Aging Lungs in European Cohorts

Deliverables

Study Website

ALEC website

Consortium Publication Policy

Publication policy

Data Managment Plan (early)

Data managment plan for the consortium

Directory of stakeholders

A list of stakeholders with an interest in ALEC work and output For inclusion in monthyly briefing see WP1

Pamphlet describing study aims and objectives available to partners for disemination

Pamphlet for dissemination describing study aims and objectives

Publications

Childhood Lung Function Predicts Adult Chronic Obstructive Pulmonary Disease and Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome

Author(s): Dinh S. Bui, John A. Burgess, Adrian J. Lowe, Jennifer L. Perret, Caroline J. Lodge, Minh Bui, Stephen Morrison, Bruce R. Thompson, Paul S. Thomas, Graham G. Giles, Judith Garcia-Aymerich, Debbie Jarvis, Michael J. Abramson, E. Haydn Walters, Melanie C. Matheson, Shyamali C. Dharmage
Published in: American Journal of Respiratory and Critical Care Medicine, Issue 196/1, 2017, Page(s) 39-46, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.201606-1272oc

A three-generation study on the association of tobacco smoking with asthma

Author(s): Simone Accordini, Lucia Calciano, Ane Johannessen, Laura Portas, Bryndis Benediktsdóttir, Randi Jacobsen Bertelsen, Lennart Bråbäck, Anne-Elie Carsin, Shyamali C Dharmage, Julia Dratva, Bertil Forsberg, Francisco Gomez Real, Joachim Heinrich, John W Holloway, Mathias Holm, Christer Janson, Rain Jögi, Bénédicte Leynaert, Andrei Malinovschi, Alessandro Marcon, Jesús Martínez-Moratalla Rovira
Published in: International Journal of Epidemiology, 2018, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyy031

Leisure-time vigorous physical activity is associated with better lung function: the prospective ECRHS study

Author(s): Elaine Fuertes, Anne-Elie Carsin, Josep M Antó, Roberto Bono, Angelo Guido Corsico, Pascal Demoly, Thorarinn Gislason, José-Antonio Gullón, Christer Janson, Deborah Jarvis, Joachim Heinrich, Mathias Holm, Bénédicte Leynaert, Alessandro Marcon, Jesús Martinez-Moratalla, Dennis Nowak, Silvia Pascual Erquicia, Nicole M Probst-Hensch, Chantal Raherison, Wasif Raza, Francisco Gómez Real, Melissa
Published in: Thorax, Issue 73/4, 2018, Page(s) 376-384, ISSN 0040-6376
Publisher: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2017-210947

Dietary antioxidants and 10-year lung function decline in adults from the ECRHS survey

Author(s): Vanessa Garcia-Larsen, James F. Potts, Ernst Omenaas, Joachim Heinrich, Cecilie Svanes, Judith Garcia-Aymerich, Peter G. Burney, Deborah L. Jarvis
Published in: European Respiratory Journal, Issue 50/6, 2017, Page(s) 1602286, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.1183/13993003.02286-2016

Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study

Author(s): Alessandro Marcon, Francesca Locatelli, Dirk Keidel, Anna B Beckmeyer-Borowko, Isa Cerveri, Shyamali C Dharmage, Elaine Fuertes, Judith Garcia-Aymerich, Joachim Heinrich, Medea Imboden, Christer Janson, Ane Johannessen, Bénédicte Leynaert, Silvia Pascual Erquicia, Giancarlo Pesce, Emmanuel Schaffner, Cecilie Svanes, Isabel Urrutia, Deborah Jarvis, Nicole M Probst-Hensch, Simone Accordini
Published in: Thorax, 2018, Page(s) thoraxjnl-2017-211289, ISSN 0040-6376
Publisher: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2017-211289

Age at menarche and lung function: a Mendelian randomization study

Author(s): Dipender Gill, Nuala A. Sheehan, Matthias Wielscher, Nick Shrine, Andre F. S. Amaral, John R. Thompson, Raquel Granell, Bénédicte Leynaert, Francisco Gómez Real, Ian P. Hall, Martin D. Tobin, Juha Auvinen, Susan M. Ring, Marjo-Riitta Jarvelin, Louise V. Wain, John Henderson, Deborah Jarvis, Cosetta Minelli
Published in: European Journal of Epidemiology, Issue 32/8, 2017, Page(s) 701-710, ISSN 0393-2990
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10654-017-0272-9

Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring

Author(s): R. J. Bertelsen, M. Rava, A. E. Carsin, S. Accordini, B. Benediktsdóttir, J. Dratva, K. A. Franklin, J. Heinrich, M. Holm, C. Janson, A. Johannessen, D. L. Jarvis, R. Jogi, B. Leynaert, D. Norback, E. R. Omenaas, C. Raherison, J. L. Sánchez-Ramos, V. Schlünssen, T. Sigsgaard, S. C. Dharmage, C. Svanes
Published in: Clinical & Experimental Allergy, Issue 47/5, 2017, Page(s) 627-638, ISSN 0954-7894
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cea.12906

