European Health Data and Evidence Network

Rezultaty

Second Report on the implementation of the analytical pipeline for personalized medicine

This deliverable will provide an update on the analytical pipeline for patient-level prediction and risk effect estimation. Moreover, it will contain results of proof-of-concept studies in these domains.

Report on educational and training material for the developed analytical tools (1)

Report on the training materials that have been developed and a status on the delivery to the different target audiences (SME's, researchers, hospitals and GPs, registries and biobanks etc.).

Yearly Progress report on technical framework (4)

A description of the progress on the technical platform and outlook for the following 12 months.

Yearly Progress report on technical framework (2)

A description of the progress on the technical platform and outlook for the following 12 months.

Selected priority therapeutic areas

A short report on the completion of task 2.1

Final version of the Framework for quality benchmarking

This deliverable will offer the comprehensive framework.

Yearly Progress report on technical framework (1)

A description of the progress on the technical platform and outlook for the following 12 months.

Report on key data source/s of interest for WP1 Use Cases

This report will provide the rationale for mapping different types of data as relevant for the proposed use cases.

First Report on educational and training material for the developed analytical tools

This deliverable will provide an update on the creation of educational and training material for the analytical tools developed in this work package.

"Results of ""validation"" Use Case 1 study"

A validation study, replicating analyses on RMM Effectiveness (Use Case 1) using unmapped as well as OMOP-mapped data will be conducted. A report with its results will be delivered by the end of Month 37.

Results of first Use Case 2 study

A report with results from the first proof-of-concept drug/device safety study will be submitted by Month 53

Results of Use Case 3 study

The results of Use Case 3 studies will be reported by Month 48.

Report on Federated Network Studies (1)

These deliverables will update on the deployment of the study execution pipeline in the context of the Use Case in WP1-3 and possibly for other stakeholders later in the project.

Ethics Advisory Board nomination

Nomination of the Ethics Advisory Board pursuant to the Ethics Review

Report on liaison with other BD4BO projects

This deliverable will report on the relationship and collaborations established with other BD4BO projects, with an evaluation of results obtained and impact.

Selection of use cases for personalized medicine

We will perform a survey including all the stakeholders to develop a list to use cases for the personalized medicine pipeline. This will include prediction and risk effect estimation use cases.

Workshop for HTA and payer community: demonstrate the OMOP-CDM for generating meaningful HTA + payer evidence (2)

Short workshop report of the second workshop (task 2.5)

Third Report on the implementation of the analytical pipeline for personalized medicine

This deliverable will provide an update on the analytical pipeline, including the disease trajectory pipeline.

First Report on the implementation of selected use cases in the data network

This report describes the progress made on testing the analytical pipelines in the data network.

First report on community building

This deliverable will report the results of deployment of outreach activities in terms of stakeholders (both institutions and professionals) successfully involved in EHDEN and established working dynamics, describing gaps and areas that should be reinforced according to the evolution of the field.

ICHOM standards defined using OMOP terminology

This deliverable provides insight on how the prioritized ICHOM standard sets as defined in D2.1 can be implemented using the OMOP-CDM.

Analysis of potential Public-Private Partnership exploitation models

This deliverable will analyse both successful and unsuccessful exploitation models used by initiatives similar to EHDEN, studying their application domain and their potential to serve as blueprint for EHDEN sustainability.

Roadmap for interoperability solutions

Description of the process for and technology applied for interoperability with other 'standard' platforms.

Workshop for HTA and payer community: demonstrate the OMOP-CDM for generating meaningful HTA + payer evidence

Short workshop report of the first workshop (task 2.5)

Report on SME Certification Procedure and Data Source Grant Awarding Procedure developed and implemented

Report on SME Certification Procedure and Data Source Grant Awarding Procedure developed and implemented. This will include the Open Call announcement text and instructions for applicants, definition of selection and evaluation committees and description of eligibility criteria.

Stakeholder mapping

This deliverable will report on the different stakeholder types that will need a value proposition for successful outreach, including if necessary sub-categories.

Report on Federated Network Studies (2)

These deliverables will update on the deployment of the study execution pipeline in the context of the Use Case in WP1-3 and possibly for other stakeholders.

Final Report on the implementation of the analytical pipeline for personalized medicine

This deliverable will provide an update on the analytical pipeline, including the disease trajectory pipeline

First Report on the implementation of the analytical pipeline for personalized medicine

This deliverable will provide an update on the analytical pipeline for patient-level prediction and risk effect estimation

First version of the Framework for quality benchmarking

This deliverable will contain the description of the quality management and control framework with a primary focus on the mapping process, also incorporating stakeholder consultations.

Report on Quality Assurance and Control Procedures

This report discusses the implementation of the quality assurance and control procedures for the full eco-system.

Yearly Progress report on technical framework (3)

A description of the progress on the technical platform and outlook for the following 12 months

Technical framework design and architecture

The identification of the individual components, the functional and technical integration of these components in the EHDEN platform are the subject of this first deliverable.

Assessment of regulatory requirements for patient-level decision making

Report on the mapping of regulatory requirements across Europe for risk prediction models.

Implementation of RMM Effectiveness testing methods

Tools for interrupted time series analyses will be integrated and fully accessible as part of the EHDEN toolkit.

OMOP-CDM enhancements for Outcome Driven Healthcare

This deliverable describes the changes needed in the OMOP-CDM to capture the information for the ICHOM standard sets and Patient Reported Outcomes in general. This includes structural changes as well as changes to the Standardized Vocabularies.

Training materials on methods for RMM effectiveness testing

We will provide online training materials for researchers to conduct ITS analyses within the EHDEN ecosystem.

