MicroRNAs in the Pathogenesis, Treatment and Prevention of Epilepsy

Informations projet

EPIMIRNA

N° de convention de subvention: 602130

Projet clôturé

Date de début 1 Septembre 2013

Date de fin 31 Août 2018

Financé au titre de

• Specific Programme "Cooperation": Health

Coût total € 15 567 904,02

Contribution de l’UE € 11 586 858,00

Coordonné par

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

Objectif

Epilepsy is a major burden for patients and health systems worldwide. It is a common chronic neurological disorder affecting people of all ages, and the shortfall in existing treatments means that 30% of patients continue to suffer uncontrolled seizures. MicroRNAs (miRNA) are a recently-discovered, network-level layer of gene expression regulation that controls protein levels of entire signaling pathways. Research on miRNAs has unprecedented potential to (i) further our understanding of the underlying disease processes, (ii) deliver novel signatures and prognostic markers for response to therapy, and (iii) deliver novel therapeutics and drug targets. EpiMiRNA consortium members have pioneered discoveries on brain-specific miRNAs, established that miRNA changes are a feature of the pathophysiology of human temporal lobe epilepsy and have demonstrated experimentally that altering miRNA function can potently suppress epileptic seizures and seizure-damage. EpiMiRNA brings together experts on the neurobiology of miRNAs with the leading researchers working on miRNAs in epilepsy, epilepsy geneticists, leaders in miRNA-target detection, proteomics, and systems biology with research-intensive SMEs pursuing miRNA therapeutics and treatments for pharmacoresistant epilepsy. Through highly collaborative, inter-disciplinary and inter-sectorial research, EpiMiRNA will explain the mechanism by which miRNAs contribute to epileptogenesis, characterize genetic variation of miRNA in patients, evaluate seizure-suppressing effects of miRNAs in experimental models, identify novel miRNA modulatory molecules as potential future therapeutics, and develop miRNAs as prognostic markers to identify patients who respond to novel, non-pharmacological therapeutic interventions including brain stimulation. EpiMiRNA will generate the necessary critical mass in biomedical, clinical and industry/SME research to track, treat and prevent seizures and improve the clinical management of epilepsy patients.

Champ scientifique

• natural sciences › biological sciences › neurobiology
• medical and health sciences › basic medicine › neurology › epilepsy
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics
• medical and health sciences › basic medicine › physiology › pathophysiology

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Thème(s)

• HEALTH.2013.2.2.1-4 - Patho-physiology and therapy of epilepsy and epileptiform disorders

Appel à propositions

FP7-HEALTH-2013-INNOVATION-1
Voir d’autres projets de cet appel

Régime de financement

CP-IP - Large-scale integrating project

Coordinateur

ROYAL COLLEGE OF SURGEONS IN IRELAND

• Contribution de l’UE: € 2 418 033,00
• Adresse: ST STEPHEN'S GREEN 123 ; 2 Dublin ; Irlande
• Région: Ireland › Northern and Western › Border
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: David Henshall (Prof.)
• Coût total: Aucune donnée

Participants (18)

PHILIPPS UNIVERSITAET MARBURG

Allemagne

• Contribution de l’UE: € 2 887 839,00
• Adresse: BIEGENSTRASSE 10 ; 35037 Marburg
• Région: Hessen › Gießen › Marburg-Biedenkopf
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Margret Keller (Ms.)
• Coût total: Aucune donnée

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Pays-Bas

• Contribution de l’UE: € 526 180,00
• Adresse: HEIDELBERGLAAN 100 ; 3584 CX Utrecht
• Région: West-Nederland › Utrecht › Utrecht
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Jeroen Pasterkamp (Dr.)
• Coût total: Aucune donnée

UNIVERSITY COLLEGE LONDON

• Contribution de l’UE: € 418 085,00
• Adresse: GOWER STREET ; WC1E 6BT LONDON
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Stephanie Schorge (Dr.)
• Coût total: Aucune donnée

UNIVERSITA DEGLI STUDI DI VERONA

Italie

• Contribution de l’UE: € 399 540,00
• Adresse: VIA DELL ARTIGLIERE 8 ; 37129 Verona
• Région: Nord-Est › Veneto › Verona
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Paolo Fabene (Prof.)
• Coût total: Aucune donnée