Respiratory symptoms are more common among short sleepers independent of obesity

Author(s): Erla Björnsdóttir, Christer Janson, Eva Lindberg, Erna Sif Arnardottir, Bryndís Benediktsdóttir, Judith Garcia-Aymerich, Anne Elie Carsin, Francisco Gómez Real, Kjell Torén, Joachim Heinrich, Dennis Nowak, José Luis Sánchez-Ramos, Pascal Demoly, Sandra Dorado Arenas, Ramon Coloma Navarro, Vivi Schlünssen, Chantal Raherison, Debbie L Jarvis, Thorarinn Gislason
Published in: BMJ Open Respiratory Research, Issue 4/1, 2017, Page(s) e000206, ISSN 2052-4439
Publisher: BMJ
DOI: 10.1136/bmjresp-2017-000206

Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies

Author(s): Matthew Machin, André F. S. Amaral, Matthias Wielscher, Faisal I. Rezwan, Medea Imboden, Marjo-Riitta Jarvelin, Ian M. Adcock, Nicole Probst-Hensch, John W. Holloway, Deborah L. Jarvis
Published in: BMC Pulmonary Medicine, Issue 17/1, 2017, ISSN 1471-2466
Publisher: BioMed Central
DOI: 10.1186/s12890-017-0397-3

Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway

Author(s): N. O. Jõgi, C. Svanes, S. P. Siiak, E. Logan, J. W. Holloway, J. Igland, A. Johannessen, M. Levin, F. G. Real, V. Schlunssen, W. G. C. Horsnell, R. J. Bertelsen
Published in: Clinical & Experimental Allergy, Issue 48/1, 2018, Page(s) 66-77, ISSN 0954-7894
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cea.13055

Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life

Author(s): Dinh S Bui, Caroline J Lodge, John A Burgess, Adrian J Lowe, Jennifer Perret, Minh Q Bui, Gayan Bowatte, Lyle Gurrin, David P Johns, Bruce R Thompson, Garun S Hamilton, Peter A Frith, Alan L James, Paul S Thomas, Deborah Jarvis, Cecilie Svanes, Melissa Russell, Stephen C Morrison, Iain Feather, Katrina J Allen, Richard Wood-Baker, John Hopper, Graham G Giles, Michael J Abramson, Eugene H Walters,
Published in: The Lancet Respiratory Medicine, 2018, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/S2213-2600(18)30100-0

Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey

Author(s): Theodore Lytras, Manolis Kogevinas, Hans Kromhout, Anne-Elie Carsin, Josep M Antó, Hayat Bentouhami, Joost Weyler, Joachim Heinrich, Dennis Nowak, Isabel Urrutia, Jesús Martinez-Moratalla, José Antonio Gullón, Antonio Pereira-Vega, Chantal Raherison-Semjen, Isabelle Pin, Pascal Demoly, Bénédicte Leynaert, Simona Villani, Thorarinn Gislason, Cecilie Svanes, Mathias Holm, Bertil Forsberg, Dan
Published in: Thorax, 2018, Page(s) thoraxjnl-2017-211158, ISSN 0040-6376
Publisher: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2017-211158

Body silhouettes as a tool to reflect obesity in the past

Author(s): Marianne Lønnebotn, Cecilie Svanes, Jannicke Igland, Karl A. Franklin, Simone Accordini, Bryndís Benediktsdóttir, Hayat Bentouhami, José A. G. Blanco, Roberto Bono, Angelo Corsico, Pascal Demoly, Shyamali Dharmage, Sandra Dorado Arenas, Judith Garcia, Joachim Heinrich, Mathias Holm, Christer Janson, Debbie Jarvis, Bénédicte Leynaert, Jesús Martinez-Moratalla, Dennis Nowak, Isabelle Pin, Cha
Published in: PLOS ONE, Issue 13/4, 2018, Page(s) e0195697, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0195697

Prediction models for the development of COPD: a systematic review

Author(s): Melanie Matheson, Gayan Bowatte, Jennifer Perret, Adrian Lowe, Chamara Senaratna, Graham Hall, Nick de Klerk, Louise Keogh, Christine McDonald, Nilakshi T Waidyatillake, Peter Sly, Deborah Jarvis, Michael Abramson, Caroline Lodge, Shyamali Dharmage
Published in: International Journal of Chronic Obstructive Pulmonary Disease, Issue Volume 13, 2018, Page(s) 1927-1935, ISSN 1178-2005
Publisher: DovePress
DOI: 10.2147/COPD.S155675