Publikacje

Supporting Pharmacovigilance Signal Validation and Prioritization with Analyses of Routinely Collected Health Data: Lessons Learned from an EHDEN Network Study

Autorzy: Gauffin, Oskar; Brand, Judith S.; Hedfors Vidlin, Sara; Sartori, Daniele; Asikainen, Suvi; Català, Martí; Chalabi, Etir; Dedman, Daniel; Danilovic, Ana; Duarte-Salles, Talita; García Morales, Maria Teresa; Hiltunen, Saara; Jödicke, Annika M.; Lazarevic, Milan; Mayer, Miguel A.; Miladinovic, Jelena; Mitchell, Joseph; Pistillo, Andrea; Ramírez-Anguita, Juan Manuel; Reyes, Carlen; Rudolph, Annet
Opublikowane w: Drug Safety, 2023, ISSN 0114-5916
Wydawca: Adis International Ltd.
DOI: 10.1007/s40264-023-01353-w

The added value of text from Dutch general practitioner notes in predictive modeling

Autorzy: Seinen, Tom M.; Kors, Jan A.; van Mulligen, Erik M.; Fridgeirsson, Egill; Rijnbeek, Peter R.
Opublikowane w: J Am Med Inform Assoc, 2023, ISSN 1527-974X
Wydawca: Oxford University Press
DOI: 10.1093/jamia/ocad160

Development and validation of patient-level prediction models for symptoms, hospitalization and treatment initiation amongst prostate cancer patients on watchful waiting

Autorzy: Sebastiaan Remmers, Lana Lai Yin Hui, Carolin Schimmelpfennig, Peter-Paul Willemsen, Markus Kreuz, Philip Cornford, Nicolas Mottet, Nazanin Zounemat-Kermani
Opublikowane w: Protocol Exhange, 2021, ISSN 2043-0116
Wydawca: Nature Publisher
DOI: 10.21203/rs.3.pex-1525/v1

A standardized analytics pipeline for reliable and rapid development and validation of prediction models using observational health data

Autorzy: Sara Khalid, Cynthia Yang, Clair Blacketer, View ORCID ProfileTalita Duarte-Salles, Sergio Fernández-Bertolín, Chungsoo Kim, Rae Woong Park, Jimyung Park, Martijn Schuemie, View ORCID ProfileAnthony Sena, View ORCID ProfileMarc A. Suchard, Seng Chan You, Peter Rijnbeek, Jenna Reps
Opublikowane w: Computer Methods and Programs in Biomedicine, 2021, ISSN 0169-2607
Wydawca: Elsevier BV
DOI: 10.1016/j.cmpb.2021.106394

Smoking and COVID-19 Infection and Related Mortality: A Prospective Cohort Analysis of UK Biobank Data.

Autorzy: Prats-Uribe A, Xie J, Prieto-Alhambra D, Petersen I.
Opublikowane w: Clin Epidemiol, 2021, ISSN 1179-1349
Wydawca: Dove Medical Press Ltd
DOI: 10.2147/clep.s300597

Body Mass Index and Risk of COVID-19 Diagnosis, Hospitalization, and Death: A Cohort Study of 2 524 926 Catalans

Autorzy: Recalde M, Pistillo A, Fernandez-Bertolin S, Roel E, Aragon M, Freisling H, Prieto-Alhambra D, Burn E, Duarte-Salles T.
Opublikowane w: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Wydawca: The Endocrine Society
DOI: 10.1210/clinem/dgab546

Seek COVER: using a disease proxy to rapidly develop and validate a personalized risk calculator for COVID-19 outcomes in an international network

Autorzy: Williams, Ross D.; Markus, Aniek F.; Yang, Cynthia; Duarte-Salles, Talita; DuVall, Scott L.; Falconer, Thomas; Jonnagaddala, Jitendra; Kim, Chungsoo; Rho, Yeunsook; Williams, Andrew E.; Alberga Machado, Amanda; Ho An, Min; Aragón, María; Areia, Carlos; Burn, Edward; Hwa Choi, Young; Drakos, Ioannis; Fernandes Abrahão, Maria Tereza; Fernández‐Bertolín, Sergio; Hripcsak, George; Skov Kaas‐H
Opublikowane w: BMC Med Res Methodol, 2022, ISSN 1471-2288
Wydawca: BioMed Central
DOI: 10.1186/s12874-022-01505-z

The natural history of symptomatic COVID-19 during the first wave in Catalonia.

Autorzy: Burn E, Tebé C, Fernandez-Bertolin S, Aragon M, Recalde M, Roel E, Prats-Uribe A, Prieto-Alhambra D, Duarte-Salles T.
Opublikowane w: Nature Communications, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-21100-y

COVID-19 in patients with autoimmune diseases: characteristics and outcomes in a multinational network of cohorts across three countries.

Autorzy: Tan EH, Sena AG, Prats-Uribe A, You SC, Ahmed WU, Kostka K, Reich C, Duvall SL, Lynch KE, Matheny ME, Duarte-Salles T, Bertolin SF, Hripcsak G, Natarajan K, Falconer T, Spotnitz M, Ostropolets A, Blacketer C, Alshammari TM, Alghoul H, Alser O, Lane JCE, Dawoud DM, Shah K, Yang Y, Zhang L, Areia C, Golozar A, Recalde M, Casajust P, Jonnagaddala J, Subbian V, Vizcaya D, Lai LYH, Nyberg F, Morales DR
Opublikowane w: Rheumatology, 2021, ISSN 1462-0324
Wydawca: Oxford University Press
DOI: 10.1093/rheumatology/keab250

Characteristics and Outcomes of Over 300,000 Patients with COVID-19 and History of Cancer in the United States and Spain.

