Development of a Prophylactic Ebola Vaccine Using an Heterologous Prime-Boost Regimen – Sofia ref.: 115854 | EBOVAC1 | Project | Results | H2020 | CORDIS

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Ebola virus glycoprotein stimulates IL-18–dependent natural killer cell responses

Autori: Helen R. Wagstaffe, Elizabeth A. Clutterbuck, Viki Bockstal, Jeroen N. Stoop, Kerstin Luhn, Macaya Douoguih, Georgi Shukarev, Matthew D. Snape, Andrew J. Pollard, Eleanor M. Riley, and Martin R. Goodier.
Pubblicato in: The Journal of Clinical Investigation, Numero 130(7), 2020, Pagina/e 3936-3946, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci132438

An online decision tree for vaccine efficacy trial design during infectious disease epidemics: The InterVax-Tool.

Autori: Steven E. Bellan, Rosalind M. Eggo, Pierre-Stéphane Gsell, Adam J. Kucharski, Natalie E. Dean, Richard Donohue, Matt Zook, W. John Edmunds, Frank Odhiambo, Ira M. Longini, Marc Brisson, Barbara E. Mahon, Ana Maria Henao-Restrepo.
Pubblicato in: Vaccine, Numero 37, 2019, Pagina/e 4376-4381, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2019.06.019

Assessing the performance of real-time epidemic forecasts: A case study of Ebola in the Western Area region of Sierra Leone, 2014-15

Autori: Sebastian Funk, Anton Camacho, Adam J. Kucharski, Rachel Lowe, Rosalind M. Eggo, W. John Edmunds
Pubblicato in: PLOS Computational Biology, Numero 15/2, 2019, Pagina/e e1006785, ISSN 1553-7358
Editore: PLOS
DOI: 10.1371/journal.pcbi.1006785

Partnership for Research on Ebola Vaccination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries.

Autori: Moses Badio, Edouard Lhomme, Mark Kieh, Abdoul Habib Beavogui, Stephen B. Kennedy, Seydou Doumbia, Bailah Leigh, Samba O. Sow, Alpha Diallo, Daniela Fusco, Matthew Kirchoff, Monique Termote, Renaud Vatrinet, Deborah Wentworth, Helène Esperou, H. Clifford Lane, Jerome Pierson, Deborah Watson-Jones, Céline Roy, Eric D’Ortenzio, Brian Greenwood, Genevieve Chêne, Laura Richert, James D. Neaton, Y
Pubblicato in: Trials, Numero 22, 2021, Pagina/e 86, ISSN 1745-6215
Editore: BioMed Central
DOI: 10.1186/s13063-021-05035-9

A model for establishment, maintenance and reactivation of the immune response after vaccination against Ebola virus.

Autori: Irene Balelli, Chloé Pasin, Mélanie Prague, Fabien Crauste, Thierry Van Effelterre, Viki Bockstal, Laura Solforosi and Rodolphe Thiébaut.
Pubblicato in: Journal of Theoretical Biology, Numero 495 (2020), 2020, Pagina/e 110254, ISSN 0022-5193
Editore: Academic Press
DOI: 10.1016/j.jtbi.2020.110254

Comparative ethnographies of medical research: materiality, social relations, citizenship and hope in Tanzania and Sierra Leone

Autori: Shelley Lees, Luisa Enria
Pubblicato in: International Health, Numero 12/6, 2020, Pagina/e 575-583, ISSN 1876-3413
Editore: Elsevier BV
DOI: 10.1093/inthealth/ihaa071

Safety and immunogenicity of a two-dose Ad26. ZEBOV, MVA-BN-Filo Ebola vaccine in children: a randomised, double-blind, controlled trial in Sierra Leone.

Autori: Muhammed O. Afolabi, David Ishola, Daniela Manno, Babajide Keshinro,Viki Bockstal, Baimba Rogers, Kwabena Owusu-Kyei, Alimamy Serry-Bangura, Ibrahim Swaray, Brett Lowe, Dickens Kowuor, Frank Baiden, Thomas Mooney, Elizabeth Smout, Brian Köhn, Godfrey T. Otieno, Morrison Jusu, Julie Foster, Mohamed Samai, Gibrilla Fadlu Deen, Heidi Larson, Shelley Lees, Neil Goldstein, Katherine E. Gallagher, Aug
Pubblicato in: Lancet Infectious Diseases, Numero S1473-3099(21)00128-6, 2021, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(21)00128-6

Safety and long-term immunogenicity of a two-dose Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen in adults: a randomised, double-blind, controlled trial in Sierra Leone.

