Antibody therapy against coronavirus (COVID-19)

Risultati finali

Opinion from EAB on the WP2 clinical work

Opinion from the Ethical Advisory Board AEB on the WP2 clinical work The AEB will revise Section 51 Ethics related to the phase I trial in WP2

Project website and logo

Project website including the description of the ATAC project and consortium, as well as news and links related to the project. The logo of the ATAC project will be included.

Pubblicazioni

Human genetic and immunological determinants of SARS-CoV-2 and Epstein–Barr virus diseases in childhood: Insightful contrasts

Autori: Qiang Pan-Hammarström, Jean-Laurent Casanova
Pubblicato in: Journal of Internal Medicine, 2023, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1111/joim.13628

Humoral and cellular response before and after the fourth BNT162b2 vaccine dose in patients with solid tumors on active treatment

Autori: Lasagna A, Bergami F, Lilleri D, Percivalle E, Quaccini M, Comolli G, Sarasini A, Sammartino JC, Ferrari A, Arena F, Cicognini D, Schiavo R, Lo Cascio G, Baldanti F, Pedrazzoli P, Cassaniti I.
Pubblicato in: Annals of Oncology, 2022, Pagina/e S0923-7534, ISSN 0923-7534
Editore: Oxford University Press
DOI: 10.1016/j.annonc.2022.07.012

SARS-CoV-2 specific T-cell immunity in COVID-19 convalescent patients and unexposed controls measured by ex vivo ELISpot assay

Autori: Irene Cassaniti, Elena Percivalle, Federica Bergami, Antonio Piralla, Giuditta Comolli, Raffaele Bruno, Marco Vecchia, Margherita Sambo, Marta Colaneri, Valentina Zuccaro, Marco Benazzo, Carlo Robotti, Anna Calastri, Eugenia Maiorano, Alessandro Ferrari, Giuseppe Cambiè, Fausto Baldanti
Pubblicato in: Clinical Microbiology and Infection, 2021, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2021.03.010

Six-month humoral and cellular immune response to the third dose of BNT162b2 anti-SARS-CoV-2 vaccine in patients with solid tumors: a longitudinal cohort study with a focus on the variants of concern

Autori: Lasagna A, Bergami F, Lilleri D, Percivalle E, Quaccini M, Serra F, Comolli G, Sarasini A, Sammartino JC, Ferrari A, Arena F, Secondino S, Cicognini D, Schiavo R, Lo Cascio G, Cavanna L, Baldanti F, Pedrazzoli P, Cassaniti I
Pubblicato in: ESMO Open, Numero 7, 2022, Pagina/e 100574, ISSN 2059-7029
Editore: Elsevier
DOI: 10.1016/j.esmoop.2022.100574

Characteristics and outcome of vaccinated and non-vaccinated patients hospitalized in a single Italian HUB for COVID-19 during the Delta and Omicron waves in Northern Italy

Autori: Francesca Rovida, Giuliana Lucia Esposito, Marco Rissone, Viola Novelli, Sara Cutti, Alba Muzzi, Claudia Rona, Emanuela Bertoli, Marinella Daglio, Antonio Piralla, Stefania Paolucci, Giulia Campanini, Guglielmo Ferrari, Federica Giardina, Federica Zavaglio, Daniele Lilleri, Anna Maria Grugnetti, Giuseppina Grugnetti, Anna Odone, Carlo Marena, Fausto Baldanti
Pubblicato in: International Journal of Infectious Diseases, Numero 122, 2022, Pagina/e 420-426, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1016/j.ijid.2022.06.028

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

Autori: Matteo Stravalaci, Isabel Pagani, Elvezia Maria Paraboschi, Mattia Pedotti, Andrea Doni, Francesco Scavello, Sarah N. Mapelli, Marina Sironi, Chiara Perucchini, Luca Varani, Milos Matkovic, Andrea Cavalli, Daniela Cesana, Pierangela Gallina, Nicoletta Pedemonte, Valeria Capurro, Nicola Clementi, Nicasio Mancini, Pietro Invernizzi, Rafael Bayarri-Olmos, Peter Garred, Rino Rappuoli, Stefano Duga, Ba
Pubblicato in: Nature Immunology, Numero 23, 2022, Pagina/e 275-286, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-021-01114-w

X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia

Autori: Hassan Abolhassani, Ahmad Vosughimotlagh, Takaki Asano, Nils Landegren, Bertrand Boisson, Samaneh Delavari, Paul Bastard, Maribel Aranda‑Guillén, Yating Wang, Fanglei Zuo, Fabian Sardh, Harold Marcotte, Likun Du, Shen‑Ying Zhang, Qian Zhang, Nima Rezaei, Olle Kämpe, Jean‑Laurent Casanova, Lennart Hammarström, Qiang Pan‑Hammarström
Pubblicato in: Journal of Clinical Immunology, 2021, ISSN 0271-9142
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-021-01151-y

