Smart optical and ultrasound diagnostics of breast cancer

Rezultaty

Benchmark configuration and data assessing functional working of acquisition and processing hardware and software on the mockup system

Benchmark configuration and data assessing functional working of acquisition and processing hardware and software on the mockup system key performance indicator 4

Report on clinical validation

Final evaluation of the proposed SOLUS system from a clinical viewpoint key performance indicators 8 9 and 13

Performance assessment of the single optode

Performance assessment of the single optode (key performance indicator 3)

Definition of procedures for routine tests
Performance assessment of DOT with US priors
Definition of protocols for system characterization
Design of multi-modal phantoms for DOT-US
Authorization for the clinical use of the multi-modal optical/US prototype

Authorization from the Italian Ministry of Health for the clinical use of the multimodal opticalUS prototype

Approval of clinical protocol by ethical committee
Definition of paradigms representing exemplary breast lesions cases
Performances assessment of optode components

Performances assessment of optode components (key performance indicators 1 and 2)

Final characterization of the SOLUS prototype

Final characterization of the SOLUS prototype key performance indicator 5

Visual identity and online presence

Report summarising the project's visual identity and online presence

Final Data Management Plan
Updated Data Management Plan
First release of the Data Management Plan

Initial release of the SOLUS Data Management Plan

Publikacje

"Rivelatore a singolo fotone ad area larga con funzionalità di time-gating"

Autorzy: Tosi, A.; Villa, F.; Zappa, F.; Torricelli, A.; Dalla Mora, A.; Contini, D.; Pifferi, G.; Taroni, P.; Di Sieno, L.; Buttafava, M.; Conca, E.; Scrofani, G.; Tisa, S.
Opublikowane w: 2018
Wydawca: Politecnico di Milano

Bimodal ultrasonic probe comprising an optical device for diagnosis

Autorzy: Taroni, Paola; Tosi, Alberto; Pifferi, Antonio Giovanni; Dalla Mora, Alberto
Opublikowane w: 2019
Wydawca: Politecnico di Milano

WIDE-AREA SINGLE-PHOTON DETECTOR WITH TIME-GATING CAPABILITY

Autorzy: Tosi, Alberto; Villa, Federica Alberta; Zappa, Franco; Torricelli, Alessandro; Dalla Mora, Alberto; Contini, Davide; Pifferi, Antonio Giovanni; Taroni, Paola; Di Sieno, Laura; Buttafava, Mauro; Conca, Enrico; Scrofani, Gabriele; Tisa, Simone
Opublikowane w: 2019
Wydawca: Politecnico di Milano

Time-domain diffuse optics with 86 mm2 fast-gated SiPM for extreme light harvesting

Autorzy: L. Di Sieno, E. Ferocino, E. Conca, V. Sesta, M. Buttafava, F. Villa, F. Zappa, D. Contini, A. Torricelli, P. Taroni, A. Tosi, A. Pifferi, A. Dalla Mora
Opublikowane w: Optics Letters, Numer 46/2, 2021, Strona(/y) 424, ISSN 0146-9592
Wydawca: Optical Society of America
DOI: 10.1364/ol.413577

In vivo test-driven upgrade of a time domain multi-wavelength optical mammograph

Autorzy: Giulia Maffeis, Edoardo Ferocino, Alberto Dalla Mora, Antonio Pifferi, Rinaldo Cubeddu, Paola Taroni
Opublikowane w: Biomedical Optics Express, Numer 12/2, 2021, Strona(/y) 1105, ISSN 2156-7085
Wydawca: The Optical Society
DOI: 10.1364/boe.412210

The SiPM revolution in time-domain diffuse optics

Autorzy: Alberto Dalla Mora, Laura Di Sieno, Anurag Behera, Paola Taroni, Davide Contini, Alessandro Torricelli, Antonio Pifferi
Opublikowane w: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Numer 978, 2020, Strona(/y) 164411, ISSN 0168-9002
Wydawca: Elsevier BV
DOI: 10.1016/j.nima.2020.164411

