European AIDS Vaccine Initiative 2020

Rezultaty

EAVI2020 Public Events:

Two major events (M30 & M72) will be organised to disseminate project results and share its main findings across relevant stakeholders, i.e. clinical communities and patients

EAVI2020 Publications

Submission of up to 100 peerreviewed publications during the programme

Marketing and Dissemination Kit

Marketing and promotional materials developed for the EAVI2020 project, activities and outcomes.

EAVI2020 Website

EAVI2020 main platform for knowledge sharing and promotional activities

Up-selection of optimal T cell vaccine regimen

Up-selection of optimal T cell vaccine regimen according to breadth, potency and durability of cellular antiviral response

Up-selection of optimal humoral vaccine regimen

Upselection of optimal humoral vaccine regimen according to breadth potency and durability of induced antiviral Abs

Report on EAVI2020 training program

Report on outcomes of EAVI2020 training program

Publikacje

TL1A–DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1–Specific T Cell Responses

Autorzy: Bruna Oriol-Tordera, Alex Olvera, Clara Duran-Castells, Anuska Llano, Beatriz Mothe, Marta Massanella, Judith Dalmau, Carmela Ganoza, Jorge Sanchez, Maria Luz Calle, Bonaventura Clotet, Javier Martinez-Picado, Eugènia Negredo, Julià Blanco, Dennis Hartigan-O'Connor, Christian Brander, Marta Ruiz-Riol
Opublikowane w: The Journal of Immunology, Numer 205/12, 2020, Strona(/y) 3348-3357, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.2000933

Development and Preclinical Evaluation of an Integrase Defective Lentiviral Vector Vaccine Expressing the HIVACAT T Cell Immunogen in Mice

Autorzy: Alessandra Gallinaro, Martina Borghi, Maria Franca Pirillo, Serena Cecchetti, Roberta Bona, Andrea Canitano, Zuleika Michelini, Antonio Di Virgilio, Alex Olvera, Christian Brander, Donatella Negri, Andrea Cara
Opublikowane w: Molecular Therapy - Methods & Clinical Development, Numer 17, 2020, Strona(/y) 418-428, ISSN 2329-0501
Wydawca: Elsevier
DOI: 10.1016/j.omtm.2020.01.013

Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy

Autorzy: Morante V, Borghi M, Farina I, Michelini Z, Grasso F, Gallinaro A, Cecchetti S, Di Virgilio A, Canitano A, Pirillo MF, Bona R, Cara A, Negri D
Opublikowane w: Viruses, 2021, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13020355

Strategies for Immunomonitoring after Vaccination and during Infection

Autorzy: Adam L, Rosenbaum P, Bonduelle O, Combadière B
Opublikowane w: MDPI Vaccines, 2021, ISSN 2076-393X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9040365

Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control

Autorzy: Bruna Oriol-Tordera, Maria Berdasco, Anuska Llano, Beatriz Mothe, Cristina Gálvez, Javier Martinez-Picado, Jorge Carrillo, Julià Blanco, Clara Duran-Castells, Carmela Ganoza, Jorge Sanchez, Bonaventura Clotet, Maria Luz Calle, Alex Sánchez-Pla, Manel Esteller, Christian Brander, Marta Ruiz-Riol
Opublikowane w: PLOS Pathogens, Numer 16/8, 2020, Strona(/y) e1008678, ISSN 1553-7374
Wydawca: Public Library of Science San Francisco
DOI: 10.1371/journal.ppat.1008678

Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes

Autorzy: Dominik Damm, Ehsan Suleiman, Hannah Theobald, Jannik T. Wagner, Mirjam Batzoni, Bianca Ahlfeld, Bernd Walkenfort, Jens-Christian Albrecht, Jidnyasa Ingale, Lifei Yang, Mike Hasenberg, Richard T. Wyatt, Karola Vorauer-Uhl, Klaus Überla, Vladimir Temchura
Opublikowane w: Pharmaceutics, 2022, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071385

Innate cell markers that predict anti-HIV neutralizing antibody titers in vaccinated macaques.

