Final Report Summary - RHOA IN INFLAMMATION (role of a small GTPase, RhoA, in skin inflammation)
Since retinoic acid signaling was shown to affect skin tumor formation, we tested skin tumor formation in mice with a keratinocyte-restricted deletion of the RhoA gene. Indeed, skin tumor formation was strongly altered. We currently investigate this phenotype further.
During the project period, Dr. Peyrollier contributed to 4 original publications and 1 review. The manuscript on the regulation of retinoic acid signaling by RhoA is considered to be her major publication. This documented scientific activity is believed to increase her chances to find a job in biomedical research.