Autorzy: Roel E, Pistillo A, Recalde M, Sena AG, Fernández-Bertolín S, Aragón M, Puente D, Ahmed WU, Alghoul H, Alser O, Alshammari TM, Areia C, Blacketer C, Carter W, Casajust P, Culhane AC, Dawoud D, DeFalco F, DuVall SL, Falconer T, Golozar A, Gong M, Hester L, Hripcsak G, Tan EH, Jeon H, Jonnagaddala J, Lai LYH, Lynch KE, Matheny ME, Morales DR, Natarajan K, Nyberg F, Ostropolets A, Posada JD, Prats
Opublikowane w: Cancer Epidemiol Biomarkers Prev., 2021, ISSN 1055-9965
Wydawca: American Association for Cancer Research
DOI: 10.1158/1055-9965.epi-21-0266

Characterizing the incidence of adverse events of special interest for COVID-19 vaccines across eight countries: a multinational network cohort study

Autorzy: Xintong Li; Anna Ostropolets; Rupa Makadia; Azza Shaoibi; Gowtham Rao; Anthony G. Sena; Eugenia Martinez-Hernandez; Antonella Delmestri; Katia Verhamme; Peter R Rijnbeek; Talita Duarte-Salles; Marc Suchard; Patrick Ryan; George Hripcsak; Daniel Prieto-Alhambra
Opublikowane w: BMJ, 2021, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmj.n1435

Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Autorzy: Edward Burn, Seng Chan You, Anthony G. Sena, Kristin Kostka, Hamed Abedtash, Maria Tereza F. Abrahão, Amanda Alberga, Heba Alghoul, Osaid Alser, Thamir M. Alshammari, Maria Aragon, Carlos Areia, Juan M. Banda, Jaehyeong Cho, Aedin C. Culhane, Alexander Davydov, Frank J. DeFalco, Talita Duarte-Salles, Scott DuVall, Thomas Falconer, Sergio Fernandez-Bertolin, Weihua Gao, Asieh Golozar, Jill Hardin,
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-18849-z

Towards an Interoperable Ecosystem of Research Cohort and Real-world Data Catalogues Enabling Multi-center Studies

Autorzy: Morris Swertz, Esther van Enckevort, José Luis Oliveira, Isabel Fortier, Julie Bergeron, Nicolas H Thurin, Eleanor Hyde, Alexander Kellmann, Romin Pahoueshnja, Miriam Sturkenboom, Marianne Cunnington, Anne-Marie Nybo Andersen, Yannick Marcon, Gonçalo Gonçalves, Rosa Gini
Opublikowane w: Yearbook of Medical Informatics, 2023, ISSN 2364-0502
Wydawca: Thieme Group
DOI: 10.1055/s-0042-1742522

Transforming Estonian health data to the Observational Medical Outcomes Partnership (OMOP) Common Data Model: lessons learned

Autorzy: Oja, Marek; Tamm, Sirli; Mooses, Kerli; Pajusalu, Maarja; Talvik, Harry-Anton; Ott, Anne; Laht, Marianna; Malk, Maria; Lõo, Marcus; Holm, Johannes; Haug, Markus; Šuvalov, Hendrik; Särg, Dage; Vilo, Jaak; Laur, Sven; Kolde, Raivo; Reisberg, Sulev
Opublikowane w: JAMIA Open, 2023, ISSN 2574-2531
Wydawca: Oxford University Press
DOI: 10.1093/jamiaopen/ooad100

"Research Protocol for an Observational Health Data Analysis to Assess the Long-term Outcomes of Prostate Cancer Patients Undergoing non-interventional Management (i.e. Watchful Waiting) and the Impact of Comorbidities and Life Expectancy - PIONEER IMI's ""Big Data for Better Outcomes"" program"

Autorzy: Giorgio Gandaglia, Kees van Bochove, Anders Bjartell, Alberto Briganti, Phil Conford, Susan Evans Axelsson, Asieh Golozar, Mieke Van Hemelrijck, Katharina Beyer, Peter-Paul Willemse, Muhammad Imran Omar, James N’Dow, Alex Asiimwe, Monique Roobol, Robert Snijder, Carl Steinbeisser, Roderick Van Den Bergh, Samuel Fatoba, Ariel Achtman, Thamir M Alshammari, Nicolas Thurin, Adam Kinnaird, Sebastian
Opublikowane w: Protocol Exchange, 2021, ISSN 2043-0116
Wydawca: Nature Publication
DOI: 10.21203/rs.3.pex-1468/v1

Trajectories: a framework for detecting temporal clinical event sequences from health data standardized to the OMOP Common Data Model

Autorzy: Luis H John, Jan A Kors, Jenna M Reps, Patrick B Ryan, Peter R Rijnbeek
Opublikowane w: JAMIA Open, 2022, ISSN 2574-2531
Wydawca: Oxford University Press on behalf of the American Medical Informatics Association
DOI: 10.1093/jamiaopen/ooac021

Applying Machine Learning in Distributed Data Networks for Pharmacoepidemiologic and Pharmacovigilance Studies: Opportunities, Challenges, and Considerations

Autorzy: Jenna Wong, Daniel Prieto‑Alhambra, Peter R. Rijnbeek, Rishi J. Desai, Jenna M. Reps, Sengwee Toh
Opublikowane w: Drug Safety, 2022, ISSN 0114-5916
Wydawca: Adis International Ltd.
DOI: 10.1007/s40264-022-01158-3

Implementation of the COVID-19 Vulnerability Index Across an International Network of Health Care Data Sets: Collaborative External Validation Study.

Autorzy: Reps JM, Kim C, Williams RD, Markus AF, Yang C, Duarte-Salles T, Falconer T, Jonnagaddala J, Williams A, Fernández-Bertolín S, DuVall SL, Kostka K, Rao G, Shoaibi A, Ostropolets A, Spotnitz ME, Zhang L, Casajust P, Steyerberg EW, Nyberg F, Kaas-Hansen BS, Choi YH, Morales D, Liaw ST, Abrahão MTF, Areia C, Matheny ME, Lynch KE, Aragón M, Park RW, Hripcsak G, Reich CG, Suchard MA, You SC, Ryan P
Opublikowane w: JMIR Med Inform, 2021, ISSN 2291-9694
Wydawca: JMIR Publications
DOI: 10.2196/21547

A standardized framework for risk-based assessment of treatment effect heterogeneity in observational healthcare databases

