Skip to main content
European Commission logo
español español
CORDIS - Resultados de investigaciones de la UE
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary
Contenido archivado el 2024-06-18

Mitochondria as regulators of fungal virulence

Objetivo

Fungal diseases represent a significant and growing threat to human health, particularly since the AIDS pandemic and increasing use of immunosuppressive drugs has produced a massive population of people with impaired immunity who are vulnerable to fungal infections. A great challenge in medical mycology is to understand how fungal virulence evolves. The vast majority of fungal species are not human pathogens and, for those that are, virulence appears to have evolved independently on many different occasions. Identifying the step(s) that convert an environmental fungus into a human pathogen, as well as subsequent changes in virulence within a pathogenic lineage, is therefore of fundamental importance. Based on a number of lines of evidence, I hypothesise that a critical regulator of fungal virulence in animal hosts is the activity of the fungal mitochondrion, an energy-generating organelle present in almost all eukaryotes. I propose to test this hypothesis comprehensively by combining genetic and cell biological approaches with high-resolution imaging methods.

Convocatoria de propuestas

ERC-2013-CoG
Consulte otros proyectos de esta convocatoria

Régimen de financiación

ERC-CG - ERC Consolidator Grants

Institución de acogida

THE UNIVERSITY OF BIRMINGHAM
Aportación de la UE
€ 1 991 629,00
Dirección
Edgbaston
B15 2TT Birmingham
Reino Unido

Ver en el mapa

Región
West Midlands (England) West Midlands Birmingham
Tipo de actividad
Higher or Secondary Education Establishments
Investigador principal
Robin Charles May (Dr.)
Contacto administrativo
Xavier Rodde (Mr.)
Enlaces
Coste total
Sin datos

Beneficiarios (1)