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

Autori: Yeonsu Kim, Xiaoyan Zheng, Kathrin Eschke, M Zeeshan Chaudhry, Federico Bertoglio, Adriana Tomić, Astrid Krmpotić, Markus Hoffmann, Yotam Bar-On, Julia Boehme, Dunja Bruder, Thomas Ebensen , Linda Brunotte , Stephan Ludwig, Martin Messerle, Carlos Guzman, Ofer Mandelboim, Michael Hust, Stefan Pöhlmann, Stipan Jonjić, Luka Čičin-Šain
Pubblicato in: Cellular and Molecular Immunology, Numero 19, 2022, Pagina/e 234-244, ISSN 1672-7681
Editore: Nature Publishing Group
DOI: 10.1038/s41423-021-00814-5

Evaluation of the Neutralizing Antibodies Response against 14 SARS-CoV-2 Variants in BNT162b2 Vaccinated Naïve and COVID-19 Positive Healthcare Workers from a Northern Italian Hospital

Autori: Josè Camilla Sammartino, Irene Cassaniti, Alessandro Ferrari, Federica Giardina, Guglielmo Ferrari, Federica Zavaglio, Stefania Paolucci, Daniele Lilleri, Antonio Piralla, Fausto Baldanti and Elena Percivalle
Pubblicato in: Vaccines, Numero 10, 2022, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10050703

A snapshot of the immunogenicity, efficacy and safety of a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors: a longitudinal cohort study

Autori: A. Lasagna, F. Agustoni, E. Percivalle, S. Borgetto, A. Paulet, G. Comolli, A. Sarasini, F. Bergami, J. C. Sammartino, A. Ferrari, F. Zavaglio, F. Arena, D. Lilleri, S. Secondino, M. Falzoni, R. Schiavo, C. Klersy, G. Lo Cascio, L. Cavanna, F. Baldanti, P. Pedrazzoli, I. Cassaniti
Pubblicato in: ESMO Open, Numero Volume 6, Numero 5, 2021, Pagina/e 100272, ISSN 0923-7534
Editore: Oxford University Press
DOI: 10.1016/j.esmoop.2021.100272

SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects

Autori: Yating Wang, Hassan Abolhassani, Lennart Hammarström, and Qiang Pan-Hammarström
Pubblicato in: Acta Biochimica et Biophysica Sinica,, Numero 54, 2022, Pagina/e 836-846, ISSN 1672-9145
Editore: Institute of Biochemistry and Cell Biology
DOI: 10.3724/abbs.2022071

Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome

Autori: Hassan Abolhassani, Nils Landegren, Paul Bastard, Marie Materna, Mohammadreza Modaresi, Likun Du, Maribel Aranda Guillén, Fabian Sardh, Fanglei Zuo, Peng Zhang, Harold Marcotte, Nico Marr, Taushif Khan, Manar Ata, Fatima Al Ali, Remi Pescarmona, Alexandre Belot, Vivien Béziat, Qian Zhang, Jean Laurent Casanova, Olle Kämpe, Shen Ying Zhang, Lennart Hammarström, Qiang Pan Hammarström
Pubblicato in: Journal of Clinical Immunology, 2022, Pagina/e 1-13, ISSN 0271-9142
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-022-01215-7

Heterologous inactivated virus/mRNA vaccination response to BF.7, BQ.1.1, and XBB.1

Autori: Fanglei Zuo, Rui Sun, Hassan Abolhassani, Likun Du, Yating Wang, Stelios Vlachiotis, Federico Bertoglio, Maren Schubert, Nima Rezaei, Zahra Chavoshzadeh, Concetta Guerra, Andrea Cavalli, Juni Andréll, Makiko Kumagai-Braesch, Yintong Xue, Yunlong Cao, Michael Hust, Davide F. Robbiani, Xiaoliang Sunney Xie, Lennart Hammarström, Harold Marcotte, and Qiang Pan-Hammarström
Pubblicato in: The Lancet Regional Health - Western Pacific, Numero 33, 2023, Pagina/e 100762, ISSN 2666-6065
Editore: Elsevier Ltd.
DOI: 10.1016/j.lanwpc.2023.100762

