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European platform for neurodegenerative disorders

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

White Paper V1: Gaps and requirements

Among other work and research carried out in WP2/T2.1, The White Paper will also incorporate the work of the ELSI Officer (T2.4), who will assemble the relevant ELSI documentation before the start of each case study (ethics review approvals/amendments, information sheets and consent forms, incidental findings policies, material transfer agreements etc.) A clear statement on the ethics of the case studies explicitly confirming verification/documentation of consent, incidental findings, and ethics review confirmations will be included in the annual reports of the ELSI Officer. These reports will incorporate the following related to HUMANS: 1. Detailed information on the informed consent procedures that will be implemented for the participation of humans (including the follow-up of the cohorts and the consultation to the stakeholders) must be provided. These will be kept on file and provided to IMI JU upon request. 2. If applicable, details on incidental findings policy must be provided. 3. The concerned consortium members must confirm that opinions/approvals by ethics committees and/or competent authorities for the research with humans have been obtained prior to the start of the research in T5.6 and are kept on file. They must be provided to IMI JU upon request. the annual reports of the ELSI Officer will also incorporate the following related to HUMAN CELLS (all of the information/documentation will be provided to IMI JU upon request):1. In case human cells/tissues are obtained within the project, details on cell/tissue types must be kept on file. The concerned consortium members must confirm that the specific approval has been obtained prior to the start of the research activity raising ethics issue and that it is kept on file. 2. In case human cells/tissues are obtained from another project, details on cell/tissue types must be kept on file. The concerned consortium members must confirm that authorisation has been obtained from the primary owner of cells/tissues (including references to ethics approval) prior to the start of the research activity raising ethics issue and that it is kept on file. 3. In case human cells/tissues are obtained from a biobank, details on the cell/tissue types and on the biobank and access to it, must be kept on file prior to the start of the research activity raising ethics issue. 4. The concerned consortium members must confirm that they have obtained all the relevant documents for using, producing or collecting human cells or tissues (e.g., ethics approval, import licence, accreditation/designation/authorisation/licensing) prior to the start of the research activity raising ethics issue and that they are kept on file.

SOP minimal dataset for data glossary

SOP minimal dataset for data glossary from T33 SOP minimal dataset

Framework design & roadmap of the EPND Platform node of ADWB defining standards, biobank facilities, federated components, roles and time plan

Framework design roadmap of the EPND Platform node of ADWB defining standards biobank facilities federated components roles and time plan

Data Management Plan

The Data Management Plan DMP will report on the following data protection requirements partner verification and confirmation of any special derogations of data subject rights in crossborder contexts international transfers partner declarations of compliance with national frameworks transparent DPO contact information and GDPR role assignments Verification and documentation will be carried out by the ELSI Officer as part of T242 The Officer will review a checklist of each of these elements as part of assisting cohorts in implementing the consortium materialdata transfer agreement templates The DMP will also incorporate data protection issues especially sections 4 Data security and 5 Ethics of the DMP template1 The concerned consortium members must check and confirm to IMI JU if special derogations pertaining to the rights of data subjects or the processing of genetic andor health data have been established under the national legislation of the country where the research takes place and provide a declaration of compliance with respective national legal frameworks2 If applicable if case personal data are transferred from the EU to a nonEU country or international organisation confirmation that such transfers are in accordance with Chapter V of the General Data Protection Regulation 2016679 GDPR must be provided3 The consortium members must confirm that contact details of the Data Protection Officer DPO were made available to all data subjects involved in the research For the members of the consortium not required to appoint a DPO under the General Data Protection Regulation a detaileddata protection policy for the project must be elaborated and kept on file It must be provided to IMI JU upon request4 The role of controllerjoint controller and data processor among consortiums partners must be clarified In particular in case of joint controllership the consortium must clarify if and how Article 26 of the GDPR will be implemented also concerning the agreement referred to in paragraph 1 of that provision

Data Protection Impact Assessment
Report on kick-off meeting

Report on kickoff meeting

Online publication EPND glossary, core data models and metadata specifications as a FAIR implementation profile
Second Annual ESAB meeting minutes

