Epigenetics towards systems biology

Project Information

EPIGENESYS

Grant agreement ID: 257082

Project closed

Start date 1 October 2010

End date 31 March 2016

Funded under

• Specific Programme "Cooperation": Health

Total cost € 15 952 636,25

EU contribution € 11 995 024,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Objective

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is needed to understand their dynamic functional relationships. This NoE identified 4 areas aiming at: 1) characterizing the molecular dynamics of epigenetic systems at the single molecule and cell level, 2) linking genotypes to epigenotypes, 3) investigating how environmental, developmental and metabolic signals act upon the epigenome, and 4) understanding epigenetic inheritance through replication, mitosis and meiosis. The common objective is to address fundamental epigenetic mechanisms in quantitative terms both spatially and temporally. The ultimate goal is to express the underlying dynamic events in mathematical terms in order to model and predict how the balance between maintenance and erasure of epigenetic information varies in specific developmental contexts under normal or pathological conditions. A major effort on data management and technology will provide standardised protocols for processing, normalising, and analysing each type of epigenetics data set. Common platforms, tools and resources including a key multilayer toolbox will be implemented for wide use and easy access for researchers, within the NoE and the epigenetics community at large. This NoE will function as an essential bridge between epigenetics researchers and the systems biology community. In the NoE, 22 teams will join efforts to address Epigenetics questions from a systems biology perspective. The combination of a strong training plan together with extension through open targeted calls to recruit young talent will further contribute to build a coherent new EpiGeneSys Area of European Research.

Fields of science

• natural sciences › biological sciences › genetics › epigenetics

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH.2010.2.1.2-2 - Establishing the foundations to enable systems biology of complex biological processes relevant to human health. FP7-HEALTH-2010-two-stage

Call for proposal

FP7-HEALTH-2010-two-stage
See other projects for this call

Funding Scheme

NoE - Network of Excellence

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

• EU contribution: € 3 891 210,72
• Address: RUE MICHEL ANGE 3 ; 75794 Paris ; France
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Julie Zittel (Mrs.)
• Total cost: No data

Participants (27)

INSTITUT CURIE

France

• EU contribution: € 488 400,00
• Address: RUE D ULM 26 ; 75231 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Corinne Cumin (Ms.)
• Total cost: No data

THE BABRAHAM INSTITUTE

United Kingdom

• EU contribution: € 724 000,00
• Address: Babraham Hall ; CB22 3AT Cambridge
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Research Organisations
• Administrative Contact: Caroline Edmonds (Dr.)
• Total cost: No data

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

• EU contribution: € 253 878,00
• Address: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Keith Cann (Mr.)
• Total cost: No data

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

• EU contribution: € 264 000,00
• Address: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford
• Region: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Linda Polik (Ms.)
• Total cost: No data

CANCER RESEARCH UK LBG

United Kingdom

• EU contribution: € 260 660,00
• Address: 2 Redman Place ; E20 1JQ LONDON
• Region: London › Inner London — West › Camden and City of London
• Activity type: Research Organisations
• Administrative Contact: Louisa Jacobs (Ms.)
• Total cost: No data

UNIVERSITY COLLEGE LONDON

• EU contribution: € 701 270,40
• Address: GOWER STREET ; WC1E 6BT LONDON
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Greta Borg-Carbott (Ms.)
• Total cost: No data

THE UNIVERSITY OF EDINBURGH

United Kingdom

• EU contribution: € 383 999,00
• Address: OLD COLLEGE, SOUTH BRIDGE ; EH8 9YL Edinburgh
• Region: Scotland › Eastern Scotland › Edinburgh
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Helen New (Ms.)
• Total cost: No data

UNIVERSITY OF DUNDEE

United Kingdom

• EU contribution: € 318 999,20
• Address: Nethergate ; DD1 4HN Dundee
• Region: Scotland › Eastern Scotland › Angus and Dundee City
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Zoe Kidd (Ms.)
• Total cost: No data

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

• EU contribution: € 564 000,00
• Address: HOFGARTENSTRASSE 8 ; 80539 Munchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Research Organisations
• Administrative Contact: Daniela Moll
• Total cost: No data

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

• EU contribution: € 742 799,00
• Address: GESCHWISTER SCHOLL PLATZ 1 ; 80539 MUNCHEN
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Axel Imhof (Prof.)
• Total cost: No data

Novartis Forschungsstiftung

Participation ended

Switzerland

• EU contribution: € 362 945,76
• Address: Maulbeerstrasse 66 ; 4058 BASEL
• Activity type: Research Organisations
• Administrative Contact: Dorothy Searles (Ms.)
• Total cost: No data

