CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.
Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.
Leistungen
A catalogue of spliceogenic and non-spliceogenic variants (consensus site variants, nonsense variants, and indel variants) causing deleterious or non-deleterious splicing alterations in the 11 BC-HR genes.
Risk model validationReport on model validation in KARMA and GC-HBOC. The final BOADICEA model will be evaluated in two prospective cohort studies (KARMA and GC-HBOC). Sequencing data from the BRIDGES panel, together with data on the SNP polygenic risk score (PRS), lifestyle risk factors and breast density, will be obtained from ~1,500 cases and 1,500 matched controls. The model will be evaluated for calibration and discrimination, and compared with the existing BOADICEA model.
Results from RIgORouS analysisReport on the analysis results of the RIgORouS pipeline for 250 VUS.
Risk estimates Panel 1Report on risk estimates for variants in genes on Panel 1 The principal strategy will be to estimate risks for categories of variants defined by insilico and functional characterization We will estimate hazard ratios using a maximum likelihood approach The advantage of this approach is that the same method can be used for the populationbased and clinicbased studies
Report on BOADICEA-PLUSReport on BOADICEA-PLUS, including risk estimates for genes on BRIDGES Panel. The BOADICEA online interface will be upgraded to incorporate data on variants in BC genes, in addition to common variants, family history, lifestyle risk factors and breast density, thus providing individualised absolute risk estimates for breast cancer by subtype, and, where possible, other cancers. An interface to allow sequence variant files to be read automatically will be developed. We will provide a direct link to the Alamut database, so that users can query data on the variant classification.
A template for psychological interventionA report presenting a template for psychological intervention, and a structured psychological evaluation and intervention concept. This will entail a questionnaire addressing the specific psychosocial difficulties and needs that counselees attending cancer genetics clinics in France, Germany and Spain may present during the course of counselling. A specific scoring procedure and interpretation was provided by the PAHC validation study. The intervention concept is to screen and monitor counselees’ needs for additional intervention, and to improve the care provided in genetics clinics according to evolving knowledge, technology and practice.
Predictive value of functional analysesReport on predictive value of functional analyses in reanalysis of Panel 1 dataset Once functional analysis and detailed insilicostructural predictions have been completed WP4 we will then rederive risk estimates for those Panel 1 genes based an updated classification scheme that incorporates functional predictions BRIDGESv2 We will evaluate for each gene using regression analyses whether functional prediction is associated with risk after adjustment for the insilico prediction Since the genes evaluated in WP4 are all involved in DNA repair and are being subject to similar functional assays it may be feasible to perform global analyses across genes
Survey results of BOADICEA-PLUSA comprehensive description of survey results of BOADICEA-PLUS users. Online surveys among genetic counselors on the use of BOADICEA-PLUS, by analyzing the number and type of website connections and by using online questionnaires. We will use two validated instruments for our evaluation: the System Usability Scale (SUS) and the Center for Healthcare Evaluation Provider Satisfaction Questionnaire (CHCE-PSQ). These instruments have been recently used to evaluate the uptake of an online tool to guide BRCA1/2 mutation carrier women in their prophylactic surgery decisions.
Combined analysis of exome and gene panel sequencingA report of the analysis of the data that were used to select the genes for panel 2 (specifically from the combined analysis of COMPLEXO and PERSPECTIVE).
Position report on best practice and recommendations for genetic counsellingPosition report on best practice and recommendations for genetic counseling based on the use of BOADICEAPLUS D55 and Task 55
Final MeetingWe will organise a final meeting together with BCAST which will be open to a much wider community than just the consortium members in order to provide a much broader dissemination of project results
Survey results of BOADICEAA comprehensive description of survey results of current BOADICEA users. Online surveys among genetic counselors on the use of the present BOADICEA tool, by analyzing the number and type of BOADICEA website connections and by using online questionnaires. We will use two validated instruments for our evaluation: the System Usability Scale (SUS) and the Center for Healthcare Evaluation Provider Satisfaction Questionnaire (CHCE-PSQ). These instruments have been recently used to evaluate the uptake of an online tool to guide BRCA1/2 mutation carrier women in their prophylactic surgery decisions.
