Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer

Informazioni relative al progetto

NANOTHER

ID dell’accordo di sovvenzione: 213631

Progetto chiuso

Data di avvio 1 Settembre 2008

Data di completamento 31 Agosto 2012

Finanziato da

• Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Costo totale € 11 556 307,55

Contributo UE € 8 408 483,00

Coordinato da

FUNDACION GAIKER
Spain

Obiettivo

The breakthrough objective of NANOTHER is to develop & characterise a novel nanoparticle system that will be used as a therapeutic agent or diagnosis tool for breast cancer, colorectal cancer & bone metastasis. Theranostics, the development of nanoparticles with both functionalities, will also be carried out using the hyperthermic effect to kill tumour cells or to release the selected drug . The nanoparticles used in NANOTHER will be selected based on previous studies. Therefore, only polymeric micelles core-shell nanoparticles and magnetic nanoparticles will be included in the study. The nanoparticles will be functionalised by attaching targeting molecules, depending on the type of cancer to be treated or diagnosed. Labels for diagnosis will include fluorescent or contrast phase probes, which will later be imaged and analysed with the appropriate equipment optimised during the project. Therapeutic agents will be loaded on to the nanoparticle, including drugs like doxorubicin, and new marine pharmacological compounds already in clinical trials. One of the most innovative aspects of this proposal is the use of siRNA as the therapeutic agent. The use of magnetic nanoparticles as a theranostic mechanism is also an innovative aspect of the proposal, as these nanoparticles can be activated to kill tumour cells detected depending on a positive or negative diagnostic. The project has been structured in seven different sub-projects including aspects like toxicology, biocompatibility of the nanodevices, and also efficacy and biodistribution of the system. In vitro (cellular models) & in vivo assays (small animals; mice) will be used for the study of diagnosis & therapy. The latter will be kept to the minimum necessary to study the efficiency & biodistribution and always taking into account the three Rs & national / EU norms. The NANOTHER consortium includes 18 top-level partners from 8 EU countries as the critical mass required to achieve ambitious project objectives.

Campo scientifico

Not validated

• medical and health sciences › clinical medicine › oncology › breast cancer
• medical and health sciences › clinical medicine › oncology › colorectal cancer
• engineering and technology › nanotechnology › nano-materials
• medical and health sciences › basic medicine › toxicology

Parole chiave

• RNAi
• biodistribution
• cancer
• diagnosis
• efficiency
• hyperthermia
• nanoparticle
• therapy
• toxicology

Programma(i)

• FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Argomento(i)

• NMP-2007-4.0-4 - Substantial innovation in the European medical industry: development of nanotechnology-based systems for in-vivo diagnosis and therapy (in coordination with topic HEALTH-2007-2.4.1-7 and HEALTH-2007-1.2-3 in Theme 1 "Health")

Invito a presentare proposte

FP7-NMP-2007-LARGE-1
Vedi altri progetti per questo bando

Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

FUNDACION GAIKER

• Contributo UE: € 1 187 724,90
• Indirizzo: PARQUE TECNOLOGICO DE VIZCAYA, EDIFICIO 202 ; 48170 Zamudio ; Spagna
• Regione: Noreste › País Vasco › Bizkaia
• Tipo di attività: Research Organisations
• Contatto amministrativo: Oscar Salas (Mr.)
• Costo totale: Nessun dato

Partecipanti (18)

TEL AVIV UNIVERSITY

Israele

• Contributo UE: € 810 170,25
• Indirizzo: RAMAT AVIV ; 69978 Tel Aviv
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Lea Pais (Ms.)
• Costo totale: Nessun dato

PHARMA MAR SA

Spagna

• Contributo UE: € 332 380,50
• Indirizzo: AVDA DE LOS REYES 1 POLIGONO INDUSTRIAL LA MINA COLMENAR VIEJO ; 28770 Madrid
• Regione: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Elena Calleja (Ms.)
• Costo totale: Nessun dato

FEYECON DEVELOPMENT & IMPLEMENTATION BV

Paesi Bassi

• Contributo UE: € 121 800,00
• Indirizzo: HOGEWEYSELAAN 221 ; 1382 JL Weesp
• Regione: West-Nederland › Noord-Holland › Het Gooi en Vechtstreek
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Annet. Helena Butter-Duits (Ms.)
• Costo totale: Nessun dato

CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI

Italia

• Contributo UE: € 951 284,00
• Indirizzo: VIA GIUSTI 9 ; 50121 Firenze
• Regione: Centro (IT) › Toscana › Firenze
• Tipo di attività: Research Organisations
• Contatto amministrativo: Daniele Consigli (Mr.)
• Costo totale: Nessun dato

