Objective
Helminth and ectoparasitic infections of ruminants and poultry have a huge impact on the biological efficiency of these vital food sources. Indiscriminate antiparasitic use has led to drug resistance across the globe. The main alternative to the dwindling supply of antiparasitics is vaccines. Here, in the PARAGONE project, findings from previous EU and other-funded projects on parasite vaccine development will be exploited to take a number of promising prototypes towards commercialisation. Partners from the Europe, China, Uruguay, SMEs and pharma, will directly move forward prototypes against the ruminant helminths Fasciola hepatica, Cooperia spp., Ostertagia ostertagi, Teladorsagia circumcincta and Haemonchus contortus and, the ectoparasitic mites, Psoroptes ovis (ruminants) and Dermanyssus gallinae (poultry). They will utilise novel adjuvants or delivery systems to maximise efficacy of some of the prototypes. Moreover, immunology studies will focus on pathogens that have previously proved problematic, often because they release immunosuppressive molecules that must be overcome for vaccines to work or because recombinant vaccines have failed to elicit protection observed with native prototypes. State-of-the-art technologies will be used to interrogate host/parasite interactions to define key signatures of protection that can be used to inform delivery systems that will enhance immunity, while other studies will define polymorphism in current vaccine candidates to ensure derived prototypes will be fit-for-purpose across geographic scales. Fundamental, is engagement of the scientists with pharma and other stakeholders (farmers, veterinarians, regulators) via many dissemination activities that will be used to obtain feedback on how the vaccines can be best deployed in the field. The output will be at least two prototypes to the point of uptake by pharma, government or philanthropic agencies, and a clear pathway to commercialisation for all prototypes studied.
Fields of science
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistance
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- agricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandry
- natural sciencesmathematicsapplied mathematicsmathematical model
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
EH26 0PZ Penicuik
United Kingdom
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Participants (21)
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
EH26 0PZ PENICUICK
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
9 Dublin
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28006 Madrid
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35001 Las Palmas De Gran Canaria
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
35001 Las Palmas
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Participation ended
730046 Lanzhou, Gansu
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1433 AS
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BT7 1NN Belfast
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NW1 OTU London
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4 Dublin
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14005 Cordoba
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11200 Montevideo
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9000 Gent
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S35 1QN SHEFFIELD
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
OX2 8QJ OXFORD
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
EH16 4UX EDINBURGH
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
26169 Friesoythe
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Participation ended
G12 8QQ GLASGOW
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1348 Louvain La Neuve
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G1 1XQ Glasgow
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L69 7ZX Liverpool
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