Autorzy: Alexandros Rekkas; David van Klaveren; Patrick B. Ryan; Ewout W. Steyerberg; David M. Kent; Peter R. Rijnbeek
Opublikowane w: NPJ Digital Medicine, 2023, ISSN 2398-6352
Wydawca: Springer Mature
DOI: 10.1038/s41746-023-00794-y

BIcenter: A collaborative Web ETL solution based on a reflective software approach

Autorzy: Almeida, João R.; Coelho, Leonardo; Oliveira, José L.
Opublikowane w: SoftwareX, 2022, ISSN 2352-7110
Wydawca: Amsterdam: Elsevier B.V.
DOI: 10.1016/j.softx.2021.100892

Growing backlog of planned surgery due to covid-19

Autorzy: Carr A, Smith JA, Camaradou J, Prieto-Alhambra D.
Opublikowane w: BMJ, 2021, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmj.n339

Mortality, falls and fracture risk are positively associated with frailty: a SIDIAP cohort study of 890,000 patients

Autorzy: Middleton R, Poveda JL, Orfila Pernas F, Martinez Laguna D, Diez Perez A, Nogués X, Carbonell Abella C, Reyes C, Prieto-Alhambra D.
Opublikowane w: J Gerontol A Biol Sci Med Sci, 2021, ISSN 1079-5006
Wydawca: Gerontological Society of America
DOI: 10.1093/gerona/glab102

Estimating individualized treatment effects from randomized controlled trials: a simulation study to compare risk-based approaches

Autorzy: Rekkas, Alexandros; Rijnbeek, Peter R.; Kent, David M.; Steyerberg, Ewout W.; van Klaveren, David
Opublikowane w: BMC Med Res Methodol, Numer 18, 2023, ISSN 1471-2288
Wydawca: BioMed Central
DOI: 10.1186/s12874-023-01889-6

Using the Data Quality Dashboard to Improve the EHDEN Network

Autorzy: Clair Blacketer, Erica A Voss, Frank DeFalco, Nigel Hughes, Martijn J Schuemie, Maxim Moinat, Peter R Rijnbeek
Opublikowane w: Journal of Applied Sciences, 2021, ISSN 2076-3417
Wydawca: MDPI
DOI: 10.3390/app112411920

Learning patient-level prediction models across multiple healthcare databases: evaluation of ensembles for increasing model transportability

Autorzy: Jenna Marie Reps, Ross D. Williams, Martijn J. Schuemie , Patrick B. Ryan and Peter R. Rijnbeek
Opublikowane w: BMC Medical Informatics and Decision Making, 2022, ISSN 1472-6947
Wydawca: BioMed Central
DOI: 10.1186/s12911-022-01879-6

Common Problems, Common Data Model Solutions: Evidence Generation for Health Technology Assessment

Autorzy: Seamus Kent, Edward Burn, Dalia Dawoud, Pall Jonsson, Jens Torup Østby, Nigel Hughes, Peter Rijnbeek, Jacoline C. Bouvy
Opublikowane w: PharmacoEconomics, 2020, ISSN 1170-7690
Wydawca: Adis International Ltd.
DOI: 10.1007/s40273-020-00981-9

Logistic regression models for patient-level prediction based on massive observational data: Do we need all data?

Autorzy: Luis H John, Jan A Kors, Jenna M Reps, Patrick B Ryan, Peter R Rijnbeek
Opublikowane w: Int J Med Inform, 2022, ISSN 1386-5056
Wydawca: Elsevier BV
DOI: 10.1016/j.ijmedinf.2022.104762

Avoiding fragmentation: The potential of synergistic efforts across the IMI portfolio

Autorzy: Díaz, Carlos; Killin, Lewis; Hughes, Nigel
Opublikowane w: Front Neurol, 2022, ISSN 1664-2295
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.1050360

Standardizing registry data to the OMOP Common Data Model: experience from three pulmonary hypertension databases

Autorzy: Patricia Biedermann, Rose Ong, Alexander Davydov, Alexandra Orlova, Philip Solovyev, Hong Sun, Graham Wetherill, Monika Brand, Eva-Maria Didden
Opublikowane w: BMC Medical Research Methodology, 2021, ISSN 1471-2288
Wydawca: BioMed Central
DOI: 10.1186/s12874-021-01434-3

Characteristics and outcomes of 627 044 COVID-19 patients living with and without obesity in the United States, Spain, and the United Kingdom

Autorzy: Recalde M, Roel E, Pistillo A, Sena AG, Prats-Uribe A, Ahmed WU, Alghoul H, Alshammari TM, Alser O, Areia C, Burn E, Casajust P, Dawoud D, DuVall SL, Falconer T, Fernández-Bertolín S, Golozar A, Gong M, Lai LYH, Lane JCE, Lynch KE, Matheny ME, Mehta PP, Morales DR, Natarjan K, Nyberg F, Posada JD, Reich CG, Rijnbeek PR, Schilling LM, Shah K, Shah NH, Subbian V, Zhang L, Zhu H, Ryan P, Prieto-Alh
Opublikowane w: International Journal of Obesity, 2022, ISSN 0307-0565
Wydawca: Nature Publishing Group
DOI: 10.1038/s41366-021-00893-4

Use of unstructured text in prognostic clinical prediction models: a systematic review

Autorzy: Seinen, Tom M.; Fridgeirsson, Egill A.; Ioannou, Solomon; Jeannette, Daniel; John, Luis H.; Kors, Jan A.; Markus, Aniek F.; Pera, Victor; Reekas, Alexandros; Williams, Ross D.; Yang, Cynthia; van Mulligen, Erik M.; Rijnbeek, Peter R.
Opublikowane w: J Am Med Inform Assoc, 2022, ISSN 1067-5027
Wydawca: Hanley and Belfus, Inc.
DOI: 10.1093/jamia/ocac058

Trends in the conduct and reporting of clinical prediction model development and validation: a systematic review