Autori: David Ishola, Daniela Manno, Muhammed O. Afolabi, Babajide Keshinro, Viki Bockstal, Baimba Rogers, Kwabena Owusu-Kyei, Alimamy Serry-Bangura, Ibrahim Swaray, Brett Lowe, Dickens Kowuor, Frank Baiden, Thomas Mooney, Elizabeth Smout, Brian Köhn, Godfrey T. Otieno, Morrison Jusu, Julie Foster, Mohamed Samai, Gibrilla Fadlu Deen, Heidi Larson, Shelley Lees, Neil Goldstein, Katherine E. Gallagher, Aug
Pubblicato in: Lancet Infectious Diseases, Numero S1473-3099(21)00128-6, 2021, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(21)00125-0

Modelling results from The impact of control strategies and behavioural changes on the elimination of Ebola from Lofa County, Liberia

Autori: Funk, Sebastian; Iza Ciglenecki; Tiffany, Amanda; Gignoux, Etienne; Camacho, Anton; Eggo, Rosalind M.; Kucharski, Adam J.; W. John Edmunds; Bolongei, Josephus; Azuma, Phillip; Clement, Peter; Tamba, Alpha; Sterk, Esther; Telfer, Barbara; Engel, Gregory; Parker, Lucy Anne; Suzuki, Motoi; Heijenberg, Nico; Reeder, Bruce
Pubblicato in: Philosophical Transactions of the Royal Society, Numero 1, 2017, ISSN 0962-8436
Editore: Royal Society of London
DOI: 10.1098/rstb.2016.0302

Implementation of accelerated research: strategies for implementation as applied in a phase 1 Ad26.ZEBOV, MVA-BN-Filo two-dose Ebola vaccine clinical trial in Uganda

Autori: Jonathan Kitonsa, Abu-Baker Ggayi, Zacchaeus Anywaine, Eva Kisaakye, Laura Nsangi, Vincent Basajja, Mary Nyantaro, Deborah Watson-Jones, Georgi Shukarev, Ine Ilsbroux, Cynthia Robinson, Pontiano Kaleebu
Pubblicato in: Global Health Action, Numero 13/1, 2020, Pagina/e 1829829, ISSN 1654-9716
Editore: Co-Action Publishing
DOI: 10.1080/16549716.2020.1829829

Estimating the probability of demonstrating vaccine efficacy in the declining Ebola epidemic: a Bayesian modelling approach

Autori: Anton Camacho, Rosalind M Eggo, Sebastian Funk, Conall H Watson, Adam J Kucharski, W John Edmunds
Pubblicato in: BMJ Open, Numero 5/12, 2015, Pagina/e e009346, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2015-009346

Duration of Ebola virus RNA persistence in semen of survivors: population-level estimates and projections

Autori: Rosalind M Eggo, Conall H Watson, Anton Camacho, Adam J Kucharski, Sebastian Funk, W John Edmunds
Pubblicato in: Eurosurveillance, Numero 20/48, 2015, Pagina/e Volume 20, 2015, ISSN 1025-496X
Editore: Centre Europeen pour la Surveillance Epidemiologique du SIDA
DOI: 10.2807/1560-7917.ES.2015.20.48.30083

Effectiveness of Ring Vaccination as Control Strategy for Ebola Virus Disease

Autori: Adam J. Kucharski, Rosalind M. Eggo, Conall H. Watson, Anton Camacho, Sebastian Funk, W. John Edmunds
Pubblicato in: Emerging Infectious Diseases, Numero 22/1, 2016, Pagina/e 105-108, ISSN 1080-6040
Editore: US National Center for Infectious Diseases
DOI: 10.3201/eid2201.151410

A two-dose heterologous prime-boost vaccine regimen eliciting sustained immune responses to Ebola Zaire could support a preventive strategy for future outbreaks

