Specificity of Antibiotic Resistance Evolution

Informations projet

SPECRESEVO

N° de convention de subvention: 302628

Projet clôturé

Date de début 1 Mars 2012

Date de fin 28 Février 2014

Financé au titre de

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coût total € 184 709,40

Contribution de l’UE € 184 709,40

Coordonné par

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

Objectif

"Bacterial resistance to antibiotics is a major problem for global public health, but we have an incomplete understanding of the evolutionary and genetic factors that drive the spread of resistance. This proposal is motivated by the concept that some of the key processes in resistance evolution depend on the specificity of the genetic mechanisms involved, which is at present unclear. Specificity here refers to variation of the phenotypic effects of mutations across genotypes (epistasis) or environments. I will use a combination of microbial experimental evolution, DNA sequencing and evolutionary genetics to address this problem. My objectives are to: (1) quantify the specificity of antibiotic resistance mutations across different concentrations of a range of antibiotics; (2) identify genetic mechanisms that ameliorate growth defects caused by resistance mutations (compensatory adaptation) in different resistant genotypes in both the presence and absence of antibiotics; (3) test whether compensatory adaptation to the cost of one resistance mutation can also recover the cost of other resistance mutations against the same or other antibiotics. This work will improve our understanding of the genetic and evolutionary factors that drive antibiotic resistance evolution."

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.

• sciences médicales et de la santé › sciences de la santé › santé publique et environnementale
• sciences naturelles › sciences biologiques › génétique › ADN
• sciences naturelles › sciences biologiques › génétique › mutation
• sciences médicales et de la santé › médecine fondamentale › pharmacologie et pharmacie › produit pharmaceutique › antibiotique
• sciences médicales et de la santé › médecine fondamentale › pharmacologie et pharmacie › résistance aux médicaments › résistance aux antibiotiques

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thème(s)

• FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Appel à propositions

FP7-PEOPLE-2011-IEF
Voir d’autres projets de cet appel

Régime de financement

MC-IEF - Intra-European Fellowships (IEF)

Coordinateur

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

• Contribution de l’UE: € 184 709,40
• Adresse: Raemistrasse 101 ; 8092 Zuerich ; Suisse
• Région: Schweiz/Suisse/Svizzera › Zürich › Zürich
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: Aucune donnée