A high-throughput functional analysis system (RIgORouS) for 11 BC-HR genes. The final analysis pipeline (RIgORouS) exploits three read-out systems (Figure 3.1d): 1. RAD51 foci analysis 2. Analysis of homologous recombination 3. Analysis of sensitivity to PARPi
Validated instruments for the identification of patients with psychological distressValidated instruments for the identification of patients with psychological distress and structured intervention concept. We will assess the Psychosocial Aspects of Hereditary Cancer (PAHC), and the Distress Thermometer, in women undergoing genetic testing for breast cancer risk in Cancer Genetic Clinics from different EU countries. The PAHC questionnaire is dedicated to cancer genetic clinics, and has recently been validated in Dutch cancer clinics; it will be translated into English, German, French, and Spanish. Moreover, the PAHC will be modified and validated in the same cohort for the evaluation of psychosocial distress in post-test counselling concerning the uptake of preventive measures (postPAHC). A cross-cultural validity of both versions will be performed through the first patients included in the prospective observational study. At least 312 patients will be accrued in the institutes of P7 and P8, according to published recommendations.
A panel of validated minigene-based splicing assaysA panel of validated minigene-based splicing assays for 11 BC-HR genes. We will synthesize minigenes covering all exons for the selected BC-HR genes. Constructs will be transfected into human epithelial (breast cancer) cell lines. RNA will be extracted and minigene transcripts will be amplified using plasmid-specific primers and analysed by CEP and Sanger sequencing.
A catalogue of naturally occurring alternative splicingA catalogue of naturally occurring alternative splicing events in lymphocytes and epithelial breast tissue in 11 BC-HR genes. We will use GENCODE annotations (retrieved from Ensemble) to predict alternative splicing events occurring in the 11 BC-HR genes. This information will be used to design a set of overlapping cDNA amplicons covering the full-length reference transcript of each gene. Subsequently, RNA from lymphocytes (healthy blood donors) and from normal breast tissue (either commercially available or from cosmetic surgery) will be used for analysis of RT-PCR amplicons by capillary electrophoresis (CEP) and direct sequencing by Sanger. This will yield a catalogue of alternative splicing for each of the BC-HR genes, as well as tissue-specific differences therein.
Patient decision aid for counseleesA patient decision aid PDA will be developed in a multidisciplinary team including patients We will first assess the content of a PDA for the uptake of preventive measures in women with moderate disease risk and define topic content target audience distribution strategy and objectives of the information Then we will establish content based on a literature review user expectations and other sources of information and develop the PDA based on the methods of evidencebased medicine and established quality criteria DISCERN IPDAS and others The PDA will be tested for readability understanding and presentation ie of risks and an option grid wwwoptiongridorg will be designed to help counselors and counselees talk about how best to handle disease risk with a strong focus on evidencebased preventive measures
