Rezultaty
Education program designed to accompany the professional growth of the researchers hired for the project
Learning Modules online on websiteWe will work with each WP to prepare the learning modules described in D4.03. Working with members of each WP we will create slide audiocasts describing each project for the website.
Recipes and food solutions for industrial products, schools and other institutes, cook bookCreation of food recipes that will be made public through a cook book that aimes at the multiple stakeholders of the project
Go online of public project website, Eat2beNICE website internal part onlineCorporate design and public part of Eat2BeNICE website set up to disseminate results to the public. Eat2BeNICE website internet for internal use and project monitoring
Learning Modules update online (posted per schedule)The slide audiocasts prepared in D404 will be updated with either supplementary or replacement audiocasts depending on the needs of each WP
Program designed to accompany the professional growth of young researchers hired for the project
Manuscript on the effect of the interaction between the microbiome and host genome on impulsive/compulsive behaviourIt is yet unknown how host genes affect microbial metabolite effects The deliverable will contain a manuscript addressing the interaction between host candidate genes functionally selected bacterial communities
Manuscript on the effect of physical activity on microbiome composition and its relation with impulsive/compulsive behaviourPhysical activity modifies the gut microbiome relative abundance The deliverable will contain a manuscript addressing the mechanisms involved in the interaction between PA diet and microbiome
Training documentationWe will document what we have done to train researchers to communicate their results to achieve maximal societal impact
Manuscript 1: effects of dietary intake and lifestyle across lifespan stratified by sex and SESThe deliverable will contain a manuscript describing the association between dietary risk factors and lifestyle behavior related with maladaptive behavior
Manuscript: Effects of Mediterranean diet on symptoms of impulsivity, compulsivity and aggressionThe deliverable will contain a manuscript about the identification of dietary factors from the mediterranena diet on impulsivity compulsivity and addiction
Manuscript: Effect of nutrition, lifestyle, impulsivity, compulsivity on the brain (UK Biobank)Using the UK biobank we will detect the small effects of dietary risk factors in impulsivity, compulsivity and addiction and brain variables (MRI derived). Results will be summarized in a manuscript.
Manuscript: Analysis of joint effects of PA and nutrition on resilient behaviour in CRC 1193Resilience is key to cope with maladaptive behavior The deliverable will contain a manuscript addressing how diet can protect you by making you more resilient
Manuscript: Cross-replication of results in the BALB/cJ and BTBR mice and Tph2 knockout miceWe will generalize the behavioral findings of the BALBcJ and BTBR mice using the Tph2 mice emphasizing effects on aggression and impulsivity Results will be summarized in a manuscript
Manuscript: Analysis of joint effects of PA and nutrition on impulsive symptoms in CoCA-PROUDThe deliverable will contain a manuscript describing the effects of Physical Activity PA dietary factors as predictors of impulsivity compulsivity and addiction in the CoCAPROUD cohort
Manuscript: Validation of selected epigenetically modified candidate genes derived from human cohorts profiling in the BALB/cJ and Tph2-modified mouse modelsThe deliverable will contain a manuscript addressing the identification of mechanistic pathways involved in epigenetic process for candidate genes derived from human cohorts using mouse models
Manuscript: Effects of elimination diet on symptoms of impulsivity, compulsivity and aggressionThe deliverable will contain a manuscript addressing the effect that Restriction diet RED has on the change improvement in impulsivity compulsivity and addiction
Manuscript 4: how genetic contributions to impulsivity and compulsivity depend on dietary intake and lifestyle using twin modellingThe deliverable will contain a manuscript addressing the interaction analysis between candidate genespathways and dietary factors and their relation with maladaptive behavior using twin data
Manuscript 7: a genome-wide by environment interaction study (GWEIS) on impulsivity and compulsivityThe deliverable will contain a manuscript addressing the genegene interaction analysis at the genomewide level for the risk of maladaptive behavior
Manuscript 3: how lifestyle may enhance harmful/beneficial effects of diet or cancel these outThe deliverable will contain a manuscript describing the relationship between diet characteristics and lifestyle factors
Manuscript 6: candidate gene pathways x diet/lifestyle interactions on impulsivity and compulsivityThe deliverable will contain a manuscript addressing threeway interaction analysis of genes and environment as predictors of maladaptive behavior and impulsivity at different age ranges
Manuscript 5: offspring candidate gene pathways x maternal diet/lifestyle interactions during pregnancy on offspring impulsivity and compulsivityThe deliverable will contain a manuscript addressing threeway interaction analysis of genes and environment as predictors of maladaptive behavior
Manuscript: Nutritional and exercise intervention-induced epigenetic modification of a set of novel candidate genes in the BALB/cJ and Tph2-modified mouse modelsThe deliverable will contain a manuscript describing physical exercise as a modifier of epigenetic processes using brain tissue in mousemodels
