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RNA-codified release of cytotoxic peptides from PNA prodrugs as a new therapeutic approach to cancer

Cel

In this proposal we intend to develop a new medicinal chemistry concept base on cell-personalized delivery of tailored drugs. Relying on basic chemical tools such as proximity-induced acyl transfer reactions and catalytic turnover- we will use RNA biomarkers of cancer cells to trigger the specific expression of cytotoxic drugs. This approach, in addition to contribute to basic science in chemistry and chemical and cell biology and suggest new therapeutic strategies, might allow to overcome the most important observed complications in cancer treatment: selectivity and resistance.

Zaproszenie do składania wniosków

FP7-PEOPLE-2010-IEF
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

HUMBOLDT-UNIVERSITAET ZU BERLIN
Wkład UE
€ 163 242,40
Adres
UNTER DEN LINDEN 6
10117 Berlin
Niemcy

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Region
Berlin Berlin Berlin
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Ulrich Winderl (Mr.)
Linki
Koszt całkowity
Brak danych