An e-Learning tool for genetic counsellorsAn elearning tool for counselors in the posttest setting including a video tutorial and a manual will be developed in three steps 1 a systematic literature review will be conducted to identify evidencebased counseling programs and routinely used information formats for posttest counseling for health care professionals 2 results from the questionnaire for BOADICEA users will be considered in order to grip users needs 3 validation of the prototype in focus group discussions with genetic counsellors and patients at risk for hereditary breast and ovarian cancer syndrome We plan on 6 to 10 focus groups based on selective sampling Each group will comprise between 6 to 10 participants Cancer family clinics from different countries will be invited to participate The number of focus groups will depend on the achievement of a theoretical saturation of 80 An interview guide will be developed to advice focus group interviews Interviews will be taped transcribed verbatim and evaluated using the software MAXQDA
Dissemination of sequence variants in public domain through locusspecific Leiden Opensource Variant databases LOVD All variants detected in the genes analyzed in the 60000 individuals will be deposited in the public domain through genespecific LOVD databases
Upgraded Alamut ToolOnline Alamut tool upgraded with risk estimates from BRIDGES The results from risk analyses D31 D33 will be used to provide summary evaluations of the evidence for each geneclass being associated with risk and the relative risk of breast cancer and other cancers associated with each variant These results will be made available through the Alamut genome browser
Project WebsiteLaunch of project website with information on project related matters for the general public and a passwordprotected part for members of the consortium
Veröffentlichungen
Autoren:
Tim Carver, Simon Hartley, Andrew Lee, Alex P. Cunningham, Stephanie Archer, Chantal Babb de Villiers, Jonathan Roberts, Rod Ruston, Fiona M. Walter, Marc Tischkowitz, Douglas F. Easton, Antonis C. Antoniou
Veröffentlicht in:
Cancer Epidemiology Biomarkers & Prevention, Ausgabe 30/3, 2021, Seite(n) 469-473, ISSN 1055-9965
Herausgeber:
American Association for Cancer Research
DOI:
10.1158/1055-9965.epi-20-1319
Autoren:
Pooja Middha Kapoor, Nasim Mavaddat, Parichoy Pal Choudhury, Amber N Wilcox, Sara Lindström, Sabine Behrens, Kyriaki Michailidou, Joe Dennis, Manjeet K Bolla, Qin Wang, Audrey Jung, Zomoroda Abu-Ful, Thomas Ahearn, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Lesl
Veröffentlicht in:
JNCI: Journal of the National Cancer Institute, Ausgabe 113/3, 2020, Seite(n) 329-337, ISSN 0027-8874
Herausgeber:
Oxford University Press
DOI:
10.1093/jnci/djaa056
Autoren:
Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O
Veröffentlicht in:
Nature Communications, Ausgabe 11/1, 2020, Seite(n) 3833, ISSN 2041-1723
Herausgeber:
Nature Publishing Group
DOI:
10.1038/s41467-020-17680-w
Autoren:
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Víctor Lorca, Alicia Gómez-Sanz, Sara Carvalho, Jamie Allen, Mar Infante, Pedro Pérez-Segura, Conxi Lázaro, Douglas F. Easton, Peter Devilee, Maaike P. G. Vreeswijk, Miguel de la Hoya, Eladio A. Velasco
Veröffentlicht in:
Cancers, Ausgabe 13/11, 2021, Seite(n) 2845, ISSN 2072-6694
Herausgeber:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cancers13112845
Autoren:
Jingjing Liu, Wendy J. C. Prager - van der Smissen, J. Margriet Collée, Manjeet K. Bolla, Qin Wang, Kyriaki Michailidou, Joe Dennis, Thomas U. Ahearn, Kristiina Aittomäki, Christine B. Ambrosone, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Norbert Arnold, Kristan J. Aronson, Annelie Augustinsson, Päivi Auvinen, Heiko Becher, Matthias W. Beckmann, Sabine Behre
Veröffentlicht in:
Scientific Reports, Ausgabe 10/1, 2020, ISSN 2045-2322