Large-Area, Fast-Gated Digital SiPM With Integrated TDC for Portable and Wearable Time-Domain NIRS

Autorzy: Enrico Conca, Vincenzo Sesta, Mauro Buttafava, Federica Villa, Laura Di Sieno, Alberto Dalla Mora, Davide Contini, Paola Taroni, Alessandro Torricelli, Antonio Pifferi, Franco Zappa, Alberto Tosi
Opublikowane w: IEEE Journal of Solid-State Circuits, Numer 55/11, 2020, Strona(/y) 3097-3111, ISSN 0018-9200
Wydawca: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jssc.2020.3006442

Probe-hosted large area silicon photomultiplier and high-throughput timing electronics for enhanced performance time-domain functional near-infrared spectroscopy

Autorzy: L. Di Sieno, A. Behera, S. Rohilla, E. Ferocino, D. Contini, A. Torricelli, B. Krämer, F. Koberling, A. Pifferi, A. Dalla Mora
Opublikowane w: Biomedical Optics Express, Numer 11/11, 2020, Strona(/y) 6389, ISSN 2156-7085
Wydawca: The Optical Society
DOI: 10.1364/boe.400868

Chromophore decomposition in multispectral time-resolved diffuse optical tomography

Autorzy: Judy Zouaoui, Laura Di Sieno, Lionel Hervé, Antonio Pifferi, Andrea Farina, Alberto Dalla Mora, Jacques Derouard, Jean-Marc Dinten
Opublikowane w: Biomedical Optics Express, Numer 8/10, 2017, Strona(/y) 4772, ISSN 2156-7085
Wydawca: The Optical Society
DOI: 10.1364/BOE.8.004772

Time-domain diffuse optical tomography using silicon photomultipliers: feasibility study

Autorzy: Laura Di Sieno, Judy Zouaoui, Lionel Hervé, Antonio Pifferi, Andrea Farina, Edoardo Martinenghi, Jacques Derouard, Jean-Marc Dinten, Alberto Dalla Mora
Opublikowane w: Journal of Biomedical Optics, Numer 21/11, 2016, Strona(/y) 116002, ISSN 1083-3668
Wydawca: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.JBO.21.11.116002

High throughput detection chain for time domain optical mammography

Autorzy: Edoardo Ferocino, Edoardo Martinenghi, Alberto Dalla Mora, Antonio Pifferi, Rinaldo Cubeddu, Paola Taroni
Opublikowane w: Biomedical Optics Express, Numer 9/2, 2018, Strona(/y) 755, ISSN 2156-7085
Wydawca: The Optical Society
DOI: 10.1364/boe.9.000755

Non-invasive optical estimate of tissue composition to differentiate malignant from benign breast lesions: A pilot study

Autorzy: Paola Taroni, Anna Maria Paganoni, Francesca Ieva, Antonio Pifferi, Giovanna Quarto, Francesca Abbate, Enrico Cassano, Rinaldo Cubeddu
Opublikowane w: Scientific Reports, Numer 7, 2017, Strona(/y) 40683, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep40683

Instrumental, optical and geometrical parameters affecting time-gated diffuse optical measurements: a systematic study

Autorzy: Anurag Behera, Laura Di Sieno, Antonio Pifferi, Fabrizio Martelli, Alberto Dalla Mora
Opublikowane w: Biomedical Optics Express, Numer 9/11, 2018, Strona(/y) 5524, ISSN 2156-7085
Wydawca: The Optical Society
DOI: 10.1364/boe.9.005524

Systematic study of the effect of ultrasound gel on the performances of time-domain diffuse optics and diffuse correlation spectroscopy

