Uncovering the Role of Cancer Associated Fibroblasts in Facilitating Breast Cancer Metastasis

Project Information

MetCAF

Grant agreement ID: 637069

DOI 10.3030/637069

Project closed

EC signature date 26 June 2015

Start date 1 July 2015

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 281 958,75

EU contribution € 1 281 958,75

Coordinated by

TEL AVIV UNIVERSITY
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis

Author(s): Lea Monteran, Nour Ershaid, Idan Sabah, Ibrahim Fahoum, Yael Zait, Ophir Shani, Noam Cohen, Anat Eldar-Boock, Ronit Satchi-Fainaro, Neta Erez
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-70788-3

Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity

Author(s): Ophir Shani, Yael Raz, Lea Monteran, Ye'ela Scharff, Oshrat Levi-Galibov, Or Megides, Hila Shacham, Noam Cohen, Dana Silverbush, Camilla Avivi, Roded Sharan, Asaf Madi, Ruth Scherz-Shouval, Iris Barshack, Ilan Tsarfaty, Neta Erez
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60745

Fibroblast-Derived IL33 Facilitates Breast Cancer Metastasis by Modifying the Immune Microenvironment and Driving Type 2 Immunity

Author(s): Ophir Shani, Tatiana Vorobyov, Lea Monteran, Dor Lavie, Noam Cohen, Yael Raz, Galia Tsarfaty, Camila Avivi, Iris Barshack, Neta Erez
Published in: Cancer Research, Issue 80/23, 2020, Page(s) 5317-5329, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-2116

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

Author(s): Nour Ershaid, Yoray Sharon, Hila Doron, Yael Raz, Ophir Shani, Noam Cohen, Lea Monteran, Leonor Leider-Trejo, Amir Ben-Shmuel, Muhammad Yassin, Motti Gerlic, Adit Ben-Baruch, Metsada Pasmanik-Chor, Roni Apte, Neta Erez
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12370-8

Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer

Author(s): Yael Raz, Noam Cohen, Ophir Shani, Rachel E. Bell, Sergey V. Novitskiy, Lilach Abramovitz, Carmit Levy, Michael Milyavsky, Leonor Leider-Trejo, Harold L. Moses, Dan Grisaru, Neta Erez
Published in: The Journal of Experimental Medicine, Issue 215/12, 2018, Page(s) 3075-3093, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20180818

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment

Author(s): Lea Monteran, Neta Erez
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Front Immunol
DOI: 10.3389/fimmu.2019.01835

Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

Author(s): N Cohen, O Shani, Y Raz, Y Sharon, D Hoffman, L Abramovitz, N Erez
Published in: Oncogene, 2017, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/onc.2017.65

Other (1)

Evolution of metastases-associated fibroblasts in the lung microenvironment is driven by stage-specific transcriptional plasticity

Author(s): Ophir Shani, ProfileYael Raz, Or Megides, Hila Shacham, Noam Cohen, Dana Silverbush, Lea Monteran, Roded Sharan, Ilan Tsarfaty, Neta Erez
Published in: 2019
Publisher: bioRxiv
DOI: 10.1101/778936