Autorzy: Van Tilbeurgh M, Maisonnasse P, Palgen JL, Tolazzi M, Aldon Y, Dereuddre-Bosquet N, Cavarelli M, Beignon AS, Marcos-Lopez E, Gallouet AS, Gilson E, Ozorowski G, Ward AB, Bontjer I, McKay PF, Shattock RJ, Scarlatti G, Sanders RW, Le Grand R
Opublikowane w: Cell Reports Medicine, 2022, ISSN 2666-3791
Wydawca: Cell Press Elsevier
DOI: 10.1016/j.xcrm.2022.100751

Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques

Autorzy: Maria Blasi, Elizabeth C. Wescott, Erich J. Baker, Benjamin Mildenberg, Celia LaBranche, Wes Rountree, Barton F. Haynes, Kevin O. Saunders, M. Anthony Moody, Donatella Negri, Sampa Santra, Andrea Cara, Mary E. Klotman
Opublikowane w: npj Vaccines, Numer 5/1, 2020, Strona(/y) 1--9, ISSN 2059-0105
Wydawca: Nature Publishing Group
DOI: 10.1038/s41541-020-0186-5

Intramolecular quality control: HIV-1 Envelope gp160 signal-peptide cleavage as a functional folding checkpoint.

Autorzy: Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Van der Woude P, De Taeye SW, Van den Kerkhof TLGM, Klasse PJ, Ozorowski G, Van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Opublikowane w: Cell Reports, 2021, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2021.109646

Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms

Autorzy: Philip J.M. Brouwer, Rogier W. Sanders
Opublikowane w: Current Opinion in HIV and AIDS, Numer 14/4, 2019, Strona(/y) 302-308, ISSN 1746-630X
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/coh.0000000000000549

Structure-guided envelope trimer design in HIV-1 vaccine development: a narrative review

Autorzy: Derking R, Sanders RW
Opublikowane w: Journal of the International AIDS Society, 2021, ISSN 1758-2652
Wydawca: International AIDS Society
DOI: 10.1002/jia2.25797

Specificity of CD8+ T-Cell Responses Following Vaccination with Conserved Regions of HIV-1 in Nairobi, Kenya

Autorzy: Yehia S. Mohamed, Nicola J. Borthwick, Nathifa Moyo, Hayato Murakoshi, Tomohiro Akahoshi, Francesca Siliquini, Zara Hannoun, Alison Crook, Peter Hayes, Patricia E. Fast, Gaudensia Mutua, Walter Jaoko, Sandra Silva-Arrieta, Anuska Llano, Christian Brander, Masafumi Takiguchi, Tomáš Hanke
Opublikowane w: Vaccines, Numer 8/2, 2020, Strona(/y) 260, ISSN 2076-393X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8020260

Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein

Autorzy: Jelle van Schooten, Elinaz Farokhi, Anna Schorcht, Tom L. G. M. van den Kerkhof, Hongmei Gao, Patricia van der Woude, Judith A. Burger, Tim G. Rijkhold Meesters, Tom Bijl, Riham Ghalaiyini, Hannah L. Turner, Jessica Dorning, Barbera D. C. van Schaik, Antoine H. C. van Kampen, Celia C. Labranche, Robyn L. Stanfield, Devin Sok, David C. Montefiori, Dennis R. Burton, Michael S. Seaman, Gabriel Ozorow
Opublikowane w: Nature communications, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-32208-0

Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates

Autorzy: Jelle van Schooten, Ilja C. Bontjer, J. A. Burger, Rogier W. Sanders, Marit J. van Gils
Opublikowane w: NPJ Vaccines, 2022, ISSN 2059-0105
Wydawca: Nature Research
DOI: 10.1038/s41541-022-00576-9

Novel Approaches Towards a Functional Cure of HIV/AIDS

Autorzy: Lucia Bailon, Beatriz Mothe, Lance Berman, Christian Brander
Opublikowane w: Drugs, Numer 80/9, 2020, Strona(/y) 859-868, ISSN 0012-6667
Wydawca: Adis International Ltd.
DOI: 10.1007/s40265-020-01322-y

Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity

Autorzy: Yi-Yu Lin, Ian Belle, Maria Blasi, Min-Nung Huang, Anne F. Buckley, Wes Rountree, Mary E. Klotman, Andrea Cara, Donatella Negri
Opublikowane w: Molecular Therapy - Methods & Clinical Development, Numer 17, 2020, Strona(/y) 532-544, ISSN 2329-0501
Wydawca: Elsevier
DOI: 10.1016/j.omtm.2020.03.008

Glycans in HIV-1 vaccine design – engaging the shield

Autorzy: Deimel LP, Xue X, Sattentau QJ
Opublikowane w: Trends in Microbiology, 2022, ISSN 0966-842X
Wydawca: Elsevier BV
DOI: 10.1016/j.tim.2022.02.004

Novel Nested Peptide Epitopes Recognized by CD4+ T Cells Induced by HIV-1 Conserved-Region Vaccines

Autorzy: Nicola Borthwick, Sandra Silva-Arrieta, Anuska Llano, Masafumi Takiguchi, Christian Brander, Tomáš Hanke
Opublikowane w: Vaccines, Numer 8/1, 2020, Strona(/y) 28, ISSN 2076-393X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8010028

Dichotomy in Neutralizing Antibody Induction to Peptide-Conjugated Vaccine in Squalene Emulsion Contrast With Aluminum Hydroxide Formulation

Autorzy: Bonduelle O, Chaudesaigues C, Tolazzi M, Suleiman E, De Bernard S, Alves K, Nourikyan J, Bohec M, Baudrin LG, Katinger D, Debré P, Scarlatti G, Vieillard V, Combadiere B
Opublikowane w: Frontiers in Immunology, 2022, ISSN 1664-3224
Wydawca: Frontiers Media
DOI: 10.3389/fimmu.2022.848571

Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein

Autorzy: M. M. van Haaren, L. E. McCoy, J. L. Torres, W. Lee, C. A. Cottrell, J. L. Copps, P. van der Woude, A. Yasmeen, S. W. de Taeye, A. Torrents de la Peña, J. P. Moore, D. R. Burton, P. J. Klasse, A. B. Ward, R. W. Sanders, M. J. van Gils
Opublikowane w: Journal of Virology, 2021, ISSN 1098-5514
Wydawca: American Society for Microbiology
DOI: 10.1128/jvi.00094-21

Transcriptome Sequencing of Peripheral Blood Mononuclear Cells from Elite Controller-Long Term Non Progressors

Autorzy: Francisco Díez-Fuertes, Humberto Erick De La Torre-Tarazona, Esther Calonge, Maria Pernas, María del Mar Alonso-Socas, Laura Capa, Javier García-Pérez, Anavaj Sakuntabhai, José Alcamí
Opublikowane w: Scientific Reports, Numer 9/1, 2019, Strona(/y) 1--13, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-50642-x

Immunogenicity, safety, and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs

Autorzy: Maria Blasi, Donatella Negri, Kevin O. Saunders, Erich J. Baker, Hannah Stadtler, Celia LaBranche, Benjamin Mildenberg, Georgeanna Morton, Andrew Ciarla, Xiaoying Shen, Yunfei Wang, Wes Rountree, Bala Balakumaran, Sampa Santra, Barton F. Haynes, Anthony M. Moody, Andrea Cara, Mary E. Klotman
Opublikowane w: npj Vaccines, Numer 5/1, 2020, Strona(/y) 1--12, ISSN 2059-0105
Wydawca: Nature Publishing Group
DOI: 10.1038/s41541-020-00252-w

Comparison of blood and lymph node cells after intramuscular injection with HIV envelope immunogens

Autorzy: Suzanne Day, Charandeep Kaur, Hannah M. Cheeseman, Emily de Groot, Leon R. McFarlane, Maniola Tanaka, Sofia Coelho, Tom Cole, Nana-Marie Lemm, Adrian Lim, Rogier W. Sanders, Becca Asquith, Robin J. Shattock and Katrina M. Pollock
Opublikowane w: Frontiers in Immunology, 2022, ISSN 1664-3224
Wydawca: Frontiers Media
DOI: 10.3389/fimmu.2022.991509