Herausgeber:
Nature Publishing Group
DOI:
10.1038/s41598-020-65665-y
Autoren:
Nora Pashayan, Antonis C. Antoniou, Urska Ivanus, Laura J. Esserman, Douglas F. Easton, David French, Gaby Sroczynski, Per Hall, Jack Cuzick, D. Gareth Evans, Jacques Simard, Montserrat Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Giorgi Rossi, Jelle Wesseling, Davi
Veröffentlicht in:
Nature Reviews Clinical Oncology, Ausgabe 17/11, 2020, Seite(n) 716-716, ISSN 1759-4774
Herausgeber:
Nature Publishing Group
DOI:
10.1038/s41571-020-0412-0
Autoren:
Amber N Hurson, Parichoy Pal Choudhury, Chi Gao, Anika Hüsing, Mikael Eriksson, Min Shi, Michael E Jones, D Gareth R Evans, Roger L Milne, Mia M Gaudet, Celine M Vachon, Daniel I Chasman, Douglas F Easton, Marjanka K Schmidt, Peter Kraft, Montserrat Garcia-Closas, Nilanjan Chatterjee, Christopher G Scott, Brian D Carter, Kara Martin, Elaine F Harkness, Mark N Brook, Thomas U Ahearn, Nasim Mavadda
Veröffentlicht in:
International Journal of Epidemiology, 2021, ISSN 0300-5771
Herausgeber:
Oxford University Press
DOI:
10.1093/ije/dyab036
Autoren:
Pei Sze Ng, Jia Wern Pan, Muhammad Mamduh Ahmad Zabidi, Pathmanathan Rajadurai, Cheng Har Yip, Oscar M. Reuda, Alison M. Dunning, Antonis C. Antoniou, Douglas F. Easton, Carlos Caldas, Suet-Feung Chin, Soo Hwang Teo
Veröffentlicht in:
npj Breast Cancer, Ausgabe 7/1, 2021, Seite(n) 46, ISSN 2374-4677
Herausgeber:
Springer Nature
DOI:
10.1038/s41523-021-00254-4
Autoren:
Julia Dick, Viktoria Aue, Simone Wesselmann, Anne Brédart, Sylvie Dolbeault, Peter Devilee, Dominique Stoppa-Lyonnet, Rita K. Schmutzler, Kerstin Rhiem
Veröffentlicht in:
Breast Care, Ausgabe 16/4, 2021, Seite(n) 389-395, ISSN 1661-3791
Herausgeber:
Karger AG
DOI:
10.1159/000511136
Autoren:
Maria Escala-Garcia, Anna Morra, Sander Canisius, Jenny Chang-Claude, Siddhartha Kar, Wei Zheng, Stig E. Bojesen, Doug Easton, Paul D. P. Pharoah, Marjanka K. Schmidt
Veröffentlicht in:
BMC Medicine, Ausgabe 18/1, 2020, Seite(n) 327, ISSN 1741-7015
Herausgeber:
BioMed Central
DOI:
10.1186/s12916-020-01797-2
Autoren:
Teresa Sullivan, Eswary Thirthagiri, Chan‐Eng Chong, Stacey Stauffer, Susan Reid, Eileen Southon, Tiara Hassan, Aravind Ravichandran, Eldarina Wijaya, Joanna Lim, Nur Aishah Mohd Taib, Farhana Fadzli, Cheng Har Yip, Mikael Hartman, Jingmei Li, Rob M. Dam, Susan L. North, Ranabir Das, Douglas F. Easton, Kajal Biswas, Soo‐Hwang Teo, Shyam K. Sharan
Veröffentlicht in:
Human Mutation, Ausgabe 42/2, 2021, Seite(n) 200-212, ISSN 1059-7794
Herausgeber:
John Wiley & Sons Inc.
DOI:
10.1002/humu.24154
Autoren:
Weiva Sieh, Joseph H. Rothstein, Robert J. Klein, Stacey E. Alexeeff, Lori C. Sakoda, Eric Jorgenson, Russell B. McBride, Rebecca E. Graff, Valerie McGuire, Ninah Achacoso, Luana Acton, Rhea Y. Liang, Jafi A. Lipson, Daniel L. Rubin, Martin J. Yaffe, Douglas F. Easton, Catherine Schaefer, Neil Risch, Alice S. Whittemore, Laurel A. Habel
Veröffentlicht in:
Nature Communications, Ausgabe 11/1, 2020, Seite(n) 5116, ISSN 2041-1723
Herausgeber:
Nature Publishing Group
DOI:
10.1038/s41467-020-18883-x
Autoren:
Helian Feng, Alexander Gusev, Bogdan Pasaniuc, Lang Wu, Jirong Long, Zomoroda Abu‐full, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Antonis C. Antoniou, Adalgeir Arason, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Ella Asseryanis, Paul L. Auer, Jacopo Azzollini, Judith Balmaña, Rosa B. Barkardottir, Daniel R. Barnes, Daniel Barrowdale, Matthias W. Beckmann, Sabine Behrens,
Veröffentlicht in:
Genetic Epidemiology, Ausgabe 44/5, 2020, Seite(n) 442-468, ISSN 0741-0395
Herausgeber:
John Wiley & Sons Inc.
