Combining epidemiology and radiobiology to assess cancer risks<br/>in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below

Project Information

EPIRADBIO

Grant agreement ID: 269553

Project closed

Start date 1 April 2011

End date 31 March 2015

Funded under

• EURATOM: Nuclear fission and radiation protection

Total cost € 9 935 943,80

EU contribution € 5 818 073,20

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

Objective

Recent epidemiological studies suggest that cancer risk after exposures with doses comparable to the dose limits for occupationally exposed workers may be larger than assumed by ICRP in the derivation of these limits. The value of cancer risk from such exposures and its dependence on tissue, radiation type and individual factors is largely unknown. The innovative approach proposed here combines epidemiology and radiobiology in order to quantify cancer risks after low-dose or low-dose-rate exposures to ionizing radiation. Key factors of radiation induced carcinogenesis such as genomic instability will be measured in cancer tissues and blood samples from members of the following radio-epidemiological cohorts: French Haemangioma Cohort, Mayak Worker Cohort and thyroid cancer cases after the Chernobyl accident. Inter-cellular communication after exposure to low-dose radiation exposure and its influence on apoptosis, cell proliferation, differentiation and genomic instability will be explored with 2D cell cultures and 3D tissue models. This includes research on stem cells, which will be isolated from healthy human breast tissue. The results of the radiobiological studies will be integrated in the development of models of carcinogenesis for evaluation of major epidemiological cohorts: Atomic Bomb Survivors, French-Swedish-Italian Thyroid Cancer Cohort, Mayak Worker Cohort, Swedish Haemangioma Cohort, UkrAm Cohort on thyroid cancer after the Chernobyl accident, and UK National Registry for Radiation Workers. Cancer risk will be determined for the breast, lung, thyroid and the digestive tract after low-dose-rate exposure to low-LET radiation (external gamma radiation and internal radiation from 131I) and to high-LET radiation (alpha-particles from incorporated plutonium). Lifetime cancer risks including individual risk factors will be calculated to establish a new basis for deriving dose limits and estimating cancer risks including those from medical diagnostic exposures.

Fields of science

• medical and health sciences › health sciences › public health › epidemiology
• natural sciences › physical sciences › nuclear physics
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › clinical medicine › oncology

Programme(s)

• FP7-EURATOM-FISSION - EURATOM: Nuclear fission and radiation protection

Topic(s)

• Fission-2010-3.1.1 - Contribution to low-dose risk research in Europe

Call for proposal

FP7-Fission-2010
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

• EU contribution: € 1 408 000,00
• Address: INGOLSTADTER LANDSTRASSE 1 ; 85764 Neuherberg ; Germany
• Region: Bayern › Oberbayern › München, Landkreis
• Activity type: Research Organisations
• Administrative Contact: Jurgen Ertel (Dr.)
• Total cost: No data

Participants (19)

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

• EU contribution: € 448 000,00
• Address: RUE LEBLANC 25 ; 75015 PARIS 15
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Jacqueline Hiridjee (Ms.)
• Total cost: No data

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

• EU contribution: € 333 002,00
• Address: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford
• Region: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Linda Polik (Ms.)
• Total cost: No data

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

• EU contribution: € 323 000,00
• Address: RUE DE TOLBIAC 101 ; 75654 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Teddy Petris (Mr.)
• Total cost: No data

SATEILYTURVAKESKUS

Finland

• EU contribution: € 302 856,00
• Address: JOKINIEMENKUJA 1 ; 01370 Vantaa
• Region: Manner-Suomi › Helsinki-Uusimaa › Helsinki-Uusimaa
• Activity type: Research Organisations
• Administrative Contact: Liisa Sirkka (Ms.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DI PAVIA

Italy

• EU contribution: € 338 000,00
• Address: STRADA NUOVA 65 ; 27100 Pavia
• Region: Nord-Ovest › Lombardia › Pavia
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Maria Brunelli (Dr.)
• Total cost: No data

