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Contenuto archiviato il 2024-06-18

Targeted delivery of dietary flavanols for optimal human cell function: Effect on cardiovascular health

Obiettivo

Nutrition, i.e. our daily diet, is a major life style factor, greatly impacting on human health and disease. Epidemiological evidence suggests that diets rich in plant-based foods and beverages decrease the risk for cardiovascular morbidity and mortality. Various phytochemical constituents, in particular a class of compounds called flavanols, have been avidly investigated in recent years. Current dietary interventions in humans using flavanol-containing foods have substantiated epidemiological data indicating various potential dietary flavanol-mediated bioactivities, including improved vascular function, decreased blood pressure, attenuated platelet clotting, and improved immune responses. Latest innovations in flavanol analytics, chemistry, food processing technology, and cardiovascular function analysis make the elucidation of underlying mechanisms of flavanol bioactivity not just possible, but also impactful with regard to dietary advice and public health. Thus, a practical application of novel findings emanating from flavanol research in terms of a science/evidence-based development represents a worthwhile endeavour. This entails development of novel food ingredients, and innovative nutrient-delivery matrices. Such novel, nutritionally responsible food formulations hold the potential to open novel avenues in the prevention and amelioration of cardiovascular diseases in Europe. FLAVIOLA aims at: (i) illuminating the cellular and sub-cellular effects of flavanols and their main human metabolites; (ii) investigating key parameters of dietary flavanol absorption, clearance and efficacy towards surrogate markers of cardiovascular function in humans; (iii) developing innovative, functional, and nutritionally responsible food matrices for optimised dietary flavanol delivery; and finally (iv) demonstrating cardiovascular benefits and safety for a newly developed prototype food product.

Invito a presentare proposte

FP7-KBBE-2008-2B
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Coordinatore

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Contributo UE
€ 600 800,00
Indirizzo
UNIVERSITAETSSTRASSE 1
40225 Dusseldorf
Germania

Mostra sulla mappa

Regione
Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Doris Neubert (Ms.)
Collegamenti
Costo totale
Nessun dato

Partecipanti (7)