PARAGONE: vaccines for animal parasites

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Website designed mounted on the WWW and publicised Work to be led by the 5M publishing arm of BAHL

A bank of Fasciola hepatica phenotypes will be established and the stocks held at QUB

A three day workshop will be held in ULPGC on the subject of immunological tools and livestock models of infection This will be open to PhD and postDocs from across the consortium as well as to young scientists from other relevant laboratories working on ruminant vaccinology A small number of scholarships will be available to facilitate travel and attendance of the workshop participants

Stakeholder Meeting III: Stakeholders' Input to Prototype Development

This Stakeholders View meeting will take place in ULPGC and will be an interface meeting of partner scientists from across the consortium with farmers and veterinarians to discuss the pros and cons of vaccination versus chemical treatment of parasites Feedback from this meeting will be used to help inform product design a focus of WP4 Demonstration

Publications

Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans

Auteurs: Andres Garcia-Campos, Alessandra Ravidà, D. Linh Nguyen, Krystyna Cwiklinski, John P. Dalton, Cornelis H. Hokke, Sandra O’Neill, Grace Mulcahy
Publié dans: PLOS Neglected Tropical Diseases, Numéro 10/5, 2016, Page(s) e0004688, ISSN 1935-2735
Éditeur: PLOS
DOI: 10.1371/journal.pntd.0004688

Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica

Auteurs: Maria Teresa Ruiz-Campillo, Veronica Molina Hernandez, Alejandro Escamilla, Michael Stevenson, Jose Perez, Alvaro Martinez-Moreno, Sheila Donnelly, John P. Dalton, Krystyna Cwiklinski
Publié dans: Scientific Reports, Numéro 7/1, 2017, Page(s) 1-14, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-03094-0

Distribution of Foxp3+ T cells in the liver and hepatic lymph nodes of goats and sheep experimentally infected with Fasciola hepatica

Auteurs: A. Escamilla, R. Zafra, J. Pérez, T.N. McNeilly, I.L. Pacheco, L. Buffoni, F.J. Martínez-Moreno, V. Molina-Hernández, A. Martínez-Moreno
Publié dans: Veterinary Parasitology, Numéro 230, 2016, Page(s) 14-19, ISSN 0304-4017
Éditeur: Elsevier BV
DOI: 10.1016/j.vetpar.2016.10.020

Th1/Th2 balance in the liver and hepatic lymph nodes of vaccinated and unvaccinated sheep during acute stages of infection with Fasciola hepatica

Auteurs: I.L. Pacheco, N. Abril, N. Morales-Prieto, M.J. Bautista, R. Zafra, A. Escamilla, M.T. Ruiz, A. Martínez-Moreno, J. Pérez
Publié dans: Veterinary Parasitology, Numéro 238, 2017, Page(s) 61-65, ISSN 0304-4017
Éditeur: Elsevier BV
DOI: 10.1016/j.vetpar.2017.03.022

Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep

Auteurs: A. Escamilla, R. Pérez-Caballero, R. Zafra, M.J. Bautista, I.L. Pacheco, M.T. Ruiz, M.S. Martínez-Cruz, A. Martínez-Moreno, V. Molina-Hernández, J. Pérez
Publié dans: Veterinary Parasitology, Numéro 238, 2017, Page(s) 49-53, ISSN 0304-4017
Éditeur: Elsevier BV
DOI: 10.1016/j.vetpar.2017.03.015

Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host

Auteurs: Krystyna Cwiklinski, Heather Jewhurst, Paul McVeigh, Tara Barbour, Aaron G. Maule, Jose Tort, Sandra M. O'Neill, Mark W. Robinson, Sheila Donnelly, John P. Dalton
Publié dans: Molecular & Cellular Proteomics, Numéro 17/4, 2018, Page(s) 792-809, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.RA117.000445

Advances in Fasciola hepatica research using ‘omics’ technologies

Auteurs: Krystyna Cwiklinski, John P. Dalton
Publié dans: International Journal for Parasitology, Numéro 48/5, 2018, Page(s) 321-331, ISSN 0020-7519
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpara.2017.12.001

Antibody recognition of cathepsin L1-derived peptides in Fasciola hepatica -infected and/or vaccinated cattle and identification of protective linear B-cell epitopes

Auteurs: Laura Garza-Cuartero, Thomas Geurden, Suman M. Mahan, John M. Hardham, John P. Dalton, Grace Mulcahy
Publié dans: Vaccine, Numéro 36/7, 2018, Page(s) 958-968, ISSN 0264-410X
Éditeur: Elsevier BV
DOI: 10.1016/j.vaccine.2018.01.020

The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity

Auteurs: Akane Tanaka, Venkata Sita Rama Raju Allam, Jennifer Simpson, Natalia Tiberti, Jenna Shiels, Joyce To, Maria Lund, Valery Combes, Sinead Weldon, Cliff Taggart, John P. Dalton, Simon Phipps, Maria B. Sukkar, Sheila Donnelly
Publié dans: Journal of Allergy and Clinical Immunology, 2018, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2018.01.050

Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora

Auteurs: Ana González-Hernández, Jimmy Borloo, Iris Peelaers, Stijn Casaert, Georges Leclercq, Edwin Claerebout, Peter Geldhof
Publié dans: International Journal for Parasitology, Numéro 48/1, 2018, Page(s) 41-49, ISSN 0020-7519
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpara.2017.07.002

The immunoregulatory effects of co-infection with Fasciola hepatica : From bovine tuberculosis to Johne's disease

Auteurs: Amalia Naranjo Lucena, Laura Garza Cuartero, Grace Mulcahy, Annetta Zintl
Publié dans: The Veterinary Journal, Numéro 222, 2017, Page(s) 9-16, ISSN 1090-0233
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.tvjl.2017.02.007

Migration of Fasciola hepatica newly excysted juveniles is inhibited by high-mannose and oligomannose-type N-glycan-binding lectins

Auteurs: ANDRES GARCIA-CAMPOS, ALAN W. BAIRD, GRACE MULCAHY
Publié dans: Parasitology, Numéro 144/13, 2017, Page(s) 1708-1717, ISSN 0031-1820
Éditeur: Cambridge University Press
DOI: 10.1017/S003118201700124X

Fasciola hepatica infection reduces Mycobacterium bovis burden and mycobacterial uptake and suppresses the pro-inflammatory response

Auteurs: L. Garza-Cuartero, J. O'Sullivan, A. Blanco, J. McNair, M. Welsh, R. J. Flynn, D. Williams, P. Diggle, J. Cassidy, G. Mulcahy
Publié dans: Parasite Immunology, Numéro 38/7, 2016, Page(s) 387-402, ISSN 0141-9838
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pim.12326

Network Analysis of the Systemic Response to Fasciola hepatica Infection in Sheep Reveals Changes in Fibrosis, Apoptosis, Toll-Like Receptors 3/4, and B Cell Function

Auteurs: Yan Fu, John A. Browne, Kate Killick, Grace Mulcahy
Publié dans: Frontiers in Immunology, Numéro 8, 2017, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2017.00485

Host protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response

Auteurs: Ana González-Hernández, Stefanie Van Coppernolle, Jimmy Borloo, Frederik Van Meulder, Oonagh Paerewijck, Iris Peelaers, Georges Leclercq, Edwin Claerebout, Peter Geldhof
Publié dans: Scientific Reports, Numéro 6, 2016, Page(s) 29496, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep29496

Fasciola hepatica induces eosinophil apoptosis in the migratory and biliary stages of infection in sheep

Auteurs: A. Escamilla, M.J. Bautista, R. Zafra, I.L. Pacheco, M.T. Ruiz, S. Martínez-Cruz, A. Méndez, A. Martínez-Moreno, V. Molina-Hernández, J. Pérez
Publié dans: Veterinary Parasitology, Numéro 216, 2016, Page(s) 84-88, ISSN 0304-4017
Éditeur: Elsevier BV
DOI: 10.1016/j.vetpar.2015.12.013

Impeding movement of the poultry red mite, Dermanyssus gallinae

Auteurs: James Pritchard, Tatiana Küster, David George, Olivier Sparagano, Fiona Tomley
Publié dans: Veterinary Parasitology, Numéro 225, 2016, Page(s) 104-107, ISSN 0304-4017
Éditeur: Elsevier BV
DOI: 10.1016/j.vetpar.2016.06.006

Fasciolosis in South America: epidemiology and control challenges

Auteurs: C. Carmona, J.F. Tort
Publié dans: Journal of Helminthology, 2016, Page(s) 1-11, ISSN 0022-149X
Éditeur: CABI Publishing
DOI: 10.1017/S0022149X16000560

Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection

Auteurs: Yan Fu, Andreas L. Chryssafidis, John A. Browne, Jack O'Sullivan, Paul A. McGettigan, Grace Mulcahy
Publié dans: PLOS Neglected Tropical Diseases, Numéro 10/9, 2016, Page(s) e0005015, ISSN 1935-2735
Éditeur: PLOS
DOI: 10.1371/journal.pntd.0005015

Progress in the development of subunit vaccines for gastrointestinal nematodes of ruminants

Auteurs: Matthews JB, Geldhof P, Tzelos T, Claerebout E
Publié dans: Parasite Immunol., Numéro 10/12, 2016, ISSN 1365-3024
Éditeur: Blackwell
DOI: 10.1111/pim.12391

Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host

Auteurs: Alessandra Ravidà, Krystyna Cwiklinski, Allison M. Aldridge, Paul Clarke, Roisin Thompson, Jared Q. Gerlach, Michelle Kilcoyne, Cornelis H. Hokke, John P. Dalton, Sandra M. O'Neill
Publié dans: Molecular & Cellular Proteomics, Numéro 15/10, 2016, Page(s) 3139-3153, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.M116.059774

Fasciola hepatica Surface Coat Glycoproteins Contain Mannosylated and Phosphorylated N-glycans and Exhibit Immune Modulatory Properties Independent of the Mannose Receptor

