Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy

Project Information

DESIRE

Grant agreement ID: 602531

Project closed

Start date 1 October 2013

End date 30 September 2018

Funded under

• Specific Programme "Cooperation": Health

Total cost € 16 461 000,77

EU contribution € 11 995 646,00

Coordinated by

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy

Objective

DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cognitive and behavioral impairments. EDD are the most frequent drug-resistant pediatric epilepsies carrying a lifelong perspective of disability and reduced quality of life. Although EDD collectively represent a major medical and socio-economic burden, their molecular diagnosis, pathogenic mechanisms (PM) and rationale treatment are poorly understood. Specific objectives of DESIRE are to advance the state of the art with respect to: (1) the genetic and epigenetic causes and PM of EDD, particularly epileptogenic MCD, to elucidate molecular networks and disrupted protein complexes and search for common bases for these apparently heterogeneous disorders. (2) the diagnostic tools (biomarkers) and protocols through the study of a unique and well-characterized cohort of children to provide standardized diagnosis for patient stratification and research across Europe. (3) treatment of EDD using randomized, multidisciplinary clinical protocols and testing preclinical strategies in experimental models to also address novel preventative strategies. The workplan spans from clinical observation, to whole exome studies, cellular and animal models and basic research, identification of biomarkers and improvement of diagnostic methods, and back to the clinical trials and assessment of innovative, targeted treatment strategies. The consortium partners have an outstanding track record in genetics, basic neurophysiology, neuropathology and clinical research. Specialized expertise will be made available by the SMEs involved to develop novel diagnostic tools for tailored treatment approaches.

Fields of science

Not validated

• medical and health sciences › basic medicine › neurology › epilepsy

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH.2013.2.2.1-4 - Patho-physiology and therapy of epilepsy and epileptiform disorders

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITA DEGLI STUDI DI FIRENZE

• EU contribution: € 903 321,90
• Address: Piazza San Marco 4 ; 50121 Florence ; Italy
• Region: Centro (IT) › Toscana › Firenze
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Alessandro Mugelli (Prof.)
• Total cost: No data

Participants (27)

FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA

Italy

• EU contribution: € 1 013 251,37
• Address: VIA GIOVANNI CELORIA 11 ; 20133 Milano
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Research Organisations
• Administrative Contact: Francesca Grechi (Dr.)
• Total cost: No data

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

• EU contribution: € 1 770 973,65
• Address: RUE DE TOLBIAC 101 ; 75654 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Dominique Nobile (Mr.)
• Total cost: No data

UNIVERSITATSKLINIKUM ERLANGEN

Germany

• EU contribution: € 1 281 152,00
• Address: MAXIMILIANSPLATZ 2 ; 91054 Erlangen
• Region: Bayern › Mittelfranken › Erlangen, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Katrin Faber (Dr.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DI VERONA

Italy

• EU contribution: € 392 785,71
• Address: VIA DELL ARTIGLIERE 8 ; 37129 Verona
• Region: Nord-Est › Veneto › Verona
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Sonia Ricciardi (Mrs.)
• Total cost: No data

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

• EU contribution: € 711 009,42
• Address: RUE MICHEL ANGE 3 ; 75794 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Sophie Deschaintres (Ms.)
• Total cost: No data

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italy

• EU contribution: € 920 571,81
• Address: VIA MOREGO 30 ; 16163 Genova
• Region: Nord-Ovest › Liguria › Genova
• Activity type: Research Organisations
• Administrative Contact: Claudia Schiaffino (Ms.)
• Total cost: No data

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

• EU contribution: € 249 920,95
• Address: CALLE SERRANO 117 ; 28006 Madrid
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Research Organisations
• Administrative Contact: Alberto Sereno Álvarez (Mr.)
• Total cost: No data

KING'S COLLEGE LONDON

United Kingdom

• EU contribution: € 499 610,00
• Address: STRAND ; WC2R 2LS London
• Region: London › Inner London — West › Camden and City of London
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Paul Labbett (Mr.)
• Total cost: No data

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

• EU contribution: € 267 694,58
• Address: Chariteplatz 1 ; 10117 Berlin
• Region: Berlin › Berlin › Berlin
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eveline Fräßdorf (Ms.)
• Total cost: No data

KLINIKUM DER UNIVERSITAET ZU KOELN

Germany

• EU contribution: € 249 704,40
• Address: Kerpener Strasse 62 ; 50937 Koeln
• Region: Nordrhein-Westfalen › Köln › Köln, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Petra Schreiner-Kaub (Mrs.)
• Total cost: No data

