The continuum between healthy ageing and idiopathic Parkinson Disease within a propagation perspective of inflammation and damage: the search for new diagnostic, prognostic and therapeutic targets

Deliverables

Plan for Using and Disseminating Foreground

A final Plan for Disseminating and Using of Foreground will be produced at the end of the project (M48).

The structure of the PROPAG-AGEING website will have to be developed in consultation with all Participants: anyway, top-level areas are likely to providing general information, announcements, bulletin boards, and discussion forums, etc.; they will include sub-domains for each WP, with access control options. Once the site has been created, the ongoing work will mainly require maintenance and update of the website server and of its contents, on the one hand, and security operations (protection against attack from hackers and spammers), on the other hand. The website will include a reserved area for the Participants’ access only that will be used to exchange information and documents among the Participants.

Publications

A frailty index for UK Biobank participants

Author(s): Hagg, Sara; Pedersen, Nancy; Jylhava, Juulia; Williams, Dylan
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences., Issue 2, 2018, ISSN 1758-535X
Publisher: Oxford University Press
DOI: 10.1101/233692

Circulating insulin-like growth factors and Alzheimer disease

Author(s): Dylan M. Williams, Ida K. Karlsson, Nancy L. Pedersen, Sara Hägg
Published in: Neurology, Issue 90/4, 2018, Page(s) e291-e297, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000004854

Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity

Author(s): Claudio Franceschi, Stefano Salvioli, Paolo Garagnani, Magda de Eguileor, Daniela Monti, Miriam Capri
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2017.00982

"Acceleration of leukocytes’ epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer"

Author(s): Danielle Fernandes Durso, Maria Giulia Bacalini, Claudia Sala, Chiara Pirazzini, Elena Marasco, Massimiliano Bonafé, Ítalo Faria do Valle, Davide Gentilini, Gastone Castellani, Ana Maria Caetano Faria, Claudio Franceschi, Paolo Garagnani, Christine Nardini
Published in: Oncotarget, Issue 8/14, 2017, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.15573

Gelified Biofluids for High-Resolution Magic Angle Spinning 1 H NMR Analysis: The Case of Urine

Author(s): Panteleimon G. Takis, Leonardo Tenori, Enrico Ravera, Claudio Luchinat
Published in: Analytical Chemistry, Issue 89/2, 2016, Page(s) 1054-1058, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.6b04318

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process

Author(s): Maria Giulia Bacalini, Joris Deelen, Chiara Pirazzini, Marco De Cecco, Cristina Giuliani, Catia Lanzarini, Francesco Ravaioli, Elena Marasco, Diana van Heemst, H. Eka D. Suchiman, Roderick Slieker, Enrico Giampieri, Rina Recchioni, Fiorella Mercheselli, Stefano Salvioli, Giovanni Vitale, Fabiola Olivieri, Annemieke M. W. Spijkerman, Martijn E. T. Dollé, John M. Sedivy, Gastone Castellani, Claudio
Published in: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2017, Page(s) glw185, ISSN 1079-5006
Publisher: Gerontological Society of America
DOI: 10.1093/gerona/glw185

Deconvoluting interrelationships between concentrations and chemical shifts in urine provides a powerful analysis tool

Author(s): Panteleimon G. Takis, Hartmut Schäfer, Manfred Spraul, Claudio Luchinat
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01587-0

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Author(s): Aurelia Santoro, Rita Ostan, Marco Candela, Elena Biagi, Patrizia Brigidi, Miriam Capri, Claudio Franceschi
Published in: Cellular and Molecular Life Sciences, Issue 75/1, 2018, Page(s) 129-148, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-017-2674-y

Author(s): Francesco Ravaioli, Maria Bacalini, Claudio Franceschi, Paolo Garagnani
Published in: Genes, Issue 9/1, 2018, Page(s) 39, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes9010039

Implementing a method for studying longitudinal DNA methylation variability in association with age

Author(s): Yunzhang Wang, Nancy L. Pedersen, Sara Hägg
Published in: Epigenetics, Issue 13/8, 2018, Page(s) 866-874, ISSN 1559-2294
Publisher: Landes Bioscience
DOI: 10.1080/15592294.2018.1521222

