A Systems medicine approach to chronic inflammatory disease

Rezultaty

Report on the maintenance of website, updating with project news, results, success information

A report on the maintenance of the Project Website including the updating with project news results and success Information will be submitted

Summer School on Systems Medicine

To disseminate knowledge and expertise also beyond SYSCID we will organize a summer school on Systems Medicine

Open access summary report

An open access questionnaire to assess each partners experiences with the process and their general opinion that has been developed by Eurice in direct collaboration with the infrastructure project OpenAIRE wwwopenaireeu will be used to collect partner feedback to be merged into an open access summary report at the end of the project

Final report on integrated analyses and model

This document will describe the machine learning methods employed for antigen prediction in the datasets integrated

Public project website

Eurice will be in charge of the set-up and maintenance of the public project website, which will serve as an additional showcase for presenting the project’s activities and achievements.

SYSCID movie

In addition to standard print materials such as project leaflets and posters, audio-visual material like a project movie will be produced to support dissemination to the interested public including patients.

Publikacje

Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations

Autorzy: Degenhardt, F., G. Mayr, M. Wendorff, G. Boucher, E. Ellinghaus, D. Ellinghaus, H. ElAbd, E. Rosati, M. Hübenthal, S. Juzenas, S. Abedian, H. Vahedi, B. K. Thelma, S. K. Yang, B. D. Ye, J. H. Cheon, L. W. Datta, N. E. Daryani, P. Ellul, M. Esaki, Y. Fuyuno, D. P. B. McGovern, T. Haritunians, M. Hong, G. Juyal, E. S. Jung, M. Kubo, S. Kugathasan, T. L. Lenz, S. Leslie, R. Malekzadeh, V. Midha, A.
Opublikowane w: Human Molecular Genetics, 2021, ISSN 0964-6906
Wydawca: Oxford University Press
DOI: 10.1093/hmg/ddab017

Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation

Autorzy: Kevin Baßler, Wataru Fujii, Theodore S Kapellos, Erika Dudkin, Nico Reusch, Ari Horne, Benedikt Reiz Malte D Luecken, Collins Osei-Sarpong, Stefanie Warnat-Herresthal, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Allon Wagner, Patrick Günther, Carmen Pizarro, Tina Schreiber, Rainer Knoll, Lisa Holsten, Charlotte Kröger, Elena De Domenico, Matthias Becker, Kristian Händler, Christian T Wohnhaas
Opublikowane w: Frontiers in Immunology, Numer 16643224, 2022, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2022.917232

Demyelination with autoimmune features: a distinct clinical entity? Results from a longitudinal cohort

Autorzy: Dionysis Nikolopoulos, Dimitris Kitsos, Matilda Papathanasiou, Maria Chondrogianni, Aikaterini Theodorou, Panagiotis Garantziotis, Antigone Pieta, Triantafyllos Doskas, George Bertsias, Konstantinos Voumvourakis, Dimitrios T Boumpas, Antonis Fanouriakis
Opublikowane w: Rheumatology, Numer 14620324, 2021, ISSN 1462-0324
Wydawca: Oxford University Press
DOI: 10.1093/rheumatology/keaa902

Cross-species transcriptome analysis for early detection and specific therapeutic targeting of human lupus nephritis

Autorzy: Eleni Frangou, Panagiotis Garantziotis, Maria Grigoriou, Aggelos Banos, Dionysis Nikolopoulos, Antigone Pieta, Stavros A Doumas, Antonis Fanouriakis, Aikaterini Hatzioannou, Theodora Manolakou, Themis Alissafi, Panayotis Verginis, Emmanouil Athanasiadis, Emmanouil Dermitzakis, George Bertsias, Anastasia Filia, Dimitrios T Boumpas
Opublikowane w: Annals of the Rheumatic Diseases, Numer 00034967, 2022, ISSN 0003-4967
Wydawca: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-222069

Neutrophils in COVID-19

Autorzy: Nico Reusch, Elena De Domenico, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Kevin Baßler, Joachim L. Schultze, Anna C. Aschenbrenner
Opublikowane w: Frontiers in Immunology, Numer 12, 2021, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2021.652470

Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases

Autorzy: Jerko Štambuk, Frano Vučković , Siniša Habazin, Maja Hanić, Mislav Novokmet, Susanna Nikolaus, Florian Tran, Stefan Schreiber, Andre Franke, Philip Rosenstiel, Gordan Lauc, Konrad Aden, Marija Pezer
Opublikowane w: International Journal of Molecular Sciences, Numer 14220067, 2022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23158473

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

Autorzy: Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael To Vinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, Kim Melanie Kaiser, Gereon J. Rieke, Jenny Bischoff, Malte B. Monin, Christoph Hoffmeister, Stefan Schlabe, Elena De Domenico, Nico Reusch Kristian Händler, Gary Reynolds, Nils Blüthgen, Gudrun Hack, Claudia Finnemann, Hans D. Nischalke, Christian P. Strassburg, Em
Opublikowane w: Immunity, Numer 00928674, 2021, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2021.09.002

Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR

Autorzy: Michael Scherer; Gilles Gasparoni; Souad Rahmouni; Tatiana I. Shashkova; Marion Arnoux; Edouard Louis; Arina Nostaeva; Diana Avalos; Emmanouil T. Dermitzakis; Emmanouil T. Dermitzakis; Yurii S. Aulchenko; Thomas Lengauer; Paul A. Lyons; Michel Georges; Jörn Walter
Opublikowane w: Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-17 (2021), Numer 17568935, 2021, ISSN 1756-8935
Wydawca: BioMed Central
DOI: 10.17863/cam.77053

Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state

Autorzy: Caterina Carraro, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Arik Horne, Marie Oestreich, Stefanie Warnat-Herresthal, Tim Helbing, Michele De Franco, Kristian Haendler, Sach Mukherjee, Thomas Ulas, Valentina Gandin, Richard Goettlich, Anna C Aschenbrenner, Joachim L Schultze, and Barbara Gatto
Opublikowane w: eLife, Numer 2050084X, 2022, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.78012

Swarm Learning for decentralized and confidential clinical machine learning

Autorzy: Stefanie Warnat-Herresthal, Hartmut Schultze, Krishnaprasad Lingadahalli Shastry, Sathyanarayanan Manamohan, Saikat Mukherjee, Vishesh Garg, Ravi Sarveswara, Kristian Händler, Peter Pickkers, N. Ahmad Aziz, Sofia Ktena, Florian Tran, Michael Bitzer, Stephan Ossowski, Nicolas Casadei, Christian Herr, Daniel Petersheim, Uta Behrends, Fabian Kern, Tobias Fehlmann, Philipp Schommers, Clara Lehmann, M
Opublikowane w: Nature, Numer 594/7862, 2021, Strona(/y) 265-270, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-021-03583-3

Optimized workflow for single-cell transcriptomics on infectious diseases including COVID-19

Autorzy: Elena De Domenico, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Matthias Becker, Kristian Händler, Joachim L. Schultze
Opublikowane w: STAR Protocols, Numer 1/3, 2020, Strona(/y) 100233, ISSN 2666-1667
Wydawca: ScienceDirect
DOI: 10.1016/j.xpro.2020.100233

Differential associations between a priori diet quality scores and markers of cardiovascular health in women: cross-sectional analyses from TwinsUK

Autorzy: Olatz Mompeo, Sarah E. Berry, Tim D. Spector, Cristina Menni, Massimo Mangino, Rachel Gibson
Opublikowane w: British Journal of Nutrition, 2020, Strona(/y) 1-11, ISSN 0007-1145
Wydawca: CABI Publishing
DOI: 10.1017/s000711452000495x

Molecular Taxonomy of Systemic Lupus Erythematosus Through Data-Driven Patient Stratification: Molecular Endotypes and Cluster-Tailored Drugs

Autorzy: Panagiotis Garantziotis, Dimitrios Nikolakis, Stavros Doumas, Eleni Frangou, George Sentis, Anastasia Filia, Antonis Fanouriakis, George Bertsias and Dimitrios T. Boumpas
Opublikowane w: Frontiers in Immunology, Numer 16643224, 2022, ISSN 1664-3224
Wydawca: Froniters Media S.A.
DOI: 10.3389/fimmu.2022.860726

The Relation between Red Meat and Whole-Grain Intake and the Colonic Mucosal Barrier: A Cross-Sectional Study

