Rezultaty
The final exploitation sustainability and business plans and activities of UNITI partners
Report on Gender and Equal OpportunitiesThis deliverable will provide sexdisaggregated data on the project workforce on the impact of the working environment and on the career and professional mobility
Midterm Recruitment ReportThe Midterm Recruitment Report will summarize the recruitment progress at the half time of the clinical trial
Dissemination and communication PlanThis report will include the overall project dissemination and communication strategy and planning, and a description of the main promotional material and tools that will be used. It will include a comprehensive set of dissemination elements including: logo, banner, flyer, brochure, poster, official short description, the project website plus the entire social network that will be used to advertise the activities of the project. Dissemination material will be edited in English and the languages of all partners involved.
Report on legal and ethical issues monitoringThis deliverable will cover all issues described in Task 15 of the proposalWithin this Task the legal and ethical issues throughout the whole duration of the project will be monitored In addition a data privacy framework will be developed that covers the internal processing of personal data within the project including the following ethical and legal aspects i Patients specific voluntary explicit and informed consent ii evaluation and analysis of specific broad and tiered consent especially for genetic samples iii procedures for withdrawing consent iv appropriate anonymisation and pseudonymisation techniques v lawful use processing transfer storage access of sensitive healthrelated data vi potential liabilities vii accordance with GDPR viii feedback process for individuals ix regulatory issues and related EU as well as national legislation x establishment of collecting and shipping procedures
Analysis of medical adherence on existing m-health dataThe deliverable will mainly report on1 predictors of medical adherence and2 phenotypes associated to medical adherence
Report on status of posting resultsThe results of the clinical trial need to be posted in a publicly available clinical trial registry This deliverable will need to report about the successful public posting of the results
Final report on RCT, Dissemination, communication and community buildingThis deliverable will be a final document summarizing the results of the RCT the UNITI dissemination activities communication and community building activities
UNITI Health socio-economic impact analysisThe deliverable aims to report on the socio-economic impact factors of tinnitus to health care and society in Europe.Furthermore it will evaluate the effect of the UNITI treatment and intervention on the health-care costs. A health economic model of tinnitus will be created.
First study subject approvals packageThe first study subject approvals package will contain the documents about the ethics approvals for the clinical trial at all centers.
Exploitation Plan and innovation management reportPresent the innovation management and exploitation strategy and activities of partners It will describe the business cases for the different stakeholders
The deliverable will report on the UNITI in-silico model, which will demonstrate the relevance and reliability of the treatment methods, and thus facilitating and accelerating the international (regulatory) acceptance. The in-silico model will combine existing electrophysiological data along with experimental ones, and an integrated approach taking into consideration the following aspects: (a) scientific relevance, characterisation, standardisation and affordability of a tinnitus-treatment model. (b) machine- learning diversity in the training and validation sets to cover a variety of mechanisms of action, (c) strategic fit (e.g. prioritisation of approaches for further compound testing in lead identification and optimisation and support in decision making).
UNITI's Ensemble-based prediction modelsThe deliverable will report on ensemble mechanisms that combine i models derived with the WP3 methods from the clinicspecific data ii models derived from the Layer 2 data a dedicated voting scheme will be built to this purpose This voting scheme will take into account the distribution of the phenotypes identified in the tasks of layer 2 inside each clinic Next to predictions on outcome predictions on medical adherence will also be supported
The deliverable will outline how the scientific data will be handled during the project and after the project.
The UNITI website will be online before M3 of the project. The deliverable will officially report about this.
Publikacje
Autorzy:
Carsten Vogel; Johannes Schobel; Winfried Schlee; Milena Engelke; Rüdiger Pryss
Opublikowane w:
43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021
Wydawca:
IEEE
DOI:
10.1109/embc46164.2021
Autorzy:
Konstantinos Bromis, Michail Sarafidis, Ourania Manta, Ioannis Kouris, Eleftheria Vellidou, Winfried Schlee, and Dimitrios Koutsouris
Opublikowane w:
44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2022
Wydawca:
IEEE
DOI:
10.1109/embc48229.2022.9871331
Autorzy:
Schleicher, M., Hamacher, S., Naujoks, M., Günther, K., Schmidt, T., Pryss, R., ... & Spiliopoulou, M.