The epigenetic landscape of age-related diseases: the geroscience perspective

Author(s): Noémie Gensous, Maria Giulia Bacalini, Chiara Pirazzini, Elena Marasco, Cristina Giuliani, Francesco Ravaioli, Giacomo Mengozzi, Claudia Bertarelli, Maria Giustina Palmas, Claudio Franceschi, Paolo Garagnani
Published in: Biogerontology, Issue 18/4, 2017, Page(s) 549-559, ISSN 1389-5729
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10522-017-9695-7

Impact of demography and population dynamics on the genetic architecture of human longevity

Author(s): Cristina Giuliani, Marco Sazzini, Chiara Pirazzini, Maria Giulia Bacalini, Elena Marasco, Guido Alberto Gnecchi Ruscone, Fang Fang, Stefania Sarno, Davide Gentilini, Anna Maria Di Blasio, Paolina Crocco, Giuseppe Passarino, Daniela Mari, Daniela Monti, Benedetta Nacmias, Sandro Sorbi, Carlo Salvarani, Mariagrazia Catanoso, Davide Pettener, Donata Luiselli, Svetlana Ukraintseva, Anatoliy Yashin, Cl
Published in: Aging, 2018, ISSN 1945-4589
Publisher: Impact Journals, LLC
DOI: 10.18632/aging.101515

The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease

Author(s): Claire Halsband, Antonia Zapf, Friederike Sixel-Döring, Claudia Trenkwalder, Brit Mollenhauer
Published in: Movement Disorders Clinical Practice, Issue 5/2, 2018, Page(s) 171-176, ISSN 2330-1619
Publisher: Wiley
DOI: 10.1002/mdc3.12591

Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome

Author(s): T. Guastafierro, M. G. Bacalini, A. Marcoccia, D. Gentilini, S. Pisoni, A. M. Di Blasio, A. Corsi, C. Franceschi, D. Raimondo, A. Spanò, P. Garagnani, F. Bondanini
Published in: Clinical Epigenetics, Issue 9/1, 2017, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-017-0389-4

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Author(s): Claudio Franceschi, Paolo Garagnani, Cristina Morsiani, Maria Conte, Aurelia Santoro, Andrea Grignolio, Daniela Monti, Miriam Capri, Stefano Salvioli
Published in: Frontiers in Medicine, Issue 5, 2018, ISSN 2296-858X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fmed.2018.00061

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

Author(s): Steve Horvath, Chiara Pirazzini, Maria Giulia Bacalini, Davide Gentilini, Anna Maria Di Blasio, Massimo Delledonne, Daniela Mari, Beatrice Arosio, Daniela Monti, Giuseppe Passarino, Francesco De Rango, Patrizia D'Aquila, Cristina Giuliani, Elena Marasco, Sebastiano Collino, Patrick Descombes, Paolo Garagnani, Claudio Franceschi
Published in: Aging, Issue 7/12, 2015, Page(s) 1159-1170, ISSN 1945-4589
Publisher: Impact Journals, LLC
DOI: 10.18632/aging.100861

Antemortem Prediction of Braak Stage

Author(s): Jesper O.E. Carlson, Margaret Gatz, Nancy L. Pedersen, Caroline Graff, Inger Nennesmo, Anna-Karin Lindström, Lotte Gerritsen
Published in: Journal of Neuropathology & Experimental Neurology, Issue 74/11, 2015, Page(s) 1061-1070, ISSN 0022-3069
Publisher: American Association of Neuropathologists, Inc.
DOI: 10.1097/NEN.0000000000000251

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

Author(s): Vittorio Calabrese, Aurelia Santoro, Daniela Monti, Rosalia Crupi, Rosanna Di Paola, Saverio Latteri, Salvatore Cuzzocrea, Mario Zappia, James Giordano, Edward J. Calabrese, Claudio Franceschi
Published in: Free Radical Biology and Medicine, Issue 115, 2018, Page(s) 80-91, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2017.10.379