Autorzy: Cynthia Yang, Jan A Kors, Solomon Ioannou, Luis H John, Aniek F Markus, Alexandros Rekkas, Maria A J de Ridder, Tom M Seinen, Ross D Williams, Peter R Rijnbeek
Opublikowane w: J Am Med Inform Assoc, 2022, ISSN 1067-5027
Wydawca: Hanley and Belfus, Inc.
DOI: 10.1093/jamia/ocac002

Association between covid-19 vaccination, SARS-CoV-2 infection, and risk of immune mediated neurological events: population based cohort and self-controlled case series analysis

Autorzy: Xintong Li, Berta Raventós, Elena Roel, Andrea Pistillo, Eugenia Martinez-Hernandez, Antonella Delmestri, Carlen Reyes, Victoria Strauss, Daniel Prieto-Alhambra, Edward Burn, Talita Duarte-Salles
Opublikowane w: BMJ, 2022, ISSN 1756-1833
Wydawca: BMA
DOI: 10.1136/bmj-2021-068373

TreatmentPatterns: An R package to facilitate the standardized development and analysis of treatment patterns across disease domains

Autorzy: Aniek F Markus , Katia M C Verhamme, Jan A Kors, Peter R Rijnbeek
Opublikowane w: Comput Methods Programs Biomed, 2022, ISSN 0169-2607
Wydawca: Elsevier BV
DOI: 10.1016/j.cmpb.2022.107081

Characteristics and outcomes of COVID-19 patients with and without asthma from the United States, South Korea, and Europe

Autorzy: Morales, Daniel R.; Ostropolets, Anna; Lai, Lana; Sena, Anthony; DuVall, Scott; Suchard, Marc; Verhamme, Katia; Rijnbeek, Peter; Posada, Joe; Ahmed, Waheed; Alshammary, Thamer; Alghoul, Heba; Alser, Osaid; Areia, Carlos; Blacketer, Clair; Burn, Edward; Casajust, Paula; Chan You, Seng; Dawoud, Dalia; Golozar, Asieh; Gong, Menchung; Jonnagaddala, Jitendra; Lynch, Kristine; Matheny, Michael; Minty, E
Opublikowane w: Journal of Asthma, 2022, ISSN 0277-0903
Wydawca: Marcel Dekker Inc.
DOI: 10.1080/02770903.2021.2025392

Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience.

Autorzy: Duarte-Salles T, Vizcaya D, Pistillo A, Casajust P, Sena AG, Lai LYH, Prats-Uribe A, Ahmed WU, Alshammari TM, Alghoul H, Alser O, Burn E, You SC, Areia C, Blacketer C, DuVall S, Falconer T, Fernandez-Bertolin S, Fortin S, Golozar A, Gong M, Tan EH, Huser V, Iveli P, Morales DR, Nyberg F, Posada JD, Recalde M, Roel E, Schilling LM, Shah NH, Shah K, Suchard MA, Zhang L, Zhang Y, Williams AE, Reich C
Opublikowane w: Pedatrics, 2021, ISSN 0031-4005
Wydawca: American Academy of Pediatrics
DOI: 10.1542/peds.2020-042929

Why predicting risk can’t identify ‘risk factors’: empirical assessment of model stability in machine learning across observational health databases

Autorzy: Aniek F. Markus, Peter R. Rijnbeek, Jenna R. Reps
Opublikowane w: Proceedings of Machine Learning Research, 2022, ISSN 2640-3498
Wydawca: Cambridge MA: JMLR
DOI: 10.5281/zenodo.7377296

Opioid use, postoperative complications, and implant survival after unicompartmental versus total knee replacement: a population-based network study

Autorzy: Edward Burn, James Weaver, Daniel Morales, Albert Prats-Uribe, Antonella Delmestri, Victoria Y Strauss, Ying He, Danielle E Robinson, Rafael Pinedo-Villanueva, Spyros Kolovos, Talita Duarte-Salles, William Sproviero, Dahai Yu, Michel Van Speybroeck, Ross Williams, Luis H John, Nigel Hughes, Anthony G Sena, Ruth Costello, Belay Birlie, David Culliford, Caroline O'Leary, Henry Morgan, Theresa Burkar
Opublikowane w: The Lancet Rheumatology, Numer 1/4, 2019, Strona(/y) e229-e236, ISSN 2665-9913
Wydawca: Elsevier
DOI: 10.1016/s2665-9913(19)30075-x

Patient data discovery platforms as enablers of biomedical and translational research: A systematic review

Autorzy: Alina Trifan, José Luís Oliveira
Opublikowane w: Journal of Biomedical Informatics, Numer 93, 2019, Strona(/y) 103154, ISSN 1532-0464
Wydawca: Academic Press
DOI: 10.1016/j.jbi.2019.103154

Cancer and the risk of coronavirus disease 2019 diagnosis, hospitalisation and death: A population-based multistate cohort study including 4 618 377 adults in Catalonia, Spain

Autorzy: Roel E, Pistillo A, Recalde M, Fernández-Bertolín S, Aragón M, Soerjomataram I, Jenab M, Puente D, Prieto-Alhambra D, Burn E, Duarte-Salles T.
Opublikowane w: Cancer Epidemiology, 2021, ISSN 1877-7821
Wydawca: Elsevier BV
DOI: 10.1002/ijc.33846

A two-stage workflow to extract and harmonize drug mentions from clinical notes into observational databases

Autorzy: Almeida, João Rafael; Figueira Silva, João; Matos, Sérgio; Oliveira, José Luís
Opublikowane w: Journal of Biomedical Informatics, 2022, ISSN 1532-0464
Wydawca: Academic Press
DOI: 10.1016/j.jbi.2021.103849

Feasibility and evaluation of a large-scale external validation approach for patient-level prediction in an international data network: validation of models predicting stroke in female patients newly diagnosed with atrial fibrillation

Autorzy: Jenna M. Reps, Ross D. Williams, Seng Chan You, Thomas Falconer, Evan Minty, Alison Callahan, Patrick B. Ryan, Rae Woong Park, Hong-Seok Lim, Peter Rijnbeek
Opublikowane w: BMC Medical Research Methodology, Numer 20/1, 2020, ISSN 1471-2288
Wydawca: BioMed Central
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Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study