Annual ESAB meeting minutes as part of Task 6.2

EPND Cohort Classification Scheme
Roadmap and tools for stakeholder engagement

Roadmap and tools for stakeholder engagement as part of Task 6.2

Project management tools for project tracking and reporting
Interim data management plan
SOP for biomarker validation

SOP for biomarker validation from T34 SOP validation

Phase 1 Evaluation
"General Assembly (GA) meeting #1: minutes and decisions"

General Assembly GA meeting 1 minutes and decisions

Best practices for biobanking

Best practices for biobanking from T31 Best practices for biobanking

SOP body materials collection

SOP body materials collection from T32 SOP body materials collection

Publications

Facilitating the use of the target product profile in academic research: a systematic review

Author(s): Aliaa Ibnidris, Nektarios Liaskos, Ece Eldem, Angus Gunn, Johannes Streffer, Michael Gold, Mike Rea, Stefan Teipel, Alejandra Gardiol, Marina Boccardi
Published in: Journal of Translational Medicine, Issue 22, 2024, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/s12967-024-05476-1

CSF proteomics in autosomal dominant Alzheimer’s disease highlights parallels with sporadic disease

Author(s): Emma L van der Ende, Sjors G J G In ‘t Veld, Iris Hanskamp, Sven van der Lee, Janna I R Dijkstra, Yanaika S Hok-A-Hin, Elena R Blujdea, John C van Swieten, David J Irwin, Alice Chen-Plotkin, William T Hu, Afina W Lemstra, Yolande A L Pijnenburg, Wiesje M van der Flier, Marta del Campo, Charlotte E Teunissen, Lisa Vermunt
Published in: Brain, Issue 146, 2023, Page(s) 4495-4507, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awad213

The clinical importance of suspected non-Alzheimer disease pathophysiology

Author(s): Stephanie J. B. Vos, Aurore Delvenne, Clifford R. Jack, Dietmar R. Thal, Pieter Jelle Visser
Published in: Nature Reviews Neurology, Issue 20, 2024, Page(s) 337-346, ISSN 1759-4758
Publisher: Nature Publishing Group
DOI: 10.1038/s41582-024-00962-y

Alzheimer’s Disease and Cognitive Decline in Patients with Cardiovascular Diseases Along the Heart-Brain Axis

Author(s): Calvin Trieu, Argonde C. van Harten, Anna E. Leeuwis, Lieza G. Exalto, Astrid M. Hooghiemstra, Inge M.W. Verberk, Cor P. Allaart, Hans-Peter Brunner-La Rocca, L. Jaap Kappelle, Robert J. van Oostenbrugge, Geert-Jan Biessels, Charlotte E. Teunissen, Wiesje M. van der Flier, null null
Published in: Journal of Alzheimer’s Disease, Issue 98, 2024, Page(s) 987-1000, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-231096

Elevated plasma sclerostin is associated with high brain amyloid-β load in cognitively normal older adults

Author(s): Jun Yuan, Steve Pedrini, Rohith Thota, James Doecke, Pratishtha Chatterjee, Hamid R. Sohrabi, Charlotte E. Teunissen, Inge M. W. Verberk, Erik Stoops, Hugo Vanderstichele, Bruno P. Meloni, Christopher Mitchell, Stephanie Rainey-Smith, Kathryn Goozee, Andrew Chi Pang Tai, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Junjie Gao, Delin Liu, Frank Mastaglia, Charles Inderjeeth, Minghao Zheng, Ralp
Published in: npj Aging, Issue 9, 2023, ISSN 2731-6068
Publisher: Springer Nature
DOI: 10.1038/s41514-023-00114-4

Revised criteria for the diagnosis and staging of Alzheimer’s disease

Author(s): Clifford R. Jack, Scott J. Andrews, Thomas G. Beach, Teresa Buracchio, Billy Dunn, Ana Graf, Oskar Hansson, Carole Ho, William Jagust, Eric McDade, Jose Luis Molinuevo, Ozioma C. Okonkwo, Luca Pani, Michael S. Rafii, Philip Scheltens, Eric Siemers, Heather M. Snyder, Reisa Sperling, Charlotte E. Teunissen, Maria C. Carrillo
Published in: Nature Medicine, Issue 30, 2024, Page(s) 2121-2124, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-024-02988-7