Age at puberty and risk of asthma: A Mendelian randomisation study

Author(s): Cosetta Minelli, Diana A. van der Plaat, Bénédicte Leynaert, Raquel Granell, Andre F. S. Amaral, Miguel Pereira, Osama Mahmoud, James Potts, Nuala A. Sheehan, Jack Bowden, John Thompson, Debbie Jarvis, George Davey Smith, John Henderson
Published in: PLOS Medicine, Issue 15/8, 2018, Page(s) e1002634, ISSN 1549-1676
Publisher: PloS Medicine
DOI: 10.1371/journal.pmed.1002634

Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study

Author(s): Elaine Fuertes, Iana Markevych, Deborah Jarvis, Danielle Vienneau, Kees de Hoogh, Josep Maria Antó, Gayan Bowatte, Roberto Bono, Angelo G. Corsico, Margareta Emtner, Thorarinn Gislason, José Antonio Gullón, Joachim Heinrich, John Henderson, Mathias Holm, Ane Johannessen, Bénédicte Leynaert, Alessandro Marcon, Pierpaolo Marchetti, Jesús Martínez Moratalla, Silvia Pascual, Nicole Probst-Hensc
Published in: Environment International, Issue 120, 2018, Page(s) 364-372, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/J.ENVINT.2018.07.032

Occupational exposure to solvents and lung function decline: A population based study

Author(s): Sheikh M Alif, Shyamali Dharmage, Geza Benke, Martine Dennekamp, John Burgess, Jennifer L Perret, Caroline Lodge, Stephen Morrison, David Peter Johns, Graham Giles, Lyle Gurrin, Paul S Thomas, John Llewelyn Hopper, Richard Wood-Baker, Bruce Thompson, Iain Feather, Roel Vermeulen, Hans Kromhout, Debbie Jarvis, Judith Garcia Aymerich, E Haydn Walters, Michael J Abramson, Melanie Claire Matheson
Published in: Thorax, 2019, Page(s) thoraxjnl-2018-212267, ISSN 0040-6376
Publisher: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2018-212267

DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma

Author(s): Ayoung Jeong, Medea Imboden, Akram Ghantous, Alexei Novoloaca, Anne-Elie Carsin, Manolis Kogevinas, Christian Schindler, Gianfranco Lovison, Zdenko Herceg, Cyrille Cuenin, Roel Vermeulen, Deborah Jarvis, André Amaral, Florian Kronenberg, Paolo Vineis, Nicole Probst-Hensch
Published in: International Journal of Environmental Research and Public Health, Issue 16/4, 2019, Page(s) 600, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph16040600

Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)

Author(s): Kai Triebner, Simone Accordini, Lucia Calciano, Ane Johannessen, Bryndís Benediktsdóttir, Ersilia Bifulco, Pascal Demoly, Shyamali C. Dharmage, Karl A. Franklin, Judith Garcia-Aymerich, José Antonio Gullón Blanco, Joachim Heinrich, Mathias Holm, Debbie Jarvis, Rain Jõgi, Eva Lindberg, Jesús Martínez-Moratalla, Nerea Muniozguren Agirre, Isabelle Pin, Nicole Probst-Hensch, Chantal Raherison,
Published in: Maturitas, Issue 120, 2019, Page(s) 29-34, ISSN 0378-5122
Publisher: Elsevier BV
DOI: 10.1016/j.maturitas.2018.11.007

Time and age trends in smoking cessation in Europe

Author(s): Giancarlo Pesce, Alessandro Marcon, Lucia Calciano, Jennifer L. Perret, Michael J. Abramson, Roberto Bono, Jean Bousquet, Alessandro G. Fois, Christer Janson, Deborah Jarvis, Rain Jõgi, Bénédicte Leynaert, Dennis Nowak, Vivi Schlünssen, Isabel Urrutia-Landa, Giuseppe Verlato, Simona Villani, Torsten Zuberbier, Cosetta Minelli, Simone Accordini
Published in: PLOS ONE, Issue 14/2, 2019, Page(s) e0211976, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0211976

Restrictive spirometry pattern is associated with low physical activity levels. A population based international study

Author(s): Anne-Elie Carsin, Elaine Fuertes, Emmanuel Schaffner, Debbie Jarvis, Josep M. Antó, Joachim Heinrich, Valeria Bellisario, Cecilie Svanes, Dirk Keidel, Medea Imboden, Joost Weyler, Dennis Nowak, Jesus Martinez-Moratalla, José-Antonio Gullón, José Luis Sanchez Ramos, Seraina Caviezel, Anna Beckmeyer-Borowko, Chantal Raherison, Isabelle Pin, Pascal Demoly, Isa Cerveri, Simone Accordini, Thorarinn
Published in: Respiratory Medicine, Issue 146, 2019, Page(s) 116-123, ISSN 0954-6111
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.rmed.2018.11.017