Manuscript 2: effects of dietary intake during pregnancy on offspring impulsivity and compulsivityThe deliverable will contain a manuscript describing the role of dietary factors in the pregnant mother as predictive factor of the childs behavior
Manuscript on the effect of dietary interventions on microbiome composition and its relation with impulsive/compulsive behaviourThe deliverable will contain a manuscript addressing how the dietary interventions used in the RCTs modify the relative abundance of the microbiome and behavior
Manuscript: Analysis of joint effects of PA and nutrition on impulsive symptoms in CRC 1193The deliverable will contain a manuscript describing the effects of PA dietary factors as predictors of impulsivity compulsivity and addiction in the CRC1193 cohort
Manuscript: Effects of physical activity on brain measuresThe deliverable will contain a manuscript describing the effects the PA has on MRIderived variables
Registration number of clinical studies in a WHO- or ICMJE- approved registryInformation pertinent to the registration of the RCTs to the proper entities & authorities.
Manuscript: Effects of vitamin supplementation on brain measuresThe deliverable will contain a manuscript describing the effects the vitamin supplementation has on MRIderived variables
Manuscript on the mediation effect of the microbiome composition and metabolism on the brain- (impulsive/compulsive) behaviour relationshipThe deliverable will contain a manuscript addressing how the relative abundance of the gut microbiome mediates on brain measures MRI based and behavior We will identify microbial communities involved in this process
Manuscript: Predictors of clinical response to nutritional interventionsThe deliverable will contain a manuscript on how effective the dietary interventions in improving clinical symptoms are as measured and controlled through the RCTs are
Manuscript on the effect of early diet (birth to 2.5y) on microbiome composition and its relation with impulsive/compulsive behaviourAge is crucial for microbiome development The deliverable will contain a manuscript describing the effect that diet on early life has on early life behavior
Manuscript: Effect of nutrition, lifestyle, microbiome and impulsivity, compulsivity on the brain (MATRICS)The deliverable will contain a manuscript addressing the relation between key microbial communities in behavior accounting for age diet and PA in the MATRICS human cohorts
Manuscript: Effects of probiotics on symptoms of impulsivity, compulsivity and aggressionThe deliverable will contain a manuscript addressing the effect of probiotics products on the risk and variation of impulsivity compulsivity and addiction
Manuscript: Effects of elimination diet on brain measuresThe deliverable will contain a manuscript addressing the effects the Restriction elimination Diet RED has on MRIderived variables
Manuscript: Novel epigenetically regulated genes following nutritional and exercise intervention in human cohortsThe deliverable will contain a manuscript addressing how diet and nutrition can modify the epigenetic regulation of candidate genes in human samples
Manuscript on the predictive power of selected diet/exercise/inflammation biomarkers for impulsive/compulsive behaviourInflammation is a key path for microbiome related effects on human behavior The deliverable will contain a manuscript on the role of candidate inflammation markers in behavior
Manuscript: Epigenetically moderated candidate genes for impulsive/compulsive and addictive behaviour in selected human cohortsWe will identify candidate genes for brain measures MRI based and maladaptive behavior that are actively modified by epigenetic processes in human cohorts Results will be summarized in a manuscript
Manuscript: Effects of supplements on symptoms of impulsivity, compulsivity and aggressionThe deliverable will contain a manuscript addressing the effect of nutritional supplements products on the risk and variation of impulsivity compulsivity and addiction
Manuscript: Analysis of joint effects of PA and nutrition on impulsive / compulsive symptoms in ECPBHSThe deliverable will contain a manuscript describing the effects of PA dietary factors as predictors of impulsivity compulsivity and addiction in the ECPBHS cohort
Manuscript: Effect of nutrition, lifestyle, microbiome and impulsivity, compulsivity on the brain (IMpACT)The deliverable will contain a manuscript addressing the relation between key microbial communities in behavior accounting for age diet and PA in the IMpACT human cohorts
Publikacje
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Nat Genet, Numer 54, 2022, Strona(/y) 1470-1478, ISSN 1061-4036
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Laura Vilar-Ribó, Cristina Sánchez-Mora, Paula Rovira, Vanesa Richarte, Montserrat Corrales, Christian Fadeuilhe, Lorena Arribas, Miquel Casas, Josep Antoni Ramos-Quiroga, Marta Ribasés, María Soler Artigas
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Numer Volume 186, Numer 3, 2020, Strona(/y) 140-150, ISSN 1552-4841
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Wiley-Liss Inc
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Georg C. Ziegler, Franziska Radtke, Maria Rosaria Vitale, André Preuße, Eva Klopocki, Stefan Herms, Klaus-Peter Lesch
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Stem Cell Research, Numer Volume 56, 2021, Strona(/y) 102526, ISSN 1873-5061
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10.1016/j.scr.2021.102526
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Testa, G.; Mora-Maltas, B.; Camacho-Barcia, L.; Granero, R.; Lucas, I.; Agüera, Z.; Jiménez-Murcia, S.; Baños, R.; Bertaina-Anglade, V.; Botella, C.; et al.