Autori: Georgi Shukarev, Benoit Callendret, Kerstin Luhn, Macaya Douoguih
Pubblicato in: Human Vaccines & Immunotherapeutics, Numero 13/2, 2017, Pagina/e 266-270, ISSN 2164-5515
Editore: Landes Bioscience
DOI: 10.1080/21645515.2017.1264755

Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study

Autori: Daouda Sissoko, Sophie Duraffour, Romy Kerber, Jacques Seraphin Kolie, Abdoul Habib Beavogui, Alseny-Modet Camara, Géraldine Colin, Toni Rieger, Lisa Oestereich, Bernadett Pályi, Stephanie Wurr, Jeremie Guedj, Thi Huyen Tram Nguyen, Rosalind M Eggo, Conall H Watson, W John Edmunds, Joseph Akoi Bore, Fara Raymond Koundouno, Mar Cabeza-Cabrerizo, Lisa L Carter, Liana Eleni Kafetzopoulou, Eeva Kuis
Pubblicato in: The Lancet Global Health, Numero 5/1, 2017, Pagina/e e80-e88, ISSN 2214-109X
Editore: Elsevier BV
DOI: 10.1016/S2214-109X(16)30243-1

Power, fairness and trust: understanding and engaging with vaccine trial participants and communities in the setting up the EBOVAC-Salone vaccine trial in Sierra Leone

Autori: Luisa Enria, Shelley Lees, Elizabeth Smout, Thomas Mooney, Angus F. Tengbeh, Bailah Leigh, Brian Greenwood, Deborah Watson-Jones, Heidi Larson
Pubblicato in: BMC Public Health, Numero 16/1, 2016, ISSN 1471-2458
Editore: BioMed Central
DOI: 10.1186/s12889-016-3799-x

Real-time forecasting of infectious disease dynamics with a stochastic semi-mechanistic model

Autori: Sebastian Funk, Anton Camacho, Adam J. Kucharski, Rosalind M. Eggo, W. John Edmunds
Pubblicato in: Epidemics, Numero 22, 2018, Pagina/e 56-61, ISSN 1755-4365
Editore: Elsevier BV
DOI: 10.1016/j.epidem.2016.11.003

Safety and Immunogenicity of Novel Adenovirus Type 26– and Modified Vaccinia Ankara–Vectored Ebola Vaccines

Autori: Iain D. Milligan, Malick M. Gibani, Richard Sewell, Elizabeth A. Clutterbuck, Danielle Campbell, Emma Plested, Elizabeth Nuthall, Merryn Voysey, Laura Silva-Reyes, M. Juliana McElrath, Stephen C. De Rosa, Nicole Frahm, Kristen W. Cohen, Georgi Shukarev, Nicola Orzabal, Wilbert van Duijnhoven, Carla Truyers, Nora Bachmayer, Daniel Splinter, Nathaly Samy, Maria Grazia Pau, Hanneke Schuitemaker, Kers
Pubblicato in: JAMA, Numero 315/15, 2016, Pagina/e 1610, ISSN 0098-7484
Editore: American Medical Association
DOI: 10.1001/jama.2016.4218

Simulation-guided phase 3 trial design to evaluate vaccine effectiveness to prevent Ebola virus disease infection: Statistical considerations, design rationale, and challenges

Autori: An Vandebosch, Robin Mogg, Nele Goeyvaerts, Carla Truyers, Brian Greenwood, Debby Watson-Jones, Guillermo Herrera-Taracena, Wim Parys, Tony Vangeneugden
Pubblicato in: Clinical Trials: Journal of the Society for Clinical Trials, Numero 13/1, 2016, Pagina/e 57-65, ISSN 1740-7745
Editore: SAGE Publications
DOI: 10.1177/1740774515621059

Real-time dynamic modelling for the design of a cluster-randomized phase 3 Ebola vaccine trial in Sierra Leone

Autori: A. Camacho, R.M. Eggo, N. Goeyvaerts, A. Vandebosch, R. Mogg, S. Funk, A.J. Kucharski, C.H. Watson, T. Vangeneugden, W.J. Edmunds
Pubblicato in: Vaccine, Numero 35/4, 2017, Pagina/e 544-551, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2016.12.019