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

Autori: Federico Bertoglio, Doris Meier, Nora Langreder, Stephan Steinke, Ulfert Rand, Luca Simonelli, Philip Alexander Heine, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Maximilian Ruschig, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Dorina Schäckermann, Mattia Pedotti, Philipp Kuhn, Susanne Zock-Emmenthal, Johannes Wöhrle, Normann Kilb, Tobias Herz, Marlies Becker, Martina Grasshoff,
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21609-2

Immunogenicity and safety after the third dose of BNT162b2 anti-SARS-CoV-2 vaccine in patients with solid tumors on active treatment: a prospective cohort study

Autori: A. Lasagna, F. Bergami, D. Lilleri, E. Percivalle, M. Quaccini, N. Alessio, G. Comolli, A. Sarasini, J. C. Sammartino, A. Ferrari, F. Arena, S. Secondino, D. Cicognini, R. Schiavo, G. Lo Cascio, L. Cavanna, F. Baldanti, P. Pedrazzoli, I. Cassaniti
Pubblicato in: ESMO Open, Numero 7, 2022, ISSN 0020-0255
Editore: Elsevier BV
DOI: 10.1016/j.esmoop.2022.100458

Baculovirus-Free SARS-CoV-2 Virus-like Particle Production in Insect Cells for Rapid Neutralization Assessment

Autori: by Marcel Jaron, Michael Lehky, Marta Zarà, Chris Nicole Zaydowicz, Aidin Lak, Rico Ballmann, Philip Alexander Heine, Esther Veronika Wenzel, Kai-Thomas Schneider, Federico Bertoglio, Susanne Kempter, Reinhard Wolfgang Köster, Silvia Stella Barbieri, Joop van den Heuvel, Michael Hust, Stefan Dübel and Maren Schubert
Pubblicato in: Viruses, Numero 14(10), 2022, Pagina/e 1-16, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14102087

Incidence of SARS-CoV-2 infection in health care workers from Northern Italy based on antibody status: immune protection from secondary infection- A retrospective observational case-controlled study

Autori: Francesca Rovida, Irene Cassaniti, Elena Percivalle, Antonella Sarasini, Stefania Paolucci, Catherine Klersy, Sara Cutti, Viola Novelli, Carlo Marena, Francesco Luzzaro, Giovanni De Vito, Roberta Schiavo, Giuliana Lo Cascio, Daniele Lilleri, Faust Baldanti
Pubblicato in: International Journal of Infectious Diseases, 2021, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/j.ijid.2021.07.003

Analysis of the humoral and cellular immune response after a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors with or without chemotherapy: an update after 6 months of follow-up

Autori: Lasagna A, Lilleri D, Agustoni F, Percivalle E, Borgetto S, Alessio N, Comolli G, Sarasini A, Bergami F, Sammartino JC, Ferrari A, Zavaglio F, Arena F, Secondino S, Falzoni M, Schiavo R, Lo Cascio G, Cavanna L, Baldanti F, Pedrazzoli P, Cassaniti I.
Pubblicato in: ESMO Open, Numero 7, 2022, Pagina/e 100359, ISSN 2059-7029
Editore: Elsevier B.V.
DOI: 10.1016/j.esmoop.2021.100359

Enhanced SARS-CoV-2 neutralization by dimeric IgA

Autori: Zijun Wang, Julio C. C. Lorenzi, Frauke Muecksch, Shlomo Finkin, Charlotte Viant, Christian Gaebler, Melissa Cipolla, Hans-Heinrich Hoffmann, Thiago Y. Oliveira, Deena A. Oren, Victor Ramos, Lilian Nogueira, Eleftherios Michailidis, Davide F. Robbiani, Anna Gazumyan, Charles M. Rice, Theodora Hatziioannou, Paul D. Bieniasz, Marina Caskey, Michel C. Nussenzweig
Pubblicato in: Science Translational Medicine, 2020, Pagina/e eabf1555, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abf1555

Antibody therapy for COVID-19

Autori: Lennart Hammarstrom, Harold Marcotte, Antonio Piralla, Fausto Baldanti, Qiang Pan Hammarström
Pubblicato in: Current Opinion in Allergy Clinical Immunology, Numero 21, 2022, Pagina/e 553-558, ISSN 1528-4050
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/aci.0000000000000787

Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant

Autori: Maren Schubert; Federico Bertoglio; Stephan Steinke; Philip Alexander Heine; Mario Alberto Ynga-Durand; Henrike Maass; Josè Camilla Sammartino; Irene Cassaniti; Fanglei Zuo; Likun Du; Janin Korn; Marko Milošević; Esther Veronika Wenzel; Fran Krstanović; Saskia Polten; Marina Pribanić-Matešić; Ilija Brizić; Fausto Baldanti; Lennart Hammarström; Stefan Dübel; Alan Šustić; Harold Marcotte
Pubblicato in: BMC Biomedicine, Numero 20, 2022, Pagina/e 102, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-022-02312-5

Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein

Autori: Filippo Bianchini, Virginia Crivelli, Morgan E. Abernathy, Concetta Guerra, Martin Palus,Jonathan Muri, Harold Marcotte, Antonio Piralla, Mattia Pedotti, Raoul De Gasparo, Luca Simonelli, Milos Matkovic, Chiara Toscano, Maira Biggiogero, Veronica Calvaruso, Pavel Svoboda, Tomás Cervantes Rincón, Tommaso Fava, Lucie Podešvová, Akanksha A. Shanbhag, Andrea Celoria, Jacopo Sgrignani, Michal St
Pubblicato in: Science Immunology, Numero eade0958, 2023, ISSN 2470-9468
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciimmunol.ade0958

Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19

Autori: Hassan Abolhassani, Samaneh Delavari, Nils Landegren, Sima Shokri, Paul Bastard, Likun Du, Fanglei Zuo, Reza Hajebi, Farhad Abolnezhadian, Sara Iranparast, Mohammadreza Modaresi, Ahmad Vosughimotlagh, Fereshte Salami, Maribel Aranda-Guillen, Aurelie Cobat, Harold Marcotte, Shen-Ying Zhang, MD, Qian Zhang, Nima Rezaei, Jean-Laurent Casanova, Olle Kampe, Lennart Hammarstrom, and Qiang Pan-Hammarstro
Pubblicato in: The Journal of Allergy and Clinical Immunology, Numero 150 (5), 2022, Pagina/e 1059-1073, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2022.09.005

Impact of immunosuppressive treatment on the immunogenicity of mRNA COVID-19 vaccine in vulnerable patients with giant cell arteritis

Autori: Paolo Delvino, Alice Bartoletti, Irene Cassaniti, Federica Bergami, Daniele Lilleri, Fausto Baldanti, Emanuele Bozzalla Cassione, Alessandro Biglia, Carlomaurizio Montecucco, Sara Monti
Pubblicato in: Rheumatology, 2021, ISSN 1462-0324
Editore: Oxford University Press
DOI: 10.1093/rheumatology/keab776

19n01, a broadly neutralizing antibody against omicron BA.1, BA.2, BA.4/5, and other SARS-CoV-2 variants of concern

Autori: Melissa Garcıa-Vega, Edgar A. Melgoza-Gonzalez, Sofıa Hernandez-Valenzuela, Diana Hinojosa-Trujillo, Monica Resendiz-Sandoval, Mara Anais Llamas-Covarrubias, Martın Loza-Lopez,Olivia Valenzuela, Alan Soto-Gaxiola, Miguel A. Hernandez-Onate, Veronica Mata-Haro, Irene Cassaniti, Jose Camilla Sammartino, Alessandro Ferrari, Luca Simonelli, Mattia Pedotti, Rui Sun, Fanglei Zuo, Fausto Baldanti, Luc
Pubblicato in: iScience, Numero 26, 2023, Pagina/e 10562, ISSN 2589-0042
Editore: Elsevier
DOI: 10.1016/j.isci.2023.106562

Limited cross-variant neutralization after primary Omicron infection: consideration for a variant-containing booster

Autori: Harold Marcotte, Qiang Pan-Hammarström, Lennart Hammarström
Pubblicato in: Signal Transduction and Targeted Therapy, Numero 7, 2022, Pagina/e 294, ISSN 2095-9907
Editore: Springer Nature
DOI: 10.1038/s41392-022-01146-0

ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens

Autori: Colin R. Zamecnik, Jayant V. Rajan, Kevin A. Yamauchi, Sabrina A. Mann, Rita P. Loudermilk, Gavin M. Sowa, Kelsey C. Zorn, Bonny D. Alvarenga, Christian Gaebler, Marina Caskey, Mars Stone, Philip J. Norris, Wei Gu, Charles Y. Chiu, Dianna Ng, James R. Byrnes, Xin X. Zhou, James A. Wells, Davide F. Robbiani, Michel C. Nussenzweig, Joseph L. DeRisi, Michael R. Wilson
Pubblicato in: Cell Reports Medicine, Numero 1/7, 2020, Pagina/e 100123, ISSN 2666-3791
Editore: Cell press
DOI: 10.1016/j.xcrm.2020.100123

Spread of multiple SARS-CoV-2 lineages April-August 2020 anticipated the second pandemic wave in Lombardy (Italy)