Autorzy: Laura Di Sieno, Davide Contini, Giuseppe Lo Presti, Lorenzo Cortese, Tony Mateo, Bogdan Rosinski, Elena Venturini, Pietro Panizza, Mireia Mora, Gloria Aranda, Mattia Squarcia, Andrea Farina, Turgut Durduran, Paola Taroni, Antonio Pifferi, Alberto Dalla Mora
Opublikowane w: Biomedical Optics Express, Numer 10/8, 2019, Strona(/y) 3899, ISSN 2156-7085
Wydawca: The Optical Society
DOI: 10.1364/boe.10.003899

Multi Simulation Platform for Time Domain Diffuse Optical Tomography: An Application to a Compact Hand-Held Reflectance Probe

Autorzy: Edoardo Ferocino, Antonio Pifferi, Simon Arridge, Fabrizio Martelli, Paola Taroni, Andrea Farina
Opublikowane w: Applied Sciences, Numer 9/14, 2019, Strona(/y) 2849, ISSN 2076-3417
Wydawca: MDPI
DOI: 10.3390/app9142849

Time-Gated Single-Photon Detection in Time-Domain Diffuse Optics: A Review

Autorzy: Alberto Dalla Mora, Laura Di Sieno, Rebecca Re, Antonio Pifferi, Davide Contini
Opublikowane w: Applied Sciences, Numer 10/3, 2020, Strona(/y) 1101, ISSN 2076-3417
Wydawca: MDPI
DOI: 10.3390/app10031101

Enhanced diffuse optical tomographic reconstruction using concurrent ultrasound information

Autorzy: G. Di Sciacca, L. Di Sieno, A. Farina, P. Lanka, E. Venturini, P. Panizza, A. Dalla Mora, A. Pifferi, P. Taroni, S. R. Arridge
Opublikowane w: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Numer 379/2240, 2021, Strona(/y) 20200195, ISSN 1364-503X
Wydawca: Royal Society of London
DOI: 10.1098/rsta.2020.0195

SPAD-based asynchronous-readout array detectors for image-scanning microscopy

Autorzy: Mauro Buttafava, Federica Villa, Marco Castello, Giorgio Tortarolo, Enrico Conca, Mirko Sanzaro, Simonluca Piazza, Paolo Bianchini, Alberto Diaspro, Franco Zappa, Giuseppe Vicidomini, Alberto Tosi
Opublikowane w: Optica, Numer 7:7, 2020, Strona(/y) 755-765, ISSN 2334-2536
Wydawca: Optical Society of America
DOI: 10.1364/optica.391726

Broadband Time Domain Diffuse Optical Reflectance Spectroscopy: A Review of Systems, Methods, and Applications

Autorzy: Sanathana Konugolu Venkata Sekar, Pranav Lanka, Andrea Farina, Alberto Dalla Mora, Stefan Andersson-Engels, Paola Taroni, Antonio Pifferi
Opublikowane w: Applied Sciences, Numer 9/24, 2019, Strona(/y) 5465, ISSN 2076-3417
Wydawca: MDPI
DOI: 10.3390/app9245465

Fast-Gated Digital Silicon Photomultiplier Maximizes Light Harvesting and Depth Sensitivity in Time-Domain Diffuse Optics

Autorzy: Alberto Dalla Mora, Laura Di Sieno, Edoardo Ferocino, Enrico Conca, Vincenzo Sesta, Mauro Buttafava, Federica Villa, Franco Zappa, Davide Contini, Alessandro Torricelli, Paola Taroni, Alberto Tosi, and Antonio Pifferi
Opublikowane w: European Conferences on Biomedical Optics 2021 (ECBO), 2021, Strona(/y) ES1B.3, ISBN 978-1-943580-95-8
Wydawca: Optica Publishing Group

SOLUS Project: Bringing Innovation into Breast Cancer Diagnosis and in the Time-Domain Diffuse Optical Field

