Personalized oncolytic vaccines for cancer immunotherapy

Publikacje

Characterization of a novel OX40 ligand and CD40 ligand-expressing oncolytic adenovirus used in the PeptiCRAd cancer vaccine platform

Autorzy: Erkko Ylösmäki, Leena Ylösmäki, Manlio Fusciello, Beatriz Martins, Petra Ahokas, Hanne Cojoc, Arttu Uoti, Sara Feola, Anna Kreutzman, Tuuli Ranki, Julia Karbach, Tapani Viitala, Petri Priha, Elke Jäger, Sari Pesonen, Vincenzo Cerullo
Opublikowane w: Molecular Therapy - Oncolytics, Numer 20, 2021, Strona(/y) 459-469, ISSN 2372-7705
Wydawca: Cell Press
DOI: 10.1016/j.omto.2021.02.006

Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma

Autorzy: Jacopo Chiaro, Henna H.E. Kasanen, Thomas Whalley, Cristian Capasso, Mikaela Grönholm, Sara Feola, Karita Peltonen, Firas Hamdan, Micaela Hernberg, Siru Mäkelä, Hanna Karhapää, Paul E. Brown, Beatriz Martins, Manlio Fusciello, Erkko O. Ylösmäki, Dario Greco, Anna S. Kreutzman, Satu Mustjoki, Barbara Szomolay, Vincenzo Cerullo
Opublikowane w: Cancer Immunology Research, Numer 9/8, 2021, Strona(/y) 981-993, ISSN 2326-6066
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-20-0814

Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids

Autorzy: Firas Hamdan, Erkko Ylösmäki, Jacopo Chiaro, Yvonne Giannoula, Maeve Long, Manlio Fusciello, Sara Feola, Beatriz Martins, Michaela Feodoroff, Gabriella Antignani, Salvatore Russo, Otto Kari, Moon Hee Lee, Petrus Järvinen, Harry Nisen, Anna Kreutzman, Jeanette Leusen, Satu Mustjoki, Thomas G McWilliams, Mikaela Grönholm, Vincenzo Cerullo
Opublikowane w: Journal for ImmunoTherapy of Cancer, Numer 9/8, 2021, Strona(/y) e003000, ISSN 2051-1426
Wydawca: BMJ journal
DOI: 10.1136/jitc-2021-003000

Therapeutic Cancer Vaccination with Immunopeptidomics-Discovered Antigens Confers Protective Antitumor Efficacy

Autorzy: Karita Peltonen, Sara Feola, Husen M. Umer, Jacopo Chiaro, Georgios Mermelekas, Erkko Ylösmäki, Sari Pesonen, Rui M. M. Branca, Janne Lehtiö, Vincenzo Cerullo
Opublikowane w: Cancers, Numer 13/14, 2021, Strona(/y) 3408, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13143408

PeptiCHIP: A Microfluidic Platform for Tumor Antigen Landscape Identification

Autorzy: Sara Feola, Markus Haapala, Karita Peltonen, Cristian Capasso, Beatriz Martins, Gabriella Antignani, Antonio Federico, Vilja Pietiäinen, Jacopo Chiaro, Michaela Feodoroff, Salvatore Russo, Antti Rannikko, Manlio Fusciello, Satu Koskela, Jukka Partanen, Firas Hamdan, Sari M. Tähkä, Erkko Ylösmäki, Dario Greco, Mikaela Grönholm, Tuija Kekarainen, Masoumeh Eshaghi, Olga L. Gurvich, Seppo Ylä-H
Opublikowane w: ACS Nano, 2021, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.1c04371

GAMER-Ad: a novel and rapid method for generating recombinant adenoviruses

Autorzy: Firas Hamdan, Beatriz Martins, Michaela Feodoroff, Yvonne Giannoula, Sara Feola, Manlio Fusciello, Jacopo Chiaro, Gabriella Antignani, Mikaela Grönholm, Erkko Ylösmäki, Vincenzo Cerullo
Opublikowane w: Molecular Therapy - Methods & Clinical Development, Numer 20, 2021, Strona(/y) 625-634, ISSN 2329-0501
Wydawca: Cell Press
DOI: 10.1016/j.omtm.2021.01.014

Patient-Derived Organoids for Precision Cancer Immunotherapy

Autorzy: Mikaela Grönholm, Michaela Feodoroff, Gabriella Antignani, Beatriz Martins, Firas Hamdan, Vincenzo Cerullo
Opublikowane w: Cancer Research, Numer 81/12, 2021, Strona(/y) 3149-3155, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-4026

Expression of DAI by an oncolytic vaccinia virus boosts the immunogenicity of the virus and enhances antitumor immunity.