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Mol Psychiatry, Numer 27, 2022, Strona(/y) 4464–4473, ISSN 1359-4184
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Lin Li, Mark J Taylor, Katarina Bälter, Tian Xie , Berit Skretting Solberg , Jan Haavik , Alejandro Arias Vásquez , Catharina A Hartman , Henrik Larsson
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Genes, Numer 2021 Dec 24;13(1):47, 2022, ISSN 2073-4425
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Multidisciplinary Digital Publishing Institute (MDPI)
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10.3390/genes13010047
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Judit Cabana-Domínguez, Ester Antón-Galindo, Noèlia Fernàndez-Castillo, Euginia L. Singgih, Aet O’Leary, William HG Norton, Tatyana Strekalova, Annette Schenck, Andreas Reif, Klaus-Peter Lesch, David Slattery, Bru Cormand
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Neuropsychopharmacology, Numer 45/7, 2020, Strona(/y) 1188-1195, ISSN 0893-133X
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"""Strekalova, T.;
Veniaminova, E.; Svirin, E.;
Kopeikina, E.; Veremeyko, T.;
Yung, A.W.Y.; Proshin, A.; Tan, S.Z.K.;
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10.3390/biom11121759
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Carlos Gómez-Martínez; Nancy Babio; Jordi Júlvez; Stephanie K. Nishi; Fernando Fernández-Aranda; Miguel Ángel Martínez-González; Aida Cuenca-Royo; Rebeca Fernández; Susana Jiménez-Murcia; Rafael de la Torre; Xavier Pintó; Mirjam Bloemendaal; Montse Fitó; Dolores Corella; Alejandro Arias; Jordi Salas-Salvadó
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Int J. Behav Nutr Phys Act, Numer 44, 2022, ISSN 1479-5868
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BioMed Central
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10.1186/s12966-022-01335-8
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Mol Psychiatry, Numer 27, 2022, Strona(/y) 3739–3748, ISSN 1359-4184
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Weidner Magdalena T., Lardenoije Roy, Eijssen Lars, Mogavero Floriana, De Groodt Lilian P. M. T., Popp Sandy, Palme Rupert, Förstner Konrad U., Strekalova Tatyana, Steinbusch Harry W. M., Schmitt-Böhrer Angelika G., Glennon Jeffrey C., Waider Jonas, van den Hove Daniel L. A., Lesch Klaus-Peter
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Frontiers in Neuroscience, Numer VOLUME=13, 2019, ISSN 1662-453X
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10.3389/fnins.2019.00460
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Schapovalova Olesia, Gorlova Anna, de Munter Johannes, Sheveleva Elisaveta, Eropkin Mikhail, Gorbunov Nikita, Sicker Michail, Umriukhin Aleksei, Lyubchyk Sergiy, Lesch Klaus-Peter, Strekalova Tatyana, Schroeter Careen A.
