B cell receptor engagement and signalling in chronic lymphocytic leukemia: identify the structural and functional requirements for disease development and progression.

Project Information

BCRES-CLL

Grant agreement ID: 101023721

DOI 10.3030/101023721

Project closed

EC signature date 1 April 2021

Start date 31 March 2022

End date 30 March 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 183 473,28

EU contribution € 183 473,28

Coordinated by

UNIVERSITA DEGLI STUDI DI GENOVA
Italy

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Altered Mitochondrial Dynamic in Lymphoblasts and Fibroblasts Mutated for FANCA-A Gene: The Central Role of DRP1

Author(s): Nadia Bertola, Silvia Bruno, Cristina Capanni, Marta Columbaro, Andrea Nicola Mazzarello, Fabio Corsolini, Stefano Regis, Paolo Degan, Enrico Cappelli and Silvia Ravera
Published in: International Journal of Molecular Sciences, 2023, ISSN 1661-6596
Publisher: MDPI
DOI: 10.3390/ijms24076557

Effects of Deacetylase Inhibition on the Activation of the Antioxidant Response and Aerobic Metabolism in Cellular Models of Fanconi Anemia

Author(s): Nadia Bertola, Stefano Regis, Silvia Bruno, Andrea Nicola Mazzarello, Martina Serra, Michela Lupia, Federica Sabatini, Fabio Corsolini, Silvia Ravera and Enrico Cappelli
Published in: Antioxidants, 2023, ISSN 2076-3921
Publisher: MDPI
DOI: 10.3390/antiox12051100

Characterizing Features of Human Circulating B Cells Carrying CLL-Like Stereotyped Immunoglobulin Rearrangements

Author(s): Davide Bagnara; Monica Colombo; Daniele Reverberi; Serena Matis; Rosanna Massara; Niccolò Cardente; Gianluca Ubezio; Vanessa Agostini; Luca Agnelli; Luca Agnelli; Antonino Neri; Martina Cardillo; Stefano Vergani; Fabio Ghiotto; Fabio Ghiotto; Andrea Nicola Mazzarello; Fortunato Morabito; Fortunato Morabito; Giovanna Cutrona; Manlio Ferrarini; Franco Fais; Franco Fais
Published in: Frontiers in Oncology, Vol 12 (2022), 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.894419

Unexpected chronic lymphocytic leukemia B cell activation by bisphosphonates

Author(s): Andrea N. Mazzarello, Elena Gugiatti, Vanessa Cossu, Nadia Bertola, Davide Bagnara, Sonia Carta, Silvia Ravera, Chiara Salvetti, Adalberto Ibatici, Fabio Ghiotto, Monica Colombo, Giovanna Cutrona, Cecilia Marini, Gianmario Sambuceti, Franco Fais, Silvia Bruno
Published in: Cancer Immunology, Immunotherapy, 2024, ISSN 0340-7004
Publisher: Springer Verlag
DOI: 10.1007/s00262-023-03588-z

CLL stereotyped B-cell receptor immunoglobulin sequences are recurrent in the B-cell repertoire of healthy individuals: Apparent lack of central and early peripheral tolerance censoring

Author(s): Stefano Vergani, Davide Bagnara, Andreas Agathangelidis, Anita Kar Yun Ng , Gerardo Ferrer, Andrea N Mazzarello, Florencia Palacios, Sophia Yancopoulos, Xiao-Jie Yan, Jaqueline C Barrientos, Kanti R Rai, Kostas Stamatopoulos, Nicholas Chiorazzi
Published in: Frontiers Media S. A., 2023, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.1112879

Old and New Facts and Speculations on the Role of the B Cell Receptor in the Origin of Chronic Lymphocytic Leukemia

Author(s): Davide Bagnara, Andrea Nicola Mazzarello, Fabio Ghiotto , Monica Colombo, Giovanna Cutrona, Franco Fais, Manlio Ferrarini
Published in: International Journal of Molecular Sciences, Vol 23, Iss 22, p 14249 (2022), 2022, ISSN 1661-6596
Publisher: MDPI
DOI: 10.3390/ijms232214249

Unexpected CD5+ B Cell Lymphocytosis during SARS-CoV-2 Infection: Relevance for the Pathophysiology of Chronic Lymphocytic Leukemia

Author(s): Andrea Nicola Mazzarello, Brisejda Koroveshi, Daniela Guardo, Lorella Lanza, Fabio Ghiotto, Silvia Bruno and Enrico Cappelli
Published in: Journal of Clinical Medicine, 2023, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm12030998

Characterization of the Intraclonal Complexity of Chronic Lymphocytic Leukemia B Cells: Potential Influences of B-Cell Receptor Crosstalk with Other Stimuli

Author(s): Andrea N. Mazzarello, Mark Fitch, Martina Cardillo, Anita Ng, Sabreen Bhuiya, Esha Sharma,Davide Bagnara, Jonathan E. Kolitz, Jacqueline C. Barrientos, Steven L. Allen, Kanti R. Rai, Joanna Rhodes, Marc K. Hellerstein and Nicholas Chiorazzi
Published in: Cancers, 2023, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15194706