Persisting Transgenesis

Project Information

PERSIST

Grant agreement ID: 222878

Project closed

Start date 1 January 2009

End date 30 June 2013

Funded under

• Specific Programme "Cooperation": Health

Total cost € 14 731 788,72

EU contribution € 11 181 411,00

Coordinated by

UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy

Objective

For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize on recent discoveries in gene expression control to develop radical solutions to the problem of precisely controlling the fate and expression of exogenous genetic information in gene therapy with applications in these and other deadly diseases. Our proposal combines 20 of Europe’s outstanding experts from 8 countries in the field of genetic engineering for persisting gene expression. Partners have pioneered the use of Zinc Finger Nucleases, engineered recombinases and transposases for gene targeting, synthetic promoters, epigenetic switches and micro-RNA for regulating gene expression, developed state-of-the-art gene delivery platforms based on lentiviral, AAV and gutless adenoviral vectors, conducted front-line clinical trials, and productively collaborated in previous FP projects. PERSIST includes 16 work packages of which 6 focus on vector innovations (part A: emerging technologies), 6 on applications & evaluation (part B), 1 on process development and the remaining 2 on training/dissemination and project management including IPR issues. Targeting deadly diseases, such as inherited immunodeficiencies, storage disorders and haemophilias, PERSIST is in line with the Strategic Research Agenda (SRA) of the Innovative Medicines Initiative (IMI) and will result in: faster discovery and development of better medicines; more attractive professional environment for scientists; better European expertise and know-how to attract biomedical R&D investment in Europe; and a stronger competitive advantage for SMEs, spin-offs and start-ups to enhance Europe’s economy.

Fields of science

• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › chemical sciences › inorganic chemistry › transition metals

Keywords

• Clinical applications
• Gene targeting
• Gene therapy
• Gutless adenoviral vector
• Hemophilias
• Immunodeficiencies
• Inherited diseases
• Lentiviral vectors
• Site-specific gene editing
• Storage disorders

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2007-1.4-4 - Development of emerging gene therapy tools and technologies for clinical application

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITA VITA-SALUTE SAN RAFFAELE

• EU contribution: € 974 143,80
• Address: VIA OLGETTINA 58 ; 20132 Milano ; Italy
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Raffaella Voltolini (Dr.)
• Total cost: No data

Participants (28)

NOVAMEN SAS

Participation ended

France

• EU contribution: No data
• Address: Rue de la République 69 ; 69002 LYON
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Vincent Grosbois (Mr.)
• Total cost: No data

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

• EU contribution: € 577 960,00
• Address: RUE DE TOLBIAC 101 ; 75654 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Hélène Brun (Ms.)
• Total cost: No data

BUNDESINSTITUT FUR IMPFSTOFFE UND BIOMEDIZINISCHE ARZNEIMITTEL

Germany

• EU contribution: € 457 905,00
• Address: PAUL-EHRLICH-STRASSE 51-59 ; 63225 Langen
• Region: Hessen › Darmstadt › Offenbach, Landkreis
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Stefanie Larisch (Ms.)
• Total cost: No data

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

• EU contribution: € 826 774,44
• Address: Carl-Neuberg-Strasse 1 ; 30625 Hannover
• Region: Niedersachsen › Hannover › Region Hannover
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Tobias Quick (Mr.)
• Total cost: No data

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

• EU contribution: € 358 950,00
• Address: BATIMENT CE 3316 STATION 1 ; 1015 Lausanne
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Vaud
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Lena Farneman Andersson (Ms.)
• Total cost: No data

UNIVERSITY COLLEGE LONDON

• EU contribution: € 683 600,00
• Address: GOWER STREET ; WC1E 6BT LONDON
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Kent Lee (Mr.)
• Total cost: No data

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Participation ended

Germany

• EU contribution: € 20 498,16
• Address: Chariteplatz 1 ; 10117 Berlin
• Region: Berlin › Berlin › Berlin
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eveline Frädorf (Mr.)
• Total cost: No data

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

• EU contribution: € 412 440,00
• Address: GESCHWISTER SCHOLL PLATZ 1 ; 80539 MUNCHEN
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Anja Ehrhardt (Dr.)
• Total cost: No data

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)

Participation ended

Germany

• EU contribution: € 244 503,00
• Address: ROBERT ROSSLE STRASSE 10 ; 13125 Berlin
• Region: Berlin › Berlin › Berlin
• Activity type: Research Organisations
• Administrative Contact: Wolfgang Kuehlewind (Mr.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA

Italy

• EU contribution: € 411 400,00
• Address: VIA UNIVERSITA 4 ; 41121 Modena
• Region: Nord-Est › Emilia-Romagna › Modena
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Fabio Prati (Prof.)
• Total cost: No data

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

• EU contribution: € 411 000,00
• Address: ALBINUSDREEF 2 ; 2333 ZA Leiden
• Region: West-Nederland › Zuid-Holland › Agglomeratie Leiden en Bollenstreek
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Erika Eikens-Bedijn (Ms.)
• Total cost: No data

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

• EU contribution: € 935 150,01
• Address: DR MOLEWATERPLEIN 40 ; 3015 GD Rotterdam
• Region: West-Nederland › Zuid-Holland › Groot-Rijnmond
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Henk Isselman (Mr.)
• Total cost: No data