STOCKHOLMS UNIVERSITET

Sweden

• EU contribution: € 303 000,00
• Address: UNIVERSITETSVAGEN 10 ; 10691 Stockholm
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eva Petterson (Ms.)
• Total cost: No data

THE QUEEN'S UNIVERSITY OF BELFAST

United Kingdom

• EU contribution: € 302 569,20
• Address: UNIVERSITY ROAD LANYON BUILDING ; BT7 1NN Belfast
• Region: Northern Ireland › Northern Ireland › Belfast
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Kevin Prise (Prof.)
• Total cost: No data

UNIVERSITAET ROSTOCK

Germany

• EU contribution: € 303 000,00
• Address: UNIVERSITATSPLATZ 1 ; 18055 Rostock
• Region: Mecklenburg-Vorpommern › Mecklenburg-Vorpommern › Rostock, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Guido Hildebrandt (Prof.)
• Total cost: No data

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

• EU contribution: € 313 000,00
• Address: GESCHWISTER-SCHOLL-PLATZ ; 72074 Tuebingen
• Region: Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Falko Fend (Prof.)
• Total cost: No data

FEDERAL STATE UNITARY ENTERPRISE SOUTHERN URALS BIOPHYSICS INSTITUTE OF FEDERAL MEDICOBIOLOGICAL AGENCY

Russia

• EU contribution: € 308 000,00
• Address: OZYORSKOE SHOSSE 19 ; 456780 OZYORSK
• Activity type: Research Organisations
• Administrative Contact: Tamara Azizova (Dr.)
• Total cost: No data

GOETEBORGS UNIVERSITET

Sweden

• EU contribution: € 193 000,00
• Address: VASAPARKEN ; 405 30 Goeteborg
• Region: Södra Sverige › Västsverige › Västra Götalands län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Erik Holmberg (Dr.)
• Total cost: No data

KAROLINSKA INSTITUTET

Sweden

• EU contribution: € 152 870,00
• Address: Nobels Vag 5 ; 17177 Stockholm
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Maria Von Witting (Ms.)
• Total cost: No data

HEALTH PROTECTION AGENCY HPA

Participation ended

United Kingdom

• EU contribution: € 8 852,00
• Address: BUCKINGHAM PALACE ROAD 151 ; SW1W 9SZ London
• Activity type: Research Organisations
• Administrative Contact: Beril Short (Ms.)
• Total cost: No data

V.P. KOMISARENKO INSTITUTE OF ENDOCRINOLOGY AND METABOLISM

Ukraine

• EU contribution: € 73 000,00
• Address: VYSHGORODSKA STR 69 ; 04114 KIYV
• Activity type: Research Organisations
• Administrative Contact: Tetiana Bogdanova (Prof.)
• Total cost: No data

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

• EU contribution: € 273 776,00
• Address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON
• Region: London › Inner London — West › Westminster
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Tania Palalic (Ms.)
• Total cost: No data

VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Netherlands

• EU contribution: No data
• Address: De Boelelaan 1105 ; 1081 HV Amsterdam
• Region: West-Nederland › Noord-Holland › Groot-Amsterdam
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Michel Telkamp (Mr.)
• Total cost: No data

SEMIOSHKINA NATALIA

Germany

• EU contribution: € 76 800,00
• Address: LIEBIGSTRASSE 3 ; 80538 MUNCHEN
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Natalia Semioshkina (Dr.)
• Total cost: No data

STICHTING VU

Netherlands

• EU contribution: € 223 200,00
• Address: DE BOELELAAN 1105 ; 1081 HV Amsterdam
• Region: West-Nederland › Noord-Holland › Groot-Amsterdam
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Michel Telkamp
• Total cost: No data

Department of Health

United Kingdom

• EU contribution: € 134 148,00
• Address: Quarry House, Quarry Hill ; LS2 7UE Leeds
• Region: Yorkshire and the Humber › West Yorkshire › Leeds
• Activity type: Research Organisations
• Administrative Contact: Svetlana Carr (Mrs.)
• Total cost: No data