Opublikowane w:
2022 IEEE 35th International Symposium on Computer-Based Medical Systems (CBMS), 2022
Wydawca:
IEEE
DOI:
10.1109/cbms55023.2022.00047
Autorzy:
Noor Jamaludeen, Vishnu Unnikrishnan, Ruediger Pryss, Johannes Schobel, Winfried Schlee, Myra Spiliopoulou
Opublikowane w:
2021 IEEE 34th International Symposium on Computer-Based Medical Systems (CBMS), 2021, Strona(/y) 354-359, ISBN 978-1-6654-4121-6
Wydawca:
IEEE
DOI:
10.1109/cbms52027.2021.00110
Autorzy:
Ourania Manta; Michail Sarafidis; Winfried Schlee; Christos Consoulas; Dimitrios Kikidis; Dimitrios Koutsouris
Opublikowane w:
44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2022
Wydawca:
IEEE
DOI:
10.1109/embc48229.2022.9871392
Autorzy:
Unnikrishnan, V., Schleicher, M., Puga, C., Pryss, R., Vogel, C., Schlee, W., & Spiliopoulou, M.
Opublikowane w:
Advances in Intelligent Data Analysis XXI: 21st International Symposium on Intelligent Data Analysis, IDA 2023, Louvain-la-Neuve, Belgium, April 12–14, 2023, Proceedings, 2023
Wydawca:
Springer-Verlag
DOI:
10.1007/978-3-031-30047-9_36
Autorzy:
Schleicher, M., Pryss, R., Schobel, J., Schlee, W., & Spiliopoulou, M.
Opublikowane w:
2022 IEEE 9th International Conference on Data Science and Advanced Analytics (DSAA), Numer 2022, 2022, Strona(/y) 1-10
Wydawca:
IEEE
DOI:
10.1109/dsaa54385.2022.10032390
Autorzy:
Schleicher, M., Pryss, R., Schlee, W., & Spiliopoulou, M.
Opublikowane w:
Artificial Intelligence in Medicine: International Conference on Artificial Intelligence in Medicine. Proceedings, Numer 2022, 2022, ISBN 978-3-031-09341-8
Wydawca:
Springer-Verlag
DOI:
10.1007/978-3-031-09342-5_30
Autorzy:
Kleinau, A., Fluegel, S., Pryss, R., Vogel, C., Engelke, M., Schlee, W., Unnikrishnan, V., & Spiliopoulou, M.
Opublikowane w:
2023 IEEE 36th International Symposium on Computer-Based Medical Systems (CBMS), 2023
Wydawca:
IEEE
DOI:
10.1109/cbms58004.2023.00196
Autorzy:
Clara Puga, Uli Niemann, Vishnu Unnikrishnan, Miro Schleicher, Winfried Schlee, and Myra Spiliopoulou
Opublikowane w:
2021, ISBN 978-1-6654-2099-0
Wydawca:
IEEE
DOI:
10.1109/dsaa53316.2021.9564158
Autorzy:
Sarafidis, M., Manta, O., Kouris, I., Schlee, W., Kikidis, D., Vellidou, E., & Koutsouris, D.