Autorzy: Mohamad Jawhara, Signe Bek Sørensen, Berit Lilienthal Heitmann, Þórhallur Ingi Halldórsson, Andreas Kristian Pedersen, Vibeke Andersen
Opublikowane w: Nutrients, Numer 12/6, 2020, Strona(/y) 1765, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12061765

Association Between Human Gut Microbiome and N-Glycan Composition of Total Plasma Proteome

Autorzy: Vyacheslav A Petrov , Sodbo Zh Sharapov, Lev Shagam, Arina V Nostaeva, Marija Pezer, Dalin Li, Maja Hanić, Dermot McGovern, Edouard Louis, Souad Rahmouni, Gordan Lauc, Michel Georges, Yurii S Aulchenko
Opublikowane w: Frontiers in Mircrobiology, Numer 1664302X, 2022, ISSN 1664-302X
Wydawca: Frontiers Media
DOI: 10.3389/fmicb.2022.811922

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Autorzy: Philipp Georg, Rosario Astaburuaga-García, Lorenzo Bonaguro, Sophia Brumhard, Laura Michalick, Lena, J. Lippert, Tomislav Kostevc, Christiane Gäbel, Maria Schneider, Mathias Streitz, Vadim Demichev, Ioanna Gemünd, Matthias Barone, Pinkus Tober-Lau, Elisa T. Helbig, David Hillus, Lev Petrov, Julia Stein, Hannah-Philine Dey, Daniela Paclik, Christina Iwert, Michael Mülleder, Simran, Kaur Aulakh,
Opublikowane w: Cell, Numer 00928674, 2021, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2021.12.040

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Autorzy: Urmo Võsa; Annique Claringbould; Annique Claringbould; Harm-Jan Westra; Marc Jan Bonder; Patrick Deelen; Biao Zeng; Holger Kirsten; Ashis Saha; Roman Kreuzhuber; Roman Kreuzhuber; Roman Kreuzhuber; Seyhan Yazar; Harm Brugge; Roy Oelen; Dylan H. de Vries; Monique G. P. van der Wijst; Silva Kasela; Natalia Pervjakova; Isabel Alves; Marie-Julie Favé; Mawusse Agbessi; Mark W. Christiansen; Rick Jans
Opublikowane w: Nature Genetics, Numer 24, 2021, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-021-00913-z

Differential Gene Expression in Circulating CD14+ Monocytes Indicates the Prognosis of Critically Ill Patients with Sepsis

Autorzy: Anke Liepelt; Philipp Hohlstein; Hendrik Gussen; Jia Xue; Anna C. Aschenbrenner; Anna C. Aschenbrenner; Thomas Ulas; Lukas Buendgens; Klaudia Theresa Warzecha; Matthias Bartneck; Tom Luedde; Christian Trautwein; Joachim L. Schultze; Alexander Koch; Frank Tacke; Frank Tacke
Opublikowane w: Journal of Clinical Medicine, Numer 7, 2020, Strona(/y) 127, ISSN 2077-0383
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.18154/rwth-2020-04417

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Autorzy: Anna C. Aschenbrenner, Maria Mouktaroudi, Benjamin Krämer, Marie Oestreich, Nikolaos Antonakos, Melanie Nuesch-Germano, Konstantina Gkizeli, Lorenzo Bonaguro, Nico Reusch, Kevin Baßler, Maria Saridaki, Rainer Knoll, Tal Pecht, Theodore S. Kapellos, Sarandia Doulou, Charlotte Kröger, Miriam Herbert, Lisa Holsten, Arik Horne, Ioanna D. Gemünd, Nikoletta Rovina, Shobhit Agrawal, Kilian Dahm, Mart
Opublikowane w: Genome Medicine, Numer 13/1, 2021, ISSN 1756-994X
Wydawca: BioMed Central
DOI: 10.1186/s13073-020-00823-5

A novel unconventional T cell population enriched in Crohn's disease

Autorzy: Rosati, Elisa, Gabriela Rios Martini, Mikhail V. Pogorelyy, Anastasia A. Minervina, Frauke Degenhardt, Mareike Wendorff, Soner Sari, Gabriele Mayr, Antonella Fazio, Christel Marie Dowds, Charlotte Hauser, Florian Tran, Witigo von Schönfels, Julius Pochhammer, Maria A. Salnikova, Charlot Jaeckel, Johannes Boy Gigla, Sanaz Sedghpour Sabet, Matthias Hübenthal, Esther Schiminsky, Stefan Schreiber, P
Opublikowane w: Gut, 2022, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-325373