Auteurs: Alessandra Ravidà, Allison M. Aldridge, Nicole N. Driessen, Ferry A. H. Heus, Cornelis H. Hokke, Sandra M. O’Neill
Publié dans: PLOS Neglected Tropical Diseases, Numéro 10/4, 2016, Page(s) e0004601, ISSN 1935-2735
Éditeur: Plos
DOI: 10.1371/journal.pntd.0004601

A prospective view of animal and human Fasciolosis

Auteurs: K. Cwiklinski, S. M. O'Neill, S. Donnelly, J. P. Dalton
Publié dans: Parasite Immunology, Numéro 38/9, 2016, Page(s) 558-568, ISSN 0141-9838
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pim.12343

The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica : Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis

Auteurs: Krystyna Cwiklinski, Eduardo de la Torre-Escudero, Maria Trelis, Dolores Bernal, Philippe J. Dufresne, Gerard P. Brennan, Sandra O'Neill, Jose Tort, Steve Paterson, Antonio Marcilla, John P. Dalton, Mark W. Robinson
Publié dans: Molecular & Cellular Proteomics, Numéro 14/12, 2015, Page(s) 3258-3273, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.M115.053934

Unexpected Activity of a Novel Kunitz-type Inhibitor

Auteurs: David Smith, Irina G. Tikhonova, Heather L. Jewhurst, Orla C. Drysdale, Jan Dvořák, Mark W. Robinson, Krystyna Cwiklinski, John P. Dalton
Publié dans: Journal of Biological Chemistry, Numéro 291/37, 2016, Page(s) 19220-19234, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M116.724344

The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

Auteurs: R. Alvarado, J. To, M. E. Lund, A. Pinar, A. Mansell, M. W. Robinson, B. A. OBrien, J. P. Dalton, S. Donnelly
Publié dans: The FASEB Journal, Numéro 28/09/2016, 2016, Page(s) 1 - 11, ISSN 0892-6638
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201500093R

A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

Auteurs: Maria E. Lund, Judith Greer, Aakanksha Dixit, Raquel Alvarado, Padraig McCauley-Winter, Joyce To, Akane Tanaka, Andrew T. Hutchinson, Mark W. Robinson, Ann M. Simpson, Bronwyn A. O’Brien, John P. Dalton, Sheila Donnelly
Publié dans: Scientific Reports, Numéro 6, 2016, Page(s) 37789, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep37789

The rational simplification of a recombinant cocktail vaccine to control the parasitic nematode Teladorsagia circumcincta

Auteurs: Alasdair J. Nisbet, Tom N. McNeilly, Daniel R.G. Price, E. Margaret Oliver, Yvonne Bartley, Mairi Mitchell, Javier Palarea-Albaladejo, Jacqueline B. Matthews
Publié dans: International Journal for Parasitology, Numéro 49/3-4, 2019, Page(s) 257-265, ISSN 0020-7519
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpara.2018.10.006

Identification of reference genes for real-time PCR cytokine gene expression studies in sheep experimentally infected with Fasciola hepatica

Auteurs: I. L. Pacheco, N. Abril, R. Zafra, N. Morales-Prieto, V. Molina Hernández, M. T. Ruiz, R. Perez-Caballero, A. Martínez-Moreno, J. Pérez
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-37672-7

Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection

Auteurs: Raúl Pérez-Caballero, Leandro Buffoni, F. Javier Martínez-Moreno, Rafael Zafra, Verónica Molina-Hernández, José Pérez, Álvaro Martínez-Moreno
Publié dans: Parasites & Vectors, Numéro 11/1, 2018, ISSN 1756-3305
Éditeur: BioMed Central
DOI: 10.1186/s13071-018-3072-5

Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis

Auteurs: Raúl Pérez-Caballero, F. Javier Martínez-Moreno, Rafael Zafra, Verónica Molina-Hernández, Isabel L. Pacheco, M. Teresa Ruiz-Campillo, Alejandro Escamilla, José Pérez, Álvaro Martínez-Moreno, Leandro Buffoni
Publié dans: Parasites & Vectors, Numéro 11/1, 2018, ISSN 1756-3305
Éditeur: BioMed Central
DOI: 10.1186/s13071-018-3250-5

Low allelic diversity in vaccine candidates genes from different locations sustain hope for Fasciola hepatica immunization

Auteurs: Maria Fernanda Dominguez, Javier González-Miguel, Carlos Carmona, John P. Dalton, Krystyna Cwiklinski, José Tort, Mar Siles-Lucas
Publié dans: Veterinary Parasitology, Numéro 258, 2018, Page(s) 46-52, ISSN 0304-4017
Éditeur: Elsevier BV
DOI: 10.1016/j.vetpar.2018.06.011

Impacts of breed type and vaccination on Teladorsagia circumcincta infection in native sheep in Gran Canaria

Auteurs: Jorge F. González, Julia N. Hernández, Cynthia Machín, Tara Pérez-Hernández, Harry W. Wright, Yolanda Corripio-Miyar, Daniel R. G. Price, Jacqueline B. Matthews, Tom N. McNeilly, Alasdair J. Nisbet
Publié dans: Veterinary Research, Numéro 50/1, 2019, Page(s) 1-7, ISSN 1297-9716
Éditeur: SpringerNature
DOI: 10.1186/s13567-019-0646-y

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