Objectif
Epidemiological evidence has established a link between cardiovascular disease and exposure of the heart and major vessels to doses above 500mGy. At lower doses the evidence for a detrimental effect is inconclusive. In part, this is due to the lack of appropriate epidemiological studies, coupled with lack of knowledge of the processes involved that is needed for construction of mathematical models. The ProCardio consortium will study cardiovascular outcomes in childhood cancer survivors where the radiation doses given to the heart are available. These data will be interrogated using new mathematical models developed from the data from our molecular and biological studies. These will use state-of-the-art technologies to map cardiovascular changes after photon irradiation at both low doses and low dose rates. This will be complemented by comparative studies using high LET irradiation. We will apply an integrative approach to combine transcriptional (mRNA and miRNA) and translational (proteomics) studies to understand the disease processes. High throughput proteomics (ICPL, SILAC and label-free analysis) will be used to identify new biomarkers of radiation-induced cardiovascular disease for future molecular epidemiological studies. These will be validated using the archives of cardiovascular tissue samples from the Mayak facility.
Champ scientifique
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- natural sciencesphysical sciencesnuclear physics
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health sciencesclinical medicineoncology
- natural sciencesmathematicsapplied mathematicsmathematical model
Appel à propositions
FP7-Fission-2011
Voir d’autres projets de cet appel
Régime de financement
CP-FP - Small or medium-scale focused research projectCoordinateur
85764 Neuherberg
Allemagne
Voir sur la carte
Participants (12)
08003 BARCELONA
Voir sur la carte
94805 Villejuif
Voir sur la carte
64291 Darmstadt
Voir sur la carte
Participation terminée
SW1W 9SZ London
Voir sur la carte
00196 Roma
Voir sur la carte
1160 Bruxelles / Brussel
Voir sur la carte
80333 Muenchen
Voir sur la carte
B15 2TT Birmingham
Voir sur la carte
3721 MA Bilthoven
Voir sur la carte
456780 OZYORSK
Voir sur la carte
1105AZ Amsterdam
Voir sur la carte
LS2 7UE Leeds
Voir sur la carte