Objective
EU-MASCARA is a collaborative project that aims to improve diagnosis of cardiovascular diseases and prediction of cardiovascular risk by analysing a panel of biomarkers. EU-MASCARA aims to examine genetic, proteomic and metabolomic markers together with markers of inflammation, oxidative stress and cardiac remodelling to study their incremental diagnostic and predictive value over and above existing diagnostic and predictive algorithms. For this purpose a large number of cohorts from different European regions, both patient and population cohorts, that have been accurately assessed for cardiovascular phenotypes are readily available to the consortium. Access to clinical samples and to standardised cardiovascular phenotypes will be granted by a strong clinical platform as one of the key work packages of EU-MASCARA. Both cross-sectional and prospective analyses will be performed that will result in the development of improved risk prediction scores. The consortium is heavily supported by contributions of SMEs in key areas of the proposed research: biomarker testing, data handling and analysis, assay development and project management. EU-MASCARA is further characterised by a strong integrative approach both within and across work packages, with results from one task informing strategies of research in other tasks. With a dedicated bioinformatics and health economic platform the most robust biomarkers will be selected and analysed for their benefit in clinical practice. EU-MASCARA will rigorously validate biomarkers that have been proposed to be associated with cardiovascular disease and risk across different disease entities and also in independent general population samples. The most robust biomarkers will be implemented in novel biochip based assays for clinical use.
Call for proposal
FP7-HEALTH-2011-two-stage
See other projects for this call
Funding Scheme
CP-FP - Small or medium-scale focused research projectCoordinator
G12 8QQ Glasgow
United Kingdom
See on map
Participants (15)
Participation ended
8010 Graz
See on map
1180 Wien
See on map
3000 Leuven
See on map
30625 Hannover
See on map
10117 Berlin
See on map
30659 Hannover
See on map
20145 Milano
See on map
20126 MILANO
See on map
6200 MD Maastricht
See on map
1105 AZ AMSTERDAM
See on map
31008 Pamplona
See on map
46010 Valencia
See on map
BT29 4QY Crumlin
See on map
HD1 3BD Huddersfield
See on map
52074 Aachen
See on map