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Frontiers in Medicine, Numer 9, 2022, ISSN 2296-858X
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10.3389/fmed.2022.952977
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Jip Gudden; Alejandro Arias Vasquez; Mirjam Bloemendaal
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Nutrients, Numer 13(9), 2021, Strona(/y) 3166, ISSN 2072-6643
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10.20944/preprints202108.0528.v1
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Judit Cabana-Dominguez; Laura Domingo Rodriguez; Elena Martín-García; Noèlia Fernàndez-Castillo; Rafael Maldonado; Bru Cormand
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Addiction Biology, Numer 27(5), 2022, Strona(/y) e13201, ISSN 1369-1600
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10.1111/adb.13201
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Annick Bosch, Margreet Bierens, Ardine G. de Wit, Verena Ly, Jessica van der Velde, Heleen de Boer, Gerry van Beek, Danielle Appelman, Sacha Visser, Lisa Bos, Jolanda van der Meer, Niki Kamphuis, Jos M. T. Draaisma, Rogier Donders, Gigi H. H. van de Loo-Neus, Pieter J. Hoekstra, Marco Bottelier, Alejandro Arias-Vasquez, Helen Klip, Jan K. Buitelaar, Saskia W. van den Berg & Nanda N. Rommelse
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BMC Psychiatry, 2020, ISSN 1471-244X
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10.1186/s12888-020-02576-2
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David Diouf, Maria Rosaria Vitale, Johanna Eva Maria Zöller, Ana-Magdalena Pineau, Eva Klopocki, Catharina Hamann, Georg Christoph Ziegler, Tim Vanmierlo, Daniel Van den Hove, Klaus-Peter Lesch
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Stem Cell Research, Numer 67, 2023, ISSN 1873-5061
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J Clin Invest., 2022, ISSN 0021-9738
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Niklas Kästner; S. Helene Richter; Sarah Urbanik; Joachim Kunert; Jonas Waider; Klaus-Peter Lesch; Klaus-Peter Lesch; Klaus-Peter Lesch; Sylvia Kaiser; Norbert Sachser
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Scientific Reports, Numer 9, 2019, ISSN 2045-2322
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Acta Neuropsychiatr, Numer 34(4), 2022, Strona(/y) 201-211, ISSN 0924-2708
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Frontiers in Genetics, Numer 12, 2021, ISSN 1664-8021
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Annebirth Steinmann; Alea Ruf; Kira F. Ahrens; Andreas Reif; Silke Matura
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Nutrients; Volume 14; Numer 18; Pages: 3673, Numer 38, 2022, ISSN 2072-6643
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Neural Plasticity, 2017, ISSN 1687-5443
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Hindawi Publishing Corporation
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Int. J. Mol. Sci., Numer 24(2), 2023, Strona(/y) 915, ISSN 1422-0067
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Neuroscience Applied,, Numer 1, 2022, ISSN 2772-4085
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Numer 1-15, 2023, ISSN 1552-4841
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Wiley-Liss Inc
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10.1002/ajmg.b.32926
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Neuropsychopharmacology, Numer Volume 25, Numer 12, 2022, Strona(/y) 1014-1025, ISSN 1461-1457
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Cambridge University Press
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10.1093/ijnp/pyac052
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Martínez JA, Alonso-Gómez ÁM, Gómez-Gracia E, Vioque J, Romaguera D, López-
Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem JL, Bueno-Cavanillas
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10.1002/mnfr.202101058
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Tatyana Strekalova; Evgeniy Svirin; Jonas Waider; Anna Gorlova; Raymond Cespuglio; Allan V. Kalueff; Igor Pomytkin; Angelika G. Schmitt-Boehrer; Klaus-Peter Lesch; Daniel C. Anthony; Daniel C. Anthony
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European Neuropsychopharmacology, Numer Volume 41, 2020, Strona(/y) 160-166, ISSN 0924-977X
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Frontiers in Genetics, Numer 11, 2020, ISSN 1664-8021
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, Numer Volume 86, 2018, Strona(/y) 45-51, ISSN 0278-5846
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Elsevier BV
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Psychoneuroendocrinology, Numer 150, 2023, Strona(/y) 106030, ISSN 0306-4530
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Jon-Ruben van Rhijn, Yan Shi, Maren Bormann, Britt Mossink, Monica Frega, Hatice Recaioglu, Marina Hakobjan, Teun Klein Gunnewiek, Chantal Schoenmaker, Elizabeth Palmer, Laurence Faivre, Sarah Kittel-Schneider, Dirk Schubert, Han Brunner, Barbara Franke, Nael Nadif Kasri
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Neurobiology of Disease, Numer Volume 163, 2022, Strona(/y) 105587, ISSN 0969-9961
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Jaanus Harro, Kariina Laas, Diva Eensoo, Triin Kurrikoff, Katre Sakala, Mariliis Vaht, Jüri Parik, Jarek Mäestu, Toomas Veidebaum
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Nat Genet, Numer 55, 2023, Strona(/y) 198-208, ISSN 1061-4036
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