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature

Author(s): Maria Giulia Bacalini, Claudio Franceschi, Davide Gentilini, Francesco Ravaioli, Xiaoyuan Zhou, Daniel Remondini, Chiara Pirazzini, Cristina Giuliani, Elena Marasco, Noémie Gensous, Anna Maria Di Blasio, Ewa Ellis, Roberto Gramignoli, Gastone Castellani, Miriam Capri, Stephen Strom, Christine Nardini, Matteo Cescon, Gian Luca Grazi, Paolo Garagnani
Published in: The Journals of Gerontology: Series A, 2018, ISSN 1079-5006
Publisher: Gerontological Society of America
DOI: 10.1093/gerona/gly048

Nutrition and Inflammation: Are Centenarians Similar to Individuals on Calorie-Restricted Diets?

Author(s): Claudio Franceschi, Rita Ostan, Aurelia Santoro
Published in: Annual Review of Nutrition, Issue 38/1, 2018, Page(s) 329-356, ISSN 0199-9885
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-nutr-082117-051637

The peculiar aging of human liver: A geroscience perspective within transplant context

Author(s): Cristina Morsiani, Maria Giulia Bacalini, Aurelia Santoro, Paolo Garagnani, Salvatore Collura, Antonia D’Errico, Magda de Eguileor, Gian Luca Grazi, Matteo Cescon, Claudio Franceschi, Miriam Capri
Published in: Ageing Research Reviews, Issue 51, 2019, Page(s) 24-34, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2019.02.002

Human Aging and Longevity Are Characterized by High Levels of Mitokines

Author(s): Maria Conte, Rita Ostan, Cristina Fabbri, Aurelia Santoro, Giulia Guidarelli, Giovanni Vitale, Daniela Mari, Federica Sevini, Miriam Capri, Marco Sandri, Daniela Monti, Claudio Franceschi, Stefano Salvioli
Published in: The Journals of Gerontology: Series A, Issue 74/5, 2018, Page(s) 600-607, ISSN 1079-5006
Publisher: Gerontological Society of America
DOI: 10.1093/gerona/gly153

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Author(s): Claudio Franceschi, Paolo Garagnani, Paolo Parini, Cristina Giuliani, Aurelia Santoro
Published in: Nature Reviews Endocrinology, Issue 14/10, 2018, Page(s) 576-590, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-018-0059-4

Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities

Author(s): Vittorio Calabrese, Aurelia Santoro, Angela Trovato Salinaro, Sergio Modafferi, Maria Scuto, Ferdaous Albouchi, Daniela Monti, James Giordano, Mario Zappia, Claudio Franceschi, Edward J Calabrese
Published in: Journal of Neuroscience Research, Issue 96/10, 2018, Page(s) 1641-1662, ISSN 0360-4012
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jnr.24244

Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohorts

Author(s): Diana L. Santos Ferreira, Dylan M. Williams, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, George Davey Smith, Marjo-Riitta Jarvelin, Debbie A. Lawlor
Published in: PLOS Medicine, Issue 14/8, 2017, Page(s) e1002376, ISSN 1549-1676
Publisher: Public Library of Science
DOI: 10.1371/journal.pmed.1002376

The Dual Role of the Pervasive “Fattish” Tissue Remodeling With Age

Author(s): Maria Conte, Morena Martucci, Marco Sandri, Claudio Franceschi, Stefano Salvioli
Published in: Frontiers in Endocrinology, Issue 10, 2019, ISSN 1664-2392
Publisher: Frontiers
DOI: 10.3389/fendo.2019.00114

Accelerated bio‐cognitive aging in Down syndrome: State of the art and possible deceleration strategies

Author(s): Claudio Franceschi, Paolo Garagnani, Noémie Gensous, Maria Giulia Bacalini, Maria Conte, Stefano Salvioli
Published in: Aging Cell, Issue 18/3, 2019, Page(s) e12903, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.12903

The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

Author(s): Paolo Abondio, Marco Sazzini, Paolo Garagnani, Alessio Boattini, Daniela Monti, Claudio Franceschi, Donata Luiselli, Cristina Giuliani
Published in: Genes, Issue 10/3, 2019, Page(s) 222, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10030222

Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians

Author(s): Gianluca Storci, Sabrina De Carolis, Alessio Papi, Maria Giulia Bacalini, Noémie Gensous, Elena Marasco, Anna Tesei, Francesco Fabbri, Chiara Arienti, Michele Zanoni, Anna Sarnelli, Spartaco Santi, Fabiola Olivieri, Emanuela Mensà, Silvia Latini, Manuela Ferracin, Stefano Salvioli, Paolo Garagnani, Claudio Franceschi, Massimiliano Bonafè
Published in: Cell Death & Differentiation, Issue 26/9, 2019, Page(s) 1845-1858, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-018-0255-8

Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism

Author(s): Maria Caracausi, Veronica Ghini, Chiara Locatelli, Martina Mericio, Allison Piovesan, Francesca Antonaros, Maria Chiara Pelleri, Lorenza Vitale, Rosa Anna Vacca, Federica Bedetti, Maria Chiara Mimmi, Claudio Luchinat, Paola Turano, Pierluigi Strippoli, Guido Cocchi
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-20834-y

NMR-based metabolomics identifies patients at high risk of death within two years after acute myocardial infarction in the AMI-Florence II cohort

Author(s): Alessia Vignoli, Leonardo Tenori, Betti Giusti, Panteleimon G. Takis, Serafina Valente, Nazario Carrabba, Daniela Balzi, Alessandro Barchielli, Niccolò Marchionni, Gian Franco Gensini, Rossella Marcucci, Claudio Luchinat, Anna Maria Gori
Published in: BMC Medicine, Issue 17/1, 2019, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-018-1240-2

Uniqueness of the NMR approach to metabolomics

Author(s): Panteleimon G. Takis, Veronica Ghini, Leonardo Tenori, Paola Turano, Claudio Luchinat
Published in: TrAC Trends in Analytical Chemistry, 2018, Page(s) 115300, ISSN 0165-9936
Publisher: Elsevier BV
DOI: 10.1016/j.trac.2018.10.036

High-Throughput Metabolomics by 1D NMR

Author(s): Alessia Vignoli, Veronica Ghini, Gaia Meoni, Cristina Licari, Panteleimon G. Takis, Leonardo Tenori, Paola Turano, Claudio Luchinat
Published in: Angewandte Chemie International Edition, Issue 58/4, 2019, Page(s) 968-994, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201804736

Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality

Author(s): Rita Ostan, Daniela Monti, Daniela Mari, Beatrice Arosio, Davide Gentilini, Evelyn Ferri, Giuseppe Passarino, Francesco De Rango, Patrizia D’Aquila, Stefano Mariotti, Renato Pasquali, Flaminia Fanelli, Laura Bucci, Claudio Franceschi, Giovanni Vitale
Published in: The Journals of Gerontology: Series A, Issue 74/6, 2018, Page(s) 802-810, ISSN 1079-5006
Publisher: Gerontological Society of America
DOI: 10.1093/gerona/gly194

First evidence of association between past environmental exposure to dioxin and DNA methylation of CYP1A1 and IGF2 genes in present day Vietnamese population

Author(s): Cristina Giuliani, David Biggs, Thanh Tin Nguyen, Elena Marasco, Sara De Fanti, Paolo Garagnani, Minh Triet Le Phan, Viet Nhan Nguyen, Donata Luiselli, Giovanni Romeo
Published in: Environmental Pollution, Issue 242, 2018, Page(s) 976-985, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2018.07.015

The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental stimuli

Author(s): Christine Nardini, Jean-Francois Moreau, Noémie Gensous, Francesco Ravaioli, Paolo Garagnani, Maria Giulia Bacalini
Published in: Seminars in Immunology, Issue 40, 2018, Page(s) 49-60, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2018.10.009

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

Author(s): Cristina Giuliani, Paolo Garagnani, Claudio Franceschi
Published in: Circulation Research, Issue 123/7, 2018, Page(s) 745-772, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.118.312562

Deep Graph Infomax

Author(s): Veličković, Petar; Fedus, William; Hamilton, William L; Liò, Pietro; Bengio, Yoshua; Hjelm, R Devon
Published in: Issue 2, 2019
Publisher: University of Cambridge
DOI: 10.17863/CAM.40744

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