The aging germ cell – biological pathways, risk factors and mechanisms underlying an increasing medical and socio-economic problem

Project Information

GermAge

Grant agreement ID: 634113

DOI 10.3030/634113

Project closed

EC signature date 7 April 2015

Start date 1 May 2015

End date 31 October 2020

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 350 598,75

EU contribution € 5 350 598,75

Coordinated by

TECHNISCHE UNIVERSITAET DRESDEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Public web site

The initial version of the website will contain the collaboration and communication tools and it will describe the vision and of the project as well as the structure and role of the partners. The enhanced version will additionally contain the specific section targeted to the end users.

Publications

Peer reviewed articles (16)

Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes

Author(s): Shuhei Yoshida, Sui Nishiyama, Lisa Lister, Shu Hashimoto, Tappei Mishina, Aurélien Courtois, Hirohisa Kyogoku, Takaya Abe, Aki Shiraishi, Meenakshi Choudhary, Yoshiharu Nakaoka, Mary Herbert, Tomoya S. Kitajima
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16488-y

Oocyte aneuploidy—more tools to tackle an old problem

Author(s): Chris Lodge, Mary Herbert
Published in: Proceedings of the National Academy of Sciences, Issue 117/22, 2020, Page(s) 11850-11852, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2005739117

SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation

Author(s): Ansgar Zoch, Tania Auchynnikava, Rebecca V. Berrens, Yuka Kabayama, Theresa Schöpp, Madeleine Heep, Lina Vasiliauskaitė, Yuvia A. Pérez-Rico, Atlanta G. Cook, Alena Shkumatava, Juri Rappsilber, Robin C. Allshire, Dónal O’Carroll
Published in: Nature, Issue 584/7822, 2020, Page(s) 635-639, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2557-5

Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2

Author(s): François McNicoll, Anne Kühnel, Uddipta Biswas, Kai Hempel, Gabriela Whelan, Gregor Eichele, Rolf Jessberger
Published in: Life Science Alliance, Issue 3/3, 2020, Page(s) e201900564, ISSN 2575-1077
Publisher: Life Science Alliance
DOI: 10.26508/lsa.201900564

CTCF contributes in a critical way to spermatogenesis and male fertility

Author(s): Abrahan Hernández-Hernández, Ingrid Lilienthal, Nanaho Fukuda, Niels Galjart, Christer Höög
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep28355

SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage

Author(s): Uddipta Biswas, Michelle Stevense, Rolf Jessberger
Published in: Current Biology, Issue 28/2, 2018, Page(s) 249-261.e4, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2017.12.020

APC/C Cdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity

Author(s): Ahmed Rattani, Randy Ballesteros Mejia, Katherine Roberts, Maurici B. Roig, Jonathan Godwin, Michael Hopkins, Manuel Eguren, Luis Sanchez-Pulido, Elwy Okaz, Sugako Ogushi, Magda Wolna, Jean Metson, Alberto M. Pendás, Marcos Malumbres, Béla Novák, Mary Herbert, Kim Nasmyth
Published in: Current Biology, Issue 27/10, 2017, Page(s) 1462-1476.e5, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2017.04.023

How Meiosis Creates the Single-Copy Genome

Author(s): Mary Herbert, Attila Toth
Published in: Developmental Cell, Issue 40/1, 2017, Page(s) 3-4, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2016.12.019

Sexual dimorphism in the width of the mouse synaptonemal complex

Author(s): Ana Agostinho, Anna Kouznetsova, Abrahan Hernández-Hernández, Kristoffer Bernhem, Hans Blom, Hjalmar Brismar, Christer Höög
Published in: Journal of Cell Science, Issue 131/5, 2018, Page(s) jcs212548, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.212548

Meiosis and Maternal Aging: Insights from Aneuploid Oocytes and Trisomy Births

Author(s): Mary Herbert, Dimitrios Kalleas, Daniel Cooney, Mahdi Lamb, Lisa Lister
Published in: Cold Spring Harbor Perspectives in Biology, Issue 7/4, 2015, Page(s) a017970, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a017970

High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation

Author(s): Ana Agostinho, Otto Manneberg, Robin van Schendel, Abrahan Hernández‐Hernández, Anna Kouznetsova, Hans Blom, Hjalmar Brismar, Christer Höög
Published in: EMBO reports, Issue 17/6, 2016, Page(s) 901-913, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201642030

Post‐metaphase correction of aberrant kinetochore‐microtubule attachments in mammalian eggs

Author(s): Anna Kouznetsova, Tomoya S Kitajima, Hjalmar Brismar, Christer Höög
Published in: EMBO reports, Issue 20/8, 2019, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201947905

A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

Author(s): Marcos Morgan, Yuka Kabayama, Christian Much, Ivayla Ivanova, Monica Di Giacomo, Tatsiana Auchynnikava, Jack Michael Monahan, Dimitrios Michael Vitsios, Lina Vasiliauskaitė, Stefano Comazzetto, Juri Rappsilber, Robin Campbell Allshire, Bo Torben Porse, Anton James Enright, Dónal O’Carroll
Published in: Cell Research, Issue 29/3, 2019, Page(s) 221-232, ISSN 1001-0602
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-018-0128-1

Mutations in the stromal antigen 3 (STAG3) gene cause male infertility due to meiotic arrest

Author(s): N van der Bijl, A Röpke, U Biswas, M Wöste, R Jessberger, S Kliesch, C Friedrich, F Tüttelmann
Published in: Human Reproduction, 2019, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1093/humrep/dez204

Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes

Author(s): Judith Reichmann, Karen Dobie, Lisa M. Lister, James H. Crichton, Diana Best, Marie MacLennan, David Read, Eleanor S. Raymond, Chao-Chun Hung, Shelagh Boyle, Katsuhiko Shirahige, Howard J. Cooke, Mary Herbert, Ian R. Adams
Published in: Journal of Cell Biology, Issue 219/5, 2020, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201702123

TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing

Author(s): Theresa Schöpp, Ansgar Zoch, Rebecca V. Berrens, Tania Auchynnikava, Yuka Kabayama, Lina Vasiliauskaitė, Juri Rappsilber, Robin C. Allshire, Dónal O’Carroll
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17372-5

Non-peer reviewed articles (1)

GermAge, The aging germ cell ? biological pathways, risk factors and mechanisms underlying anincreasing medical and socio-economic problem, HORIZON2020

Author(s): Rolf Jessberger
Published in: Impact, Issue 2017/10, 2017, Page(s) 15-17, ISSN 2398-7073
Publisher: Science ImpactLtd.
DOI: 10.21820/23987073.2017.10.15