Immune Responses to Novel Adenovirus Type 26 and Modified Vaccinia Virus Ankara–Vectored Ebola Vaccines at 1 Year

Autori: Rebecca L. Winslow, Iain D. Milligan, Merryn Voysey, Kerstin Luhn, Georgi Shukarev, Macaya Douoguih, Matthew D. Snape
Pubblicato in: JAMA, Numero 317/10, 2017, Pagina/e 1075, ISSN 0098-7484
Editore: American Medical Association
DOI: 10.1001/jama.2016.20644

“We are the heroes because we are ready to die for this country”: Participants' decision-making and grounded ethics in an Ebola vaccine clinical trial

Autori: Angus Fayia Tengbeh, Luisa Enria, Elizabeth Smout, Thomas Mooney, Mike Callaghan, David Ishola, Bailah Leigh, Deborah Watson-Jones, Brian Greenwood, Heidi Larson, Shelley Lees
Pubblicato in: Social Science & Medicine, Numero 203, 2018, Pagina/e 35-42, ISSN 0277-9536
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.socscimed.2018.03.008

Citizens, dependents, sons of the soil: Defining political subjectivities through encounters with biomedicine during the Ebola epidemic in Sierra Leone

Autori: Luisa Enria, Shelley Lees
Pubblicato in: Medicine Anthropology Theory | An open-access journal in the anthropology of health, illness, and medicine, Numero 5/4, 2018, ISSN 2405-691X
Editore: Medicine Anthropology Theory
DOI: 10.17157/mat.5.4.512

Stability and suitability for storage and distribution of Ad26.ZEBOV/MVA-BN®-Filo heterologous prime-boost Ebola vaccine

Autori: Martinus A.H. Capelle, Lara Babich, J.P. Els van Deventer-Troost, Doris Salerno, Kelly Krijgsman, Ulrike Dirmeier, Britt Raaby, Janik Adriaansen
Pubblicato in: European Journal of Pharmaceutics and Biopharmaceutics, Numero 129, 2018, Pagina/e 215-221, ISSN 0939-6411
Editore: Elsevier BV
DOI: 10.1016/j.ejpb.2018.06.001

EBOVAC-Salone: Lessons learned from implementing an Ebola vaccine trial in an Ebola-affected country

Autori: Thomas Mooney, Elizabeth Smout, Bailah Leigh, Brian Greenwood, Luisa Enria, David Ishola, Daniela Manno, Mohamed Samai, Macaya Douoguih, Deborah Watson-Jones
Pubblicato in: Clinical Trials, Numero 15/5, 2018, Pagina/e 436-443, ISSN 1740-7745
Editore: SAGE Publications
DOI: 10.1177/1740774518780678

Dynamics of the Humoral Immune Response to a Prime-Boost Ebola Vaccine: Quantification and Sources of Variation

Autori: Chloé Pasin, Irene Balelli, Thierry Van Effelterre, Viki Bockstal, Laura Solforosi, Mélanie Prague, Macaya Douoguih, Rodolphe Thiébaut
Pubblicato in: Journal of Virology, Numero 93/18, 2019, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/jvi.00579-19

Safety and Immunogenicity of a 2-Dose Heterologous Vaccine Regimen With Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: 12-Month Data From a Phase 1 Randomized Clinical Trial in Nairobi, Kenya

Autori: Gaudensia Mutua, Omu Anzala, Kerstin Luhn, Cynthia Robinson, Viki Bockstal, Dickson Anumendem, Macaya Douoguih
Pubblicato in: The Journal of Infectious Diseases, Numero 220/1, 2019, Pagina/e 57-67, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiz071

Health care worker vaccination against Ebola: Vaccine acceptance and employment duration in Sierra Leone

Autori: Mario Jendrossek, W. John Edmunds, Hana Rohan, Samuel Clifford, Thomas A. Mooney, Rosalind M. Eggo
Pubblicato in: Vaccine, Numero 37/8, 2019, Pagina/e 1101-1108, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2018.12.060

Determinants of Transmission Risk During the Late Stage of the West African Ebola Epidemic