Autori: Monica Tallarita, Federica Giardina, Federica Novazzi, Stefano Gaiarsa, Gherard Batisti Biffignandi, Stefania Paolucci ,Francesca Rovida, Antonio Piralla, Fausto Baldanti
Pubblicato in: Pediatric Allergy and Immunology, Numero 33, 2022, Pagina/e 89-92, ISSN 0905-6157
Editore: Blackwell Publishing Inc.
DOI: 10.1111/pai.13641

Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Autori: Jonathan Muri, Valentina Cecchinato, Andrea Cavalli, Akanksha A Shanbhag, Milos Matkovic, Maira Biggiogero, Pier Andrea Maida, Jacques Moritz, Chiara Toscano, Elaheh Ghovehoud , Raffaello Furlan, Franca Barbic, Antonio Voza, Guendalina De Nadai, Carlo Cervia, Yves Zurbuchen, Patrick Taeschler, Lilly A Murray, Gabriela Danelon-Sargenti, Simone Moro, Tao Gong, Pietro Piffaretti, Filippo Bianchini, V
Pubblicato in: Nature Immunology, Numero 24, 2023, Pagina/e 604-611, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-023-01445-w

Developing Recombinant Antibodies by Phage Display Against Infectious Diseases and Toxins for Diagnostics and Therapy

Autori: Kristian Daniel Ralph Roth, Esther Veronika Wenzel, Maximilian Ruschig, Stephan Steinke, Nora Langreder, Philip Alexander Heine, Kai-Thomas Schneider, Rico Ballmann, Viola Fühner, Philipp Kuhn, Thomas Schirrmann, André Frenzel, Stefan Dübel, Maren Schubert, Gustavo Marçal Schmidt Garcia Moreira, Federico Bertoglio, Giulio Russo, Michael Hust
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 11, 2021, Pagina/e 697876, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2021.697876

The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and quality under TNFα blockade.

Autori: Geisen UM, Rose R, Neumann F, Ciripoi M, Vullriede L, Reid HM, Berner DK, Bertoglio F, Hoff P, Hust M, Longardt AC, Lorentz T, Martini GR, Saggau C, Schirmer JH, Schubert M, Sümbül M, Tran F, Voß M, Zeuner R, Morrison PJ, Bacher P, Fickenscher H, Gerdes S, Peipp M, Schreiber S, Krumbholz A, Hoyer BF
Pubblicato in: Journal of Medical Virology, 2022, ISSN 0146-6615
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmv.28063

Adapting Neutralizing Antibodies to Viral Variants by Structure-Guided Affinity Maturation Using Phage Display Technology

Autori: Frederik Peissert, Mattia Pedotti, Riccardo Corbellari, Luca Simonelli, Raoul De Gasparo, Elia Tamagnini, Louis Plüss, Abdullah Elsayed, Mattia Matasci, Roberto De Luca, Irene Cassaniti, Jose’ Camilla Sammartino, Antonio Piralla, Fausto Baldanti, Dario Neri, Luca Varani
Pubblicato in: Global Challenges, 2023, ISSN 2056-6646
Editore: Wiley-VCH GmbH
DOI: 10.1002/gch2.202300088

Assessing the Efficacy of Early Therapies against SARS-CoV-2 in Hematological Patients: A Real-Life Study from a COVID-19 Referral Centre in Northern Italy

Autori: Marta Colaneri,Teresa Chiara, Pieri,Silvia Roda, Alessandra Ricciardi, Manuel Gotti, Jacqueline Ferrari, Luca Arcaini, Sara Rattotti, Antonio Piralla, Federica Giardina, Guglielmo Ferrari, Paolo Sacchi, Valentina Zuccaro, Fausto Baldanti, and Raffaele Bruno
Pubblicato in: Journal of Clinical Medicine, Numero 11(24), 2022, Pagina/e 1-12, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11247452

Mucosal IgA against SARS-CoV-2 Omicron Infection

Autori: Fanglei Zuo, Harold Marcotte, Lennart Hammarström, Qiang Pan-Hammarström
Pubblicato in: New England Journal Medecine, Numero 387, 2022, Pagina/e e55, ISSN 0028-4793
Editore: Massachusetts Medical Society
DOI: 10.1056/nejmc2213153

Development of passive immunity against SARS-CoV-2 for management of immunodeficient patients—a perspective

Autori: Lennart Hammarström, Hassan Abolhassani, Fausto Baldanti, Harold Marcotte, Qiang Pan-Hammarström
Pubblicato in: Journal of Allergy and Clinical Immunology, 2020, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2020.04.043

Prevalence of SARS-CoV-2 specific neutralising antibodies in blood donors from the Lodi Red Zone in Lombardy, Italy, as at 06 April 2020

