60, 2019, Page(s) 221-229, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2019.05.003

In Vivo Selection for Formate Dehydrogenases with High Efficiency and Specificity toward NADP +

Author(s): Liliana Calzadiaz-Ramirez, Carla Calvó-Tusell, Gabriele M. M. Stoffel, Steffen N. Lindner, Sílvia Osuna, Tobias J. Erb, Marc Garcia-Borràs, Arren Bar-Even, Carlos G. Acevedo-Rocha
Published in: ACS Catalysis, Issue 10/14, 2020, Page(s) 7512-7525, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.0c01487

InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis

Author(s): Bastian Vögeli, Raoul G. Rosenthal, Gabriele M.M. Stoffel, Tristan Wagner, Patrick Kiefer, Niña Socorro Cortina, Seigo Shima, Tobias J. Erb
Published in: Journal of Biological Chemistry, Issue 293/44, 2018, Page(s) 17200-17207, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.005405

Design and Control of Extrachromosomal Elements in Methylorubrum extorquens AM1

Author(s): Martina Carrillo, Marcel Wagner, Florian Petit, Amelie Dransfeld, Anke Becker, Tobias J. Erb
Published in: ACS Synthetic Biology, Issue 8/11, 2019, Page(s) 2451-2456, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.9b00220

Biochemical and synthetic biology approaches to improve photosynthetic CO2-fixation

Author(s): Tobias J Erb, Jan Zarzycki
Published in: Current Opinion in Chemical Biology, Issue 34, 2016, Page(s) 72-79, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2016.06.026

A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters

Author(s): Dominik Peter, Bastian Vögeli, Niña Cortina, Tobias Erb
Published in: Molecules, Issue 21/4, 2016, Page(s) 517, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules21040517

A conserved threonine prevents self-intoxication of enoyl-thioester reductases

Author(s): Raoul G Rosenthal, Bastian Vögeli, Tristan Wagner, Seigo Shima, Tobias J Erb
Published in: Nature Chemical Biology, Issue 13/7, 2017, Page(s) 745-749, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/nchembio.2375

A short history of RubisCO: the rise and fall (?) of Nature's predominant CO 2 fixing enzyme

Author(s): Tobias J Erb, Jan Zarzycki
Published in: Current Opinion in Biotechnology, Issue 49, 2018, Page(s) 100-107, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2017.07.017

A Family of Single Copy repABC -Type Shuttle Vectors Stably Maintained in the Alpha-Proteobacterium Sinorhizobium meliloti

Author(s): Johannes Döhlemann, Marcel Wagner, Carina Happel, Martina Carrillo, Patrick Sobetzko, Tobias J. Erb, Martin Thanbichler, Anke Becker
Published in: ACS Synthetic Biology, Issue 6/6, 2017, Page(s) 968-984, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.6b00320

Synthetic metabolism: metabolic engineering meets enzyme design

Author(s): Tobias J Erb, Patrik R Jones, Arren Bar-Even
Published in: Current Opinion in Chemical Biology, Issue 37, 2017, Page(s) 56-62, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2016.12.023

Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family

Author(s): Thomas Schwander, Richard McLean, Jan Zarzycki, Tobias J. Erb
Published in: Journal of Biological Chemistry, Issue 293/5, 2018, Page(s) 1702-1712, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA117.000764

Molecular Basis for Converting (2S)-Methylsuccinyl-CoA Dehydrogenase into an Oxidase

Author(s): Simon Burgener, Thomas Schwander, Elvira Romero, Marco Fraaije, Tobias Erb
Published in: Molecules, Issue 23/1, 2018, Page(s) 68, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23010068

A synthetic pathway for the fixation of carbon dioxide in vitro

Author(s): Thomas Schwander, Lennart Schada von Borzyskowski, Simon Burgener, Niña Socorro Cortina, Tobias J. Erb
Published in: Science, Issue 354/6314, 2016, Page(s) 900-904, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aah5237

Four amino acids define the CO 2 binding pocket of enoyl-CoA carboxylases/reductases

Author(s): Gabriele M. M. Stoffel, David Adrian Saez, Hasan DeMirci, Bastian Vögeli, Yashas Rao, Jan Zarzycki, Yasuo Yoshikuni, Soichi Wakatsuki, Esteban Vöhringer-Martinez, Tobias J. Erb
Published in: Proceedings of the National Academy of Sciences, Issue 116/28, 2019, Page(s) 13964-13969, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1901471116

Awakening the Sleeping Carboxylase Function of Enzymes: Engineering the Natural CO 2 -Binding Potential of Reductases

Author(s): Iria Bernhardsgrütter, Kristina Schell, Dominik M. Peter, Farshad Borjian, David Adrian Saez, Esteban Vöhringer-Martinez, Tobias J. Erb
Published in: Journal of the American Chemical Society, Issue 141/25, 2019, Page(s) 9778-9782, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b03431

Light-powered CO 2 fixation in a chloroplast mimic with natural and synthetic parts

Author(s): Tarryn E. Miller, Thomas Beneyton, Thomas Schwander, Christoph Diehl, Mathias Girault, Richard McLean, Tanguy Chotel, Peter Claus, Niña Socorro Cortina, Jean-Christophe Baret, Tobias J. Erb
Published in: Science, Issue 368/6491, 2020, Page(s) 649-654, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaz6802