MAX IV Laboratory, Lund University

Sweden

• EU contribution: € 352 551,00
• Address: Paradisgatan 5c ; 22100 LUND
• Region: Södra Sverige › Sydsverige › Skåne län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Jens Forsberg (Dr.)
• Total cost: No data

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

• EU contribution: € 627 468,00
• Address: IM NEUENHEIMER FELD 280 ; 69120 Heidelberg
• Region: Baden-Württemberg › Karlsruhe › Heidelberg, Stadtkreis
• Activity type: Research Organisations
• Administrative Contact: Bettina Crispin (Ms.)
• Total cost: No data

VIB VZW

Participation ended

Belgium

• EU contribution: € 284 403,60
• Address: SUZANNE TASSIERSTRAAT 1 ; 9052 ZWIJNAARDE - GENT
• Region: Vlaams Gewest › Prov. Oost-Vlaanderen › Arr. Gent
• Activity type: Research Organisations
• Administrative Contact: Rik Audenaert (Mr.)
• Total cost: No data

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

• EU contribution: € 350 151,00
• Address: Raemistrasse 101 ; 8092 Zuerich
• Region: Schweiz/Suisse/Svizzera › Zürich › Zürich
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Martin Fussenegger (Prof.)
• Total cost: No data

ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE

United Kingdom

• EU contribution: € 173 334,00
• Address: EGHAM HILL UNIVERSITY OF LONDON ; TW20 0EX Egham
• Region: South East (England) › Surrey, East and West Sussex › West Surrey
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Jenny Febry (Ms.)
• Total cost: No data

BIONTECH INNOVATIVE MANUFACTURING SERVICES GMBH

Germany

• EU contribution: € 328 596,00
• Address: VOLLMERSBACHSTRASSE 66 ; 55743 IDAR OBERSTEIN
• Region: Rheinland-Pfalz › Koblenz › Birkenfeld
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Andrea Schilz (Dr.)
• Total cost: No data

ASSOCIATION GENETHON

France

• EU contribution: € 497 200,00
• Address: RUE DE L INTERNATIONALE 1 BIS ; 91002 Evry
• Region: Ile-de-France › Ile-de-France › Essonne
• Activity type: Research Organisations
• Administrative Contact: Jean-Philippe Marin (Mr.)
• Total cost: No data

EUROFINS GENOMICS EUROPE PHARMA AND DIAGNOSTICS PRODUCTS & SERVICES SANGER PCR GMBH

Germany

• EU contribution: € 497 550,00
• Address: JAKOB STADLER PLATZ 7 ; 78467 Konstanz
• Region: Baden-Württemberg › Freiburg › Konstanz
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Peter Pohl (Mr.)
• Total cost: No data

AGC BIOLOGICS SPA

Italy

• EU contribution: € 311 850,00
• Address: VIA MEUCCI, 3 ; 20091 BRESSO MI
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Enrico Cappelli (Dr.)
• Total cost: No data

ACIES SAS

Participation ended

France

• EU contribution: € 19 529,19
• Address: 69 Rue de la République ; 69002 LYON
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Patrick Duvarry (Mr.)
• Total cost: No data

ABGI FRANCE

France

• EU contribution: € 260 470,81
• Address: 52 QUAI RAMBAUD ; 69002 Lyon
• Region: Auvergne-Rhône-Alpes › Rhône-Alpes › Rhône
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Vincent Grosbois (Mr.)
• Total cost: No data

CENTRO DE INVESTIGACIONES ENERGETICAS MEDIOAMBIENTALES Y TECNOLOGICAS

Spain

• EU contribution: € 66 276,00
• Address: AVENIDA COMPLUTENSE 40 ; 28040 MADRID
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Research Organisations
• Administrative Contact: Ana Collados Martin Posadillos (Ms.)
• Total cost: No data

CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS STIFTUNG

Germany

• EU contribution: € 60 000,00
• Address: PAUL EHRLICH STRASSE 42-44 ; 60596 Frankfurt
• Region: Hessen › Darmstadt › Frankfurt am Main, Kreisfreie Stadt
• Activity type: Research Organisations
• Administrative Contact: Robert Dornberger (Mr.)
• Total cost: No data

VRIJE UNIVERSITEIT BRUSSEL

Belgium

• EU contribution: € 564 635,40
• Address: PLEINLAAN 2 ; 1050 Bruxelles / Brussel
• Region: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Maria Vereeken (Ms.)
• Total cost: No data

UNIVERSITAETSKLINIKUM FREIBURG

Germany

• EU contribution: € 207 212,59
• Address: HUGSTETTER STRASSE 49 ; 79106 Freiburg
• Region: Baden-Württemberg › Freiburg › Freiburg im Breisgau, Stadtkreis
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Juergen Dreyer (Mr.)
• Total cost: No data

FONDAZIONE CENTRO SAN RAFFAELE

Italy

• EU contribution: € 265 859,00
• Address: VIA OLGETTINA 60 ; 20132 Milano
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Research Organisations
• Administrative Contact: Maria Rosa Pedrazzi (Dr.)
• Total cost: No data