Initial activities involved the development and implementation of a comprehensive data management plan, which guided the collection, processing, and analysis of environmental and archaeological data. Core drilling and sampling were carried out at key sites, including Venice, Lio Piccolo, Torcello, and Aquileia, utilizing advanced multi-proxy techniques. A set of 18 new sedimentary long continuous sedimentary cores were extracted and sampled for a multi-proxy analysis. The integration of diverse analytical techniques—sedimentological, micro-paleontological, palynological, geochemical, micro-morphological and radiocarbon dating—enabled a comprehensive reconstruction of past environments and human activities. Geochemical analyses played a crucial role in understanding the environmental and anthropogenic changes over time. This included the examination of major and trace elements, as well as stable lead isotopes, which illustrated the impact of human activities on the environment from the Bronze Age through to the Medieval period. The data highlighted the gradual accumulation of pollutants and its correlation with urbanization and preindustrial activities. A significant achievement was the integration of micro-ceramics and micro-charcoal analyses, that provided insights into the intensity and nature of human activities at specific time periods and revealing how ancient societies managed and altered their environments. These findings demonstrate the persistence of environmental degradation over millennia and provide a deeper understanding of how ancient societies influenced their surroundings.