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Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study

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Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study

Autorzy: Jennifer C E Lane, James Weaver, Kristin Kostka, Talita Duarte-Salles, Maria Tereza F Abrahao, Heba Alghoul, Osaid Alser, Thamir M Alshammari, Carlos Areia, Patricia Biedermann, Juan M Banda, Edward Burn, Paula Casajust, Kristina Fister, Jill Hardin, Laura Hester, George Hripcsak, Benjamin Skov Kaas-Hansen, Sajan Khosla, Spyros Kolovos, Kristine E Lynch, Rupa Makadia, Paras P Mehta, Daniel R Moral
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90-Day all-cause mortality can be predicted following a total knee replacement: an international, network study to develop and validate a prediction model

Autorzy: Ross D Williams, Jenna M Reps, OHDSI/EHDEN Knee Arthroplasty Group; Peter R Rijnbeek, Patrick B Ryan, Daniel Prieto-Alhambra
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Using Iterative Pairwise External Validation to Contextualize Prediction Model Performance: A Use Case Predicting 1‑Year Heart Failure Risk in Patients with Diabetes Across Five Data Sources

Autorzy: Ross D. Williams, Jenna M. Reps, Jan A. Kors, Patrick B. Ryan, Ewout Steyerberg, Katia M. Verhamme, Peter R. Rijnbeek
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Increasing trust in real-world evidence through evaluation of observational data quality

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Characteristics and outcomes of patients with COVID-19 with and without prevalent hypertension: a multinational cohort study

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Development and external validation of prediction models for adverse health outcomes in rheumatoid arthritis: A multinational real-world cohort analysis

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Renin–angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis

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A concentric circles view of health data relations facilitates understanding of sociotechnical challenges for learning health systems and the role of federated data networks

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"Evaluating a novel approach to stimulate open science collaborations: a case series of ""study-a-thon"" events within the OHDSI and European IMI communities"

Autorzy: Hughes, Nigel; Rijnbeek, Peter R.; van Bochove, Kees; Duarte-Salles, Talita; Steinbeisser, Carl; Vizcaya, David; Prieto-Alhambra, Daniel; Ryan, Patrick
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A standardized framework for risk-based assessment of treatment effect heterogeneity in observational healthcare databases

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Opublikowane w: arXiv, Numer 2, 2020, ISSN 2331-8422
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Clinical concept normalization on medical records using word embeddings and heuristics

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Baseline phenotype and 30-day outcomes of people tested for COVID-19: an international network cohort including >3.32 million people tested with real-time PCR and >219,000 tested positive for SARS-CoV-2 in South Korea, Spain and the United States

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Opublikowane w: medRxiv, 2020
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How little data do we need for patient-level prediction?

Autorzy: John, Luis H.; Kors, Jan A.; Reps, Jenna M.; Ryan, Patrick B.; Rijnbeek, Peter R.
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Body mass index and risk of COVID-19 diagnosis, hospitalisation, and death: a population-based multi-state cohort analysis including 2,524,926 people in Catalonia, Spain

Autorzy: Martina Recalde; Andrea Pistillo; Sergio Fernandez-Bertolin; Elena Roel; Maria Aragon; Heinz Freisling; Daniel Prieto-Alhambra; Edward Burn; Talita Duarte-Salles
Opublikowane w: medRxiv, 2020
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Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid widespread use for COVID-19: a multinational, network cohort and self-controlled case series study

Autorzy: Jennifer C.E.Lane; James Weaver; Kristin Kostka; Talita Duarte-Salles; Maria Tereza F. Abrahao; Heba Alghoul; Osaid Alser; Thamir M Alshammari; Patricia Biedermann; Edward Burn; Paula Casajust; Mitch Conover; Aedin C. Culhane; Alexander Davydov; Scott L. DuVall; Dmitry Dymshyts; Sergio Fernandez-Bertolin; Kristina Fišter; Jill Hardin; Laura Hester; George Hripcsak; Seamus Kent; Sajan Khosla; Spyr
Opublikowane w: medRxiv, 2020
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Heterogeneity and temporal variation in the management of COVID-19: a multinational drug utilization study including 71,921 hospitalized patients from China, South Korea, Spain, and the United States of America

Autorzy: Albert Prats-Uribe; Anthony G. Sena; Lana Yin Hui Lai; Waheed-Ul-Rahman Ahmed; Heba Alghoul; Osaid Alser; Thamir M Alshammari; Carlos Areia; William Carter; Paula Casajust; Dalia Dawoud; Asieh Golozar; Jitendra Jonnagaddala; Paras Mehta; Gong Menchung; Daniel R Morales; Fredrik Nyberg; Jose D Posada; Martina Recalde; Elena Roel; Karishma Shah; Nigam Shah; Lisa M Schilling; Vignesh Subbian; David V
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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Trajectories: a framework for detecting temporal clinical event sequences from health data standardized to the OMOP Common Data Model

Autorzy: Kadri Künnapuu, Solomon Ioannou, Kadri Ligi, Raivo Kolde, Sven Laur, Jaak Vilo, Peter R. Rijnbeek, Sulev Reisberg
Opublikowane w: medRxiv, 2021
Wydawca: medRxiv
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Using the OHDSI network to develop and externally validate a patient-level prediction model for Heart Failure in Type II Diabetes Mellitus

Autorzy: Ross D. Williams; Jenna M. Reps; Jan A Kors; Patrick B Ryan; Ewout Steyerberg; Katia M. Verhamme; Peter R. Rijnbeek
Opublikowane w: medRxiv, 2021
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Alpha-1 blockers and susceptibility to COVID-19 in benign prostate hyperplasia patients : an international cohort study