AHAVA DEAD SEA LABORATORIES LTD

Israele

• Contributo UE: € 256 492,50
• Indirizzo: ARAVA STREET 1 ; 70150 Airport City
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Ofer Achdut (Mr.)
• Costo totale: Nessun dato

ASOCIACION CENTRO DE TECNOLOGIAS DE INTERACCION VISUAL Y COMUNICACIONES-VICOMTECH

Spagna

• Contributo UE: € 347 662,50
• Indirizzo: PASEO MIKELETEGI PARQUE TECNOLOGICO DE MIRAMON 57 ; 20009 DONOSTIA / SAN SEBASTIAN
• Tipo di attività: Research Organisations
• Contatto amministrativo: Grégory Maclair (Dr.)
• Costo totale: Nessun dato

COLOROBBIA ITALIA SPA

Italia

• Contributo UE: € 505 700,00
• Indirizzo: VIA PIETRAMARINA 53 ; 50059 SOVIGLIANA VINCI
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Laura Niccolai (Dr.)
• Costo totale: Nessun dato

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS

Spagna

• Contributo UE: € 288 315,00
• Indirizzo: PARQUE TECNOLOGICO EDIFICIO 801 A ; 48160 DERIO VIZCAYA
• Regione: Noreste › País Vasco › Gipuzkoa
• Tipo di attività: Research Organisations
• Contatto amministrativo: Alfonso Egaña (Mr.)
• Costo totale: Nessun dato

DOMINION PHARMAKINE S.L.

Partecipazione conclusa

Spagna

• Contributo UE: € 158 295,05
• Indirizzo: BIZKAIA TECHNOLOGY PARK Building 801A ; 48160 DERIO
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Naiara Telleria (Dr.)
• Costo totale: Nessun dato

JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION

Belgio

• Contributo UE: € 405 051,00
• Indirizzo: Rue de la Loi 200 ; 1049 Bruxelles / Brussel
• Regione: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Tipo di attività: Research Organisations
• Contatto amministrativo: Clemens Wittwehr (Mr.)
• Costo totale: Nessun dato

HAMELN RDS AS

Slovacchia

• Contributo UE: € 275 734,43
• Indirizzo: HORNA 36 ; 900 01 MODRA
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Anna Kovácová (Ms.)
• Costo totale: Nessun dato

INSTITUT POLYTECHNIQUE DE BORDEAUX

Francia

• Contributo UE: € 952 208,72
• Indirizzo: AV DU DOCTEUR ALBERT SCHWEITZER 1 ; 33402 Talence
• Regione: Nouvelle-Aquitaine › Aquitaine › Gironde
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Sebastien Lecommandoux (Prof.)
• Costo totale: Nessun dato

TECHNOLOGIKO EKPAIDEFTIKO IDRYMA ATHINAS

Grecia

• Contributo UE: € 342 840,00
• Indirizzo: AGIOU SPYRIDONOS 28 KAI MILOU 1 ; 12210 AIGALEO
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Ifigenia Anastasakou (Ms.)
• Costo totale: Nessun dato

UNIVERSITE VICTOR SEGALEN BORDEAUX II

Francia

• Contributo UE: € 326 016,00
• Indirizzo: RUE LEO SAIGNAT 146 ; 33076 BORDEAUX CEDEX
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Jean-Michel Franconi (Prof.)
• Costo totale: Nessun dato

NuovoProbe Ltd

Regno Unito

• Contributo UE: € 278 692,00
• Indirizzo: Wigmore Street 128 ; W1U 3SA London
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Liz Spencer (Ms.)
• Costo totale: Nessun dato

ARGUS CHEMICAL SRL

Italia

• Contributo UE: € 120 848,15
• Indirizzo: VIA DEL MOLIN NUOVO 10 ; 59024 59024
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Enrico Ammannati (Dr.)
• Costo totale: Nessun dato

AYMING

Francia

• Contributo UE: € 343 880,00
• Indirizzo: RUE CHAPTAL 114 ; 92300 Levallois-Perret
• Regione: Ile-de-France › Ile-de-France › Hauts-de-Seine
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Nicolas Marin (Mr.)
• Costo totale: Nessun dato

ACONDICIONAMIENTO TARRASENSE ASSOCIACION

Spagna

• Contributo UE: € 403 388,00
• Indirizzo: CARRER DE LA INNOVACIO 2 ; 08225 Terrassa
• Regione: Este › Cataluña › Barcelona
• Tipo di attività: Research Organisations
• Contatto amministrativo: Ciro Avolio (Mr.)
• Costo totale: Nessun dato