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Content archived on 2024-06-18

Development of OPN-305 as an orphan drug for the treatment of Delayed Graft Function post solid organ transplantation

Objective

Delayed graft function (DGF) is defined as the need for dialysis within seven days of renal transplantation (DGF promotes allograft rejection, requires prolonged dialysis and hospitalisation, and increases the likelihood of graft failure and ultimately the duration of renal graft survival-expectancy. The incidence of DGF occurs in 21-44% of cases following cadaveric renal graft. Several rare diseases, particularly those of genetic origin, are associated with the requirement for solid organ transplantation as the disease progresses. At Opsona Therapeutics we have developed a novel antibody (OPN-305) which has received OMP designation (EU/3/09/638) for use in the prevention of DGF. The scientific basis of this development is the inhibition of Toll-like receptor 2 (TLR2)-mediated ischaemic reperfusion injury which has a pivotal role in the pathogenesis of DGF and its sequelae. The MABSOT project is designed to progress the development of this OMP through Phase I and II clinical trial. The successful completion of the programme will allow the continued development of OPN-305 as an OMP for the treatment of DGF in a range of solid organ transplant situations. OPN-305 development will have significant benefit to these patients and health care providers in reducing the prolonged hospitalisation of these individuals, providing greater longevity associated with the transplanted organ and enhanced quality of life for these individuals.

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Coordinator

OPSONA THERAPEUTICS LIMITED
EU contribution
€ 2 232 195,00
Address
TARA STREET ASHFORD HOUSE 2ND FLOOR
2 DUBLIN
Ireland

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Region
Ireland Northern and Western Border
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mary Reilly (Ms.)
Links
Total cost
No data

Participants (9)