Autorzy: Akihiko Nishimura; Junqing Xie; Kristin Kostka; Talita Duarte-Salles; Sergio Fernández Bertolín; María Aragón; Clair Blacketer; Azza Shoaibi; Scott L DuVall; Kristine Lynch; Michael E Matheny; Thomas Falconer; Daniel R Morales; Mitchell M Conover; Seng Chan You; Nicole Pratt; James Weaver; Anthony G Sena; Martijn J Schuemie; Jenna Reps; Christian Reich; Peter R Rijnbeek;
Opublikowane w: medRxiv, 2021
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The natural history of symptomatic COVID-19 in Catalonia, Spain: a multi-state model including 109,367 outpatient diagnoses, 18,019 hospitalisations, and 5,585 COVID-19 deaths among 5,627,520 people

Autorzy: Edward Burn, Cristian Tebe, Sergio Fernandez-Bertolin, Maria Aragon, Martina Recalde, Elena Roel, Albert Prats-Uribe, Daniel Prieto-Alhambra, Talita Duarte-Salles
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study

Autorzy: Talita Duarte-Salles, David Vizcaya, Andrea Pistillo, Paula Casajust, Anthony G. Sena, Lana Yin Hui Lai, Albert Prats-Uribe, Waheed-Ul-Rahman Ahmed, Thamir M Alshammari, Heba Alghoul, Osaid Alser, Edward Burn, Seng Chan You, Carlos Areia, Clair Blacketer, Scott DuVall, Thomas Falconer, Sergio Fernandez-Bertolin, Stephen Fortin, Asieh Golozar, Mengchun Gong, Eng Hooi Tan, Vojtech Huser, Pablo Iveli
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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Using Real World Data to Understand HIV and COVID-19 in the U.S.A. and Spain: Characterizing Co-Infected Patients Across the Care Cascade

Autorzy: Julianna Kohler; Kristin Kostka; Rupa Makadia; Roger Paredes; Talita Duarte-Salles; Scott Duvall; Alison Cheng; Asieh Golozar; Jennifer C. E. Lane; Anthony G. Sena; Peter R. Rijnbeek; Daniel R. Morales; Patrick B. Ryan; Christian Reich; Michael E. Matheny; Kristine E. Lynch; George K. Siberry; Daniel Prieto-Alhambra
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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Characteristics, outcomes, and mortality amongst 133,589 patients with prevalent autoimmune diseases diagnosed with, and 48,418 hospitalised for COVID-19: a multinational distributed network cohort analysis

Autorzy: Eng Hooi Tan; Anthony G. Sena; Albert Prats-Uribe; Seng Chan You; Waheed-Ul-Rahman Ahmed; Kristin Kostka; Christian Reich; Scott L. Duvall; Kristine E. Lynch; Michael E. Matheny; Talita Duarte-Salles; Sergio Fernandez Bertolin; George Hripcsak; Karthik Natarajan; Thomas Falconer; Matthew Spotnitz; Anna Ostropolets; Clair Blacketer; Thamir M Alshammari; Heba Alghoul; Osaid Alser; Jennifer C.E. Lane
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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Risk of depression, suicidal ideation, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multi-national network cohort study

Autorzy: Jennifer C.E Lane, James Weaver, Kristin Kostka, Talita Duarte-Salles, Maria Tereza F Abrahao, Heba Alghoul, Osaid Alser, Thamir M Alshammari, Carlos Areia, Juan M. Banda, Patricia Biedermann, Edward Burn, Paula Casajust, Kristina Fišter, Jill Hardin, Laura Hester, George Hripcsak, Benjamin Skov Kaas-Hansen, Sajan Khosla, Spyros Kolovos, Kristine E. Lynch, Rupa Makadia, Paras P. Mehta, Daniel R M
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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Deep phenotyping of 34,128 patients hospitalised with COVID-19 and a comparison with 81,596 influenza patients in America, Europe and Asia: an international network study

Autorzy: Edward Burn; Seng Chan You; Anthony Sena; Kristin Kostka; Hamed Abedtash; Maria Tereza F. Abrahao; Amanda Alberga; Heba Alghoul; Osaid Alser; Thamir M Alshammari; Maria Aragon; Carlos Areia; Juan M Banda; Jaehyeong Cho; Aedin C Culhane; Alexander Davydov; Frank J DeFalco; Talita Duarte-Salles; Scott L DuVall; Thomas Falconer; Sergio Fernandez-Bertolin; Weihua Gao; Asieh Golozar; Jill Hardin; Georg
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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Development and validation of patient-level prediction models for adverse outcomes following total knee arthroplasty

Autorzy: Ross D. Williams; Jenna M. Reps; Anthony G. Sena; Edward Burn; Ying He; Daniel R. Morales; David Culliford; Dahai Yu; Victoria Y. Strauss; Talita Duarte-Salles; Albert Prats-Uribe; Antonella Delmestri; James Weaver; William Sproviero; Danielle Robinson; Henry Morgan Stewart; Belay Birlie; Rafael Pinedo-Villanueva; Spyros Kolovos; Luis H. John; Ruth E. Costello; Michel van Speybroeck; Caroline O'Le
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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Characteristics and outcomes of 627 044 COVID-19 patients with and without obesity in the United States, Spain, and the United Kingdom

Autorzy: Martina Recalde, Elena Roel, Andrea Pistillo, Anthony G Sena, Albert Prats-Uribe, Waheed Ul-Rahman Ahmed, Heba Alghoul, Thamir M Alshammari, Osaid Alser, Carlos Areia, Edward Burn, Paula Casajust, Dalia Dawoud, Scott L DuVall, Thomas Falconer, Sergio Fernandez-Bertolin, Asieh Golozar, Mengchun Gong, Lana Yin Hui Lai, Jennifer C.E Lane, Kristine E Lynch, Michael E Matheny, Paras P Mehta, Daniel R M
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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Characteristics and outcomes of 118,155 COVID-19 individuals with a history of cancer in the United States and Spain