Autori: Elena Percivalle, Giuseppe Cambiè, Irene Cassaniti, Edoardo Vecchio Nepita, Roberta Maserati, Alessandro Ferrari, Raffaella Di Martino, Paola Isernia, Francesco Mojoli, Raffaele Bruno, Marcello Tirani, Danilo Cereda, Carlo Nicora, Massimo Lombardo, Fausto Baldanti
Pubblicato in: Eurosurveillance, Numero 25/24, 2020, ISSN 1560-7917
Editore: European Centre for Disease Prevention and Control (ECDC)
DOI: 10.2807/1560-7917.es.2020.25.24.2001031

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

Autori: Davide F. Robbiani, Christian Gaebler, Frauke Muecksch, Julio C. C. Lorenzi, Zijun Wang, Alice Cho, Marianna Agudelo, Christopher O. Barnes, Anna Gazumyan, Shlomo Finkin, Thomas Hägglöf, Thiago Y. Oliveira, Charlotte Viant, Arlene Hurley, Hans-Heinrich Hoffmann, Katrina G. Millard, Rhonda G. Kost, Melissa Cipolla, Kristie Gordon, Filippo Bianchini, Spencer T. Chen, Victor Ramos, Roshni Patel, Ju
Pubblicato in: Nature, 2020, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2456-9

Residual SARS-CoV-2 RNA in nasal swabs of convalescent COVID-19 patients: Is prolonged quarantine always justified?

Autori: Antonio Piralla, Matteo Ricchi, Maria Grazia Cusi, Paola Prati, Nadia Vicari, Giada Scarsi, Claudia Gandolfo, Gabriele Anichini, Chiara Terrosi, Elena Percivalle, Edoardo Vecchio Nepita, Federica Bergami, Monica Tallarita, Raffaella Di Martino, Alessandro Ferrari, Francesca Rovida, Giovanna Lunghi, Roberta Schiavo, Fausto Baldanti
Pubblicato in: International Journal of Infectious Diseases, Numero 102, 2021, Pagina/e 299-302, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/j.ijid.2020.10.072

Evolution of antibody immunity to SARS-CoV-2

Autori: Christian Gaebler, Zijun Wang, Julio C. C. Lorenzi, Frauke Muecksch, Shlomo Finkin, Minami Tokuyama, Alice Cho, Mila Jankovic, Dennis Schaefer-Babajew, Thiago Y. Oliveira, Melissa Cipolla, Charlotte Viant, Christopher O. Barnes, Yaron Bram, Gaëlle Breton, Thomas Hägglöf, Pilar Mendoza, Arlene Hurley, Martina Turroja, Kristie Gordon, Katrina G. Millard, Victor Ramos, Fabian Schmidt, Yiska Weis
Pubblicato in: Nature, Numero 591/7851, 2021, Pagina/e 639-644, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03207-w

Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

Autori: Raoul De Gasparo, Mattia Pedotti, Luca Simonelli, Petr Nickl, Frauke Muecksch, Irene Cassaniti, Elena Percivalle, Julio C. C. Lorenzi, Federica Mazzola, Davide Magrì, Tereza Michalcikova, Jan Haviernik, Vaclav Honig, Blanka Mrazkova, Natalie Polakova, Andrea Fortova, Jolana Tureckova, Veronika Iatsiuk, Salvatore Di Girolamo, Martin Palus, Dagmar Zudova, Petr Bednar, Ivana Bukova, Filippo Bianchin
Pubblicato in: Nature, 2021, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03461-y

SARS-CoV-2 variants inactivation of plasma units using a riboflavin and ultraviolet light-based photochemical treatment

Autori: Alessandro Ferrari, Irene Cassanitia, Josè Camilla Sammartino, Cristina Mortellaro, Claudia Del Fante, Simona De Vitis Eugenio Barone, DanielaTroletti, Federica Prati, Fausto Baldanti, Elena Percivalle, Perotti Cesare
Pubblicato in: Transfusion and Apheresis Science, 2022, ISSN 0020-0255
Editore: Elsevier BV
DOI: 10.1016/j.transci.2022.103398

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

Autori: Allison J. Greaney, Tyler N. Starr, Christopher O. Barnes, Yiska Weisblum, Fabian Schmidt, Marina Caskey, Christian Gaebler, Alice Cho, Marianna Agudelo, Shlomo Finkin, Zijun Wang, Daniel Poston, Frauke Muecksch, Theodora Hatziioannou, Paul D. Bieniasz, Davide F. Robbiani, Michel C. Nussenzweig, Pamela J. Bjorkman, Jesse D. Bloom
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24435-8

