Could we train our brains to see new colours?
For birders struggling to differentiate between male and female blue tits, the answer lies here. The crest of the male actually appears as ultraviolet (UV) to other tits, a distinction invisible to us humans. Alongside other primates, our vision only comes in three colours: red, green and blue. Many other mammals usually see in two (blue and green), while birds see a mix of four (red, green, blue and UV). If our brains can take three primary inputs and turn them into all the colours we perceive, could a bit of extra mental work unlock new hues?
Eyeing up evolution
Eyes, as we know and love them today, likely started their evolutionary journey 800 million years ago, in some of the Earth’s earliest organisms. “These ancestral creatures lived in water, so being able to recognise light sources – to differentiate day from night and indicate depth – would benefit survival,” says Baden. Consequently, evolution mutated a melatonin receptor into an opsin protein, which became the basis of almost all light receptors, leading to the vertebrate retina, over 500 million years ago during the Cambrian explosion. Fascinated by the evolution of the classic vertebrate visual system, Baden used two-photon imaging and computational analysis, alongside fieldwork with specialised cameras and light meters, to study zebra fish as models of our early ancestors. “Zebra fish have four colour receptors, known as cone cells – red, green, blue and UV, each with a distinct role to play. We found that red cones sense brightness; green and blue sense colour; while UV helps identify food. Crucially, all of the colour perception processing happens at the output synapse of the photoreceptors – in the retina itself,” explains Baden.
A product of our perception
Our visual arrangement contrasts markedly with zebra fish, whose four retinal cones function as neurons, each with distinct cell surface proteins, making the task of differentiating wavelength input direct and so, easy. The human retina has three colour receptors, each sensitive to different parts of the light spectrum. One short-wavelength cone responds to light perceived as blue. Of the other two, a middle-wavelength cone ‘senses’ green, while the remaining long-wavelength cone ‘senses’ red.
But unlike zebra fish, these are only the first stage of our colour perception.
While the ‘blue’ retina cone is distinct, the other two - nominally ‘green’ and ‘red’ - are in fact both ‘red’ cones - an original and a duplicate which responding to a slightly different wavelength senses green. Crucially, from an evolutionary and molecular perspective, they are identical. “Consequently, the retinal circuit can’t differentiate between them and so it outsources the problem to the brain. How this process works remains a mystery but likely involves a kind of algorithm established in early infant development,” notes Baden.
The brainy reason we can’t extend our colour space
But if our sense of colour is produced by the brain decoding photoreceptor signals, why can’t the neural processing be taught, or evolve, to expand our colour space, like tweaking software to manipulate digital images? “When the brain compares a cone’s signals to produce colour sensation, it guestimates the original wavelength. To achieve this, neural circuits need to know which photoreceptor they are listening to,” says Baden. “There are already so few signals to work with, yet our big brains have learned to do so. Overall the brain has likely pushed this as far as possible and is now hardwired to work with the existing wavelengths of our cones.” Ultimately even sophisticated algorithms are limited by their inputs, suggesting that the only way to expand our colour space would be to change our retinal inputs. But if evolution were ever to confer on us our lost ancestral vision, enabling us to see UV for example, this might necessitate a trade-off – increased risk of cancer, for example. Surprisingly virtually all modern vertebrates – fish, amphibians, reptiles and birds – have actually retained the full complement of ancestral colour receptors. “Far from being the gold standard of colour vision, mammals, including us, are actually the outliers, probably the result of evolutionary survival tactics going back to the age of the dinosaurs! The real question isn’t how could we see more, but how can we see as much as we do, with the little we have?” Baden concludes. Click here to find out more about Baden’s research: Seeing the world through the eyes of a fish
Keywords
NeuroVisEco, eye, colour, retina, cone cell, brain, evolution, zebra fish, wavelength