Autorzy: Hirvinen M, Capasso C, Guse K, Garofalo M, Vitale A, Ahonen M, Kuryk L, Vähä-Koskela M, Hemminki A, Fortino V, Greco D, Cerullo V.
Opublikowane w: Molecular Therapy oncolytics, Numer 23, 2016, Strona(/y) 3-16002, ISSN 2372-7705
Wydawca: Cell Press
DOI: 10.1038/mto.2016.2

Harnessing therapeutic viruses as a delivery vehicle for RNA-based therapy

Autorzy: Leena Ylösmäki, Beatrice Polini, Sara Carpi, Beatriz Martins, Elena Smertina, Sara Feola, Manlio Fusciello, Karita Peltonen, Paola Nieri, Erkko Ylösmäki, Vincenzo Cerullo
Opublikowane w: PLOS ONE, Numer 14/10, 2019, Strona(/y) e0224072, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0224072

A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines

Autorzy: Feola S, Chiaro J, Martins B, Russo S, Fusciello M, Ylösmäki E, Bonini C, Ruggiero E, Hamdan F, Feodoroff M, Antignani G, Viitala T, Pesonen S, Grönholm M, Branca RMM, Lehtiö J, Cerullo V.
Opublikowane w: eLIFE, Numer 2022 Mar 22;11, 2022, Strona(/y) e71156, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.71156

Oncolytic ImmunoViroTherapy: A long history of crosstalk between viruses and immune system for cancer treatment

Autorzy: Feola S., Russo S., Ylösmäki E., Cerullo V.
Opublikowane w: Pharmacology & Therapeutics, Numer 236, 2022, Strona(/y) 108103, ISSN 2468-1016
Wydawca: Elsevier - Sciencedirect
DOI: 10.1016/j.pharmthera.2021.108103

Novel personalized cancer vaccine platform based on Bacillus Calmette-Guèrin

Autorzy: Erkko Ylösmäki, Manlio Fusciello, Beatriz Martins, Sara Feola, Firas Hamdan, Jacopo Chiaro, Leena Ylösmäki, Matthew J Vaughan, Tapani Viitala, Prasad S Kulkarni, Vincenzo Cerullo
Opublikowane w: Journal for ImmunoTherapy of Cancer, Numer 9/7, 2021, Strona(/y) e002707, ISSN 2051-1426
Wydawca: BMJ Journals
DOI: 10.1136/jitc-2021-002707

Oncolytic Adenovirus Loaded with L-carnosine as Novel Strategy to Enhance the Antitumor Activity

Autorzy: Garofalo M, Iovine B, Kuryk L, Capasso C, Hirvinen M, Vitale A, Yliperttula M, Bevilacqua MA, Cerullo V.
Opublikowane w: Molecular Cancer Therapeutics, Numer 15(4), 2016, Strona(/y) 651-660, ISSN 1535-7163
Wydawca: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-15-0559

Pathogens: Our Allies against Cancer?

Autorzy: Buonaguro L, Cerullo V.
Opublikowane w: Molecular Therapy, Numer Jan 6; 29(1), 2021, Strona(/y) 10-12, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2020.12.005

β2-Integrin Adhesion Regulates Dendritic Cell Epigenetic and Transcriptional Landscapes to Restrict Dendritic Cell Maturation and Tumor Rejection

Autorzy: Guenther C, Faisal I, Fusciello M, Sokolova M, Harjunpää H, Ilander M, Tallberg R, Vartiainen MK, Alon R, Gonzalez-Granado JM, Cerullo V, Fagerholm SC.
Opublikowane w: Cancer Immunology Research, Numer 9(11), 2021, Strona(/y) 1354-1369, ISSN 2326-6074
Wydawca: AACR Journals
DOI: 10.1158/2326-6066.cir-21-0094

A novel cancer vaccine for melanoma based on an approved vaccine against measles, mumps, and rubella

Autorzy: Fusciello M, Ylösmäki E, Feola S, Uoti A, Martins B, Aalto K, Hamdan F, Chiaro J, Russo S, Viitala T, Cerullo V.
Opublikowane w: Molecular Therapy Oncolytics, Numer 2022 Apr 19;25, 2022, Strona(/y) 137-145, ISSN 2372-7705
Wydawca: Cell Press - Elsevier
DOI: 10.1016/j.omto.2022.04.002

A novel in silico framework to improve MHC-I epitopes and break the tolerance to melanoma

Autorzy: Cristian Capasso, Aniket Magarkar, Victor Cervera-Carrascon, Manlio Fusciello, Sara Feola, Martin Muller, Mariangela Garofalo, Lukasz Kuryk, Siri Tähtinen, Lucio Pastore, Alex Bunker, Vincenzo Cerullo
Opublikowane w: OncoImmunology, Numer 6/9, 2017, Strona(/y) e1319028, ISSN 2162-402X
Wydawca: Taylor & Francis
DOI: 10.1080/2162402X.2017.1319028

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses

Autorzy: Erkko Ylösmäki, Cristina Malorzo, Cristian Capasso, Oona Honkasalo, Manlio Fusciello, Beatriz Martins, Leena Ylösmäki, Antti Louna, Sara Feola, Henrik Paavilainen, Karita Peltonen, Veijo Hukkanen, Tapani Viitala, Vincenzo Cerullo
Opublikowane w: Molecular Therapy, Numer 26/9, 2018, Strona(/y) 2315-2325, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.06.008

Oncolytic vaccines increase the response to PD-L1 blockade in immunogenic and poorly immunogenic tumors