In vivo Effects of Romidepsin on T-Cell Activation, Apoptosis and Function in the BCN02 HIV-1 Kick&Kill Clinical Trial

Autorzy: Miriam Rosás-Umbert, Marta Ruiz-Riol, Marco A. Fernández, Marta Marszalek, Pep Coll, Christian Manzardo, Samandhy Cedeño, José M. Miró, Bonaventura Clotet, Tomáš Hanke, José Moltó, Beatriz Mothe, Christian Brander
Opublikowane w: Frontiers in Immunology, Numer 11, 2020, Strona(/y) 418, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2020.00418

Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

Autorzy: Sliepen KHEWJ, Bontjer IC, Burger JA, Brouwer PJM, Sanders RW
Opublikowane w: npj Vaccines, 2021, ISSN 2059-0105
Wydawca: Springer Nature
DOI: 10.1038/s41541-021-00364-x

Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope

Autorzy: Aguado-Garcia D, Olvera A, Brander C, Sanchez-Merino V, and Yuste E
Opublikowane w: Vaccines, 2022, ISSN 2076-393X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10040484

Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers

Autorzy: Gallinaro A, Pirillo MF, Aldon Y, Cecchetti S, Michelini Z, Tinari A, Borghi M, Canitano A, McKay PF, Bona R, Vescio MF, Grasso F, Blasi M, Baroncelli S, Scarlatti G, LaBranche C, Montefiori D, Klotman ME, Sanders RW, Shattock RJ, Negri D, Cara A
Opublikowane w: npj Vaccines, 2022, ISSN 2059-0105
Wydawca: Springer Nature
DOI: 10.1038/s41541-022-00465-1

HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)

Autorzy: Beatriz Mothe, Miriam Rosás-Umbert, Pep Coll, Christian Manzardo, Maria C. Puertas, Sara Morón-López, Anuska Llano, Cristina Miranda, Samandhy Cedeño, Miriam López, Yovaninna Alarcón-Soto, Guadalupe Gómez Melis, Klaus Langohr, Ana M. Barriocanal, Jessica Toro, Irene Ruiz, Cristina Rovira, Antonio Carrillo, Michael Meulbroek, Alison Crook, Edmund G. Wee, Jose M. Miró, Bonaventura Clotet, Ma
Opublikowane w: Frontiers in Immunology, Numer 11, 2020, Strona(/y) 823, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2020.00823

Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates

Autorzy: Jelle van Schooten, Marlies M. van Haaren, Hui Li, Laura E. McCoy, Colin Havenar-Daughton, Christopher A. Cottrell, Judith A. Burger, Patricia van der Woude, Leanne C. Helgers, Ilhan Tomris, Celia C. Labranche, David C. Montefiori, Andrew B. Ward, Dennis R. Burton, John P. Moore, Rogier W. Sanders, Shane Crotty, George M. Shaw, Marit J. van Gils
Opublikowane w: PLOS Pathogens, 2021, ISSN 1553-7366
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1009736

Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival

Autorzy: Dispinseri S, Secchi M, Pirillo MF, Tolazzi M, Borghi M, Brigatti C, De Angelis ML, Baratella M, Bazzigaluppi E, Venturi G, Sironi F, Canitano A, Marzinotto I, Tresoldi C, Ciceri F, Piemonti L, Negri D, Cara A, Lampasona V, Scarlatti G
Opublikowane w: Nature communications, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-22958-8

Strategies for inducing effective neutralizing antibody responses against HIV-1

Autorzy: Iván del Moral-Sánchez, Kwinten Sliepen
Opublikowane w: Expert Review of Vaccines, Numer 18/11, 2019, Strona(/y) 1127-1143, ISSN 1476-0584
Wydawca: Future Drugs Ltd.
DOI: 10.1080/14760584.2019.1690458

Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections

Autorzy: Luis Romero-Martin, Clara Duran-Castells, Mireia Olivella, Mı´riam Rosas-Umbert, Marta Ruiz-Riol, Jorge Sanchez, Dennis Hartigan-O´Connor, Beatriz Mothe, Àlex Olvera and Christian Brander
Opublikowane w: Frontiers in Immunology, 2022, ISSN 1664-3224
Wydawca: Frontiers Media
DOI: 10.3389/fimmu.2022.1027855