Towards a European health research and innovation cloud (HRIC)

Autorzy: F. M. Aarestrup, A. Albeyatti, W. J. Armitage, L. Augello, R. Balling, N. Benhabiles, G. Bertolini, J. G. Bjaalie,M. Black, N. Blomberg, P. Bogaert, M. Bubak, B. Claerhout, L. Clarke, B. De Meulder, G. D’Errico, A. Di Meglio, N. Forgo, C. Gans-Combe, A. E. Gray, I. Gut, A. Gyllenberg, G. Hemmrich-Stanisak, L. Hjorth, Y. Ioannidis, S. Jarmalaite, A. Kel, F. Kherif, J. O. Korbel, C. Larue, M. Lasz
Opublikowane w: Genome Medicine, Numer 1756994X, 2020, ISSN 1756-994X
Wydawca: BioMed Central
DOI: 10.1186/s13073-020-0713-z

Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases

Autorzy: Konrad Aden, Ateequr Rehman, Silvio Waschina, Wei-Hung Pan, Alesia Walker, Marianna Lucio, Alejandro Mena Nunez, Richa Bharti, Johannes Zimmerman, Johannes Bethge, Berenice Schulte, Dominik Schulte, Andre Franke, Susanna Nikolaus, Johann Oltmann Schroeder, Doris Vandeputte, Jeroen Raes, Silke Szymczak, Georg H Waetzig, Rainald Zeuner, Philippe Schmitt-Kopplin, Christoph Kaleta, Stefan Schreiber, P
Opublikowane w: Gastroenterology, 2019, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.07.025

Monocytes and Macrophages in COVID-19

Autorzy: Rainer Knoll, Joachim L. Schultze, Jonas Schulte-Schrepping
Opublikowane w: Frontiers in Immunology, Numer 16624548, 2021, ISSN 1662-4548
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.720109

A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine

Autorzy: Vibeke Andersen, Uffe Holmskov, Signe Sørensen, Mohamad Jawhara, Karina Andersen, Anette Bygum, Lone Hvid, Jakob Grauslund, Jimmi Wied, Henning Glerup, Ulrich Fredberg, Jan Villadsen, Søren Kjær, Jan Fallingborg, Seyed Moghadd, Torben Knudsen, Jacob Brodersen, Jesper Frøjk, Jens Dahlerup, Ole Nielsen, Robin Christensen, Anders Bojesen, Grith Sorensen, Steffen Thiel, Nils Færgeman, Ivan Brands
Opublikowane w: Nutrients, Numer 9/5, 2017, Strona(/y) 499, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu9050499

Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

Autorzy: Xia Shen, Lucija Klarić, Sodbo Sharapov, Massimo Mangino, Zheng Ning, Di Wu, Irena Trbojević-Akmačić, Maja Pučić-Baković, Igor Rudan, Ozren Polašek, Caroline Hayward, Timothy D. Spector, James F. Wilson, Gordan Lauc, Yurii S. Aulchenko
Opublikowane w: Nature Communications, Numer 8/1, 2017, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-017-00453-3

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

Autorzy: Susanna Nikolaus, Berenice Schulte, Natalie Al-Massad, Florian Thieme, Dominik M. Schulte, Johannes Bethge, Ateequr Rehman, Florian Tran, Konrad Aden, Robert Häsler, Natalie Moll, Gregor Schütze, Markus J. Schwarz, Georg H. Waetzig, Philip Rosenstiel, Michael Krawczak, Silke Szymczak, Stefan Schreiber
Opublikowane w: Gastroenterology, Numer 153/6, 2017, Strona(/y) 1504-1516.e2, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.08.028

Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases:protocol for a prospective cohort study of prognostic factors and personalised medicine

Autorzy: Christensen, Robin; Heitmann, Berit L; Andersen, Karina Winther; Nielsen, Ole Haagen; Sørensen, Signe Bek; Jawhara, Mohamad; Bygum, Anette; Hvid, Lone; Grauslund, Jakob; Wied, Jimmi; Glerup, Henning; Fredberg, Ulrich; Villadsen, Jan Alexander; Kjær, Søren Geill; Fallingborg, Jan; Moghadd, Seyed A G R; Knudsen, Torben; Brodersen, Jacob; Frøjk, Jesper; Dahlerup, Jens Frederik; Bojesen, Anders Bo
Opublikowane w: BMJ Open, Numer 1, 2018, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmjopen-2017-018166