Humoral and cell-mediated response against SARS-CoV-2 variants elicited by mRNA vaccine BNT162b2 in healthcare workers: a longitudinal observational study

Autori: Irene Cassaniti, Federica Bergami, Elena Percivalle, Elisa Gabanti, Josè Camilla Sammartino, Alessandro Ferrari, Kodjo Messan Guy Adzasehoun, Federica Zavaglio, Paola Zelini, Giuditta Comolli, Antonella Sarasini, Antonio Piralla, Alessandra Ricciardi, Valentina Zuccaro, Fabrizio Maggi, Federica Novazzi, Luca Simonelli, Luca Varani, Daniele Lilleri, Fausto Baldanti
Pubblicato in: Clinical Microbiology and Infection, 2022, Pagina/e 301.e1-301.e8, ISSN 1469-0691
Editore: Elsevier
DOI: 10.1016/j.cmi.2021.09.016

SARS-CoV-2–specific B- and T-cell immunity in a population-based study of young Swedish adults

Autori: Sophia Bjorkander, Likun Du, Fanglei Zuo, Sandra Ekstrom, Yating Wang, Hui Wan, Natalia Sherina, Lisanne Schoutens, Juni Andrell, Niklas Andersson, Antonios Georgelis, Anna Bergstrom, Harold Marcotte, Inger Kull, Lennart Hammarstrom, Erik Melen, and Qiang Pan-Hammarstrom, for the BAMSECOVID-19 study group
Pubblicato in: The Journal of Allergy and Clinical Immunology, Numero 149, 2022, Pagina/e 65-75.e8, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2021.10.014

Immune Response to BNT162b2 in Solid Organ Transplant Recipients: Negative Impact of Mycophenolate and High Responsiveness of SARS-CoV-2 Recovered Subjects against Delta Variant

Autori: Irene Cassaniti, Federica Bergami, Francesca Arena, Jose Camilla Sammartino, Alessandro Ferrari, Federica Zavaglio, Irene Curti, Elena Percivalle, Federica Meloni, Laura Pandolfi, Carlo Pellegrini, Annalisa Turco, Elena Seminari, Eleonora Francesca Pattonieri, Marilena Gregorini, Teresa Rampino, Antonella Sarasini, Daniele Lilleri, and Fausto Baldanti
Pubblicato in: Microorganisms, Numero 9, 2021, Pagina/e 2622, ISSN 2076-2607
Editore: MDPI
DOI: 10.3390/microorganisms9122622

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses

Autori: Fabian Schmidt, Yiska Weisblum, Frauke Muecksch, Hans-Heinrich Hoffmann, Eleftherios Michailidis, Julio C.C. Lorenzi, Pilar Mendoza, Magdalena Rutkowska, Eva Bednarski, Christian Gaebler, Marianna Agudelo, Alice Cho, Zijun Wang, Anna Gazumyan, Melissa Cipolla, Marina Caskey, Davide F. Robbiani, Michel C. Nussenzweig, Charles M. Rice, Theodora Hatziioannou, Paul D. Bieniasz
Pubblicato in: Journal of Experimental Medicine, Numero 217/11, 2020, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20201181¨

ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein

Autori: Rico Ballmann, Sven-Kevin Hotop, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine, M. Zeeshan Chaudhry, Dieter Jahn, Boas Pucker, Fausto Baldanti, Antonio Piralla, Maren Schubert, Luka Ciˇcin-Šain, Mark Brönstrup, Michael Hust, and Stefan Dübel
Pubblicato in: Viruses, Numero 14, 2022, Pagina/e 1326, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14061326

Impact of Viral Decontamination Method on Cytokine Profile of COVID-19 Patients

Autori: Anna Navarro, Federica Bergami, Elena Percivalle, Alessandro Ferrari, Teresa Lettieri, Luigi Calzolai, Antonio Piralla, Fausto Baldanti and Sabrina Gioria
Pubblicato in: Biomedicines, Numero 9, 2021, Pagina/e 1287, ISSN 2227-9059
Editore: MDPI AG
DOI: 10.3390/biomedicines9101287

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations

Autori: Federico Bertoglio, Viola Fühner, Maximilian Ruschig, Philip Alexander Heine, Leila Abassi, Thomas Klünemann, Ulfert Rand, Doris Meier, Nora Langreder, Stephan Steinke, Rico Ballmann , Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Philipp Kuhn, Peggy Riese, Dorina Schäckermann, Janin Korn, Allan Koch, M Zeeshan Chaudhry, Kathrin Eschke, Yeonsu Kim, Susanne Zock-Emmenthal, Marlies Becker, Ma
Pubblicato in: Cell Report, Numero 36, 2021, Pagina/e 109433, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109433