Safety and efficiency modifications of SIV-based integrase-defective lentiviral vectors for immunization

Autorzy: Bona R, Michelini Z, Mazzei C, Gallinaro A, Canitano A, Borghi M, Vescio MF, Di Virgilio A, Pirillo MF, Klotman ME, Negri D, Cara A
Opublikowane w: Molecular Therapy: Methods & Clinical Development, 2021, ISSN 2329-0501
Wydawca: Cell Press, Elsevier Inc
DOI: 10.1016/j.omtm.2021.09.011

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

Autorzy: Philip J. M. Brouwer, Aleksandar Antanasijevic, Marlon de Gast, Joel D. Allen, Tom P. L. Bijl, Anila Yasmeen, Rashmi Ravichandran, Judith A. Burger, Gabriel Ozorowski, Jonathan L. Torres, Celia LaBranche, David C. Montefiori, Rajesh P. Ringe, Marit J. van Gils, John P. Moore, Per Johan Klasse, Max Crispin, Neil P. King, Andrew B. Ward, Rogier W. Sanders
Opublikowane w: npj Vaccines, Numer 6/1, 2021, Strona(/y) 1-14, ISSN 2059-0105
Wydawca: Nature Publishing Group
DOI: 10.1038/s41541-021-00285-9

Genetic Co-Administration of Soluble PD-1 Ectodomains Modifies Immune Responses against Influenza A Virus Induced by DNA Vaccination

Autorzy: Pierre Tannig, Antonia Sophia Peter, Dennis Lapuente, Stephan Klessing, Anna Schmidt, Dominik Damm, Matthias Tenbusch, Klaus Überla, Vladimir Temchura
Opublikowane w: Vaccines, Numer 8/4, 2020, Strona(/y) 570, ISSN 2076-393X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040570

Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans

Autorzy: Huettner I, Krumm SA, Serna S, Brzezicka K, Monaco S, Walpole S, van Diepen A, Allan F, Hicks T, Kimuda S, Emery AM, IAVI Protocol C Investigators & The IAVI African HIV Research Network, Landais E, Hokke CH, Angulo J, Reichardt N, Doores KJ
Opublikowane w: Cell Reports, 2022, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.110611

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Autorzy: Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker,
Opublikowane w: Nature communications, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-25087-4

In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction

Autorzy: Sandra Silva-Arrieta, Philip J. R. Goulder, Christian Brander
Opublikowane w: PLOS Pathogens, Numer 16/6, 2020, Strona(/y) e1008607, ISSN 1553-7374
Wydawca: Public Library of Science San Francisco
DOI: 10.1371/journal.ppat.1008607

CD4+ T Cells Induced by Tuberculosis Subunit Vaccine H1 Can Improve the HIV-1 Env Humoral Response by Intrastructural Help

Autorzy: Stephan Klessing, Vladimir Temchura, Pierre Tannig, Antonia Sophia Peter, Dennis Christensen, Roland Lang, Klaus Überla
Opublikowane w: Vaccines, Numer 8/4, 2020, Strona(/y) 604, ISSN 2076-393X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040604

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

Autorzy: Anna K. Blakney, Paul F. McKay, Bárbara Ibarzo Yus, Yoann Aldon, Robin J. Shattock
Opublikowane w: Gene Therapy, Numer 26/9, 2019, Strona(/y) 363-372, ISSN 0969-7128
Wydawca: Nature Publishing Group
DOI: 10.1038/s41434-019-0095-2

Incoming HIV virion-derived Gag Spacer Peptide 2 (p1) is a target of effective CD8+ T cell antiviral responses

Autorzy: Yang H, Llano A, Cedeño S, von Delft A, Corcuera A, Gillespie GM, Knox A, Leneghan DB, Frater J, Stöhr W, Fidler S, Mothe B, Mak J, Brander C, Ternette N, Dorrell L
Opublikowane w: Cell Reports, 2021, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2021.109103