Autorzy: Elena Roel; Andrea Pistillo; Martina Recalde; Anthony G. Sena; Sergio Fernández-Bertolín; María Aragón; Diana Puente; Waheed-Ul-Rahman Ahmed; Heba Alghoul; Osaid Alser; Thamir M. Alshammari; Carlos Areia; Clair Blacketer; William Carter; Paula Casajust; Aedin C. Culhane; Dalia Dawoud; Frank DeFalco; Scott L. Duvall; Thomas Falconer; Asieh Golozar;
Opublikowane w: medRxiv, 2021
Wydawca: medRxiv
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Clinical characteristics, symptoms, management and health outcomes in 8,598 pregnant women diagnosed with COVID-19 compared to 27,510 with seasonal influenza in France, Spain and the US: a network cohort analysis

Autorzy: Lana Yin Hui Lai, Asieh Golozar, Anthony Sena, Andrea V. Margulis, Nuria Haro, Paula Casajust, Neus Valveny, Albert Prats-Uribe, Evan P. Minty, Waheed-Ul-Rahman Ahmed, Thamir M Alshammari, Daniel R. Morales, Heba Alghoul, Osaid Alser, Dalia Dawoud, Lin Zhang, Jose D. Posada, Nigam H. Shah, Clair Blacketer, Carlos Areia, Vignesh Subbian, Fredrik Nyberg, Jennifer C E Lane, Marc A Suchard, Mengchun G
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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Report on the EHDEN achievements during its foundational year (Nov 2018 - Oct 2019)

Autorzy: The EHDEN consortium
Opublikowane w: 2020
Wydawca: Self-published

Seek COVER: Development and validation of a personalized risk calculator for COVID-19 outcomes in an international network

Autorzy: Ross D. Williams; Aniek Markus; Cynthia Yang; Talita Duarte Salles; Scott L. DuVall; Thomas Falconer; Jitendra Jonnagaddala; Chungsoo Kim; Yeunsook Rho; Andrew Williams; Amanda Alberga; Min Ho An; María Aragón; Carlos Areia; Edward Burn; Young Hwa Choi; Iannis Drakos; Maria Tereza Fernandes Abrahão; Sergio Fernández-Bertolín; George Hripcsak; Benjamin Skov Kaas-Hansen; Prasanna L Kandukuri; J
Opublikowane w: medRxiv, Numer 16, 2020
Wydawca: medRxiv
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Can we trust the prediction model? Demonstrating the importance of external validation by investigating the COVID-19 Vulnerability (C-19) Index across an international network of observational healthcare datasets

Autorzy: Jenna M. Reps, Chungsoo Kim, Ross D. Williams, Aniek F. Markus, Cynthia Yang, Talita Duarte Salles, Thomas Falconer, Jitendra Jonnagaddala, Andrew Williams, Sergio Fernández-Bertolín, Scott L. DuVall, Kristin Kostka, Gowtham Rao, Azza Shoaibi, Anna Ostropolets, Matthew E Spotnitz, Lin Zhang, Paula Casajust, Ewout W. Steyerberg, Fredrik Nyberg, Benjamin Skov Kaas-Hansen, Young Hwa Choi, Daniel Mo
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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Renin-angiotensin system blockers and susceptibility to COVID-19: a multinational open science cohort study

Autorzy: Daniel R. Morales, Mitchell M. Conover, Seng Chan You, Nicole Pratt, Kristin Kostka, Talita Duarte-Salles, Sergio Fernández-Bertolín, Maria Aragón, Scott L. DuVall, Kristine Lynch, Thomas Falconer, Kees van Bochove, Cynthia Sung, Michael E. Matheny, Christophe G. Lambert, Fredrik Nyberg, Thamir M. Alshammari, Andrew E. Williams, Rae Woong Park, James Weaver, Anthony G. Sena, Martijn J. Schuemie
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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EHDEN - Annual report year 2

Autorzy: The EHDEN Consortium
Opublikowane w: 2021
Wydawca: Self published
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Use of dialysis, tracheostomy, and extracorporeal membrane oxygenation among 240,392 patients hospitalized with COVID-19 in the United States

Autorzy: Edward Burn; Anthony G. Sena; Albert Prats-Uribe; Matthew Spotnitz; Scott DuVall; Kristine E. Lynch; Michael E. Matheny; Fredrik Nyberg; Waheed-Ul-Rahman Ahmed; Osaid Alser; Heba Alghoul; Thamir Alshammari; Lin Zhang; Paula Casajust; Carlos Areia; Karishma Shah; Christian Reich; Clair Blacketer; Alan Andryc; Stephen Fortin; Karthik Natarajan; Mengchun Gong; Asieh Golozar; Daniel Morales; Peter Rij
Opublikowane w: medRxiv, 2020
Wydawca: medRxiv
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A secure architecture for exploring patient-level databases from distributed institutions

Autorzy: Almeida, J.R., Barraca, J.P., Oliveira, J.L.
Opublikowane w: IEEE Symposium on Computer-Based Medical Systems, 2022, ISBN 978-1-6654-6770-4
Wydawca: IEEE
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A FAIR Approach to Real-World Health Data Management and Analysis

Autorzy: Almeida, João Rafael; Silva, Jorge Miguel; Oliveira, José Luis
Opublikowane w: Numer 51, 2023
Wydawca: 2023 IEEE 36th International Symposium on Computer-based Medical Systems (CBMS)
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Clinical data integration strategies for multicentre studies

Autorzy: Almeida, João Rafael; Pazos, Alejandro; Oliveira, José Luis
Opublikowane w: 2023
Wydawca: Doctoral Conference on Computing, Electrical and Industrial Systems, Doceis 2023.
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The Book of OHDSI

Autorzy: The OHDSI Community
Opublikowane w: 2019, Strona(/y) 1-470, ISBN 978-1088-855195
Wydawca: Self published

Developing Computational Solutions for Personalized Medicine.

Autorzy: Reisberg Sulev
Opublikowane w: Numer 27/06/2019, 2019
Wydawca: University of Tartu Press

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