DOI:
10.1002/gepi.22288
Autoren:
JooYong Park, Ji-Yeob Choi, Jaesung Choi, Seokang Chung, Nan Song, Sue K. Park, Wonshik Han, Dong-Young Noh, Sei-Hyun Ahn, Jong Won Lee, Mi Kyung Kim, Sun Ha Jee, Wanqing Wen, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Mitul Shah, Don M. Conroy, Patricia A. Harrington, Rebecca Mayes, Kamila Czene, Per Hall, Lauren R. Teras, Alpa V. Patel, Fergus J. Couch, Janet E. Olson, Elinor J
Veröffentlicht in:
Cancers, Ausgabe 13/10, 2021, Seite(n) 2370, ISSN 2072-6694
Herausgeber:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cancers13102370
Autoren:
Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A. O’Mara, Joe Dennis, Jonathan P. Tyrer, Daniel R. Barnes, Lesley McGuffog, Goska Leslie, Manjeet K. Bolla, Muriel A. Adank, Simona Agata, Thomas Ahearn, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Norbert Arnold, Kristan J. Aronson, Banu K. Arun, Annelie Augustinsson, Jacopo Azzollini, Daniel Barrowdale, Car
Veröffentlicht in:
Nature Communications, Ausgabe 12/1, 2021, Seite(n) 1078, ISSN 2041-1723
Herausgeber:
Nature Publishing Group
DOI:
10.1038/s41467-020-20496-3
Autoren:
Daniele Giardiello, Michael Hauptmann, Ewout W. Steyerberg, Muriel A. Adank, Delal Akdeniz, Jannet C. Blom, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Mariël Brinkhuis, Jenny Chang-Claude, Kamila Czene, Peter Devilee, Alison M. Dunning, Douglas F. Easton, Diana M. Eccles, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Lothar Haeberle, Christopher A. Haiman,
Veröffentlicht in:
Breast Cancer Research and Treatment, Ausgabe 181/2, 2020, Seite(n) 423-434, ISSN 0167-6806
Herausgeber:
Kluwer Academic Publishers
DOI:
10.1007/s10549-020-05611-8
Autoren:
Jue‐Sheng Ong, Eske M. Derks, Mikael Eriksson, Jiyuan An, Liang‐Dar Hwang, Douglas F. Easton, Paul P. Pharoah, Andrew Berchuck, Linda E. Kelemen, Keitaro Matsuo, Georgia Chenevix‐Trench, Per Hall, Stig E. Bojesen, Penelope M. Webb, Stuart MacGregor
Veröffentlicht in:
International Journal of Cancer, Ausgabe 148/6, 2021, Seite(n) 1338-1350, ISSN 0020-7136
Herausgeber:
John Wiley & Sons Inc.