Autori: Alexis Robert, W John Edmunds, Conall H Watson, Ana Maria Henao-Restrepo, Pierre-Stéphane Gsell, Elizabeth Williamson, Ira M Longini, Keïta Sakoba, Adam J Kucharski, Alhassane Touré, Sévérine Danmadji Nadlaou, Boubacar Diallo, Mamamdou Saidou Barry, Thierno Oumar Fofana, Louceny Camara, Ibrahima Lansana Kaba, Lansana Sylla, Mohamed Lamine Diaby, Ousmane Soumah, Abdourahime Diallo, Amadou Niar
Pubblicato in: American Journal of Epidemiology, Numero 188/7, 2019, Pagina/e 1319-1327, ISSN 0002-9262
Editore: Oxford University Press
DOI: 10.1093/aje/kwz090

Safety and Immunogenicity of a 2-Dose Heterologous Vaccination Regimen With Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: 12-Month Data From a Phase 1 Randomized Clinical Trial in Uganda and Tanzania

Autori: Zacchaeus Anywaine, Hilary Whitworth, Pontiano Kaleebu, George Praygod, Georgi Shukarev, Daniela Manno, Saidi Kapiga, Heiner Grosskurth, Samuel Kalluvya, Viki Bockstal, Dickson Anumendem, Kerstin Luhn, Cynthia Robinson, Macaya Douoguih, Deborah Watson-Jones
Pubblicato in: The Journal of Infectious Diseases, Numero 220/1, 2019, Pagina/e 46-56, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiz070

Control of Ebola virus disease outbreaks: Comparison of health care worker-targeted and community vaccination strategies

Autori: Alexis Robert, Anton Camacho, W. John Edmunds, Marc Baguelin, Jean-Jacques Muyembe Tamfum, Alicia Rosello, Sakoba Kéïta, Rosalind M. Eggo
Pubblicato in: Epidemics, Numero 27, 2019, Pagina/e 106-114, ISSN 1755-4365
Editore: Elsevier BV
DOI: 10.1016/j.epidem.2019.03.001

Nonhuman primate to human immunobridging to infer the protective effect of an Ebola virus vaccine candidate.

Autori: Ramon Roozendaal, Jenny Hendriks, Thierry van Effelterre, Bart Spiessens, Liesbeth Dekking, Laura Solforosi, Dominika Czapska-Casey, Viki Bockstal, Jeroen Stoop, Daniel Splinter, Sarah Janssen, Ben van Baelen, Nadia Verbruggen, Jan Serroyen, Eline Dekeyster, Ariane Volkmann, Yvonne Wollmann, Ricardo Carrion, Luis D. Giavedoni, Cynthia Robinson, Maarten Leyssen, Macaya Douoguih, Kerstin Luhn, Maria
Pubblicato in: npj Vaccines, Numero 5/112, 2020, ISSN 2059-0105
Editore: Nature
DOI: 10.1038/s41541-020-00261-9

Parameter estimation in nonlinear mixed effect models based on ordinary differential equations: An optimal control approach

Autori: Clairon, Quentin; Pasin, Chloé; Balelli, Irene; Thiébaut, Rodolphe; Prague, Mélanie
Pubblicato in: 2021, Numero 1, 2021
Editore: HAL
DOI: 10.13140/rg.2.2.18016.81920

Diritti di proprietà intellettuale

METHODS AND COMPOSITIONS FOR INDUCING PROTECTIVE IMMUNITY AGAINST FILOVIRUS INFECTION

Numero candidatura/pubblicazione: 15 767631
Data: 2015-09-03
Candidato/i: JANSSEN VACCINES & PREVENTION BV

METHODS AND COMPOSITIONS FOR ENHANCING IMMUNE RESPONSES

Numero candidatura/pubblicazione: PCT /US15/48388
Data: 2015-09-03
Candidato/i: JANSSEN VACCINES & PREVENTION BV

METHODS AND COMPOSITIONS FOR INDUCING PROTECTIVE IMMUNITY AGAINST FILOVIRUS INFECTION

Numero candidatura/pubblicazione: PCT /US15/48357
Data: 2015-09-03
Candidato/i: JANSSEN VACCINES & PREVENTION BV

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Development of a Prophylactic Ebola Vaccine Using an Heterologous Prime-Boost Regimen – Sofia ref.: 115854

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