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

Autorzy: Christophe Caillat, Delphine Guilligay, Johana Torralba, Nikolas Friedrich, Jose L Nieva, Alexandra Trkola, Christophe J Chipot, François L Dehez, Winfried Weissenhorn
Opublikowane w: eLife, Numer 10, 2021, Strona(/y) e65005, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.65005

T-Follicular-Like CD8+ T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG

Autorzy: Luis Romero-Martin, Ferran Tarres-Freixas, Nuria Pedreño-Lopez, Maria L. Rodriguez de la Concepcio, Francesc Cunyat, Dennis Hartigan-O'Connor, Jorge Carrillo, Beatriz Mothe, Julià Blanco, Marta Ruiz-Riol, Christian Brander and Alex Olvera
Opublikowane w: Frontiers in Immunology, 2022, ISSN 1664-3224
Wydawca: Frontiers Media
DOI: 10.3389/fimmu.2022.928039

Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers

Autorzy: Anna Schorcht, Tom L. G. M. van den Kerkhof, Christopher A. Cottrell, Joel D. Allen, Jonathan L. Torres, Anna-Janina Behrens, Edith E. Schermer, Judith A. Burger, Steven W. de Taeye, Alba Torrents de la Peña, Ilja Bontjer, Stephanie Gumbs, Gabriel Ozorowski, Celia C. LaBranche, Natalia de Val, Anila Yasmeen, Per Johan Klasse, David C. Montefiori, John P. Moore, Hanneke Schuitemaker, Max Crispin,
Opublikowane w: Journal of Virology, Numer 94/24, 2020, Strona(/y) volume={94}, number={24}, year={2020},, ISSN 0022-538X
Wydawca: American Society for Microbiology
DOI: 10.1128/jvi.01214-20

Design Concepts of Virus-Like Particle-Based HIV-1 Vaccines

Autorzy: Chun-Wei Chen, Narcís Saubi, Joan Joseph-Munné
Opublikowane w: Frontiers in Immunology, Numer 11, 2020, Strona(/y) 573157, ISSN 1664-3224
Wydawca: Frontiers Media
DOI: 10.3389/fimmu.2020.573157

Neutralizing Antibodies Targeting HIV-1 gp41

Autorzy: Christophe Caillat, Delphine Guilligay, Guidenn Sulbaran, Winfried Weissenhorn
Opublikowane w: Viruses, Numer 12/11, 2020, Strona(/y) 1210, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12111210

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

Autorzy: Ronald Derking, Joel D. Allen, Christopher A. Cottrell, Kwinten Sliepen, Gemma E. Seabright, Wen-Hsin Lee, Yoann Aldon, Kimmo Rantalainen, Aleksandar Antanasijevic, Jeffrey Copps, Anila Yasmeen, Albert Cupo, Victor M. Cruz Portillo, Meliawati Poniman, Niki Bol, Patricia van der Woude, Steven W. de Taeye, Tom L.G.M. van den Kerkhof, P.J. Klasse, Gabriel Ozorowski, Marit J. van Gils, John P. Moore,
Opublikowane w: Cell Reports, Numer 35/1, 2021, Strona(/y) 108933, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2021.108933

Chimeric Human Papillomavirus-16 Virus-like Particles Presenting P18I10 and T20 Peptides from HIV-1 Envelope Induce HPV16 and HIV-1-Specific Humoral and T Cell-Mediated Immunity in BALB/c Mice

Autorzy: Jelle van Schooten, Ilja C. Bontjer, J. A. Burger, Rogier W. Sanders, Marit J. van Gils
Opublikowane w: Vaccines, 2022, ISSN 2076-393X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11010015

Host Transcriptome and Microbiota Signatures Prior to Immunization Profile Vaccine Humoral Responsiveness

Autorzy: Goncalves E, Guillen Y, Lama JR, Sanchez J, Brander C, Paredes R and Combadière B
Opublikowane w: Frontiers in Immunology, 2021, ISSN 1664-3224
Wydawca: Frontiers Media
DOI: 10.3389/fimmu.2021.657162

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines

Autorzy: Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, Tomáš Hanke
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Benzyl-2-Acetamido-2-Deoxy-α-d-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy In Vitro

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