Autorzy: Laura Di Sieno, Alberto Dalla Mora, Edoardo Ferocino, Antonio Pifferi, Alberto Tosi, Enrico Conca, Vincenzo Sesta, Andrea Giudice, Alessandro Ruggeri, Simone Tisa, Alexander Flocke, Bogdan Rosinski, Jean-Marc Dinten, Mathieu Perriollat, David Savery, Hélène Sportouche, Simon Arridge, Andrea Farina, Pietro Panizza, Elena Venturini, Peter Gordebeke, Pamela Zolda, Paola Taroni
Opublikowane w: Biophotonics Congress: Biomedical Optics 2020 (Translational, Microscopy, OCT, OTS, BRAIN), 2020, Strona(/y) STu1D.5, ISBN 978-1-943580-74-3
Wydawca: OSA
DOI: 10.1364/ots.2020.stu1d.5

SOLUS: an innovative multimodal imaging system to improve breast cancer diagnosis through diffuse optics and ultrasounds

Autorzy: Antonio Pifferi, Alberto Dalla Mora, Laura Di Sieno, Edoardo Ferocino, Alberto Tosi, Enrico Conca, Vincenzo Sesta, Andrea Giudice, Alessandro Ruggeri, Simone Tisa, Alexander Flocke, Bogdan Rosinski, Jean-Marc Dinten, Mathieu Perriollat, Christophe Fraschini, Hélène Sportouche, Simon Arridge, Giuseppe Di Sciacca, Andrea Farina, Pietro Panizza, Elena Venturini, Peter Gordebeke, Pamela Zolda, Paola
Opublikowane w: Optical Tomography and Spectroscopy of Tissue XIV, Numer 11639, 2021, Strona(/y) 116390C
Wydawca: International society for optics and photonics
DOI: 10.1117/12.2576778

Wide-area fast-gated single-photon detector with integrated TDCfor near-infrared spectroscopy applications

Autorzy: Conca, Enrico; Sesta, Vincenzo; Villa, Federica Alberta; Buttafava, Mauro; Tisa, Simone; Dalla Mora, Alberto; Contini, Davide; Torricelli, Alessandro; Pifferi, Antonio Giovanni; Di Sieno, Laura; Taroni, Paola; Zappa, Franco; Tosi, Alberto
Opublikowane w: Proceedings of Single Photon Workshop 2019, 2019
Wydawca: Politecnico di Milano

A multimodal imaging system hosting an innovative photonic module to improve breast cancer diagnosis: the SOLUS project

Autorzy: Di Sieno, L.; Dalla Mora, A.; Ferocino, E.; Pifferi, A.; Tosi, A.; Conca, E.; Sesta, V.; Giudice, A.; Ruggeri, A.; Tisa, S.; Flocke, A; Rosinski, B.; Dinten, J. -M.; Perriollat, M.; Savery, D.; Sportouche, H.; Arridge, S.; Farina, A.; Panizza, P.; Venturini, E.; Gordebeke, P.; Zolda, P.; Taroni, P.
Opublikowane w: Proceedings of Single Photon Workshop 2019, Numer 11, 2019, Strona(/y) 125
Wydawca: Politecnico di Milano

Attractive new technologies for 7-wavelength time domain optical mammography

Autorzy: Edoardo Ferocino, Edoardo Martinenghi, Alberto Dalla Mora, Antonio Pifferi, Rinaldo Cubeddu, Paola Taroni
Opublikowane w: Diffuse Optical Spectroscopy and Imaging VI, 2017, Strona(/y) 1041202
Wydawca: SPIE
DOI: 10.1117/12.2286058

Gating techniques for InGaAs/InP and silicon SPADs

Autorzy: Alberto Tosi, Mirko Sanzaro, Mauro Buttafava, Alessandro Ruggeri, Enrico Conca, Marco Renna, Federica Villa, Franco Zappa
Opublikowane w: Single Photon Workshop 2017, 2017, Strona(/y) 177
Wydawca: National Institute of Standards and Technology (NIST)