DOI:
10.1002/ijc.33308
Autoren:
Na Li, Magnus Zethoven, Simone McInerny, Lisa Devereux, Yu-Kuan Huang, Niko Thio, Dane Cheasley, Sara Gutiérrez-Enríquez, Alejandro Moles-Fernández, Orland Diez, Tu Nguyen-Dumont, Melissa C. Southey, John L. Hopper, Jacques Simard, Martine Dumont, Penny Soucy, Alfons Meindl, Rita Schmutzler, Marjanka K. Schmidt, Muriel A. Adank, Irene L. Andrulis, Eric Hahnen, Christoph Engel, Fabienne Lesueur,
Veröffentlicht in:
npj Breast Cancer, Ausgabe 7/1, 2021, Seite(n) 52, ISSN 2374-4677
Herausgeber:
Springer nature
DOI:
10.1038/s41523-021-00255-3
Autoren:
Anne Brédart, Jean-Luc Kop, Antonis C. Antoniou, Alex P. Cunningham, Antoine De Pauw, Marc Tischkowitz, Hans Ehrencrona, Sylvie Dolbeault, Léonore Robieux, Kerstin Rhiem, Douglas F. Easton, Peter Devilee, Dominique Stoppa-Lyonnet, Rita Schmutlzer
Veröffentlicht in:
Familial Cancer, 2017, ISSN 1389-9600
Herausgeber:
Kluwer Academic Publishers
DOI:
10.1007/s10689-017-0014-x
Autoren:
Anne Brédart, Jean-Luc Kop, Antonis C. Antoniou, Alex P. Cunningham, Antoine De Pauw, Marc Tischkowitz, Hans Ehrencrona, Marjanka K. Schmidt, Sylvie Dolbeault, Kerstin Rhiem, Douglas F. Easton, Peter Devilee, Dominique Stoppa-Lyonnet, Rita Schmutlzer
Veröffentlicht in:
Journal of Community Genetics, 2018, ISSN 1868-310X
Herausgeber:
Springer Verlag
DOI:
10.1007/s12687-018-0362-8
Autoren:
Tim Carver, Alex P Cunningham, Chantal Babb de Villiers, Andrew Lee, Simon Hartley, Marc Tischkowitz, Fiona M Walter, Douglas F Easton, Antonis C Antoniou
Veröffentlicht in:
Bioinformatics, Ausgabe 34/6, 2017, Seite(n) 1069-1071, ISSN 1367-4803
Herausgeber:
Oxford University Press
DOI:
10.1093/bioinformatics/btx705
Autoren:
Roger L Milne, Karoline B Kuchenbaecker, Kyriaki Michailidou, Jonathan Beesley, Siddhartha Kar, Sara Lindström, Shirley Hui, Audrey Lemaçon, Penny Soucy, Joe Dennis, Xia Jiang, Asha Rostamianfar, Hilary Finucane, Manjeet K Bolla, Lesley McGuffog, Qin Wang, Cora M Aalfs, Marcia Adams, Julian Adlard, Simona Agata, Shahana Ahmed, Habibul Ahsan, Kristiina Aittomäki, Fares Al-Ejeh, Jamie Allen, Chri
Veröffentlicht in:
Nature Genetics, Ausgabe 49/12, 2017, Seite(n) 1767-1778, ISSN 1061-4036
Herausgeber:
Nature Publishing Group
DOI:
10.1038/ng.3785
Autoren:
Kyriaki Michailidou, Sara Lindström, Joe Dennis, Jonathan Beesley, Shirley Hui, Siddhartha Kar, Audrey Lemaçon, Penny Soucy, Dylan Glubb, Asha Rostamianfar, Manjeet K. Bolla, Qin Wang, Jonathan Tyrer, Ed Dicks, Andrew Lee, Zhaoming Wang, Jamie Allen, Renske Keeman, Ursula Eilber, Juliet D. French, Xiao Qing Chen, Laura Fachal, Karen McCue, Amy E. McCart Reed, Maya Ghoussaini, Jason S. Carroll, X
Veröffentlicht in:
Nature, Ausgabe 551/7678, 2017, Seite(n) 92-94, ISSN 0028-0836