Trends in smoking initiation in Europe over 40 years: A retrospective cohort study

Author(s): Alessandro Marcon, Giancarlo Pesce, Lucia Calciano, Valeria Bellisario, Shyamali C. Dharmage, Judith Garcia-Aymerich, Thorarinn Gislasson, Joachim Heinrich, Mathias Holm, Christer Janson, Deborah Jarvis, Bénédicte Leynaert, Melanie C. Matheson, Pietro Pirina, Cecilie Svanes, Simona Villani, Torsten Zuberbier, Cosetta Minelli, Simone Accordini
Published in: PLOS ONE, Issue 13/8, 2018, Page(s) e0201881, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0201881

Association of Height Growth in Puberty with Lung Function. A Longitudinal Study

Author(s): Osama Mahmoud, Raquel Granell, Kate Tilling, Cosetta Minelli, Judith Garcia-Aymerich, John W. Holloway, Adnan Custovic, Deborah Jarvis, Jonathan Sterne, John Henderson
Published in: American Journal of Respiratory and Critical Care Medicine, Issue 198/12, 2018, Page(s) 1539-1548, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.201802-0274oc

Childhood Respiratory Risk Factor Profiles and Middle-Age Lung Function: A Prospective Cohort Study from the First to Sixth Decade

Author(s): Dinh S. Bui, Haydn E. Walters, John A. Burgess, Jennifer L. Perret, Minh Q. Bui, Gayan Bowatte, Adrian J. Lowe, Melissa A. Russell, Bruce R. Thompson, Garun S. Hamilton, Alan L. James, Graham G. Giles, Paul S. Thomas, Debbie Jarvis, Cecilie Svanes, Judith Garcia-Aymerich, Bircan Erbas, Peter A. Frith, Katrina J. Allen, Michael J. Abramson, Caroline J. Lodge, Shyamali C. Dharmage
Published in: Annals of the American Thoracic Society, Issue 15/9, 2018, Page(s) 1057-1066, ISSN 2325-6621
Publisher: American Thoracic Society
DOI: 10.1513/annalsats.201806-374oc

Childhood Body Composition Trajectories and Adolescent Lung Function: Findings from the ALSPAC Study

Author(s): Gabriela P Peralta, Elaine Fuertes, Raquel Granell, Osama Mahmoud, Célina Roda, Ignasi Serra, Deborah Jarvis, John Henderson, Judith Garcia-Aymerich
Published in: American Journal of Respiratory and Critical Care Medicine, 2019, ISSN 1073-449X
Publisher: American Thoracic Society
DOI: 10.1164/rccm.201806-1168oc

SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts

Author(s): Anna Beckmeyer-Borowko, Medea Imboden, Faisal I. Rezwan, Matthias Wielscher, Andre F. S. Amaral, Ayoung Jeong, Emmanuel Schaffner, Juha Auvinen, Sylvain Sebert, Ville Karhunen, Robert Bettschart, Alexander Turk, Marco Pons, Daiana Stolz, Florian Kronenberg, Ryan Arathimos, Gemma C. Sharp, Caroline Relton, Alexander J. Henderson, Marjo-Riitta Jarvelin, Deborah Jarvis, John W. Holloway, Nicole M. Pr
Published in: Respiratory Research, Issue 19/1, 2018, ISSN 1465-993X
Publisher: BioMed Central
DOI: 10.1186/s12931-018-0850-8

Snoring and nocturnal reflux: association with lung function decline and respiratory symptoms

Author(s): Össur Ingi Emilsson, Shadi Amid Hägg, Eva Lindberg, Karl A. Franklin, Kjell Toren, Bryndis Benediktsdottir, Thor Aspelund, Francisco Gómez Real, Bénédicte Leynaert, Pascal Demoly, Torben Sigsgaard, Jennifer Perret, Andrei Malinovschi, Deborah Jarvis, Judith Garcia-Aymerich, Thorarinn Gislason, Christer Janson
Published in: ERJ Open Research, Issue 5/2, 2019, Page(s) 00010-2019, ISSN 2312-0541
Publisher: ERS
DOI: 10.1183/23120541.00010-2019

Epigenome-wide association study of lung function level and its change

Author(s): Imboden, M
Published in: European Respiratory Journal, 2019, ISSN 0903-1936
Publisher: European Respiratory Society

Transgenerational and intergenerational epigenetic inheritance in allergic diseases

Author(s): Toril Mørkve Knudsen, Faisal I. Rezwan, Yu Jiang, Wilfried Karmaus, Cecilie Svanes, John W. Holloway
Published in: Journal of Allergy and Clinical Immunology, Issue 142/3, 2018, Page(s) 765-772, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2018.07.007

Deliverables

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