UNIVERSITATSKLINIKUM ERLANGEN

Allemagne

• Contribution de l’UE: € 599 740,00
• Adresse: MAXIMILIANSPLATZ 2 ; 91054 Erlangen
• Région: Bayern › Mittelfranken › Erlangen, Kreisfreie Stadt
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Faber Katrin (Dr.)
• Coût total: Aucune donnée

DUKE UNIVERSITY

Participation terminée

États-Unis

• Contribution de l’UE: € 271 856,00
• Adresse: ALLEN BUILDING 207 ; 27708 Durham Nc
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Cherie Lathi (Ms.)
• Coût total: Aucune donnée

UNIVERSIDADE ESTADUAL DE CAMPINAS

Brésil

• Contribution de l’UE: € 380 660,00
• Adresse: CIDADE UNIVERSITARIA ZEFERINO SN ; 13083 875 Campinas Sp
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Iscia Lopes-Cendes (Prof.)
• Coût total: Aucune donnée

AARHUS UNIVERSITET

Danemark

• Contribution de l’UE: € 548 310,00
• Adresse: NORDRE RINGGADE 1 ; 8000 Aarhus C
• Région: Danmark › Midtjylland › Østjylland
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Rikke Schultz Gjerulff (Mrs.)
• Coût total: Aucune donnée

SYDDANSK UNIVERSITET

Danemark

• Contribution de l’UE: € 620 000,00
• Adresse: CAMPUSVEJ 55 ; 5230 Odense M
• Région: Danmark › Syddanmark › Fyn
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Jens Andersen (Prof.)
• Coût total: Aucune donnée

DIXI MICROTECHNIQUES SAS

Participation terminée

France

• Contribution de l’UE: € 156 977,29
• Adresse: CHEMIN DE PALENTE 4 ESPACE ; 25025 BESANCON
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Jean-Pierre Darnis (Mr.)
• Coût total: Aucune donnée

CERBOMED GMBH

Allemagne

• Contribution de l’UE: € 232 800,00
• Adresse: Henkestrasse 91 ; 91052 ERLANGEN
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Jens Ellrich (Prof.)
• Coût total: Aucune donnée

INTERNA TECHNOLOGIES BV

Pays-Bas

• Contribution de l’UE: € 319 383,00
• Adresse: JONKERBOSPLEIN 52 ; 6534 AB Nijmegen
• Région: Oost-Nederland › Gelderland › Arnhem/Nijmegen
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Roel Schaapveld (Dr.)
• Coût total: Aucune donnée

BICOLL GMBH

Allemagne

• Contribution de l’UE: € 449 880,00
• Adresse: RICHARD RIEMERSCHMID ALLEE 27 ; 81241 MUENCHEN
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Kai Lamottke (Dr.)
• Coût total: Aucune donnée

BIOCOMPUTING PLATFORMS LTD OY

Finlande

• Contribution de l’UE: € 303 900,00
• Adresse: INNOPOLI 3 VAISALANTIE 6 ; 02130 Espoo
• Région: Manner-Suomi › Helsinki-Uusimaa › Helsinki-Uusimaa
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Anita Eliasson (Ms.)
• Coût total: Aucune donnée

GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation terminée

Allemagne

• Contribution de l’UE: € 182 102,00
• Adresse: OSKAR VON MILLER RING 29 ; 80333 Muenchen
• Région: Bayern › Oberbayern › München, Kreisfreie Stadt
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Birgit Fuchs (Mrs.)
• Coût total: Aucune donnée

TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

États-Unis

• Contribution de l’UE: € 433 356,00
• Adresse: AMSTERDAM AVENUE 1210 ROOM ; 10027 7003 New York
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: William Berger (Mr.)
• Coût total: Aucune donnée

ARTTIC

France

• Contribution de l’UE: € 307 898,00
• Adresse: 39 RUE DES MATHURINS ; 75008 Paris
• Région: Ile-de-France › Ile-de-France › Paris
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Martin Dietz (Dr.)
• Coût total: Aucune donnée

DIXI MEDICAL

France

• Contribution de l’UE: € 130 318,71
• Adresse: 2A ROUTE DE POULIGNEY ; 25640 CHAUDEFONTAINE
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Jean-Pierre Darnis (Mr.)
• Coût total: Aucune donnée