Herausgeber:
Nature Publishing Group
DOI:
10.1038/nature24284
Autoren:
Anne Brédart, Amélie Anota, Julia Dick, Violetta Kuboth, Olivier Lareyre, Antoine De Pauw, Alejandra Cano, Dominique Stoppa-Lyonnet, Rita Schmutzler, Sylvie Dolbeault, Jean-Luc Kop
Veröffentlicht in:
International Journal of Environmental Research and Public Health, Ausgabe 15/2, 2018, Seite(n) 319, ISSN 1660-4601
Herausgeber:
MDPI
DOI:
10.3390/ijerph15020319
Autoren:
Wei Xiong Wen, Jamie Allen, Kah Nyin Lai, Shivaani Mariapun, Siti Norhidayu Hasan, Pei Sze Ng, Daphne Shin-Chi Lee, Sheau Yee Lee, Sook-Yee Yoon, Joanna Lim, Shao Yan Lau, Brennan Decker, Karen Pooley, Leila Dorling, Craig Luccarini, Caroline Baynes, Don M Conroy, Patricia Harrington, Jacques Simard, Cheng Har Yip, Nur Aishah Mohd Taib, Weang Kee Ho, Antonis C Antoniou, Alison M Dunning, Douglas F
Veröffentlicht in:
Journal of Medical Genetics, Ausgabe 55/2, 2018, Seite(n) 97-103, ISSN 0022-2593
Herausgeber:
British Medical Association
DOI:
10.1136/jmedgenet-2017-104947
Autoren:
Xia Jiang, Hilary K. Finucane, Fredrick R. Schumacher, Stephanie L. Schmit, Jonathan P. Tyrer, Younghun Han, Kyriaki Michailidou, Corina Lesseur, Karoline B. Kuchenbaecker, Joe Dennis, David V. Conti, Graham Casey, Mia M. Gaudet, Jeroen R. Huyghe, Demetrius Albanes, Melinda C. Aldrich, Angeline S. Andrew, Irene L. Andrulis, Hoda Anton-Culver, Antonis C. Antoniou, Natalia N. Antonenkova, Susanne M.
Veröffentlicht in:
Nature Communications, Ausgabe 10/1, 2019, ISSN 2041-1723
Herausgeber:
Nature Publishing Group
DOI:
10.1038/s41467-018-08054-4
Autoren:
Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna I. Kiiski, Taru A. Muranen, Daniel R. Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K. Bolla, Goska Leslie, Cora M. Aalfs, Muriel A. Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A. Agnarsson, Thomas Ahearn, Kristiina Aittomäki, Christine B. Ambrosone, Lesley Andrews, Hoda Anton
Veröffentlicht in:
npj Breast Cancer, Ausgabe 5/1, 2019, ISSN 2374-4677
Herausgeber:
Springer Nature
DOI:
10.1038/s41523-019-0127-5
Autoren:
Mavaddat, N.; Michailidou, K.; Dennis, J.; Lush, M.; Fachal, L.; Lee, A.; Tyrer, J. P.; Chen, T-H; Wang, Q.; Bolla, M. K.; Yang, X.; Adank, M. A.; Ahearn, T.; Aittomäki, K.; Allen, J.; Andrulis, I. L.; Anton-Culver, H.; Antonenkova, N. N.; Arndt, V.; Aronson, K. J.; Auer, P. L.; Auvinen, P.; Barrdahl, M.; Beane Freeman, L. E.; Beckmann, M. W.; Behrens, S.; Benitez, J.; Bermisheva, M.; Bernstein,
Veröffentlicht in:
American Journal of Human Genetics , 104 (1) pp. 21-34. (2019), Ausgabe 6, 2019, ISSN 0002-9297
Herausgeber:
University of Chicago Press
Autoren:
Wu, L.; Shi, W.; Long, J.; Guo, X.; Michailidou, K.; Beesley, J.; Bolla, M. K.; Shu, X. O.; Lu, Y.; Cai, Q.; Al-Ejeh, F.; Rozali, E.; Wang, Q.; Dennis, J.; Li, B.; Zeng, C.; Feng, H.; Gusev, A.; Barfield, R. T.; Andrulis, I. L.; Anton-Culver, H.; Arndt, V.; Aronson, K. J.; Auer, P. L.; Barrdahl, M.; Baynes, C.; Beckmann, M. W.; Benitez, J.; Bermisheva, M.; Blomqvist, C.; Bogdanova, N. V.; Bojesen,
Veröffentlicht in:
Nature Genetics , 50 pp. 968-978. (2018), Ausgabe 14, 2020, ISSN 1546-1718
Herausgeber:
Springer Nature
Autoren:
Dörk, T.; Peterlongo, P.; Mannermaa, A.; Bolla, M. K.; Wang, Q.; Dennis, J.; Ahearn, T.; Andrulis, I. L.; Anton-Culver, H.; Arndt, V.; Aronson, K. J.; Augustinsson, A.; Freeman, L. E. B.; Beckmann, M. W.; Beeghly-Fadiel, A.; Behrens, S.; Bermisheva, M.; Blomqvist, C.; Bogdanova, N. V.; Bojesen, S. E.; Brauch, H.; Brenner, H.; Burwinkel, B.; Canzian, F.; Chan, T. L.; Chang-Claude, J.; Chanock, S.
Veröffentlicht in:
Scientific Reports , 9 (1) , Article 12524. (2019), Ausgabe 14, 2019, ISSN 2045-2322
Herausgeber:
Nature Publishing Group
Autoren:
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Nature Publishing Group
DOI:
10.1038/s41467-021-23162-4
Autoren:
Babatunde Adedokun, Zhaohui Du, Guimin Gao, Thomas U. Ahearn, Kathryn L. Lunetta, Gary Zirpoli, Jonine Figueroa, Esther M. John, Leslie Bernstein, Wei Zheng, Jennifer J. Hu, Regina G. Ziegler, Sarah Nyante, Elisa V. Bandera, Sue A. Ingles, Michael F. Press, Sandra L. Deming-Halverson, Jorge L. Rodriguez-Gil, Song Yao, Temidayo O. Ogundiran, Oladosu Ojengbede, William Blot, Melissa A. Troester, Kat
Veröffentlicht in:
Nature Communications, Ausgabe 12/1, 2021, Seite(n) 4198, ISSN 2041-1723
Herausgeber:
Nature Publishing Group
DOI:
10.1038/s41467-021-24327-x
Autoren:
Anne Brédart, Antoine De Pauw, Amélie Anota, Anja Tüchler, Julia Dick, Anita Müller, Jean-Luc Kop, Kerstin Rhiem, Rita Schmutzler, Peter Devilee, Dominique Stoppa-Lyonnet, Sylvie Dolbeault
Veröffentlicht in:
The Breast, Ausgabe 60, 2021, Seite(n) 38-44, ISSN 0960-9776
Herausgeber:
Churchill Livingstone
DOI:
10.1016/j.breast.2021.08.011
Autoren:
Leila Dorling, Sara Carvalho, Jamie Allen, Anna González-Neira, Craig Luccarini, Cecilia Wahlström, Karen A. Pooley, Michael T. Parsons, Cristina Fortuno, Qin Wang, Manjeet K. Bolla, Joe Dennis, Renske Keeman, M. Rosario Alonso, Nuria Álvarez, Belen Herraez, Victoria Fernandez, Rocio Núñez-Torres, Ana Osorio, Jeanette Valcich, Minerva Li, Therese Törngren, Patricia A. Harrington, Caroline Ba
Veröffentlicht in:
New England Journal of Medicine, Ausgabe 384/5, 2021, Seite(n) 428-439, ISSN 0028-4793
Herausgeber:
Massachusetts Medical Society
DOI:
10.1056/nejmoa1913948
Autoren:
Peter Devilee
Veröffentlicht in:
2018
Herausgeber:
Impact
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