Objective
In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and on their malignant leukaemic counterparts. Reference epigenomes will be generated by state-of-the-art technologies from highly purified cells for a comprehensive set of epigenetic marks in accordance with quality standards set by IHEC. This resource-generating activity will be conducted at dedicated centres to be complemented by confederated hypothesis-driven research into blood-based diseases, including common leukaemias and autoimmune disease (T1D), by epigenetic targets and compound identification, and by discovery and validation of epigenetic markers for diagnostic use. By focussing on 100 samples of known genetic variation BLUEPRINT will complete an epigenome-wide association study, maximizing the biomedical relevance of the reference epigenomes. Key to the success of BLUEPRINT will be the integration with other data sources (i.e. ICGC, 1000 genomes and ENCODE), comprehensive bioinformatic analysis, and user-friendly dissemination to the wider scientific community. The involvement of innovative companies will energize epigenomic research in the private sector by creating new targets for compounds and the development of smart technologies for better diagnostic tests. BLUEPRINT will outreach through a network of associated members and form critical alliances with leading networks in genomics and epigenomics within Europe and worldwide. Through its interdisciplinarity and scientific excellence combined with its strong commitment to networking, training and communication BLUEPRINT strives to become the cornerstone of the EU contribution to IHEC.
Fields of science
Call for proposal
FP7-HEALTH-2011-single-stage
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Funding Scheme
CP-IP - Large-scale integrating projectCoordinator
6525 XZ Nijmegen
Netherlands
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Participants (44)
WC1E 6BT London
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CB2 1TN Cambridge
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4058 BASEL
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24118 Kiel
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28029 Madrid
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20121 Milano
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69117 Heidelberg
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CB10 1SA SAFFRON WALDEN
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08908 L'Hospitalet De Llobregat
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08028 Barcelona
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80539 Munchen
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66123 Saarbrucken
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81100 Caserta
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08003 Barcelona
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E1 4NS London
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CB22 3AT Cambridge
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69117 Heidelberg
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69117 HEIDELBERG
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4102 Seraing
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75183 Uppsala
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SE16494 KISTA
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80335 Muenchen
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OX4 4GA Oxford
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53100 SIENA
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75654 Paris
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08036 Barcelona
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7610001 Rehovot
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3015 GD Rotterdam
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89081 Ulm
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EH8 9YL Edinburgh
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22100 Lund
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1165 Kobenhavn
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00185 Roma
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28760 TRES CANTOS MADRID
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1211 Geneve
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9713 GZ Groningen
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75794 Paris
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45147 Essen
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04109 Leipzig
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08034 Barcelona
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Participation ended
756 51 UPPSALA
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66386 St Ingbert
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1090 Wien
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4056 BASEL
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