Integrated In Silico Models for the Prediction of Human Repeated Dose Toxicity of Cosmetics to Optimise Safety

Project Information

COSMOS

Grant agreement ID: 266835

Project closed

Start date 1 January 2011

End date 31 December 2015

Funded under

• Specific Programme "Cooperation": Health

Total cost € 6 797 335,60

EU contribution € 3 344 666,00

Coordinated by

LIVERPOOL JOHN MOORES UNIVERSITY
United Kingdom

Objective

The COSMOS project will address the assessment needs of the cosmetics industry by delivering an integrated suite of computational tools to predict the effects of long-term exposure to cosmetic ingredients in humans, thus reducing the need for repeated dose toxicity testing in animals. To achieve this, individual modules comprising: (new) databases, thresholds of toxicological concern (TTC), in silico toxicology (grouping, read-across and QSAR), in vitro data and physiologically-based pharmacokinetic (PBPK) modelling, will be used to construct flexible workflows for assessing toxicity. The COSMOS project will be informed by the needs of industry through active stakeholder engagement, and will utilise innovative technologies from outside the cosmetics area. New databases for TTC and modelling studies will be created by harvesting US FDA legacy data for cosmetics. New and current databases will be combined to advance the state-of-the-art providing a transparent, freely-available public resource. Grouping and read-across will be achieved mechanistically and on the basis of structural similarity. The effective dose-response at the target organ will be estimated from in vitro effects and PBPK models, establishing an alternative (non-animal) basis for risk assessment. All models and Workflows developed will be transparent, fully documented and open access. The partners include world leaders committed to donating software and algorithms to support the open architecture. Data and models will be integratable with existing systems. Workflows will be automated through the KNIME software.

Fields of science

• natural sciences › computer and information sciences › software
• natural sciences › computer and information sciences › databases
• medical and health sciences › basic medicine › toxicology

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH.2010.4.2-9-4 - Computational modelling and estimation techniques. FP7-HEALTH-2010-Alternative-Testing-Strategies

Call for proposal

FP7-HEALTH-2010-Alternative-Testing
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

LIVERPOOL JOHN MOORES UNIVERSITY

• EU contribution: € 577 496,00
• Address: RODNEY STREET 2 EGERTON COURT ; L3 5UX Liverpool ; United Kingdom
• Region: North West (England) › Merseyside › Liverpool
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Mark Cronin (Prof.)
• Total cost: No data

Participants (14)

JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION

Belgium

• EU contribution: € 355 026,00
• Address: Rue de la Loi 200 ; 1049 Bruxelles / Brussel
• Region: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Activity type: Research Organisations
• Administrative Contact: Andrew Paul Worth (Dr.)
• Total cost: No data

U.S. Food & Drug Administration

United States

• EU contribution: No data
• Address: New Hampshire Avenue 10903 ; 20993 Silver Spring
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Mitchell Cheeseman (Dr.)
• Total cost: No data

HENKEL KGaA

Germany

• EU contribution: No data
• Address: HENKELSTRASSE 67 ; 40191 Dusseldorf
• Region: Nordrhein-Westfalen › Düsseldorf › Düsseldorf, Kreisfreie Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Detlef Keller (Dr.)
• Total cost: No data

Merck KGaA

Germany

• EU contribution: € 15 000,00
• Address: FRANKFURTER STRASSE 250 ; 64293 DARMSTADT
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Soheila Anzali (Dr.)
• Total cost: No data

INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES - INERIS

France

• EU contribution: € 365 000,00
• Address: PARC TECHNOLOGIQUE ALATA ; 60550 Verneuil En Halatte
• Region: Hauts-de-France › Picardie › Oise
• Activity type: Research Organisations
• Administrative Contact: Alexandre Pery (Dr.)
• Total cost: No data

INTERNATIONAL LIFE SCIENCES INSTITUTE EUROPEAN BRANCH AISBL

Belgium

• EU contribution: € 117 500,00
• Address: Av. E. Mounier 83 ; 1200 Bruxelles / Brussel
• Region: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Activity type: Research Organisations
• Administrative Contact: Nico Van Belzen (Dr.)
• Total cost: No data

ALTAMIRA LLC

United States

• EU contribution: € 237 500,00
• Address: CANDLEWOOD DRIVE 1455 ; 43235 1623 Columbus Oh
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Chihae Yang (Dr.)
• Total cost: No data

INSILICO BIOTECHNOLOGY AG

Germany

• EU contribution: € 195 000,00
• Address: MEITNERSTRASSE 9 ; 70563 Stuttgart
• Region: Baden-Württemberg › Stuttgart › Stuttgart, Stadtkreis
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Klaus Mauch (Mr.)
• Total cost: No data

KNIME.COM AG

Switzerland

• EU contribution: € 250 000,00
• Address: TECHNOPARKSTRASSE 1 ; 8005 ZURICH
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Michael Berthold (Prof.)
• Total cost: No data

MOLECULAR NETWORKS GMBH COMPUTERCHEMIE

Germany

• EU contribution: € 435 200,00
• Address: NEUMEYERSTR 28-34 ; 90411 Nurnberg
• Region: Bayern › Mittelfranken › Nürnberg, Kreisfreie Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Lothar Terfloth (Dr.)
• Total cost: No data

INSTITUT PO BIOFIZIKA I BIOMEDITSINSKO INZHENERSTVO (INSTITUTE OF BIOPHYSICS AND BIOMEDICAL ENGINEERING)

Bulgaria

• EU contribution: € 240 000,00
• Address: Akad. G. Bonchev bl. 21 ; 1113 Sofia
• Activity type: Research Organisations
• Administrative Contact: Ivanka Tsakovska (Dr.)
• Total cost: No data

KEMIJSKI INSTITUT

Slovenia

• EU contribution: € 45 000,00
• Address: HAJDRIHOVA 19 ; 1000 Ljubljana
• Region: Slovenija › Zahodna Slovenija › Osrednjeslovenska
• Activity type: Research Organisations
• Administrative Contact: Marjan Vracko (Dr.)
• Total cost: No data

UNIVERSITY OF BRADFORD

United Kingdom

• EU contribution: € 282 500,00
• Address: RICHMOND ROAD ; BD7 1DP Bradford
• Region: Yorkshire and the Humber › West Yorkshire › Bradford
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Daniel Neagu (Dr.)
• Total cost: No data

S-IN SOLUZIONI INFORMATICHE SRL

Italy

• EU contribution: € 229 444,00
• Address: VIA G FERRARI 14 ; 36100 VICENZA
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Manuela Pavan (Dr.)
• Total cost: No data