Opublikowane w:
43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021
Wydawca:
IEEE
DOI:
10.1109/embc46164.2021.9630137
Autorzy:
Winfried Schlee, Sondre Hølleland, Jan Bulla, Jorge Simoes, Patrick Neff, Stefan Schoisswohl, Stella Woelflick, Martin Schecklmann, Axel Schiller, Susanne Staudinger, Thomas Probst, Berthold Langguth
Opublikowane w:
Journal of Clinical Medicine, Numer 9/9, 2020, Strona(/y) 2756, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm9092756
Autorzy:
Johannes Allgaier, Winfried Schlee, Thomas Probst and Rüdiger Pryss
Opublikowane w:
Journal of Clinical Medicine, 2022, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm11154270
Autorzy:
Patricia Perez-Carpena; Jose Antonio Lopez-Escamez
Opublikowane w:
Crossref, Numer 3, 2022, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm11154597
Autorzy:
Sana Amanat, Alvaro Gallego-Martinez, Joseph Sollini, Patricia Perez-Carpena, Juan M. Espinosa-Sanchez, Ismael Aran, Andres Soto-Varela, Angel Batuecas‐Caletrio, Barbara Canlon, Patrick May, Christopher R. Cederroth, Jose A. Lopez-Escamez
Opublikowane w:
EBioMedicine, 2021, ISSN 2352-3964
Wydawca:
Elsevier BV
DOI:
10.1016/j.ebiom.2021.103309
Autorzy:
Winfried Schlee, Patrick Neff, Jorge Simoes, Berthold Langguth, Stefan Schoisswohl, Heidi Steinberger, Marie Norman, Myra Spiliopoulou, Johannes Schobel, Ronny Hannemann and Rüdiger Pryss
Opublikowane w:
Journal of Clinical Medicine, 2022, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm11071825
Autorzy:
Elisheba Haro-Hernandez, Patricia Perez-Carpena, Vishnu Unnikrishnan, Myra Spiliopoulou and Jose A. Lopez-Escamez
Opublikowane w:
Journal of Clinical Medicine, 2022, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm11040978
Autorzy:
Puga C, Schleicher M, Niemann U, Unnikrishnan V, Boecking B, Brueggemann P, Simoes J, Langguth B, Schlee W, Mazurek B, Spiliopoulou M.
Opublikowane w:
Front Neurosci., Numer 16, 2022, Strona(/y) 818686, ISSN 1662-453X
Wydawca:
Lausanne: Frontiers Media S.A.
DOI:
10.3389/fnins.2022.818686
Autorzy:
Vishnu Unnikrishnan, Miro Schleicher, Yash Shah, Noor Jamaludeen, Ruediger Pryss, Johannes Schobel, Robin Kraft, Winfried Schlee, Myra Spiliopoulou
Opublikowane w:
Brain Sciences, Numer 10/12, 2020, Strona(/y) 924, ISSN 2076-3425
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/brainsci10120924
Autorzy:
Natalia Trpchevska, Jan Bulla, Matilda Prada Hellberg, Niklas K. Edvall, Andra Lazar, Golbarg Mehraei, Inger Uhlen, Winfried Schlee, Barbara Canlon, Silvano Gallus, Jose Antonio Lopez-Escamez, Christopher R. Cederroth
Opublikowane w:
Journal of Clinical Medicine, Numer 9/12, 2020, Strona(/y) 3812, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm9123812
Autorzy:
Gallego-Martinez A, Escalera-Balsera A, Trpchevska N et al.
Opublikowane w:
NPJ Genom Med, Numer 7/1, 2022, ISSN 2056-7944
Wydawca:
Springer Nature
DOI:
10.1038/s41525-022-00341-w
Autorzy:
Ilias Trochidis, Alessandra Lugo, Elisa Borroni, Christopher R. Cederroth, Rilana Cima, Dimitris Kikidis, Berthold Langguth, Winfried Schlee, Silvano Gallus
Opublikowane w:
International Journal of Environmental Research and Public Health, Numer 18/13, 2021, Strona(/y) 6881, ISSN 1660-4601
Wydawca:
International Journal of Environmental Research and Public Health
DOI:
10.3390/ijerph18136881
Autorzy:
Christopher R. Cederroth, Alessandra Lugo, Niklas K. Edvall, Andra Lazar, Jose-Antonio Lopez-Escamez, Jan Bulla, Inger Uhlen, Derek J. Hoare, David M. Baguley, Barbara Canlon, Silvano Gallus
