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A Powerful Enantioselective Organocatalytic Approach to the Total Synthesis of<br/>Madangamine Alkaloids

Obiettivo

"The projet concerns the development of a powerful first total synthesis of the Madagamine alkaloids. The route starts with an organocatalytic enantioselective and diastereoselective Michael addition of cyanoacetate pronucleophiles to a nitrocyclohexene derivative, as a key step to the formation of the ABC core. When the product of this reaction is subjected to a nitro-Mannich, Mannich reaction cascade this should allow us to construct the core of the madangamine alkaloids rapidly, selectively and on scale. The overall synthetic strategy has two parts. The first concerns a fast and enantioselective assembly of diazatricyclic core common to all madangamines (ABC rings). The second concerns easy and efficient ways to build the two macrocyclic rings (D and E rings), which play a fundamental role in their biological activity. The project combines, catalysis, total synthesis, structure elucidation and evaluation of biological properties."

Invito a presentare proposte

FP7-PEOPLE-2011-IEF
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Coordinatore

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Contributo UE
€ 200 371,80
Indirizzo
WELLINGTON SQUARE UNIVERSITY OFFICES
OX1 2JD Oxford
Regno Unito

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Regione
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Gill Wells (Ms.)
Collegamenti
Costo totale
Nessun dato