UNIVERSITY COLLEGE LONDON

United Kingdom

• EU contribution: € 157 084,79
• Address: GOWER STREET ; WC1E 6BT London
• Region: London › Inner London — West › Camden and City of London
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Malgorzata Kielbasa (Ms.)
• Total cost: No data

THE UNIVERSITY OF LIVERPOOL

United Kingdom

• EU contribution: € 441 424,88
• Address: BROWNLOW HILL 765 FOUNDATION BUILDING ; L69 7ZX Liverpool
• Region: North West (England) › Merseyside › Liverpool
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Sarah Whitcombe (Mrs.)
• Total cost: No data

UNIVERSITE LIBRE DE BRUXELLES

Participation ended

Belgium

• EU contribution: € 8 541,64
• Address: AVENUE FRANKLIN ROOSEVELT 50 ; 1050 Bruxelles / Brussel
• Region: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Christine Courillon (Dr.)
• Total cost: No data

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

Germany

• EU contribution: € 297 428,10
• Address: OLSHAUSENSTRASSE 40 ; 24118 Kiel
• Region: Schleswig-Holstein › Schleswig-Holstein › Kiel, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Anja Uhlenbrok (Ms.)
• Total cost: No data

BAKER HEART AND DIABETES INSTITUTE

Australia

• EU contribution: No data
• Address: COMMERCIAL ROAD 75 VICTORIA ; 3104 Melbourne
• Activity type: Research Organisations
• Administrative Contact: Heather Gallichio (Ms.)
• Total cost: No data

UNIVERSITA TA MALTA

Malta

• EU contribution: € 121 066,90
• Address: TAL OROQQ ; 2080 L-Imsida
• Region: Malta › Malta › Malta
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Mark Debono (Mr.)
• Total cost: No data

DI.V.A.L. TOSCANA SRL

Italy

• EU contribution: € 447 610,40
• Address: VIA MADONNA DEL PIANO 6 ; 50019 Sesto Fiorentino Fi
• Region: Centro (IT) › Toscana › Firenze
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Nicoletta Rossi (Dr.)
• Total cost: No data

MICROMED S.P.A.

Italy

• EU contribution: € 401 532,00
• Address: VIA GIOTTO 2 ; 31021 MOGLIANO VENETO
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Gianpietro Favaro (Dr.)
• Total cost: No data

VARIONOSTIC GMBH

Participation ended

Germany

• EU contribution: € 215 572,80
• Address: SOFLINGER STRASSE 100 ; 89077 ULM
• Region: Baden-Württemberg › Tübingen › Ulm, Stadtkreis
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Uwe Gerstenmaier (Dr.)
• Total cost: No data

CEGAT GMBH

Germany

• EU contribution: € 298 622,70
• Address: PAUL EHRLICH STRASSE 17 ; 72076 Tubingen
• Region: Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Stefan Ohrnberger (Dr.)
• Total cost: No data

AMARNA THERAPEUTICS BV

Netherlands

• EU contribution: € 299 419,63
• Address: J H OORTWEG 21 ; 2333 CH LEIDEN
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Ben Van Leent (Mr.)
• Total cost: No data

CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL

Italy

• EU contribution: € 277 739,43
• Address: Via Giuseppe Mussi 1 ; 20154 Milano
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Carla Finocchiaro (Dr.)
• Total cost: No data

UNIVERSITA CATTOLICA DEL SACRO CUORE

Italy

• EU contribution: € 45 917,22
• Address: LARGO GEMELLI 1 ; 20123 Milano
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Filippo Leone (Mr.)
• Total cost: No data

OSPEDALE PEDIATRICO BAMBINO GESU

Italy

• EU contribution: € 92 317,54
• Address: PIAZZA SANT ONOFRIO 4 ; 00165 Roma
• Region: Centro (IT) › Lazio › Roma
• Activity type: Research Organisations
• Administrative Contact: Sonya Jane Martin (Dr.)
• Total cost: No data

ISTITUTO GIANNINA GASLINI

Italy

• EU contribution: € 192 372,40
• Address: VIA GEROLAMO GASLINI 5 ; 16147 Genova
• Region: Nord-Ovest › Liguria › Genova
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Maria Gabriella Marinari (Mrs.)
• Total cost: No data

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

• EU contribution: € 112 499,78
• Address: RUE LEBLANC 25 ; 75015 PARIS 15
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Patricia Lenormand (Mrs.)
• Total cost: No data

UNIVERSITE D'ANGERS

France

• EU contribution: € 326 500,00
• Address: RUE DE RENNES 40 ; 49035 Angers Cedex 01
• Region: Pays de la Loire › Pays de la Loire › Maine-et-Loire
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Philippe Simoneau (Prof.)
• Total cost: No data