A retrospective study assessing the characteristics of COVID‐19 convalescent plasma donors and donations

Autori: Claudia Del Fante, Massimo Franchini, Fausto Baldanti, Elena Percivalle, Claudia Glingani, Giuseppe Marano, Carlo Mengoli, Cristina Mortellaro, Gianluca Viarengo, Cesare Perotti, Giancarlo Maria Liumbruno
Pubblicato in: Transfusion, Numero 61/3, 2021, Pagina/e 830-838, ISSN 0041-1132
Editore: Blackwell Publishing Inc.
DOI: 10.1111/trf.16208

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

Autori: Weisblum Y, Schmidt F, Zhang F, DaSilva J, Poston D, Lorenzi JC, Muecksch F, Rutkowska M, Hoffmann HH, Michailidis E, Gaebler C, Agudelo M, Cho A, Wang Z, Gazumyan A, Cipolla M, Luchsinger L, Hillyer CD, Caskey M, Robbiani DF, Rice CM, Nussenzweig MC, Hatziioannou T, Bieniasz PD.
Pubblicato in: Elife, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.61312

Seroprevalence of SARS-CoV-2 in blood donors from the Lodi Red Zone and adjacent Lodi metropolitan and suburban area

Autori: Irene Cassaniti, Elena Percivalle, Antonella Sarasini, Giuseppe Cambiè, Edoardo Vecchio Nepita, Roberta Maserati, Alessandro Ferrari, Alfonso Corcione, Raffaella Di Martino, Alice Bonetti, Annapia Di Napoli, Guglielmo Ferrari, Fausto Baldanti
Pubblicato in: Clinical Microbiology and Infection, 2021, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2021.01.030

Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6–8 months after the infection

Autori: Natalia Sherina, Antonio Piralla, Likun Du, Hui Wan, Makiko Kumagai-Braesch, Juni Andréll, Sten Braesch-Andersen, Irene Cassaniti, Elena Percivalle, Antonella Sarasini, Federica Bergami, Raffaella Di Martino, Marta Colaneri, Marco Vecchia, Margherita Sambo, Valentina Zuccaro, Raffaele Bruno, Michele Sachs, Tiberio Oggionni, Federica Meloni, Hassan Abolhassani, Federico Bertoglio, Maren Schubert,
Pubblicato in: Med, Numero 2/3, 2021, Pagina/e 281-295.e4, ISSN 2666-6340
Editore: Cell pres
DOI: 10.1016/j.medj.2021.02.001

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant.

Autori: Fanglei Zuo, Hassan Abolhassani, Likun Du, Antonio Piralla, Federico Bertoglio, Leire de Campos-Mata, Hui Wan, Maren Schubert, Irene Cassaniti, Yating Wang, Josè Camilla Sammartino, Rui Sun, Stelios Vlachiotis, Federica Bergami, Makiko Kumagai-Braesch, Juni Andréll, Zhaoxia Zhang, Yintong Xue, Esther Veronika Wenzel, Luigi Calzolai, Luca Varani, Nima Rezaei, Zahra Chavoshzadeh, Fausto Baldanti,
Pubblicato in: Nature Communications, Numero 13, 2022, Pagina/e 2670, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-30340-5

Differential Kinetics of Effector and Memory Responses Induced by Three Doses of SARS-CoV-2 mRNA Vaccine in a Cohort of Healthcare Workers

Autori: Federica Bergami; Francesca Arena; Josè Camilla Sammartino; Alessandro Ferrari; Federica Zavaglio; Paola Zelini; Stefania Paolucci; Giuditta Comolli; Elena Percivalle; Daniele Lilleri; Irene Cassaniti; Fausto Baldanti
Pubblicato in: Vaccines; Volume 10; Numero 11; Pages: 1809, Numero 10, 2022, Pagina/e 1-11, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10111809

Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

Autori: Rosanna Asselta, Elvezia Maria Paraboschi, Matteo Stravalaci, Pietro Invernizzi , Paolo Bonfanti, Andrea Biondi, Isabel Pagani, Mattia Pedotti, Andrea Doni, Francesco Scavello, Sarah N. Mapelli, Marina Sironi, Chiara Perucchini, Luca Varani , Milos Matkovic, Andrea Cavalli, Daniela Cesana, Pierangela Gallina, Nicoletta Pedemonte, Valeria Capurro, Nicola Clementi, Nicasio Mancini, Rafael Bayarr
Pubblicato in: Nature Immunology, Numero 23, 2022, Pagina/e 865-867, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-022-01227-w

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