Opublikowane w:
Journal of Clinical Medicine, Numer 9/8, 2020, Strona(/y) 2412, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm9082412
Autorzy:
Dimitrios Kikidis, Evgenia Vassou, Winfried Schlee, Eleftheria Iliadou, Nikolaos Markatos, Aikaterini Triantafyllou, Berthold Langguth
Opublikowane w:
Journal of Clinical Medicine, Numer 10/8, 2021, Strona(/y) 1737, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm10081737
Autorzy:
Carlotta M Jarach, Alessandra Lugo, Marco Scala, Piet A van den Brandt, Christopher R Cederroth, Anna Odone, Werner Garavello, Winfried Schlee, Berthold Langguth, Silvano Gallus
Opublikowane w:
JAMA Neurol, 2022, ISSN 2168-6149
Wydawca:
American Medical Association
DOI:
10.1001/jamaneurol.2022.2189
Autorzy:
Miro Schleicher, Vishnu Unnikrishnan, Patrick Neff, Jorge Simoes, Thomas Probst, Rüdiger Pryss, Winfried Schlee, Myra Spiliopoulou
Opublikowane w:
Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41598-020-79527-0
Autorzy:
Dimitrios Kikidis; Evgenia Vassou; Nikolaos Markatos; Winfried Schlee; Eleftheria Iliadou
Opublikowane w:
Journal of Clinical Medicine, Numer 1, 2021, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm10132896
Autorzy:
Milena Engelke, Jorge Simões, Carsten Vogel, Stefan Schoisswohl, Martin Schecklmann, Stella Wölflick, Rüdiger Pryss, Thomas Probst, Berthold Langguth, Winfried Schlee
Opublikowane w:
PLOS Digit Health, 2023, ISSN 1932-6203
Wydawca:
Public Library of Science
DOI:
10.1371/journal.pdig.0000183
Autorzy:
Allgaier, J., Schlee, W., Langguth, B., Probst, T., & Pryss, R.
Opublikowane w:
Scientific Reports, Numer 11/1, 2021, ISSN 2045-2322
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41598-021-96731-8
Autorzy:
Saijal Shahania, Vishnu Unnikrishnan, Rüdiger Pryss, Robin Kraft, Johannes Schobel, Ronny Hannemann, Winny Schlee and Myra Spiliopoulou
Opublikowane w:
Front. Neurosc Sec. Auditory Cognitive Neuroscience, 2022, ISSN 1662-4548
Wydawca:
Frontiers Research Foundation
DOI:
10.3389/fnins.2022.836834
Autorzy:
Clara Puga; Uli Niemann; Winfried Schlee; Myra Spiliopoulou
Opublikowane w:
International Journal of Data Science and Analytics, 2023, ISSN 2364-4168
Wydawca:
Springer Nature
DOI:
10.1007/s41060-023-00431-7
Autorzy:
Stefan Schoisswohl, Berthold Langguth, Martin Schecklmann, Alberto Bernal-Robledano, Benjamin Boecking, Christopher R. Cederroth, Dimitra Chalanouli, Rilana Cima, Sam Denys, Juliane Dettling-Papargyris, Alba Escalera-Balsera, Juan Manuel Espinosa-Sanchez, Alvaro Gallego-Martinez, Efi Giannopoulou, Leyre Hidalgo-Lopez, Michael Hummel, Dimitris Kikidis, Michael Koller, Jose A. Lopez-Escamez, Steven
Opublikowane w:
Trials, 2021, ISSN 1745-6215
Wydawca:
BioMed Central
DOI:
10.1186/s13063-021-05835-z
Autorzy:
Ourania Manta, Michail Sarafidis, Nikolaos Vasileiou, Winfried Schlee, Christos Consoulas, Dimitris Kikidis, Evgenia Vassou, George K. Matsopoulos and Dimitrios D. Koutsouris
Opublikowane w:
Brain Sciences, 2022, ISSN 2076-3425
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/brainsci12121675
Autorzy:
Manta, O., Sarafidis, M., Schlee, W., Mazurek, B., Matsopoulos, G. K., and Koutsouris, D. D.
Opublikowane w:
J. Clin. Med., Numer 12/11, 2022, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm12113843
Autorzy:
Simoes, J.P., Schoisswohl, S., Schlee, W. et al.
