Skip to main content
European Commission logo
italiano italiano
CORDIS - Risultati della ricerca dell’UE
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary
Contenuto archiviato il 2024-06-18

MicroRNAs and Cancer: From Bench to Bedside

Obiettivo

Although studies addressing their role in cancer pathogenesis are at an early stage, it is apparent that specific microRNAs (miRs) and molecules involved in their biogenesis contribute to tumorigenesis. The ONCOMIRS consortium proposes a natural succession of four experimental strategies. Fist, we will DISCOVER and unveil novel miRs and components of their biogenesis machinery and investigate links between these molecules and human cancers. Secondly, we will CONNECT the information obtained on deregulated miRs with known cellular pathways involved in cancer, such as the p53 tumour suppressor pathway. This will be conducted using both forward experimentations, in which targets mRNA are experimentally identified for a number of miR aetiologically related to cancer, and reverse experimentations in which mouse models and cell lines with abrogated tumour suppressor pathways or activated oncogenes are used. To establish a causal relationship between dysregualted miRs and cancer development we will MODEL the tumorigenic processes in mice lacking or overexpressing particular miRs. Finally, since the specificity and potency of some miRs suggest that they might be promising as THERAPEUTIC agents, these models will be used in conjunction with other cancer models to explore miR-based therapeutic strategies.

Invito a presentare proposte

FP7-HEALTH-2007-A
Vedi altri progetti per questo bando

Coordinatore

VIB VZW
Contributo UE
€ 596 795,00
Indirizzo
SUZANNE TASSIERSTRAAT 1
9052 ZWIJNAARDE - GENT
Belgio

Mostra sulla mappa

Regione
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Tipo di attività
Research Organisations
Contatto amministrativo
Wim Goemaere (Mr.)
Collegamenti
Costo totale
Nessun dato

Partecipanti (6)