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

• EU contribution: € 263 600,00
• Address: Raemistrasse 101 ; 8092 Zuerich
• Region: Schweiz/Suisse/Svizzera › Zürich › Zürich
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Conrad Wenger (Mr.)
• Total cost: No data

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH

Austria

• EU contribution: € 325 228,89
• Address: DR BOHRGASSE 3 ; 1030 Wien
• Region: Ostösterreich › Wien › Wien
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Tanja Winkler (Ms.)
• Total cost: No data

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

• EU contribution: € 321 230,80
• Address: Meyerhofstrasse 1 ; 69117 Heidelberg
• Region: Baden-Württemberg › Karlsruhe › Heidelberg, Stadtkreis
• Activity type: Research Organisations
• Administrative Contact: Tom Ratcliff (Mr.)
• Total cost: No data

WEIZMANN INSTITUTE OF SCIENCE

Israel

• EU contribution: € 598 217,09
• Address: HERZL STREET 234 ; 7610001 Rehovot
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Talia Tzahor (Ms.)
• Total cost: No data

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

• EU contribution: € 149 978,00
• Address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON
• Region: London › Inner London — West › Westminster
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Tatjana Palalic (Ms.)
• Total cost: No data

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

France

• EU contribution: € 150 000,00
• Address: Rue Laurent Fries 1 ; 67404 Illkirch Graffenstaden
• Region: Grand Est › Alsace › Bas-Rhin
• Activity type: Research Organisations
• Administrative Contact: Steve Brooks (Dr.)
• Total cost: No data

STICHTING WAGENINGEN RESEARCH

Participation ended

Netherlands

• EU contribution: € 40 832,34
• Address: DROEVENDAALSESTEEG 4 ; 6708 PB Wageningen
• Region: Oost-Nederland › Gelderland › Veluwe
• Activity type: Research Organisations
• Administrative Contact: Gerard Pitlo (Mr.)
• Total cost: No data

GENOME RESEARCH LIMITED

United Kingdom

• EU contribution: € 149 996,40
• Address: WELLCOME SANGER INSTITUTE WELLCOME GENOME CAMPUS HINXTON ; CB10 1SA SAFFRON WALDEN
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Research Organisations
• Administrative Contact: David Davison (Mr.)
• Total cost: No data

INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH

Germany

• EU contribution: € 150 000,00
• Address: ACKERMANNWEG 4 ; 55128 Mainz
• Region: Rheinland-Pfalz › Rheinhessen-Pfalz › Mainz, Kreisfreie Stadt
• Activity type: Research Organisations
• Administrative Contact: Franziska Hornig (Mrs.)
• Total cost: No data

FUNDACIO CENTRE DE REGULACIO GENOMICA

Spain

• EU contribution: € 260 000,00
• Address: CARRER DOCTOR AIGUADER 88 ; 08003 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Research Organisations
• Administrative Contact: Mariana Morlans (Ms.)
• Total cost: No data

UMEA UNIVERSITET

Sweden

• EU contribution: € 150 000,00
• Address: UNIVERSITETOMRADET ; 901 87 Umea
• Region: Norra Sverige › Övre Norrland › Västerbottens län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ingela Sandström (Mrs.)
• Total cost: No data

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

• EU contribution: € 210 600,00
• Address: RUE DE TOLBIAC 101 ; 75654 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Laurie Louis-Joseph (Ms.)
• Total cost: No data

UNIVERSITAET POTSDAM

Germany

• EU contribution: € 119 178,40
• Address: AM NEUEN PALAIS 10 ; 14469 Potsdam
• Region: Brandenburg › Brandenburg › Potsdam
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Regina Gerber (Dr.)
• Total cost: No data

STICHTING RADBOUD UNIVERSITEIT

Netherlands

• EU contribution: € 150 000,00
• Address: HOUTLAAN 4 ; 6525 XZ Nijmegen
• Region: Oost-Nederland › Gelderland › Arnhem/Nijmegen
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Geurt Van Renselaar (Mr.)
• Total cost: No data

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION

Switzerland

• EU contribution: No data
• Address: FABRIKSTRASSE 2 ; 4056 BASEL
• Region: Schweiz/Suisse/Svizzera › Nordwestschweiz › Basel-Stadt
• Activity type: Research Organisations
• Administrative Contact: Dorothy Searles (Ms.)
• Total cost: No data

THE FRANCIS CRICK INSTITUTE LIMITED

United Kingdom

• EU contribution: No data
• Address: 1 MIDLAND ROAD ; NW1 1AT London
• Region: London › Inner London — West › Camden and City of London
• Activity type: Research Organisations
• Administrative Contact: Heather Joanne Woods (Ms.)
• Total cost: No data