Performance evaluation of time-domain multispectral diffuse optical tomography in the reflection geometry

Autorzy: Lionel Hervé, Judy Zouaoui, David Orive-Miguel, Laura Di Sieno, Antonio Pifferi, Andrea Farina, Alberto Dalla Mora, Jacques Derouard, Jérôme Mars, Laurent Condat, Jean-Marc Dinten
Opublikowane w: Diffuse Optical Spectroscopy and Imaging VI, 2017, Strona(/y) 25, ISBN 9781-510612839
Wydawca: SPIE
DOI: 10.1117/12.2285811

Novel Approaches to Photon Detection and Timing for 7-Wavelength Time Domain Optical Mammography

Autorzy: E. Ferocino, E. Martinenghi, A. Dalla Mora, A. Pifferi, R. Cubeddu, P. Taroni
Opublikowane w: 19th Italian National Conference on Photonic Technologies (Fotonica 2017), 2017, Strona(/y) 29 (4 .)-29 (4 .), ISBN 978-1-78561-757-7
Wydawca: Institution of Engineering and Technology
DOI: 10.1049/cp.2017.0204

How Should the New Generation of Detectors for Diffuse Optics Be? A Systematic Simulation Study

Autorzy: Laura Di Sieno, Anurag Behera, Antonio Pifferi, Fabrizio Martelli, Alberto Dalla Mora
Opublikowane w: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Strona(/y) JW3A.30, ISBN 978-1-943580-41-5
Wydawca: OSA
DOI: 10.1364/translational.2018.jw3a.30

Novel Technologies for Time-Domain Diffuse Optics: Miniaturized Wearable Devices and Bioresorbable Optical Fibers

Autorzy: Alberto Dalla Mora, Laura Di Sieno, Sanathana Konugolu Venkata Sekar, Andrea Farina, Davide Contini, Nadia G. Boetti, Daniel Milanese, Jan Nissinen, Antonio Pifferi
Opublikowane w: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Strona(/y) OF2D.6, ISBN 978-1-943580-41-5
Wydawca: OSA
DOI: 10.1364/ots.2018.of2d.6

Advances in Single-Photon Detection and Timing for Time Domain Multi-Wavelength Optical Mammography

Autorzy: Edoardo Ferocino, Edoardo Martinenghi, Alberto Dalla Mora, Antonio Pifferi, Rinaldo Cubeddu, Paola Taroni
Opublikowane w: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Strona(/y) JW3A.43, ISBN 978-1-943580-41-5
Wydawca: OSA
DOI: 10.1364/translational.2018.jw3a.43

Multi-wavelength time domain diffuse optical tomography for breast cancer: initial results on silicone phantoms

Autorzy: Edoardo Ferocino, Giuseppe Di Sciacca, Laura Di Sieno, Alberto Dalla Mora, Antonio Pifferi, Simon R. Arridge, Fabrizio Martelli, Paola Taroni, Andrea Farina
Opublikowane w: Optical Tomography and Spectroscopy of Tissue XIII, 2019, Strona(/y) 59, ISBN 9781-510623910
Wydawca: SPIE
DOI: 10.1117/12.2508657

Study of optimal measurement conditions for time-domain diffuse optics systems

Autorzy: Anurag Behera, Laura Di Sieno, Antonio Pifferi, Fabrizio Martelli, Alberto Dalla Mora
Opublikowane w: Biophotonics: Photonic Solutions for Better Health Care VI, 2018, Strona(/y) 40, ISBN 9781-510618978
Wydawca: SPIE
DOI: 10.1117/12.2307370

Large area SiPM and high throughput timing electronics: toward new generation time-domain instruments

Autorzy: Anurag Behera, Laura Di Sieno, Sumeet Rohilla, Antonio Pifferi, Alessandro Torricelli, Davide Contini, Benedikt Kraemer, Felix Koberling, Alberto Dalla Mora
Opublikowane w: Diffuse Optical Spectroscopy and Imaging VII, 2019, Strona(/y) 1, ISBN 9781-510628427
Wydawca: SPIE
DOI: 10.1117/12.2526792

