Projektbeschreibung
Den Kohlenstoffkreislauf der Meere verstehen
Obwohl marine Mikroalgen genauso viel CO2 in Form von Kohlenhydraten binden wie die Landpflanzen, ist immer noch wenig darüber bekannt, wie das Ganze auf molekularer Ebene funktioniert. Das EU-finanzierte Projekt MARINEGLYCAN wird die marine Biosphäre mithilfe eines auf chemischer Biologie und automatisierter Glykanbildung beruhenden Ansatzes untersuchen. Im Endeffekt wird MARINEGLYCAN eine nächste Generation an Instrumenten für die Entschlüsselung biologischer Informationen entwickeln, darunter Glykan-Mikroarrays, fluoreszenzmarkierte Polysaccharide, Förster-Resonanzenergietransfersonden und aktivitätsbezogene Sonden. Mit all diesen Instrumenten kann der Strom des Kohlenstoffs von der Ebene einzelner Enzyme bis hin zu voneinander abhängigen mikrobiellen Gemeinschaften systematisch erforscht werden. MARINEGLYCAN wird diese Instrumente einsetzen, um die bioaktiven Epitope sulfatierter mariner Glykane zu entdecken.
Ziel
Marine microalgae sequester as much CO2 into carbohydrates as terrestrial plants. However, the marine carbon cycle is currently not understood in molecular detail. MARINEGLYCAN seeks to explore the marine biosphere using an approach rooted in chemical biology & automated glycan assembly (AGA) by inventing new tools for deciphering biological information.
I will generate an assortment of tools: glycan microarrays, fluorescently labelled polysaccharides (FLAPS), Förster resonance energy transfer (FRET) probes, & activity-based probes (ABP) working at the Max Planck Institute (MPI) of Colloids & Interfaces in collaboration with the MPI for Marine Microbiology to allow the systematic study of the flow of carbon–from the level of individual enzymes to interdependent communities. These tools will be used to discover the bioactive epitopes of sulfated marine glycans–known to have anti-viral, anti-cancer, & neuroprotective properties. A new continuous flow photocatalytic process to access fluorinated glycans will be developed in the context of the project.
While gaining a broad range of scientific techniques including AGA & techniques used in marine glycobiology, I will gain & develop my transferable skills & expand my network. All allowing me to have a successful career in both business & academia. These skills will be obtained through workshops provided by the Max-Planck Academy, managing of PhD students & mentoring by Prof. Seeberger. The knowledge & skills I gain working on MARINEGLYCAN will provide me with the skill set to collaborate with Industry–while also carrying out basic scientific research.
MARINEGLYCAN seeks to gain a better understanding of the flow of carbon in the marine environment, allowing Europe to advance towards a green circular economy. With the potential to pave the way for the design & development of new sustainable biomaterials, biocatalysts, & medicines. MARINEGLYCAN is in line with the European Commission's & UN sustainable development goals.
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MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Koordinator
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