Longitudinal associations of serum biomarkers with early cognitive, amyloid and grey matter changes

Author(s): Steffi De Meyer, Elena R Blujdea, Jolien Schaeverbeke, Mariska Reinartz, Emma S Luckett, Katarzyna Adamczuk, Koen Van Laere, Patrick Dupont, Charlotte E Teunissen, Rik Vandenberghe, Koen Poesen
Published in: Brain, Issue 147, 2024, Page(s) 936-948, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awad330

Data and sample sharing as an enabler for large-scale biomarker research and development: The EPND perspective

Author(s): Niranjan Bose1, Anthony J. Brookes, Phil Scordis and Pieter Jelle Visser, on behalf of the EPND Consortium
Published in: Frontiers in Neurology, Issue November 2022, 2022, Page(s) online, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.1031091

Rationale and design of the ABOARD project (A Personalized Medicine Approach for Alzheimer's Disease)

Author(s): Maria A. E. Dreves, Argonde C. van Harten, Leonie N. C. Visser, Hanneke Rhodius‐Meester, Sebastian Köhler, Minke Kooistra, Janne M. Papma, Madison I. J. Honey, Marco M. Blom, Ellen M. A. Smets, Marjolein E. de Vugt, Charlotte E. Teunissen, Wiesje M. van der Flier, null null
Published in: Alzheimer's & Dementia: Translational Research & Clinical Interventions, Issue 9, 2023, ISSN 2352-8737
Publisher: Alzheimer's Association
DOI: 10.1002/trc2.12401

Informed consent in dementia research: how Public Involvement can contribute to addressing “old” and “new” challenges

Author(s): Ana Diaz, Cindy Birck, Angela Bradshaw, Jean Georges, Daphne Lamirel, Soraya Moradi-Bachiller, Dianne Gove
Published in: Frontiers in Dementia, Issue 4, 2025, ISSN 2813-3919
Publisher: Frontiers Media
DOI: 10.3389/frdem.2025.1536762

Serum Neurofilament Light and Postoperative Delirium in Cardiac Surgery: A Preplanned Secondary Analysis of a Prospective Observational Study

Author(s): Céline Khalifa, Annie Robert, Maximilien Cappe, Guillaume Lemaire, Robert Tircoveanu, Valérie Dehon, Adrian Ivanoiu, Sophie Piérard, Laurent de Kerchove, Aurélie Jacobs Sariyar, Charlotte Elisabeth Teunissen, Mona Momeni
Published in: Anesthesiology, Issue 140, 2025, Page(s) 950-962, ISSN 0003-3022
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/aln.0000000000004922

Purpose definition as a crucial step for determining the legal basis under the GDPR: implications for scientific research

Author(s): Regina Becker, Davit Chokoshvili, Adrian Thorogood, Edward S Dove, Fruzsina Molnár-Gábor, Alexandra Ziaka, Olga Tzortzatou-Nanopoulou, Giovanni Comandè
Published in: Journal of Law and the Biosciences, Issue 11, 2024, ISSN 2053-9711
Publisher: Oxford University Press
DOI: 10.1093/jlb/lsae001

16th Clinical Trials on Alzheimer's Disease (CTAD) Boston, MA (USA) October 24–27, 2023: Posters

Author(s): C. Teunissen1, I.M.W. Verberk, J. Jutte1, M.Y. Kingma, A.C. Van Harten, A. Den Braber, S. Vigneswara, M. Gouda, M.P. Van Engelen, A.W. Lemstra, Y.A.L. Pijnenbur3, W.M. Van Der Flier, M. Schut, D. Wilson
Published in: The Journal of Prevention of Alzheimer's Disease, Issue 10, 2025, Page(s) 56-240, ISSN 2274-5807
Publisher: Elsevier
DOI: 10.14283/jpad.2022.130

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