Effects of ultrasound impedance matching fluids on diffuse optical measurements

Autorzy: Laura Di Sieno, Davide Contini, Giuseppe Lo Presti, Lorenzo Cortese, Tony Mateo, Bogdan Rosinski, Elena Venturini, Pietro Panizza, Mireia Mora, Gloria Aranda, Mattia Squarcia, Andrea Farina, Turgut Durduran, Paola Taroni, Antonio Pifferi, Alberto Dalla Mora
Opublikowane w: Diffuse Optical Spectroscopy and Imaging VII, 2019, Strona(/y) 102, ISBN 9781-510628427
Wydawca: SPIE
DOI: 10.1117/12.2526925

Solid heterogeneous phantoms for multimodal ultrasound and diffuse optical imaging: an outcome of the SOLUS project for standardization

Autorzy: Laura Di Sieno, Rinaldo Cubeddu, Hélène Sportouche, David Savéry, Sanathana Konugolu Venkata Sekar, Bogdan Rosinski, Andrea Farina, Edoardo Ferocino, Pranav Lanka, Paola Taroni, Antonio Pifferi, Alberto Dalla Mora
Opublikowane w: Novel Biophotonics Techniques and Applications V, 2019, Strona(/y) 39, ISBN 9781-510628441
Wydawca: SPIE
DOI: 10.1117/12.2526645

Fitting a spectral model for component analysis in diffuse optical tomography

Autorzy: Giuseppe Di Sciacca, Edoardo Ferocino, Andrea Farina, Antonio Pifferi, Paola Taroni, Simon Arridge
Opublikowane w: Diffuse Optical Spectroscopy and Imaging VII, 2019, Strona(/y) 77, ISBN 9781-510628427
Wydawca: SPIE
DOI: 10.1117/12.2527119

A Tool for Quantitative and Systematic Simulation of Diffuse Optical Tomography with a Limited Number of Fixed Sources and Detectors

Autorzy: Edoardo Ferocino, Antonio Pifferi, Simon Arridge, Fabrizio Martelli, Paola Taroni, Andrea Farina
Opublikowane w: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Strona(/y) JTu3A.25, ISBN 978-1-943580-41-5
Wydawca: OSA
DOI: 10.1364/translational.2018.jtu3a.25

Spectral approach to time domain diffuse optical tomography for breast cancer: validation on meat phantoms

Autorzy: Edoardo Ferocino, Giuseppe Di Sciacca, Laura Di Sieno, Alberto Dalla Mora, Antonio Pifferi, Simon Arridge, Fabrizio Martelli, Paola Taroni, Andrea Farina
Opublikowane w: Diffuse Optical Spectroscopy and Imaging VII, 2019, Strona(/y) 7, ISBN 9781-510628427
Wydawca: SPIE
DOI: 10.1117/12.2526649

SOLUS: A Novel Multimodal Approach to Diffuse Optics and Ultrasound Imaging of Breast Cancer

Autorzy: Antonio Pifferi, Alberto Dalla Mora, Laura Di Sieno, Giulia Maffeis, Alberto Tosi, Enrico Conca, Vincenzo Sesta, Andrea Giudice, Alessandro Ruggeri, Simone Tisa, Alexander Flocke, Bogdan Rosinski, Jean-Marc Dinten, Mathieu Perriollat, Hélène Sportouche, Christophe Fraschini, Simon Arridge, Giuseppe Di Sciacca, Andrea Farina, Pietro Panizza, Elena Venturini, Peter Gordebeke, Pamela Zolda, and Pao
Opublikowane w: European Conferences on Biomedical Optics 2021 (ECBO), 2021, Strona(/y) ES1B.2, ISBN 978-1-943580-95-8
Wydawca: Optica Publishing Group

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