Descrizione del progetto
Nuova soluzione portatile per le scarse risorse di terapia intensiva
I sistemi sanitari di tutto il mondo sono stati sopraffatti dall’ondata di pazienti gravemente malati di COVID-19 che necessitano di un ricovero in terapia intensiva. Sebbene le percentuali esatte differiscano da uno Stato membro dell’UE all’altro, il 3-12 % della popolazione infetta ha bisogno di ventilazione meccanica. La personalizzazione del trattamento consentirà un razionamento più mirato delle scarse risorse di terapia intensiva. In quest’ottica, il progetto VASCOVID, finanziato dall’UE, sta sviluppando una piattaforma portatile non invasiva per il monitoraggio della salute in tempo reale, che combina la spettroscopia a risoluzione temporale nel vicino infrarosso e la spettroscopia di correlazione diffusa. La soluzione consentirà di testare su larga scala nuove procedure di trattamento e terapie, mirando al deterioramento microvascolare. Inoltre, ridurrà l’incidenza del fallimento dell’estubazione (reintubazione entro sette giorni) in terapia intensiva.
Obiettivo
As COVID-19 spreads worldwide, the surge in patients requiring intensive care unit (ICU) admission has been overwhelming to the healthcare systems. Critical care triage to allow the rationing of scarce ICU resources is needed but is hindered due to lack of personalization. The management of acute respiratory failure and hemodynamics is critical at the ICU. In fact, of the seven million COVID-19 cases (end of May 2020) 3-12% required mechanical ventilation which forms the primary target of VASCOVID where we focus on; (1) patient stratification derived from endothelial function evaluation, and, (2) evaluation of cardiopulmonary interactions that personalizes conservative ventilation strategies in order to avoid ventilator-induced lung injury and readiness to wean from the ventilator. VASCOVID will deploy and mature our portable, non-invasive and real-time health monitoring platform for this purpose. This platform combines two bio-photonics technologies, time-resolved near-infrared spectroscopy and diffuse correlation spectroscopy, and is the fruit of long-term collaboration between core project partners in two European projects (BabyLux and LUCA) where high technology readiness level have been achieved for neuro-monitoring and thyroid cancer screening. VASCOVID will adapt the platform to meet the needs of a typical ICU dealing with COVID-19 and other patients requiring ventilation, as well as to leverage large-scale testing of new treatment procedures and therapies aimed to address microvascular impairment and to reduce extubation failure on ICU patients weaning out of mechanical ventilation life-support. The platform is easy to deploy, cost-effective and provides real-time fast results and its transition to clinical practice will be eased through this project by pushing CE certification. Our inter-disciplinary consortium is well-suited for these activities and will interact closely with our on-going clinical study spanning four countries and a dozen hospitals.
Campo scientifico
- agricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulturefruit growing
- medical and health sciencesclinical medicinecritical care medicine
- medical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses
- medical and health sciencesclinical medicineoncology
- natural sciencesphysical sciencesopticsspectroscopy
Parole chiave
Programma(i)
Invito a presentare proposte
H2020-SC1-PHE-CORONAVIRUS-2020-2
Vedi altri progetti per questo bandoBando secondario
H2020-SC1-PHE-CORONAVIRUS-2020-2-CNECT
Meccanismo di finanziamento
IA - Innovation actionCoordinatore
08860 Castelldefels
Spagna