Autorzy: S. Feola, C. Capasso, M. Fusciello, B. Martins, S. Tähtinen, M. Medeot, S. Carpi, F. Frascaro, E. Ylosmäki, K. Peltonen, L. Pastore, V. Cerullo
Opublikowane w: OncoImmunology, 2018, Strona(/y) e1457596, ISSN 2162-402X
Wydawca: Taylor & Francis
DOI: 10.1080/2162402x.2018.1457596

Oncolytic adenoviruses coated with MHC-I tumor epitopes increase the antitumor immunity and efficacy against melanoma

Autorzy: Cristian Capasso, Mari Hirvinen, Mariangela Garofalo, Dmitrii Romaniuk, Lukasz Kuryk, Teea Sarvela, Andrea Vitale, Maxim Antopolsky, Aniket Magarkar, Tapani Viitala, Teemu Suutari, Alex Bunker, Marjo Yliperttula, Arto Urtti, Vincenzo Cerullo
Opublikowane w: OncoImmunology, Numer 5/4, 2015, Strona(/y) e1105429, ISSN 2162-402X
Wydawca: Taylor & Francis online
DOI: 10.1080/2162402X.2015.1105429

Artificially cloaked viral nanovaccine for cancer immunotherapy

Autorzy: Manlio Fusciello, Flavia Fontana, Siri Tähtinen, Cristian Capasso, Sara Feola, Beatriz Martins, Jacopo Chiaro, Karita Peltonen, Leena Ylösmäki, Erkko Ylösmäki, Firas Hamdan, Otto K. Kari, Joseph Ndika, Harri Alenius, Arto Urtti, Jouni T. Hirvonen, Hélder A. Santos, Vincenzo Cerullo
Opublikowane w: Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-019-13744-8

Oncolytic adenovirus drives specific immune response generated by a poly-epitope pDNA vaccine encoding melanoma neoantigens into the tumor site

Autorzy: Alessandra Lopes, Sara Feola, Sophie Ligot, Manlio Fusciello, Gaëlle Vandermeulen, Véronique Préat, Vincenzo Cerullo
Opublikowane w: Journal for ImmunoTherapy of Cancer, Numer 7/1, 2019, ISSN 2051-1426
Wydawca: BMC part of Spring Nature
DOI: 10.1186/s40425-019-0644-7

Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor

Autorzy: Flavia Fontana, Manlio Fusciello, Christianne Groeneveldt, Cristian Capasso, Jacopo Chiaro, Sara Feola, Zehua Liu, Ermei M. Mäkilä, Jarno J. Salonen, Jouni T. Hirvonen, Vincenzo Cerullo, Hélder A. Santos
Opublikowane w: ACS Nano, Numer 13/6, 2019, Strona(/y) 6477-6490, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.8b09613

Exploiting pre-existing immunity to enhance oncolytic cancer immunotherapy

Autorzy: Siri Tähtinen, Sara Feola, Cristian Capasso, Netta Laustio, Christianne Groeneveldt, Erkko O Ylösmäki, Leena Ylösmäki, Beatriz Martins, Manlio Fusciello, Marta Medeot, Maria Tagliamonte, Jacopo Chiaro, Firas Hamdan, Karita Peltonen, Tuuli Ranki, Luigi Buonaguro, Vincenzo Cerullo
Opublikowane w: Cancer Research, 2020, Strona(/y) canres.2062.2019, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-2062

Design and application of oncolytic viruses for cancer immunotherapy

Autorzy: Erkko Ylösmäki, Vincenzo Cerullo
Opublikowane w: Current Opinion in Biotechnology, Numer 65, 2020, Strona(/y) 25-36, ISSN 0958-1669
Wydawca: Elsevier BV
DOI: 10.1016/j.copbio.2019.11.016

Circulating microRNAs as biomarkers for early diagnosis of cutaneous melanoma

Autorzy: Sara Carpi, Beatrice Polini, Stefano Fogli, Adriano Podestà, Erkko Ylösmäki, Vincenzo Cerullo, Antonella Romanini, Paola Nieri
Opublikowane w: Expert Review of Molecular Diagnostics, Numer 20/1, 2020, Strona(/y) 19-30, ISSN 1473-7159
Wydawca: Future Drugs Ltd.
DOI: 10.1080/14737159.2020.1696194

Peptides-Coated Oncolytic Vaccines for Cancer Personalized Medicine

Autorzy: Feola S, Russo S, Martins B, Lopes A, Vandermeulen G, Fluhler V, De Giorgi C, Fusciello M, Pesonen S, Ylösmäki E, Antignani G, Chiaro J, Hamdan F, Feodoroff M, Grönholm M, Cerullo V.
Opublikowane w: Frontiers Immunology, Numer 14 April 2022; 13, 2022, Strona(/y) 826164, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2022.826164

Uncovering the Tumor Antigen Landscape: What to Know about the Discovery Process

Autorzy: Sara Feola, Jacopo Chiaro, Beatriz Martins, Vincenzo Cerullo
Opublikowane w: Cancers, Numer 12/6, 2020, Strona(/y) 1660, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061660

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