Overview of methodologies for T-cell receptor repertoire analysis

Autorzy: Elisa Rosati, C Marie Dowds, Evaggelia Liaskou, Eva Kristine Klemsdal Henriksen, Tom H Karlsen, Andre Franke
Opublikowane w: BMC Biotechnology, Numer 17/1, 2017, ISSN 1472-6750
Wydawca: BioMed Central
DOI: 10.1186/s12896-017-0379-9

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Autorzy: Yukihide Momozawa, Julia Dmitrieva, Emilie Théâtre, Valérie Deffontaine, Souad Rahmouni, Benoît Charloteaux, François Crins, Elisa Docampo, Mahmoud Elansary, Ann-Stephan Gori, Christelle Lecut, Rob Mariman, Myriam Mni, Cécile Oury, Ilya Altukhov, Dmitry Alexeev, Yuri Aulchenko, Leila Amininejad, Gerd Bouma, Frank Hoentjen, Mark Löwenberg, Bas Oldenburg, Marieke J. Pierik, Andrea E. vander M
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-04365-8

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

Autorzy: Morgane Sonia Thion, Donovan Low, Aymeric Silvin, Jinmiao Chen, Pauline Grisel, Jonas Schulte-Schrepping, Ronnie Blecher, Thomas Ulas, Paola Squarzoni, Guillaume Hoeffel, Fanny Coulpier, Eleni Siopi, Friederike Sophie David, Claus Scholz, Foo Shihui, Josephine Lum, Arlaine Anne Amoyo, Anis Larbi, Michael Poidinger, Anne Buttgereit, Pierre-Marie Lledo, Melanie Greter, Jerry Kok Yen Chan, Ido Amit,
Opublikowane w: Cell, Numer 172/3, 2018, Strona(/y) 500-516.e16, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2017.11.042

Systems Medicine in Chronic Inflammatory Diseases

Autorzy: Joachim L. Schultze, Philip Rosenstiel
Opublikowane w: Immunity, Numer 48/4, 2018, Strona(/y) 608-613, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2018.03.022

The resilience of the intestinal microbiota influences health and disease

Autorzy: Felix Sommer, Jacqueline Moltzau Anderson, Richa Bharti, Jeroen Raes, Philip Rosenstiel
Opublikowane w: Nature Reviews Microbiology, Numer 15/10, 2017, Strona(/y) 630-638, ISSN 1740-1526
Wydawca: Nature Publishing Group
DOI: 10.1038/nrmicro.2017.58

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

Autorzy: Mirna Šimurina, Noortje de Haan, Frano Vučković, Nicholas A. Kennedy, Jerko Štambuk, David Falck, Irena Trbojević-Akmačić, Florent Clerc, Genadij Razdorov, Anna Khon, Anna Latiano, Renata D'Incà, Silvio Danese, Stephan Targan, Carol Landers, Marla Dubinsky, Dermot P.B. McGovern, Vito Annese, Manfred Wuhrer, Gordan Lauc, Harry Campbell, Vlatka Zoldoš, Iain K. Permberton, Daniel Kolarich, D
Opublikowane w: Gastroenterology, Numer 154/5, 2018, Strona(/y) 1320-1333.e10, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.01.002

Profiling and genetic control of the murine immunoglobulin G glycome

Autorzy: Jasminka Krištić, Olga O. Zaytseva, Ramesh Ram, Quang Nguyen, Mislav Novokmet, Frano Vučković, Marija Vilaj, Irena Trbojević-Akmačić, Marija Pezer, Kathleen M. Davern, Grant Morahan, Gordan Lauc
Opublikowane w: Nature Chemical Biology, Numer 14/5, 2018, Strona(/y) 516-524, ISSN 1552-4450
Wydawca: Nature Publishing Group
DOI: 10.1038/s41589-018-0034-3

Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up

Autorzy: Ivan Gudelj, Perttu P. Salo, Irena Trbojević-Akmačić, Malena Albers, Dragan Primorac, Markus Perola, Gordan Lauc
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numer 1864/6, 2018, Strona(/y) 2034-2039, ISSN 0925-4439
Wydawca: Elsevier BV
DOI: 10.1016/j.bbadis.2018.03.018

N-glycome of the Lysosomal Glycocalyx is Altered in Niemann-Pick Type C Disease (NPC) Model Cells

Autorzy: Marko Kosicek, Ivan Gudelj, Anita Horvatic, Tanja Jovic, Frano Vuckovic, Gordan Lauc, Silva Hecimovic
Opublikowane w: Molecular & Cellular Proteomics, Numer 17/4, 2018, Strona(/y) 631-642, ISSN 1535-9476
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.RA117.000129

The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations

Autorzy: JN Liu, M Dolikun, J Štambuk, I Trbojević-Akmačić, J Zhang, H Wang, DQ Zheng, XY Zhang, HL Peng, ZY Zhao, D Liu, Y Sun, Q Sun, QH Li, JX Zhang, M Sun, WJ Cao, A Momčilović, G. Razdorov, LJ Wu, A Russell, YX Wang, MS Song, G Lauc, W Wang
Opublikowane w: Journal of Human Hypertension, 2018, ISSN 0950-9240
Wydawca: Nature Publishing Group
DOI: 10.1038/s41371-018-0071-0

Quantitative microbiome profiling links gut community variation to microbial load

Autorzy: Doris Vandeputte, Gunter Kathagen, Kevin D’hoe, Sara Vieira-Silva, Mireia Valles-Colomer, João Sabino, Jun Wang, Raul Y. Tito, Lindsey De Commer, Youssef Darzi, Séverine Vermeire, Gwen Falony, Jeroen Raes
Opublikowane w: Nature, Numer 551, 2017, Strona(/y) 507-511, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature24460

Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease

Autorzy: Sebastian Zeissig, Elisa Rosati, C Marie Dowds, Konrad Aden, Johannes Bethge, Berenice Schulte, Wei Hung Pan, Neha Mishra, Maaz Zuhayra, Marlies Marx, Maren Paulsen, Anne Strigli, Claudio Conrad, Dörthe Schuldt, Anupam Sinha, Henriette Ebsen, Sabin-Christin Kornell, Susanna Nikolaus, Alexander Arlt, Dieter Kabelitz, Mark Ellrichmann, Ulf Lützen, Philip C Rosenstiel, Andre Franke, Stefan Schreibe
Opublikowane w: Gut, 2018, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316023

Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases

Autorzy: Susanna Nikolaus, Georg H. Waetzig, Sven Butzin, Monika Ziolkiewicz, Natalie Al-Massad, Florian Thieme, Ulf Lövgren, Birgitte B. Rasmussen, Torsten M. Reinheimer, Dirk Seegert, Philip Rosenstiel, Silke Szymczak, Stefan Schreiber
Opublikowane w: International Journal of Colorectal Disease, Numer 33/7, 2018, Strona(/y) 927-936, ISSN 0179-1958
Wydawca: Springer Verlag
DOI: 10.1007/s00384-018-3069-8

DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome

Autorzy: Kate Joanne Howell, Judith Kraiczy, Komal M. Nayak, Marco Gasparetto, Alexander Ross, Claire Lee, Tim N. Mak, Bon-Kyoung Koo, Nitin Kumar, Trevor Lawley, Anupam Sinha, Philip Rosenstiel, Robert Heuschkel, Oliver Stegle, Matthias Zilbauer
Opublikowane w: Gastroenterology, Numer 154/3, 2018, Strona(/y) 585-598, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.10.007

Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

Autorzy: Shaza B Zaghlool, Dennis O Mook-Kanamori, Sara Kader, Nisha Stephan, Anna Halama, Rudolf Engelke, Hina Sarwath, Eman K Al-Dous, Yasmin A Mohamoud, Werner Roemisch-Margl, Jerzy Adamski, Gabi Kastenmüller, Nele Friedrich, Alessia Visconti, Pei-Chien Tsai, Tim Spector, Jordana T Bell, Mario Falchi, Annika Wahl, Melanie Waldenberger, Annette Peters, Christian Gieger, Marija Pezer, Gordan Lauc, Johann
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