Description du projet
Des études high-tech de nano-immunologie et de toxicologie consacrées à des nanomatériaux 2D prometteurs
Les nanomatériaux bidimensionnels ouvrent la voie à de nouvelles technologies pour l’optoélectronique, le stockage d’énergie, la détection et bien d’autres choses, grâce à leurs propriétés électriques, magnétiques et optiques uniques. Les MXènes en font partie: il s’agit d’une nouvelle famille de carbures, carbonitrures et nitrures de métaux de transition en 2D qui se sont révélés prometteurs pour des applications telles que les systèmes de stockage d’énergie lithium-ion et sodium-ion, le blindage contre les interférences électromagnétiques et la purification de l’eau. Ils possèdent également des propriétés antibactériennes prometteuses. Avec le soutien du programme Actions Marie Skłodowska-Curie, le projet SEE mènera des études approfondies sur les effets possibles des MXènes sur la peau et le système immunitaire. Les caractérisations effectuées permettront d’ouvrir la voie à leur utilisation dans les secteurs de la biomédecine et des nanotechnologies.
Objectif
Two-dimensional (2D) transition metal carbides/carbonitrides (MXenes), discovered by the outgoing phase Supervisor, Yury Gogotsi (H-index = 160), at Drexel University (USA), have stepped into the limelight of 2D materials (2DMs). Within the SEE project, the Fellow, Dr. Laura Fusco, will learn to produce and characterize MXenes from the most recognized leader in the field. SEE will provide a thorough evaluation of the skin impact and possible immunomodulation of a wide variety of MXenes. No study has investigated at the same time and on a large scale these key aspects for MXene safety and effective use as bioelectronics or biomedical tools applied to the skin. The outstanding peculiar scientific expertise of the Fellow, relying on the characterization of 2DM effects at the skin level depending on their physicochemical properties, will be essential to achieve the project goals. The European Fellow Supervisors, Bengt Fadeel and Lucia G. Delogu, among the most influential scientists in the field of nano-immunology and toxicology, will contribute to the Fellow training by employing the most cutting edge high-dimensional technologies at the single-cell level (e.g. CyTOF, Rhapsody and Hyperion) and pioneering cell-cell analysis systems (e.g. LIPSTIC approach) in this context. The Fellow will also explore the commercial applicability of her results during a secondment at the revolutionist biotech company Fluidigm Corporation. Within SEE, the Fellow will introduce her own novel concept of “Nano-SkinImmunity-by-design”, where the analysis of the cutaneous effects when designing MXenes (and 2DMs) will not only be relevant for their safety, but will also turn them into active tools for cutaneous applications endowed of immune properties, tailorable adjusting their physicochemical profile. By exploring these crucial aspects, SEE aims at incising the strategic field of MXenes and 2DMs as well as their role in biomedicine and nanotechnology at European level and beyond.
Champ scientifique
Mots‑clés
Programme(s)
Régime de financement
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinateur
35122 Padova
Italie