Opublikowane w:
Trials, Numer 24/472, 2023, ISSN 1745-6215
Wydawca:
BioMed Central
DOI:
10.1186/s13063-023-07303-2
Autorzy:
Carlotta Micaela Jarach, Alessandra Lugo, Chiara Stival, Cristina Bosetti, Andrea Amerio3,4, Luca Cavalieri d'Oro5, Licia Iacoviello6,7, Anna Odone8,9, David Stuckler10, Alberto Zucchi11, Piet van den Brandt12,13, Werner Garavello14, Christopher R. Cederroth15,16,17, Winfried Schlee18, Silvano Gallus1* and the LOST in Lombardia Study Investigators
Opublikowane w:
Frontiers in Neurology, Sec. Neuro-Otology, 2022, ISSN 1664-2295
Wydawca:
Frontiers Research Foundation
DOI:
10.3389/fneur.2022.838291
Autorzy:
Subash Prakash, Vishnu Unnikrishnan, Rüdiger Pryss, Robin Kraft, Johannes Schobel, Ronny Hannemann, Berthold Langguth, Winfried Schlee and Myra Spiliopoulou
Opublikowane w:
Entropy, Numer 23/12, 2021, ISSN 1099-4300
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/e23121695
Autorzy:
Franziska C. Weber, Winfried Schlee, Berthold Langguth, Martin Schecklmann, Stefan Schoisswohl, Thomas C. Wetter and Jorge Simões
Opublikowane w:
International Journal of Environmental Research and Public Health, 2022, ISSN 1661-7827
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
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10.3390/ijerph191711005
Autorzy:
Natalia Trpchevska, Maxim B Freidin, Linda Broer, Berthe C Oosterloo, Shuyang Yao, Yitian Zhou, Barbara Vona, Charles Bishop, Argyro Bizaki-Vallaskangas, Barbara Canlon, Fabio Castellana, Daniel I Chasman, Stacey Cherny, Kaare Christensen, Maria Pina Concas, Adolfo Correa, Ran Elkon, Estonian Biobank Research Team, Jonas Mengel-From, Yan Gao, Anne B S Giersch, Giorgia Girotto, Alexander Gudjonsson
Opublikowane w:
The American Journal of Human Genetics, 2022, ISSN 1537-6605
Wydawca:
American journal of human genetics
DOI:
10.1016/j.ajhg.2022.04.010
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Amanat S, Gallego-Martinez A, Lopez-Escamez JA.
Opublikowane w:
Curr Top Behav Neurosci, Numer 51, 2021, Strona(/y) 29-47, ISBN 978-3-030-85503-1
Wydawca:
Springer Cham
DOI:
10.1007/7854_2020_155
Autorzy:
Winfried Schlee, Stefan Schoisswohl, Susanne Staudinger, Axel Schiller, Astrid Lehner, Berthold Langguth, Martin Schecklmann, Jorge Simoes, Patrick Neff, Steven C. Marcrum, Myra Spiliopoulou, Uli Niemann, Miro Schleicher, Vishnu Unnikrishnan, Clara Puga, Lena Mulansky, Ruediger Pryss, Carsten Vogel, Johannes Allgaier, Efi Giannopoulou, Katalin Birki, Klairi Liakou, Rilana Cima, Johan W.S. Vlaeyen,
Opublikowane w:
Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: From Heterogeneity to Personalized Medicine, Numer 260, 2021, Strona(/y) 441-451, ISBN 9780128215869
Wydawca:
Elsevier
DOI:
10.1016/bs.pbr.2020.12.005
Autorzy:
Winfried Schlee, Berthold Langguth, Rüdiger Pryss, Johannes Allgaier, Lena Mulansky, Carsten Vogel, Myra Spiliopoulou, Miro Schleicher, Vishnu Unnikrishnan, Clara Puga, Ourania Manta, Michalis Sarafidis, Ioannis Kouris, Eleftheria Vellidou, Dimitris Koutsouris, Konstantina Koloutsou, George Spanoudakis, Christopher Cederroth, Dimitris Kikidis
Opublikowane w:
Current Topics in Behavioral Neurosciences, 2021
Wydawca:
Springer Berlin Heidelberg
DOI:
10.1007/7854_2021_229
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